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Arun Prakash, MD, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentAnesthesia
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    Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion
    NIH K08GM110497Feb 1, 2015 - Jan 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. PMID: 26196836; PMCID: PMC4537678 [Available on 09/01/16].
    2. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Sci Signal. 2015 Aug 25; 8(391):ra86. PMID: 26307013.
      View in: PubMed
    3. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1; 308(11):L1102-13. PMID: 25795726; PMCID: PMC4451399 [Available on 06/01/16].
    4. Zhang N, Francis KP, Prakash A, Ansaldi D. Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles. Nat Med. 2013 Apr; 19(4):500-5. PMID: 23455711.
      View in: PubMed
    5. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Anesthesiology. 2012 Oct; 117(4):822-35. PMID: 22890118; PMCID: PMC3477877.
    6. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012 Aug; 18(4):602-16. PMID: 22186927; PMCID: PMC3444510.
    7. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol. 2011 Jan 15; 186(2):1119-30. PMID: 21169547; PMCID: PMC3482611.
    8. Prakash A, Hellman J. Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. J Leukoc Biol. 2010 Oct; 88(4):605-7. PMID: 20884653.
      View in: PubMed
    9. Prakash A, Levy DE. Regulation of IRF7 through cell type-specific protein stability. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):50-6. PMID: 16472772; PMCID: PMC1647301.
    10. Prakash A, Smith E, Lee CK, Levy DE. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J Biol Chem. 2005 May 13; 280(19):18651-7. PMID: 15767254; PMCID: PMC1167601.
    11. Levy DE, Marié I, Prakash A. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Curr Opin Immunol. 2003 Feb; 15(1):52-8. PMID: 12495733.
      View in: PubMed
    12. Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem. 2002 Dec 20; 277(51):49417-21. PMID: 12374802.
      View in: PubMed
    13. Levy DE, Marié I, Smith E, Prakash A. Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. J Interferon Cytokine Res. 2002 Jan; 22(1):87-93. PMID: 11846979.
      View in: PubMed
    14. Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem. 2001 Mar 23; 276(12):8951-7. PMID: 11124948.
      View in: PubMed
    15. Marié I, Smith E, Prakash A, Levy DE. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol. 2000 Dec; 20(23):8803-14. PMID: 11073981; PMCID: PMC86519.
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