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Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping. bioRxiv. 2024 Nov 25.
Wang K, Nie Y, Maguire C, Syphurs C, Sheen H, Karoly M, Lapp L, Gygi JP, Jayavelu ND, Patel RK, Hoch A, IMPACC Network, Corry D, Kheradmand F, McComsey GA, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, Davis MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Hafler DA, Shaw A, Rahman A, Hough CL, Geng LN, Ozonoff A, Haddad EK, Reed EF, van Bakel H, Kim-Schultz S, Krammer F, Wilson M, Eckalbar W, Bosinger S, Langelier CR, Sekaly RP, Montgomery RR, Maecker HT, Krumholz H, Melamed E, Steen H, Pulendran B, Augustine AD, Cairns CB, Rouphael N, Becker PM, Fourati S, Shannon CP, Smolen KK, Peters B, Kleinstein SH, Levy O, Altman MC, Iwasaki A, Diray-Arce J, Ehrlich LIR, Guan L. PMID: 39651165; PMCID: PMC11623532.
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Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19. bioRxiv. 2024 Nov 16.
Maguire C, Chen J, Rouphael N, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Selaky R, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, David MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Geng LN, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze SH, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH, IMPACC Network, Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E. PMID: 39605478; PMCID: PMC11601417.
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Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nat Commun. 2024 Oct 29; 15(1):9339.
Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. PMID: 39472555; PMCID: PMC11522429.
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HumansCells
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Immediate myeloid depot for SARS-CoV-2 in the human lung. Sci Adv. 2024 Aug 02; 10(31):eadm8836.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. PMID: 39083602; PMCID: PMC11290487.
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4 Fields:
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HumansCells
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Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Nat Commun. 2024 Jun 28; 15(1):5483.
Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK. PMID: 38942804; PMCID: PMC11213873.
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2 Fields:
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HumansCells
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Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nat Commun. 2024 Jan 03; 15(1):216.
Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, Dandekar R, Shannon CP, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, van Bakel H, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS, Erle DJ, Langelier CR, Eckalbar W, Bosinger SE, IMPACC Network, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC, Montgomery RR, Becker PM, Rouphael N. PMID: 38172101; PMCID: PMC10764789.
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14 Fields:
Translation:
HumansCells
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GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins. Genome Biol. 2023 12 07; 24(1):281.
Zhu WS, Litterman AJ, Sekhon HS, Kageyama R, Arce MM, Taylor KE, Zhao W, Criswell LA, Zaitlen N, Erle DJ, Ansel KM. PMID: 38062486; PMCID: PMC10701951.
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1 Fields:
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HumansAnimalsCells
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Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208]. EBioMedicine. 2023 Dec; 98:104860.
Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Agudelo Higuita NI, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, IMPACC Study Group Members. PMID: 37918220; PMCID: PMC10643088.
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A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience. 2023 Oct 20; 26(10):107813.
Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. PMID: 37810211; PMCID: PMC10551843.
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3
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Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Res Sq. 2023 Aug 03.
Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK. PMID: 37577607; PMCID: PMC10418533.
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SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 03 14; 18(3):636-653.
Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. PMID: 36827975; PMCID: PMC9948283.
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3 Fields:
Translation:
HumansCells
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Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2. Nat Microbiol. 2023 01; 8(1):121-134.
Yang J, Xiao Y, Lidsky PV, Wu CT, Bonser LR, Peng S, Garcia-Knight MA, Tassetto M, Chung CI, Li X, Nakayama T, Lee IT, Nayak JV, Ghias K, Hargett KL, Shoichet BK, Erle DJ, Jackson PK, Andino R, Shu X. PMID: 36604514; PMCID: PMC9831272.
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6 Fields:
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HumansAnimalsCells
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Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma. Cell Genom. 2023 Jan 11; 3(1):100229.
Koh KD, Bonser LR, Eckalbar WL, Yizhar-Barnea O, Shen J, Zeng X, Hargett KL, Sun DI, Zlock LT, Finkbeiner WE, Ahituv N, Erle DJ. PMID: 36777184; PMCID: PMC9903679.
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6 Fields:
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COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Am J Respir Crit Care Med. 2022 10 15; 206(8):961-972.
Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group. PMID: 35649173; PMCID: PMC9801996.
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24 Fields:
Translation:
HumansCells
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Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19. Crit Care. 2022 09 14; 26(1):278.
Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA, COMET Consortium. PMID: 36104754; PMCID: PMC9472195.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine. 2022 Sep; 83:104208.
Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, IMPACC study group members. PMID: 35952496; PMCID: PMC9359694.
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31 Fields:
Translation:
HumansCells
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Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients. Immunity. 2022 07 12; 55(7):1284-1298.e3.
Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ, Ansel KM, Spitzer MH. PMID: 35779527; PMCID: PMC9170540.
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6 Fields:
Translation:
HumansCells
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Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. PMID: 35611333; PMCID: PMC9128787.
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Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. PMID: 35592107; PMCID: PMC9119017.
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The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium. Am J Respir Cell Mol Biol. 2022 04; 66(4):391-401.
Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Ghias K, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ. PMID: 34982656; PMCID: PMC8990122.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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A conserved immune trajectory of recovery in hospitalized COVID-19 patients. bioRxiv. 2022 Mar 16.
Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, Spitzer MH. PMID: 35313585; PMCID: PMC8936097.
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Massively parallel analysis of human 3' UTRs reveals that AU-rich element length and registration predict mRNA destabilization. G3 (Bethesda). 2022 01 04; 12(1).
Siegel DA, Le Tonqueze O, Biton A, Zaitlen N, Erle DJ. PMID: 34849835; PMCID: PMC8728028.
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18 Fields:
Translation:
HumansCells
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Discovering dominant tumor immune archetypes in a pan-cancer census. Cell. 2022 01 06; 185(1):184-203.e19.
Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, Immunoprofiler Consortium, Cai C, Zhan J, Davis KC, Kelley RK, Chapman JS, Atreya CE, Patel A, Daud AI, Ha P, Diaz AA, Kratz JR, Collisson EA, Fragiadakis GK, Erle DJ, Boissonnas A, Asthana S, Chan V, Krummel MF. PMID: 34963056; PMCID: PMC8862608.
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49 Fields:
Translation:
HumansCells
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Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Nov 30.
Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Detweiler A, Jones NG, Wu B, Darmanis S, Lynch SV, DeRisi JL, COMET Consortium, Matthay MA, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 33791731; PMCID: PMC8010763.
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1
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Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine. 2021 Oct; 40:101099.
Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B. PMID: 34490415; PMCID: PMC8410317.
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50
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Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152.
Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 34446707; PMCID: PMC8390461.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Sci Transl Med. 2021 Sep 22; 13(612):eabh2624.
van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ, UCSF COMET consortium. PMID: 34429372; PMCID: PMC8601717.
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123 Fields:
Translation:
Humans
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Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 Aug; 596(7872):E8.
Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 34341540; PMCID: PMC8328349.
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SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. bioRxiv. 2021 Jun 02.
Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. PMID: 34100012; PMCID: PMC8183007.
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PubMed Mentions:
1
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Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Res Sq. 2021 Apr 23.
Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 34013247; PMCID: PMC8132240.
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Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs. bioRxiv. 2021 Mar 10.
van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, UCSF COMET consortium, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. PMID: 33758859; PMCID: PMC7987018.
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PubMed Mentions:
1
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Epithelial miR-141 regulates IL-13-induced airway mucus production. JCI Insight. 2021 03 08; 6(5).
Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG. PMID: 33682796; PMCID: PMC8021117.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Flow-Cytometric Analysis and Purification of Airway Epithelial-Cell Subsets. Am J Respir Cell Mol Biol. 2021 03; 64(3):308-317.
Bonser LR, Koh KD, Johansson K, Choksi SP, Cheng D, Liu L, Sun DI, Zlock LT, Eckalbar WL, Finkbeiner WE, Erle DJ. PMID: 33196316; PMCID: PMC7909335.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans. Am J Respir Crit Care Med. 2021 02 15; 203(4):424-436.
Gui H, Levin AM, Hu D, Sleiman P, Xiao S, Mak ACY, Yang M, Barczak AJ, Huntsman S, Eng C, Hochstadt S, Zhang E, Whitehouse K, Simons S, Cabral W, Takriti S, Abecasis G, Blackwell TW, Kang HM, Nickerson DA, Germer S, Lanfear DE, Gilliland F, Gauderman WJ, Kumar R, Erle DJ, Martinez FD, Hakonarson H, Burchard EG, Williams LK. PMID: 32966749; PMCID: PMC7885840.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 03; 591(7848):124-130.
Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33494096; PMCID: PMC8567458.
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PubMed Mentions:
141 Fields:
Translation:
HumansCells
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COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14.
Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 33469573; PMCID: PMC7814832.
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PubMed Mentions:
3
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Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program. PLoS One. 2020; 15(11):e0242364.
Cocco MP, White E, Xiao S, Hu D, Mak A, Sleiman P, Yang M, Bobbitt KR, Gui H, Levin AM, Hochstadt S, Whitehouse K, Rynkowski D, Barczak AJ, Abecasis G, Blackwell TW, Kang HM, Nickerson DA, Germer S, Ding J, Lanfear DE, Gilliland F, Gauderman WJ, Kumar R, Erle DJ, Martinez F, Hakonarson H, Burchard EG, Williams LK. PMID: 33237978; PMCID: PMC7688161.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020 12 03; 27(6):876-889.e12.
Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. PMID: 33232663; PMCID: PMC7670929.
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PubMed Mentions:
149 Fields:
Translation:
HumansAnimalsCells
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Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv. 2020 Oct 29.
Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140050; PMCID: PMC7605559.
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PubMed Mentions:
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Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq. 2020 Oct 28.
Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140041; PMCID: PMC7605560.
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PubMed Mentions:
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Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth. Am J Respir Crit Care Med. 2020 10 01; 202(7):962-972.
Lee EY, Mak ACY, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana J, Seibold MA, Burchard EG. PMID: 32459537; PMCID: PMC7528787.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Steps toward Cell Therapy for Cystic Fibrosis. Am J Respir Cell Mol Biol. 2020 09; 63(3):275-276.
Koh KD, Erle DJ. PMID: 32648785; PMCID: PMC7462341.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells. The Journal of Immunology. 2020 May 1; 204(1_Supplement):65.9-65.9.
Castellanos CC, Ren RX, Liang LH, Laidlaw LB, Barczak BA, Rudolph RJ, Eckalbar EW, Huang HX, Cyster CJ, Locksley LR, Erle ED, Ishido IS, Shin SJ. .
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Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis. Am J Respir Cell Mol Biol. 2020 Mar; 62(3):373-381.
Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ. PMID: 31596609; PMCID: PMC7055692.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms. Cell Rep. 2019 12 17; 29(12):4212-4222.e5.
Godoy PM, Barczak AJ, DeHoff P, Srinivasan S, Etheridge A, Galas D, Das S, Erle DJ, Laurent LC. PMID: 31851944; PMCID: PMC7499898.
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PubMed Mentions:
51 Fields:
Translation:
Humans
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The airway epithelium in asthma. Adv Immunol. 2019; 142:1-34.
Bonser LR, Erle DJ. PMID: 31296301.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. J Exp Med. 2019 09 02; 216(9):2024-2037.
Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR. PMID: 31217192; PMCID: PMC6719416.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization. Genome Res. 2019 06; 29(6):896-906.
Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM. PMID: 31152051; PMCID: PMC6581050.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Singling out Th2 cells in eosinophilic esophagitis. J Clin Invest. 2019 04 08; 129(5):1830-1832.
Eckalbar WL, Erle DJ. PMID: 30958801; PMCID: PMC6486335.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Putting Mucins on the Map. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):681-682.
Bonser LR, Erle DJ. PMID: 30376352; PMCID: PMC6423107.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. J Clin Invest. 2019 01 02; 129(1):169-181.
Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG. PMID: 30383540; PMCID: PMC6307967.
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PubMed Mentions:
46 Fields:
Translation:
Humans
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Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 10 30; 25(5):1346-1358.
Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. PMID: 30380423; PMCID: PMC6261476.
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PubMed Mentions:
117 Fields:
Translation:
Humans
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Integrative approach identifies corticosteroid response variant in diverse populations with asthma. J Allergy Clin Immunol. 2019 05; 143(5):1791-1802.
Levin AM, Gui H, Hernandez-Pacheco N, Yang M, Xiao S, Yang JJ, Hochstadt S, Barczak AJ, Eckalbar WL, Rynkowski D, Samedy LA, Kwok PY, Pino-Yanes M, Erle DJ, Lanfear DE, Burchard EG, Williams LK. PMID: 30367910; PMCID: PMC6482107.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018 10; 19(10):1093-1099.
Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. PMID: 30201992; PMCID: PMC6202223.
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PubMed Mentions:
226 Fields:
Translation:
AnimalsCells
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Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 09 06; 36(9):899.
Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. PMID: 30188530.
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PubMed Mentions:
3 Fields:
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Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018 07; 559(7715):627-631.
Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. PMID: 30022164; PMCID: PMC6062473.
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PubMed Mentions:
159 Fields:
Translation:
HumansAnimalsCells
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Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Immunity. 2018 07 17; 49(1):33-41.e7.
Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. PMID: 30021144; PMCID: PMC6084797.
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PubMed Mentions:
247 Fields:
Translation:
AnimalsCells
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Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 09; 36(8):746-757.
Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. PMID: 30010675; PMCID: PMC6078798.
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PubMed Mentions:
92 Fields:
Translation:
HumansCells
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Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells. J Immunol. 2018 08 01; 201(3):1053-1061.
Zhao W, Erle DJ. PMID: 29907706; PMCID: PMC6057839.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 02 01; 197(3):313-324.
Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. PMID: 29064281; PMCID: PMC5811952.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells
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CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells. J Immunol. 2018 02 15; 200(4):1399-1412.
Oh J, Wu N, Barczak AJ, Barbeau R, Erle DJ, Shin JS. PMID: 29321275; PMCID: PMC5809249.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J Clin Med. 2017 Nov 29; 6(12).
Bonser LR, Erle DJ. PMID: 29186064; PMCID: PMC5742801.
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PubMed Mentions:
140
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CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Nucleic Acids Res. 2017 Oct 13; 45(18):10800-10810.
Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ. PMID: 28985357; PMCID: PMC5737544.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. Eur Respir J. 2017 06; 49(6).
Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE. PMID: 28642310; PMCID: PMC5898938.
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PubMed Mentions:
48 Fields:
Translation:
Humans
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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017 05 23; 19(8):1558-1571.
Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. PMID: 28538176; PMCID: PMC5587137.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. Mucosal Immunol. 2017 11; 10(6):1491-1503.
Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, Di H, Zou Y, Zhang H, Zhao J, Xu Y, Erle DJ, Zhen G. PMID: 28224996; PMCID: PMC5568519.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Dec; 17(12):1381-1387.
Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. PMID: 27749840; PMCID: PMC5275767.
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PubMed Mentions:
139 Fields:
Translation:
AnimalsCells
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Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol. PLoS One. 2016; 11(7):e0159459.
Khosravi AR, Erle DJ. PMID: 27463381; PMCID: PMC4962986.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367.
Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ. PMID: 27362652; PMCID: PMC4928999.
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PubMed Mentions:
71 Fields:
Translation:
HumansCells
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Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma. J Clin Invest. 2016 06 01; 126(6):2367-71.
Bonser LR, Zlock L, Finkbeiner W, Erle DJ. PMID: 27183390; PMCID: PMC4887179.
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PubMed Mentions:
101 Fields:
Translation:
Humans
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Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD. Eur Respir J. 2016 06; 47(6):1645-56.
Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE. PMID: 26965288.
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PubMed Mentions:
37 Fields:
Translation:
Humans
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Massively Parallel Identification of Regulatory Variants in Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S104.
Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ. PMID: 27027944; PMCID: PMC5015739.
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PubMed Mentions: Fields:
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MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19; 44(4):821-32.
Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM. PMID: 26850657; PMCID: PMC4838571.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Abstract B65: Dissecting the tumor myeloid compartment reveals rare activating antigen presenting cells, critical for T cell immunity. Tumor Microenvironment. 2015 Oct 1; b65-b65.
Broz BM, Binnewies BM, Boldajipour BB, Nelson NA, Pollock PJ, Erle ED, Barczak BA, Rosenblum RM, Daud DA, Barber BD, Amigorena AS, Veer VL, Sperling SA, Wolf WD, Krummel KM. .
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The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):536-43.
Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ. PMID: 25751668; PMCID: PMC4742895.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells. PLoS One. 2015; 10(8):e0135440.
Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT. PMID: 26270036; PMCID: PMC4535774.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13.
Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. PMID: 25795726; PMCID: PMC4451399.
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PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Dec 08; 26(6):938.
Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. PMID: 28898680.
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PubMed Mentions:
85 Fields:
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Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52.
Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. PMID: 25446897; PMCID: PMC4254577.
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PubMed Mentions:
547 Fields:
Translation:
HumansAnimalsCells
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Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma. Am J Respir Crit Care Med. 2014 Sep 15; 190(6):639-48.
Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X, Bonser LR, Zhao J, Xu Y, Erle DJ, Zhen G. PMID: 25133876; PMCID: PMC4214109.
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PubMed Mentions:
73 Fields:
Translation:
HumansCells
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Erratum: Corrigendum: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nature Immunology. 2014 Sep 1; 15(9):894-894.
Waterfield WM, Khan KI, Cortez CJ, Fan FU, Metzger MT, Greer GA, Fasano FK, Martinez-Llordella MM, Pollack PJ, Erle ED, Su SM, Anderson AM. .
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IL-17 and "TH2-high" asthma: Adding fuel to the fire? J Allergy Clin Immunol. 2014 Nov; 134(5):1187-8.
Bhakta NR, Erle DJ. PMID: 25174869.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79.
Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194; PMCID: PMC4341974.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimals
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The cell biology of asthma. J Cell Biol. 2014 Jun 09; 205(5):621-31.
Erle DJ, Sheppard D. PMID: 24914235; PMCID: PMC4050726.
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PubMed Mentions:
127 Fields:
Translation:
HumansAnimalsCells
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Massively parallel functional annotation of 3' untranslated regions. Nat Biotechnol. 2014 Apr; 32(4):387-91.
Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ. PMID: 24633241; PMCID: PMC3981918.
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PubMed Mentions:
69 Fields:
Translation:
Humans
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The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014 Mar; 15(3):258-65.
Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. PMID: 24464130; PMCID: PMC4172453.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa. Genome Med. 2014; 6(1):1.
McErlean P, Berdnikovs S, Favoreto S, Shen J, Biyasheva A, Barbeau R, Eisley C, Barczak A, Ward T, Schleimer RP, Erle DJ, Boushey HA, Avila PC. PMID: 24433494; PMCID: PMC3971347.
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PubMed Mentions:
10 Fields:
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Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics. Genomics Proteomics Bioinformatics. 2013 Dec; 11(6):368-77.
Reisdorph N, Stearman R, Kechris K, Phang TL, Reisdorph R, Prenni J, Erle DJ, Coldren C, Schey K, Nesvizhskii A, Geraci M. PMID: 24316330; PMCID: PMC4049090.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241.
Publicover PJ, Gaggar GA, Nishimura NS, Van Horn VC, Goodsell GA, Muench MM, Reinhardt RR, van Rooijen vN, Peters PA, Cyster CJ, Erle ED, Rosenthal RP, Avanesyan AL, Spolski SR, Leonard LW, Cooper CS, Baron BJ. .
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Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39.
Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290; PMCID: PMC3754256.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium. Clin Exp Allergy. 2013 Aug; 43(8):914-27.
Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS. PMID: 23889245.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1. Cardiovasc Res. 2013 Sep 01; 99(4):769-79.
Rahmutula D, Marcus GM, Wilson EE, Ding CH, Xiao Y, Paquet AC, Barbeau R, Barczak AJ, Erle DJ, Olgin JE. PMID: 23612580; PMCID: PMC3746950.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimals
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T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. The Journal of Cell Biology. 2013 Feb 18; 200(4):i9-i9.
Bronevetsky BY, Villarino VA, Eisley EC, Barbeau BR, Barczak BA, Heinz HG, Kremmer KE, Heissmeyer HV, McManus MM, Erle ED, Rao RA, Ansel AK. .
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T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32.
Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. PMID: 23382546; PMCID: PMC3570096.
View in:
PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013 Mar; 131(3):894-903.
Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM. PMID: 23333113; PMCID: PMC4013392.
View in:
PubMed Mentions:
157 Fields:
Translation:
HumansCellsPHPublic Health
-
An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89.
Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. PMID: 23304658; PMCID: PMC3538381.
View in:
PubMed Mentions:
25
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Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74.
Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. PMID: 22955319; PMCID: PMC3530212.
View in:
PubMed Mentions:
136 Fields:
Translation:
HumansCellsCTClinical Trials
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Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. BMC Med Genomics. 2012 Jun 19; 5:27.
Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE. PMID: 22713245; PMCID: PMC3408345.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):178-85.
Schroeder BW, Verhaeghe C, Park SW, Nguyenvu LT, Huang X, Zhen G, Erle DJ. PMID: 22403803; PMCID: PMC3423459.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58.
Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. PMID: 22232213; PMCID: PMC3266785.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15201-6.
Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM. PMID: 21876130; PMCID: PMC3174577.
View in:
PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
-
Toward a systematic understanding of mRNA 3' untranslated regions. Proc Am Thorac Soc. 2011 May; 8(2):163-6.
Zhao W, Blagev D, Pollack JL, Erle DJ. PMID: 21543795; PMCID: PMC3131834.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PLoS One. 2011 Jan 04; 6(1):e16004.
Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS. PMID: 21245908; PMCID: PMC3014940.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. J Allergy Clin Immunol. 2010 Aug; 126(2):347-54.
Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F. PMID: 20579713; PMCID: PMC2917502.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11489-94.
Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. PMID: 20534524; PMCID: PMC2895098.
View in:
PubMed Mentions:
625 Fields:
Translation:
AnimalsCells
-
Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2010 Mar; 298(3):L290-6.
Gu N, Kang G, Jin C, Xu Y, Zhang Z, Erle DJ, Zhen G. PMID: 19965981; PMCID: PMC2838671.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One. 2009 Aug 11; 4(8):e6580.
Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N. PMID: 19668367; PMCID: PMC2719063.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
-
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):603-10.
Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. PMID: 19628779; PMCID: PMC2753788.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol. 2009 Apr 15; 182(8):4581-9.
Klinger M, Kim JK, Chmura SA, Barczak A, Erle DJ, Killeen N. PMID: 19342632; PMCID: PMC2736618.
View in:
PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
-
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6950-5.
Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ. PMID: 19359471; PMCID: PMC2678445.
View in:
PubMed Mentions:
194 Fields:
Translation:
AnimalsCells
-
CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol. 2009 Jan 01; 182(1):623-35.
Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD. PMID: 19109196; PMCID: PMC2718444.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
-
The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model. J Immunol. 2008 Aug 01; 181(3):2203-10.
Nakagami Y, Favoreto S, Zhen G, Park SW, Nguyenvu LT, Kuperman DA, Dolganov GM, Huang X, Boushey HA, Avila PC, Erle DJ. PMID: 18641360; PMCID: PMC2491716.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):376-87.
Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ. PMID: 18029791; PMCID: PMC2258439.
View in:
PubMed Mentions:
56 Fields:
Translation:
Animals
-
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62.
Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. PMID: 17965775; PMCID: PMC2040320.
View in:
PubMed Mentions:
124 Fields:
Translation:
HumansAnimalsCells
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Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15858-63.
Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. PMID: 17898169; PMCID: PMC2000427.
View in:
PubMed Mentions:
363 Fields:
Translation:
HumansCells
-
Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9.
Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. PMID: 17641300; PMCID: PMC2219547.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Progress toward a systems biology approach to acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L290-1.
Frank JA, Erle DJ. PMID: 17575007.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51.
Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. PMID: 17468134; PMCID: PMC4212816.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals. J Immunol. 2007 Feb 01; 178(3):1457-67.
Chang WL, Coro ES, Rau FC, Xiao Y, Erle DJ, Baumgarth N. PMID: 17237394.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog. 2007 Jan; 3(1):e1.
Horsnell WG, Cutler AJ, Hoving JC, Hoving CJ, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F. PMID: 17222057; PMCID: PMC1769405.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCellsCTClinical Trials
-
Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines. The FASEB Journal. 2007 Jan 1; 21(6):a1202-a1202.
Looney LM, Barbeau BR, Barczak BA, Xiao XY, Lowell LC, Erle ED, Matthay MM. .
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Publisher Site Mentions:
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IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):244-53.
Zhen G, Park SW, Nguyenvu LT, Rodriguez MW, Barbeau R, Paquet AC, Erle DJ. PMID: 16980555; PMCID: PMC1899314.
View in:
PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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The asthma channel? Stay tuned . . . Am J Respir Crit Care Med. 2006 Jun 01; 173(11):1181-2.
Erle DJ, Zhen G. PMID: 16738260.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec 01; 172(11):1383-92.
Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. PMID: 16166618; PMCID: PMC2718436.
View in:
PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol. 2005 Sep 15; 175(6):3746-52.
Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ. PMID: 16148120.
View in:
PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
-
Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug; 116(2):305-11.
Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. PMID: 16083784.
View in:
PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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Increased DNA microarray hybridization specificity using sscDNA targets. BMC Genomics. 2005 Apr 22; 6:57.
Barker CS, Griffin C, Dolganov GM, Hanspers K, Yang JY, Erle DJ. PMID: 15847692; PMCID: PMC1090574.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy. 2005 Jan; 35(1):82-8.
Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH. PMID: 15649271; PMCID: PMC2271075.
View in:
PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
-
Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respir Res. 2004 Sep 15; 5:12.
Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ. PMID: 15377395; PMCID: PMC520828.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells. BMC Immunol. 2004 Jul 05; 5:13.
Rodriguez MW, Paquet AC, Yang YH, Erle DJ. PMID: 15236665; PMCID: PMC476736.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Asthma investigators begin to reap the fruits of genomics. Genome Biol. 2003; 4(11):232.
Erle DJ, Yang YH. PMID: 14611649; PMCID: PMC329104.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Abnormal alveolar development associated with elevated adenine nucleosides. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):38-50.
Banerjee SK, Young HW, Barczak A, Erle DJ, Blackburn MR. PMID: 12855405.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res. 2003 Jul; 13(7):1775-85.
Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ. PMID: 12805270; PMCID: PMC403751.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
-
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9.
Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. PMID: 12091879.
View in:
PubMed Mentions:
359 Fields:
Translation:
HumansAnimalsCells
-
Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells. Dev Immunol. 2002 Jun; 9(2):73-84.
Shu F, Holzmann B, Seibold F, Erle D, Kearney JF. PMID: 12739784; PMCID: PMC2276093.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression. Chest. 2002 Mar; 121(3 Suppl):80S.
Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A. PMID: 11893700.
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PubMed Mentions: Fields:
Translation:
Humans
-
The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol. 2002 Feb; 26(2):202-8.
Venkayya R, Lam M, Willkom M, Grünig G, Corry DB, Erle DJ. PMID: 11804871.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85.
Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. PMID: 11694453.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansCells
-
Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7. Immunology. 2001 Jun; 103(2):155-63.
Abramson O, Qiu S, Erle DJ. PMID: 11412302; PMCID: PMC1783237.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. Eur Respir J. 2000 May; 15(5):922-8.
Solomon C, Christian DL, Chen LL, Welch BS, Kleinman MT, Dunham E, Erle DJ, Balmes JR. PMID: 10853860.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Intraepithelial lymphocytes in the lung: a neglected lymphocyte population. Am J Respir Cell Mol Biol. 2000 Apr; 22(4):398-400.
Erle DJ, Pabst R. PMID: 10745019.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Recent advances in molecular biological techniques and their relevance to pulmonary research. Thorax. 2000 Apr; 55(4):329-39.
Robinson BW, Erle DJ, Jones DA, Shapiro S, Metzger WJ, Albelda SM, Parks WC, Boylan A. PMID: 10722774; PMCID: PMC1745722.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J Immunol. 1998 Jul 15; 161(2):952-6.
Pachynski RK, Wu SW, Gunn MD, Erle DJ. PMID: 9670974.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol Chem. 1998 Mar 13; 273(11):6104-9.
Pfaff M, Liu S, Erle DJ, Ginsberg MH. PMID: 9497328.
View in:
PubMed Mentions:
79 Fields:
Translation:
Cells
-
Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization. J Cell Biol. 1997 Oct 20; 139(2):563-71.
Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ. PMID: 9334357; PMCID: PMC2139798.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
-
Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. J Immunol. 1997 Aug 01; 159(3):1497-505.
Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ. PMID: 9233649.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph. J Immunol. 1996 May 01; 156(9):3111-7.
Abitorabi MA, Mackay CR, Jerome EH, Osorio O, Butcher EC, Erle DJ. PMID: 8617931.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8.
Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. PMID: 8666675; PMCID: PMC2120829.
View in:
PubMed Mentions:
126 Fields:
Translation:
HumansAnimalsCells
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Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 01; 183(1):109-17.
Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. PMID: 8551213; PMCID: PMC2192426.
View in:
PubMed Mentions:
167 Fields:
Translation:
AnimalsCells
-
Intraepithelial lymphocytes. Scratching the surface. Curr Biol. 1995 Mar 01; 5(3):252-4.
Erle DJ. PMID: 7780732.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol. 1994 Jul 15; 153(2):517-28.
Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. PMID: 7517418.
View in:
PubMed Mentions:
113 Fields:
Translation:
HumansAnimalsCells
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Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression. Am J Respir Cell Mol Biol. 1994 Mar; 10(3):237-44.
Erle DJ, Brown T, Christian D, Aris R. PMID: 7509610.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
-
Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules. Methods Enzymol. 1994; 245:420-51.
Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D. PMID: 7760745.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism. J Immunol. 1993 Jul 15; 151(2):717-29.
Schweighoffer T, Tanaka Y, Tidswell M, Erle DJ, Horgan KJ, Luce GE, Lazarovits AI, Buck D, Shaw S. PMID: 7687621.
View in:
PubMed Mentions:
81 Fields:
Translation:
HumansCells
-
Characterization of the leukocyte integrin subunit beta 7. Chest. 1993 Feb; 103(2 Suppl):86S.
Rüegg C, Pytela R, Erle DJ. PMID: 8428547.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
-
How do integrins integrate? The role of cell adhesion receptors in differentiation and development. Am J Respir Cell Mol Biol. 1992 May; 6(5):459-60.
Erle DJ, Pytela R. PMID: 1581071.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol. 1992 Apr; 117(1):179-89.
Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ. PMID: 1372909; PMCID: PMC2289398.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction. Chest. 1992 Mar; 101(3 Suppl):49S.
Sheppard D, Erle D, Busk M, Pytela R. PMID: 1541204.
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PubMed Mentions: Fields:
Translation:
Animals
-
Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):170-7.
Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R. PMID: 1892648.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J Biol Chem. 1991 Jun 15; 266(17):11009-16.
Erle DJ, Rüegg C, Sheppard D, Pytela R. PMID: 2040616.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
-
Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem. 1990 Jul 15; 265(20):11502-7.
Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R. PMID: 2365683.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1983 Oct; 128(4):592-6.
Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA. PMID: 6354021.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCTClinical Trials