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Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes. Pain. 2025 Mar 01; 166(3):614-630.
Franco-Enzástiga Ú, Inturi NN, Natarajan K, Mwirigi JM, Mazhar K, Schlachetzki JCM, Schumacher M, Price TJ. PMID: 39928726; PMCID: PMC11819886.
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6 Fields:
Translation:
HumansCells
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Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes. bioRxiv. 2024 Jul 10.
Franco-Enzástiga Ú, Inturi NN, Natarajan K, Mwirigi JM, Mazhar K, Schlachetzki JCM, Schumacher M, Price TJ. PMID: 38586055; PMCID: PMC10996669.
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Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic. Curr Neuropharmacol. 2024; 22(1):6-14.
Schumacher MA. PMID: 37559537; PMCID: PMC10716877.
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10 Fields:
Translation:
Humans
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Chemotherapy for pain: reversing inflammatory and neuropathic pain with the anticancer agent mithramycin A. Pain. 2024 Jan 01; 165(1):54-74.
Xu Z, Lee MC, Sheehan K, Fujii K, Rabl K, Rader G, Varney S, Sharma M, Eilers H, Kober K, Miaskowski C, Levine JD, Schumacher MA. PMID: 37366593; PMCID: PMC10723648.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. J Neuroinflammation. 2022 May 24; 19(1):118.
Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J. PMID: 35610647; PMCID: PMC9131699.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Occurrence and perceived effectiveness of activities used to decrease chemotherapy-induced peripheral neuropathy symptoms in the feet. Eur J Oncol Nurs. 2021 Oct; 54:102025.
Ogle T, Alexander K, Yates P, Paul SM, Kober KM, Conley YP, Schumacher M, Levine JD, Miaskowski C. PMID: 34500317.
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1 Fields:
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Humans
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Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014. J Am Acad Orthop Surg Glob Res Rev. 2020 01; 4(1).
Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA. PMID: 32159068; PMCID: PMC7028788.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain. Mol Pain. 2020 Jan-Dec; 16:1744806920936502.
Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C. PMID: 32586194; PMCID: PMC7322824.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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AAAPT Diagnostic Criteria for Acute Pain Following Breast Surgery. J Pain. 2020 Mar - Apr; 21(3-4):294-305.
Schreiber KL, Belfer I, Miaskowski C, Schumacher M, Stacey BR, Van De Ven T. PMID: 31493489; PMCID: PMC8290886.
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PubMed Mentions:
9 Fields:
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Humans
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2019 08; 58(2):252-263.
Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C. PMID: 31047960; PMCID: PMC6679783.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Transcription factor Sp4 is required for hyperalgesic state persistence. PLoS One. 2019; 14(2):e0211349.
Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M. PMID: 30811405; PMCID: PMC6392229.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors. Support Care Cancer. 2019 Oct; 27(10):3905-3912.
Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C. PMID: 30770977; PMCID: PMC6697247.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy. Mol Pain. 2019 Jan-Dec; 15:1744806919878088.
Kober KM, Schumacher M, Conley YP, Topp K, Mazor M, Hammer MJ, Paul SM, Levine JD, Miaskowski C. PMID: 31486345; PMCID: PMC6755139.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Pain Management and Opioid Regulation: Continuing Public Health Challenges. Am J Public Health. 2019 Jan; 109(1):31-34.
Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS. PMID: 32941766; PMCID: PMC6301400.
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18 Fields:
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Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients. Clin J Pain. 2019 01; 35(1):37-42.
Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Schumacher M, Conley YP, Hammer M, Cheung S, Borsook D, Levine JD. PMID: 30247200; PMCID: PMC6309865.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors. Mol Pain. 2018 Jan-Dec; 14:1744806918816462.
Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C. PMID: 30426838; PMCID: PMC6293373.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2018 12; 56(6):908-919.e3.
Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C. PMID: 30172061; PMCID: PMC6289693.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report. A A Pract. 2018 Jun 01; 10(11):285-287.
Peniche A, Poree L, Schumacher M, Yu X. PMID: 29851657.
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Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors. J Pain Symptom Manage. 2018 07; 56(1):88-97.
Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD. PMID: 29524582; PMCID: PMC6015523.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life. J Cancer Surviv. 2018 04; 12(2):234-245.
Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD. PMID: 29159795; PMCID: PMC5886787.
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PubMed Mentions:
39 Fields:
Translation:
Humans
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Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs. 2018 Feb; 32:1-11.
Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD. PMID: 29353626; PMCID: PMC5783195.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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America's Opioid Epidemic: Supply and Demand Considerations. Anesth Analg. 2017 11; 125(5):1667-1674.
Clark DJ, Schumacher MA. PMID: 29049112.
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PubMed Mentions:
36 Fields:
Translation:
HumansPHPublic Health
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N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475.
Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. PMID: 28701511; PMCID: PMC5544930.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions. J Pain. 2017 05; 18(5):479-489.
Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G. PMID: 28495013; PMCID: PMC7323793.
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24 Fields:
Translation:
Humans
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The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions. Pain Med. 2017 05 01; 18(5):947-958.
Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G. PMID: 28482098; PMCID: PMC5431381.
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PubMed Mentions:
25 Fields:
Translation:
Humans
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(431) Characteristics of chemotherapy induced neuropathy (CIN) in cancer survivors who received taxol. Journal of Pain. 2017 Apr 1; 18(4):s82.
Kober KK, Mastick MJ, Paul PS, Topp TK, Smoot SB, Abrams AG, Chen CL, Conley CY, Chesney CM, Bolla BK, Mausisa MG, Azor AM, Wong WM, Schumacher SM, Levine LJ, Miaskowski MC. .
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Chemotherapy-Induced Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2017 08; 54(2):204-218.e2.
Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine JD. PMID: 28063866; PMCID: PMC5496793.
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PubMed Mentions:
65 Fields:
Translation:
Humans
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Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 2016; 5.
Guan Z, Hellman J, Schumacher M. PMID: 27781082; PMCID: PMC5054801.
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11 Fields:
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The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons. Neurosci Lett. 2014 Aug 22; 578:211-6.
Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA. PMID: 24468003.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Topical capsaicin formulations in the management of neuropathic pain. Prog Drug Res. 2014; 68:105-28.
Schumacher M, Pasvankas G. PMID: 24941666.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Back pain and the mineralocorticoid receptor: is there a connection? Anesthesiology. 2012 Nov; 117(5):951-2.
Schumacher MA. PMID: 23042224.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Pain Management for the Obese Sleep Apnea Patient. ICU Director. 2012 Mar 1; 3(2):80-84.
Schumacher SM. .
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Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Mol Pain. 2011 Jun 06; 7:44.
Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA. PMID: 21645329; PMCID: PMC3121596.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma. J Pain Symptom Manage. 2011 Jul; 42(1):126-33.
Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA. PMID: 21306862.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology. 2010 Jun; 112(6):1452-63.
Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW. PMID: 20463581.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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TRPV1 splice variants: structure and function. Front Biosci (Landmark Ed). 2010 06 01; 15(3):872-82.
Schumacher MA, Eilers H. PMID: 20515731; PMCID: PMC3888216.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract. 2010 May-Jun; 10(3):185-200.
Schumacher MA. PMID: 20230457; PMCID: PMC3112370.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation. Neuroreport. 2007 Jul 02; 18(10):969-73.
Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. PMID: 17558279.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol Chem. 2007 Jul 20; 282(29):20977-90.
Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP. PMID: 17548360.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. 2007 Apr; 101(1):212-22.
Xue Q, Jong B, Chen T, Schumacher MA. PMID: 17217411.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eur J Neurosci. 2004 Nov; 20(9):2283-93.
Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA. PMID: 15525270.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure? Mol Interv. 2004 Aug; 4(4):197-9.
Eilers H, Schumacher MA. PMID: 15304555.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar; 13(3):129-39.
Ständer S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D, Steinhoff M. PMID: 14987252.
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PubMed Mentions:
135 Fields:
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HumansAnimalsCells
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The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. 2001 Aug; 76(1-3):14-20.
Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. PMID: 11549313.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine. Anesth Analg. 2001 Jul; 93(1):213-4.
Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA. PMID: 11429368.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat. Neurosci Lett. 2000 Jun 30; 287(3):215-8.
Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD. PMID: 10863033.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. J Biol Chem. 2000 Jan 28; 275(4):2756-62.
Schumacher MA, Moff I, Sudanagunta SP, Levine JD. PMID: 10644739.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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ISOLATION OF NERVE GROWTH FACTOR (NGF) REGULATED GENES IN PRIMARY AFFERENT NEURONS. Anesthesiology. 1998 Sep 1; 89(Supplement):1093a.
Schumacher SM, Moff MI, Levine LJ. .
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The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23; 389(6653):816-24.
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. PMID: 9349813.
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PubMed Mentions:
3204 Fields:
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HumansAnimalsCells
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ATP receptors in sickness, pain and death. Chem Biol. 1996 Apr; 3(4):229-32.
Brake A, Schumacher M, Julius D. PMID: 8807849.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Multiple messenger RNA species give rise to the structural diversity in acetylcholinesterase. J Biol Chem. 1988 Dec 15; 263(35):18979-87.
Schumacher M, Maulet Y, Camp S, Taylor P. PMID: 3198606.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Primary structure of acetylcholinesterase: implications for regulation and function. Fed Proc. 1986 Dec; 45(13):2976-81.
Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P. PMID: 3536598.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature. 1986 Jan 30-Feb 5; 319(6052):407-9.
Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P. PMID: 3753747.
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PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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Hepatic (Na+,K+)-ATPase: a current view of its structure, function and localization in rat liver as revealed by studies with monoclonal antibodies. Hepatology. 1985 May-Jun; 5(3):501-7.
Leffert HL, Schenk DB, Hubert JJ, Skelly H, Schumacher M, Ariyasu R, Ellisman M, Koch KS, Keller GA. PMID: 2987099.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Mechanisms of whole blood-induced cerebral arterial contraction. Neurosurgery. 1981 Sep; 9(3):275-82.
Schumacher MA, Alksne JF. PMID: 7301070.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells