Arun Prakash, MD, PhD

Title(s)Associate Professor, Anesthesia
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-1424-0932 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Rochester, Rochester, NYBachelors of Science/Arts06/1996Chemistry/History
    New York University School of Medicine, New York, NYMD/PhD06/2005Medicine/Immunology
    Santa Clara Valley Medical Center, San Jose, CA06/2006Internship in Internal Medicine
    University of California San Francisco, San Francisco, CA07/2009Anesthesiology
    University of California San Francisco, San Francisco, CA07/2011Post-doctoral Fellowship/Clinical Instructor

    Collapse Research 
    Collapse Research Activities and Funding
    Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion
    NIH K08GM110497Feb 1, 2015 - Jan 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A. NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Front Immunol. 2017; 8:1337. PMID: 29163464.
      View in: PubMed
    2. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475. PMID: 28701511.
      View in: PubMed
    3. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. PMID: 26196836.
      View in: PubMed
    4. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Sci Signal. 2015 Aug 25; 8(391):ra86. PMID: 26307013.
      View in: PubMed
    5. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. PMID: 25795726.
      View in: PubMed
    6. Zhang N, Francis KP, Prakash A, Ansaldi D. Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles. Nat Med. 2013 Apr; 19(4):500-5. PMID: 23455711.
      View in: PubMed
    7. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Anesthesiology. 2012 Oct; 117(4):822-35. PMID: 22890118.
      View in: PubMed
    8. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012 Aug; 18(4):602-16. PMID: 22186927.
      View in: PubMed
    9. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol. 2011 Jan 15; 186(2):1119-30. PMID: 21169547.
      View in: PubMed
    10. Prakash A, Hellman J. Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. J Leukoc Biol. 2010 Oct; 88(4):605-7. PMID: 20884653.
      View in: PubMed
    11. Prakash A, Levy DE. Regulation of IRF7 through cell type-specific protein stability. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):50-6. PMID: 16472772.
      View in: PubMed
    12. Prakash A, Smith E, Lee CK, Levy DE. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J Biol Chem. 2005 May 13; 280(19):18651-7. PMID: 15767254.
      View in: PubMed
    13. Levy DE, Marié I, Prakash A. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Curr Opin Immunol. 2003 Feb; 15(1):52-8. PMID: 12495733.
      View in: PubMed
    14. Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem. 2002 Dec 20; 277(51):49417-21. PMID: 12374802.
      View in: PubMed
    15. Levy DE, Marié I, Smith E, Prakash A. Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. J Interferon Cytokine Res. 2002 Jan; 22(1):87-93. PMID: 11846979.
      View in: PubMed
    16. Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem. 2001 Mar 23; 276(12):8951-7. PMID: 11124948.
      View in: PubMed
    17. Marié I, Smith E, Prakash A, Levy DE. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol. 2000 Dec; 20(23):8803-14. PMID: 11073981.
      View in: PubMed