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Arun Prakash, MD, PhD

Title(s)Associate Professor, Anesthesia
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-1424-0932 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Rochester, Rochester, NYBachelors of Science/Arts06/1996Chemistry/History
    New York University School of Medicine, New York, NYMD/PhD06/2005Medicine/Immunology
    Santa Clara Valley Medical Center, San Jose, CA06/2006Internship in Internal Medicine
    University of California San Francisco, San Francisco, CA07/2009Anesthesiology
    University of California San Francisco, San Francisco, CA07/2011Post-doctoral Fellowship/Clinical Instructor

    Collapse Research 
    Collapse Research Activities and Funding
    The Gut-Lung Axis: Immunometabolism Linking the Gut Microbiome and Lung Imunity
    NIH R01HL146753Feb 15, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion
    NIH K08GM110497Feb 1, 2015 - Jan 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology. J Trauma Acute Care Surg. 2020 06; 88(6):742-751. Kornblith LZ, Bainton CMV, Fields AT, Matthay ZA, Magid NT, Nunez-Garcia B, Prakash A, Kurien PA, Callcut RA, Cohen MJ, Bainton RJ. PMID: 32195992.
      View in: PubMed   Mentions:    Fields:    
    2. Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Front Microbiol. 2019; 10:518. Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A. PMID: 30972040.
      View in: PubMed   Mentions:
    3. Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Front Microbiol. 2019; 10:159. Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A. PMID: 30891007.
      View in: PubMed   Mentions:
    4. NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Front Immunol. 2017; 8:1337. Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A. PMID: 29163464.
      View in: PubMed   Mentions: 6     Fields:    
    5. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. PMID: 28701511.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. PMID: 26196836.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    7. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Sci Signal. 2015 Aug 25; 8(391):ra86. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J. PMID: 26307013.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. PMID: 25795726.
      View in: PubMed   Mentions:
    9. Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles. Nat Med. 2013 Apr; 19(4):500-5. Zhang N, Francis KP, Prakash A, Ansaldi D. PMID: 23455711.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    10. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Anesthesiology. 2012 Oct; 117(4):822-35. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J. PMID: 22890118.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    11. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012 Aug; 18(4):602-16. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J. PMID: 22186927.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    12. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol. 2011 Jan 15; 186(2):1119-30. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J. PMID: 21169547.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    13. Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. J Leukoc Biol. 2010 Oct; 88(4):605-7. Prakash A, Hellman J. PMID: 20884653.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Regulation of IRF7 through cell type-specific protein stability. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):50-6. Prakash A, Levy DE. PMID: 16472772.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. J Biol Chem. 2005 May 13; 280(19):18651-7. Prakash A, Smith E, Lee CK, Levy DE. PMID: 15767254.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    16. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Curr Opin Immunol. 2003 Feb; 15(1):52-8. Levy DE, Marié I, Prakash A. PMID: 12495733.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    17. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem. 2002 Dec 20; 277(51):49417-21. Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I. PMID: 12374802.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    18. Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. J Interferon Cytokine Res. 2002 Jan; 22(1):87-93. Levy DE, Marié I, Smith E, Prakash A. PMID: 11846979.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    19. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem. 2001 Mar 23; 276(12):8951-7. Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE. PMID: 11124948.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    20. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol. 2000 Dec; 20(23):8803-14. Marié I, Smith E, Prakash A, Levy DE. PMID: 11073981.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
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