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Kirsten Kangelaris, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone415-476-4852
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    Collapse Biography 
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    University of California, San FranciscoM.A.S. in Clinical Research2010 Graduate Division (Advance Training in Clinical Research)

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    Dr. Kangelaris serves as an Associate Professor of Medicine and Associate Director the Academic Hospital Medicine fellowship within the Division of Hospital Medicine. Her clinical work focuses on the care of hospitalized adults and she attends on the teaching service at Moffitt-Long hospital.

    Her research program focuses on sepsis, one of the most common causes of death among hospitalized patients. A major objective of her research is to improve understanding of the clinical and biologic heterogeneity of the disease that impacts physician recognition and disease-specific response to therapy. Her research encompasses several different approaches across the translational spectrum including electronic health record based-clinical studies, prospective clinical studies of adult patients combined with biomarker studies including DNA genomic, mRNA gene expression, plasma proteins and cell-based protein studies. She also studies early mechanisms in the development of ARDS, one of the most severe manifestations of acute organ injury in sepsis.

    Dr. Kangelaris completed medical school, internship and residency in Internal Medicine at the University of Michigan Medical School, and completed a General Medicine Research Fellowship and a Master's of Advanced Studies in Clinical Research at UCSF. She joined faculty in the Division of Hospital Medicine at UCSF in 2010. She is a Fellow of the Society of Hospital Medicine and member of the American Thoracic Society.

    Collapse Research 
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    Chemokine-related acute lung injury pathogenesis in African-American patients
    NIH/NHLBI K23HL116800Mar 1, 2013 - Feb 28, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Crit Care Med. 2020 Jun; 48(6):830-837. Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS. PMID: 32317598.
      View in: PubMed   Mentions:    Fields:    
    2. Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv. 2020 May 19. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castaneda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C. PMID: 32511476.
      View in: PubMed   Mentions:
    3. Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19. medRxiv. 2020 May 06. Shah SJ, Barish PN, Prasad PA, Kistler AL, Neff N, Kamm J, Li LM, Chiu CY, Babick JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Davis JM, Castenada GD, Consortium C, Dadasovich RM, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton JR, Hao SL, Kerkhoff AD, Kumar R, Malcolm K, Mann SA, Martinez SP, Marya R, Mick E, Mwakibete LL, Najafi N, Peluso MJ, Phelps MS, Pisco AO, Ratnasiri K, Rubio LA, Sellas AB, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C. PMID: 32511488.
      View in: PubMed   Mentions:
    4. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 2020 Jun; 46(6):1222-1231. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. PMID: 32206845.
      View in: PubMed   Mentions: 1     Fields:    
    5. Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Crit Care Med. 2020 Feb; 48(2):200-209. Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN. PMID: 31939788.
      View in: PubMed   Mentions:    Fields:    
    6. Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. Eur Respir J. 2020 Jan; 55(1). Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. PMID: 31619475.
      View in: PubMed   Mentions: 2     Fields:    
    7. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Crit Care. 2019 12 09; 23(1):400. Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD. PMID: 31818332.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Critical Care. 2019 Dec 1; 23(1):400. Brian J. Anderson, Carolyn S. Calfee, Kathleen D. Liu, John P. Reilly, Kirsten N. Kangelaris, Michael G. S. Shashaty, Aili L. Lazaar, Andrew I. Bayliffe, Robert J. Gallop, Todd A. Miano, Thomas G. Dunn, Erik Johansson, Jason Abbott, Alejandra Jauregui, Thomas Deiss, Kathryn Vessel, Annika Belzer, Hanjing Zhuo, Michael A. Matthay, Nuala J. Meyer, Jason D. Christie. .
      View in: Publisher Site   Mentions:
    9. The Association between Limited English Proficiency and Sepsis Mortality. Journal of Hospital Medicine. 2019 Nov 20; (2019-11-20 ONLINE FIRST). Zachary G Jacobs, Priya A Prasad, Margaret C Fang, Yumiko Abe-Jones, Kirsten N Kangelaris. .
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    10. The Association between Limited English Proficiency and Sepsis Mortality. J Hosp Med. 2019 Nov 20; 14:E1-E7. Jacobs ZG, Prasad PA, Fang MC, Abe-Jones Y, Kangelaris KN. PMID: 31891556.
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    11. ASSOCIATION OF ANGIOPOIETIN-2 AND ATRIAL FIBRILLATION BURDEN IN CRITICALLY ILL PATIENTS. Journal of the American College of Cardiology. 2019 Mar 1; 73(9):403. Lily Stern, Kathleen Liu, Hanjing Zhuo, Kirsten Kangelaris, Antonio Gomez, Alejandra Jauregui, Kathryn Vessel, Thomas Deiss, Jason Abbott, Ashish Agrawal, Michael Matthay, Carolyn S. Calfee, Liviu Klein. .
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    12. External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive Care Med. 2017 Aug; 43(8):1123-1131. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB. PMID: 28593401.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am J Respir Crit Care Med. 2017 02 01; 195(3):331-338. Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS. PMID: 27513822.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    14. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Survey of Anesthesiology. 2016 Dec 1; 60(6):234-235. Kirsten Neudoerffer Kangelaris, Lorraine B. Ware, Chen Yu Wang, David R. Janz, Hanjing Zhuo, Michael A. Matthay, Carolyn S. Calfee. .
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    15. The authors reply. Crit Care Med. 2016 08; 44(8):e769-70. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. PMID: 27428148.
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    16. The authors reply. Crit Care Med. 2016 08; 44(8):e771. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. PMID: 27428150.
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    17. Implementation and evaluation of a "works-in-progress" session to promote scholarship in an academic hospitalist group. J Hosp Med. 2016 10; 11(10):719-723. Patel H, Fang MC, Harrison JD, Auerbach A, Kangelaris KN. PMID: 27294477.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Jan; 44(1):120-9. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS. PMID: 26474112.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep; 43(9):1790-7. Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. PMID: 26010690.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansPHPublic Health
    20. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest. 2015 Jun; 147(6):1539-1548. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB. PMID: 26033126.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    21. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. PMID: 25795726.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    22. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. PMID: 25708422.
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    23. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA. PMID: 25643902.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    24. From storm to suppression in sepsis: are bands the link?*. Crit Care Med. 2014 Sep; 42(9):2135-6. Kangelaris KN, Seeley EJ. PMID: 25126801.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. PMID: 25593740.
      View in: PubMed   Mentions:
    26. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. PMID: 25960880.
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    27. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 2014 Oct; 29(5):718-22. Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS. PMID: 24848949.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014 Feb 18; 4(1):4. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. PMID: 24533450.
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    29. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. PMID: 24435201.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    30. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):736-42. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. PMID: 23328529.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    31. 681. Critical Care Medicine. 2012 Dec 1; 40(12):1-328. Erika Moseson, Hanjing Zhuo, John Stein, Jeff Chu, Michael Matthay, Kirsten Kangelaris, Kathleen Liu, Carolyn Calfee. .
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    32. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-1169. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. PMID: 22207676.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    33. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care. 2011 Jun 14; 1(1):21. Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD. PMID: 21906363.
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    34. Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. J Gen Intern Med. 2010 Oct; 25(10):1030-7. Kangelaris KN, Vittinghoff E, Otte C, Na B, Auerbach AD, Whooley MA. PMID: 20509052.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Genetic Testing Before Anticoagulation? A Systematic Review of Pharmacogenetic Dosing of Warfarin. Journal of General Internal Medicine. 2009 Dec 1; 24(12):1358. Kirsten Neudoerffer Kangelaris, Stephen Bent, Robert L. Nussbaum, David A. Garcia, Jeffrey A. Tice. .
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    36. Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med. 2009 May; 24(5):656-64. Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA. PMID: 19306050.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    37. Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer. JAMA. 2007 Jun 06; 297(21):2410-1. Kangelaris KN, Gruber SB. PMID: 17545691.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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