Mark Schumacher, MD, PhD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-502-7022
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    Dr. Schumacher is Professor and Chief of the Division of Pain Medicine in the Department of Anesthesia and Perioperative Care, University of California, San Francisco. He has a clinical, research and educational focus on pain medicine with an emphasis on the development of evidence – based pain care into general clinical practice that utilize non-addictive modalities to improve both the quality and safety of analgesic care. Dr. Schumacher is also the Director of the UCSF Pain and Addiction Research Center (PARC) and served on the National Academies of Science Engineering and Medicine Committee, co-authoring the report on “Pain Management and the Opioid Epidemic.” Scientifically, following his collaboration in the cloning of the Capsaicin Receptor (TRPV1), he has led a laboratory dedicated to non-addictive strategies to block the transition from acute to chronic pain through transcriptional blockade. His current NIH-funded research includes: Study of painful Chemotherapy-Induced Peripheral Neuropathy (CIPN) with the aim to develop novel therapeutics and studying Neuro-immune Mechanisms of Analgesia of the Minor Cannabinoids such as CBD as well as its developmental effects on sensory neurons. Throughout his career, he has sought ways to communicate the science and practice of pain medicine including previously directing an NIH Center of Excellence in Pain Education at UCSF.

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    Neuro-immune mechanisms of minor cannabinoids in inflammatory and neuropathic pain
    NIH R01AT010757Sep 15, 2019 - Aug 31, 2024
    Role: Co-Principal Investigator
    Capsaicin receptor subtypes in pain transduction
    NIH R01NS038737Apr 1, 1999 - Jun 30, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014. J Am Acad Orthop Surg Glob Res Rev. 2020 01; 4(1). Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA. PMID: 32159068.
      View in: PubMed   Mentions:
    2. Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors. Support Care Cancer. 2019 Oct; 27(10):3905-3912. Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C. PMID: 30770977.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Pain Management and Opioid Regulation: Continuing Public Health Challenges. Am J Public Health. 2019 Jan; 109(1):31-34. Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS. PMID: 32941766.
      View in: PubMed   Mentions: 2     Fields:    
    4. America's Opioid Epidemic: Supply and Demand Considerations. Anesth Analg. 2017 11; 125(5):1667-1674. Clark DJ, Schumacher MA. PMID: 29049112.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic Health
    5. (431) Characteristics of chemotherapy induced neuropathy (CIN) in cancer survivors who received taxol. Journal of Pain. 2017 Apr 1; 18(4):s82. K. Kober, J. Mastick, S. Paul, K. Topp, B. Smoot, G. Abrams, L. Chen, Y. Conley, M. Chesney, K. Bolla, G. Mausisa, M. Azor, M. Wong, M. Schumacher, J. Levine, C. Miaskowski. .
      View in: Publisher Site   Mentions:
    6. Back pain and the mineralocorticoid receptor: is there a connection? Anesthesiology. 2012 Nov; 117(5):951-2. Schumacher MA. PMID: 23042224.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Pain Management for the Obese Sleep Apnea Patient. ICU Director. 2012 Mar 1; 3(2):80-84. Mark A. Schumacher. .
      View in: Publisher Site   Mentions:
    8. Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Mol Pain. 2011 Jun 06; 7:44. Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA. PMID: 21645329.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma. J Pain Symptom Manage. 2011 Jul; 42(1):126-33. Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA. PMID: 21306862.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. TRPV1 splice variants: structure and function. Front Biosci (Landmark Ed). 2010 Jun 01; 15:872-82. Schumacher MA, Eilers H. PMID: 20515731.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    11. Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract. 2010 May-Jun; 10(3):185-200. Schumacher MA. PMID: 20230457.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    12. The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation. Neuroreport. 2007 Jul 02; 18(10):969-73. Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. PMID: 17558279.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. 2007 Apr; 101(1):212-22. Xue Q, Jong B, Chen T, Schumacher MA. PMID: 17217411.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    14. Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eur J Neurosci. 2004 Nov; 20(9):2283-93. Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA. PMID: 15525270.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure? Mol Interv. 2004 Aug; 4(4):197-9. Eilers H, Schumacher MA. PMID: 15304555.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Room B, 10/16/2000 2: 00 PM - 4: 00 PM (PS) The Capsaicin Receptor Variant, Stretch-inactivated Channel, Is Expressed in Small-Diameter Sensory Neurons. Anesthesiology. 2000 Sep 1; 93(3A):a-928. Mark A. Schumacher, Beverly E. Jong, Sharon L. Frey, Norman F. Capra, Jon D. Levine. .
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    17. ISOLATION OF NERVE GROWTH FACTOR (NGF) REGULATED GENES IN PRIMARY AFFERENT NEURONS. Anesthesiology. 1998 Sep 1; 89(Supplement):1093a. Mark A. Schumacher, Irene Moff, Jon D. Levine. .
      View in: Publisher Site   Mentions:
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