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David Erle, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-514-4370
ORCID ORCID Icon0000-0002-2171-0648 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MAAB06/1980Biochemistry
    University of California, San Francisco, CAMD06/1984Medicine
    University of California, San Francisco, CA06/1987Internal Medicine (Residency)
    University of California, San Francisco, CA06/1990Pulmonary Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Harvard College1980Magna cum laude
    University of California San Francisco1983Alpha Omega Alpha
    American Lung Association1990Trudeau Award
    Association of American Physicians (AAP)2018Elected member
    National Heart Lung and Blood Institute2019Outstanding Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Erle received an A.B. degree (Biochemistry) from Harvard College in 1980 and an M.D. degree from UCSF in 1984. He was trained in internal medicine and in pulmonary disease at UCSF. As a CVRI research fellow training at the UCSF Lung Biology Center, he studied leukocyte integrins with Robert Pytela and Dean Sheppard. He joined the Lung Biology Center faculty in 1990. His academic activities include laboratory research and clinical teaching. He founded the UCSF Functional Genomics Core Facility. He is a member of the Bakar ImmunoX Program, the Cardiovascular Research Institute, and the Institute for Human Genetics.

    Research Interests:

    Asthma affects ~300 million people and causes ~250,000 deaths annually. The long-term overall vision of our research program is that fundamental insights into the biology of the airway epithelium will allow us to better understand asthma and other airway diseases and provide a firm foundation for developing new approaches to prevention, cure, or treatment of these diseases.

    The concept that the airway epithelium plays a central role in asthma pathogenesis represents a relatively recent paradigm shift. We showed that direct effects of the type 2 cytokine IL-13 on resident airway cells were sufficient to induce airway hyperreactivity (AHR) and mucus overproduction. Our most important early contribution was the demonstration that IL-13-driven activation of the transcription factor (TF) STAT6 in airway epithelial cells causes AHR and mucus overproduction in mice. More recently, our studies of primary human bronchial epithelial (HBE) cells showed that IL-13 induces changes in expression, organization, and function of airway mucus glycoproteins (MUC5AC and MUC5B mucins). These changes lead to attachment (tethering) of mucus to the epithelium, prevent normal mucus clearance, and promote formation of obstructive mucus plugs that are a prominent feature of fatal asthma.

    Completed and ongoing studies in the lab are intended to help reach a deeper understanding of the molecular mechanisms underlying airway epithelial dysfunction in asthma. We study the mechanisms of gene regulation in the airway epithelium and determine the contributions of specific gene expression changes to changes in airway epithelial function. We use a variety of approaches from cell and molecular biology, genomics, and computational biology. We have adapted powerful new methods, including single cell RNA-seq (scRNA-seq), ChIP-seq, and CRISPR, for use with HBE cells as well as with cells obtained directly from individuals with asthma. We collaborate extensively with experts in asthma clinical studies, genetics and genomics, and computational biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies
    NIH R35HL145235Apr 15, 2019 - Feb 28, 2026
    Role: Principal Investigator
    Airway Epithelial Reprogramming in Asthma
    NIH R01HL138424Aug 1, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Empiric deconvolution of functional RNA elements
    NIH R01GM110251Aug 15, 2014 - Mar 31, 2019
    Role: Co-Principal Investigator
    Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA
    NIH U01HL126493Aug 1, 2014 - Apr 30, 2020
    Role: Co-Principal Investigator
    Massively parallel identification of functional 3' UTR variants in asthma
    NIH R01HL124285Aug 1, 2014 - Apr 14, 2019
    Role: Principal Investigator
    Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed Populations
    NIH R01HL118267Feb 1, 2014 - Jan 31, 2018
    Role: Subcontract PI
    UCSF Career Development Program in Omics of Lung Diseases
    NIH K12HL119997Sep 1, 2013 - May 31, 2019
    Role: Principal Investigator
    Micro-RNAs in airway epithelial differentiation and asthma
    NIH R21HL108596Apr 6, 2011 - Mar 31, 2014
    Role: Principal Investigator
    Specialized molecules with essential roles in mucus production
    NIH R01HL099101Jan 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Tools for high-throughput functional analysis of 3'UTR cis-regulatory elements
    NIH R21HG004665May 1, 2008 - Apr 30, 2010
    Role: Principal Investigator
    Understanding Asthma Endotypes
    NIH U19AI077439Apr 1, 2008 - Mar 31, 2023
    Role: Principal Investigator
    Airway Epithelial Responses to Allergic Inflammation
    NIH R01HL085089Jul 21, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Shared Microarray Facility
    NIH R01HL072301Sep 30, 2002 - Jul 31, 2007
    Role: Principal Investigator
    INTEGRIN ALPHA 4 BETA 7 AND REGULATION OF GUT IMMUNITY
    NIH R01DK054212May 1, 1999 - Apr 30, 2005
    Role: Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH P50HL056385Sep 30, 1996 - Aug 31, 2006
    Role: Co-Investigator
    MECHANISMS OF PERSISTENT AIRWAY INFLAMMATION IN ASTHMA
    NIH P01HL056385Sep 30, 1996 - Aug 31, 2001
    Role: Co-Investigator
    CHEMOKINES AS REGULATORS OF LEUKOCYTE INTEGRIN ACTIVITY
    NIH R01HL050024Feb 16, 1994 - Nov 30, 2004
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    NIH P60AR020684Sep 15, 1977 - Dec 31, 2003
    Role: Co-Investigator
    Multidisciplinary Training Program in Lung Disease
    NIH T32HL007185Jul 1, 1976 - Jun 30, 2022
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Res Sq. 2021 Apr 23. Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C. PMID: 34013247.
      View in: PubMed   Mentions:
    2. Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Mar 26. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium+ , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 33791731.
      View in: PubMed   Mentions:
    3. Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv. 2021 Mar 10. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Voyer TL, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, UCSF COMET consortium , Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. PMID: 33758859.
      View in: PubMed   Mentions:
    4. Epithelial miR-141 regulates IL-13-induced airway mucus production. JCI Insight. 2021 Mar 08; 6(5). Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG. PMID: 33682796.
      View in: PubMed   Mentions:    Fields:    
    5. The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium. bioRxiv. 2021 Feb 25. Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ. PMID: 33655249.
      View in: PubMed   Mentions:
    6. Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans. Am J Respir Crit Care Med. 2021 Feb 15; 203(4):424-436. Gui H, Levin AM, Hu D, Sleiman P, Xiao S, Mak AC, Yang M, Barczak AJ, Huntsman S, Eng C, Hochstadt S, Zhang E, Whitehouse K, Simons S, Cabral W, Takriti S, Abecasis G, Blackwell TW, Kang HM, Nickerson DA, Germer S, Lanfear DE, Gilliland F, Gauderman WJ, Kumar R, Erle DJ, Martinez FD, Hakonarson H, Burchard EG, Williams LK. PMID: 32966749.
      View in: PubMed   Mentions:    Fields:    
    7. Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 03; 591(7848):124-130. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33494096.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14. Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C. PMID: 33469573.
      View in: PubMed   Mentions:
    9. Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program. PLoS One. 2020; 15(11):e0242364. Cocco MP, White E, Xiao S, Hu D, Mak A, Sleiman P, Yang M, Bobbitt KR, Gui H, Levin AM, Hochstadt S, Whitehouse K, Rynkowski D, Barczak AJ, Abecasis G, Blackwell TW, Kang HM, Nickerson DA, Germer S, Ding J, Lanfear DE, Gilliland F, Gauderman WJ, Kumar R, Erle DJ, Martinez F, Hakonarson H, Burchard EG, Williams LK. PMID: 33237978.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020 12 03; 27(6):876-889.e12. Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. PMID: 33232663.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Flow Cytometric Analysis and Purification of Airway Epithelial Cell Subsets. Am J Respir Cell Mol Biol. 2020 Nov 16. Bonser LR, Koh KD, Johansson K, Choksi SP, Cheng D, Liu L, Sun DI, Zlock LT, Eckalbar WL, Finkbeiner WE, Erle DJ. PMID: 33196316.
      View in: PubMed   Mentions: 1     Fields:    
    12. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv. 2020 Oct 29. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140050.
      View in: PubMed   Mentions:
    13. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq. 2020 Oct 28. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140041.
      View in: PubMed   Mentions:
    14. Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth. Am J Respir Crit Care Med. 2020 10 01; 202(7):962-972. Lee EY, Mak ACY, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana J, Seibold MA, Burchard EG. PMID: 32459537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Steps toward Cell Therapy for Cystic Fibrosis. Am J Respir Cell Mol Biol. 2020 09; 63(3):275-276. Koh KD, Erle DJ. PMID: 32648785.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis. Am J Respir Cell Mol Biol. 2020 03; 62(3):373-381. Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ. PMID: 31596609.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms. Cell Rep. 2019 12 17; 29(12):4212-4222.e5. Godoy PM, Barczak AJ, DeHoff P, Srinivasan S, Etheridge A, Galas D, Das S, Erle DJ, Laurent LC. PMID: 31851944.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. The airway epithelium in asthma. Adv Immunol. 2019; 142:1-34. Bonser LR, Erle DJ. PMID: 31296301.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. J Exp Med. 2019 09 02; 216(9):2024-2037. Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR. PMID: 31217192.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization. Genome Res. 2019 06; 29(6):896-906. Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM. PMID: 31152051.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. Singling out Th2 cells in eosinophilic esophagitis. J Clin Invest. 2019 04 08; 129(5):1830-1832. Eckalbar WL, Erle DJ. PMID: 30958801.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Putting Mucins on the Map. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):681-682. Bonser LR, Erle DJ. PMID: 30376352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. J Clin Invest. 2019 01 02; 129(1):169-181. Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG. PMID: 30383540.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 10 30; 25(5):1346-1358. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. PMID: 30380423.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    25. Integrative approach identifies corticosteroid response variant in diverse populations with asthma. J Allergy Clin Immunol. 2019 05; 143(5):1791-1802. Levin AM, Gui H, Hernandez-Pacheco N, Yang M, Xiao S, Yang JJ, Hochstadt S, Barczak AJ, Eckalbar WL, Rynkowski D, Samedy LA, Kwok PY, Pino-Yanes M, Erle DJ, Lanfear DE, Burchard EG, Williams LK. PMID: 30367910.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    26. Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018 10; 19(10):1093-1099. Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. PMID: 30201992.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    27. Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 09 06; 36(9):899. Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. PMID: 30188530.
      View in: PubMed   Mentions: 1     Fields:    
    28. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018 07; 559(7715):627-631. Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. PMID: 30022164.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    29. Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Immunity. 2018 07 17; 49(1):33-41.e7. Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. PMID: 30021144.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    30. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 09; 36(8):746-757. Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. PMID: 30010675.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    31. Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells. J Immunol. 2018 08 01; 201(3):1053-1061. Zhao W, Erle DJ. PMID: 29907706.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 02 01; 197(3):313-324. Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. PMID: 29064281.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells. J Immunol. 2018 02 15; 200(4):1399-1412. Oh J, Wu N, Barczak AJ, Barbeau R, Erle DJ, Shin JS. PMID: 29321275.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J Clin Med. 2017 Nov 29; 6(12). Bonser LR, Erle DJ. PMID: 29186064.
      View in: PubMed   Mentions:
    35. CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Nucleic Acids Res. 2017 Oct 13; 45(18):10800-10810. Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ. PMID: 28985357.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    36. Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. Eur Respir J. 2017 06; 49(6). Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE. PMID: 28642310.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    37. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017 05 23; 19(8):1558-1571. Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. PMID: 28538176.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 04 20; 169(3):497-509.e13. Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. PMID: 28431248.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    39. Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. Mucosal Immunol. 2017 11; 10(6):1491-1503. Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, Di H, Zou Y, Zhang H, Zhao J, Xu Y, Erle DJ, Zhen G. PMID: 28224996.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    40. A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Dec; 17(12):1381-1387. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. PMID: 27749840.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    41. Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol. PLoS One. 2016; 11(7):e0159459. Khosravi AR, Erle DJ. PMID: 27463381.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    42. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ. PMID: 27362652.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    43. Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma. J Clin Invest. 2016 06 01; 126(6):2367-71. Bonser LR, Zlock L, Finkbeiner W, Erle DJ. PMID: 27183390.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    44. Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD. Eur Respir J. 2016 06; 47(6):1645-56. Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE. PMID: 26965288.
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    45. Massively Parallel Identification of Regulatory Variants in Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S104. Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ. PMID: 27027944.
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    46. MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19; 44(4):821-32. Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM. PMID: 26850657.
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    47. The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):536-43. Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ. PMID: 25751668.
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    48. Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells. PLoS One. 2015; 10(8):e0135440. Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT. PMID: 26270036.
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    49. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. . 2015 Jun 01; 308(11):L1102-13. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. PMID: 25795726.
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    50. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Dec 08; 26(6):938. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. PMID: 28898680.
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    51. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. PMID: 25446897.
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    52. Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma. Am J Respir Crit Care Med. 2014 Sep 15; 190(6):639-48. Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X, Bonser LR, Zhao J, Xu Y, Erle DJ, Zhen G. PMID: 25133876.
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    53. Erratum: Corrigendum: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nature Immunology. 2014 Sep 1; 15(9):894-894. Michael Waterfield, Imran S Khan, Jessica T Cortez, Una Fan, Todd Metzger, Alexandra Greer, Kayla Fasano, Marc Martinez-Llordella, Joshua L Pollack, David J Erle, Maureen Su, Mark S Anderson. .
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    54. IL-17 and "TH2-high" asthma: Adding fuel to the fire? J Allergy Clin Immunol. 2014 Nov; 134(5):1187-8. Bhakta NR, Erle DJ. PMID: 25174869.
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    55. Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194.
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    56. The cell biology of asthma. J Cell Biol. 2014 Jun 09; 205(5):621-31. Erle DJ, Sheppard D. PMID: 24914235.
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    57. Massively parallel functional annotation of 3' untranslated regions. Nat Biotechnol. 2014 Apr; 32(4):387-91. Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ. PMID: 24633241.
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    58. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014 Mar; 15(3):258-65. Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. PMID: 24464130.
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    59. Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa. Genome Med. 2014; 6(1):1. McErlean P, Berdnikovs S, Favoreto S, Shen J, Biyasheva A, Barbeau R, Eisley C, Barczak A, Ward T, Schleimer RP, Erle DJ, Boushey HA, Avila PC. PMID: 24433494.
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    60. Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics. Genomics Proteomics Bioinformatics. 2013 Dec; 11(6):368-77. Reisdorph N, Stearman R, Kechris K, Phang TL, Reisdorph R, Prenni J, Erle DJ, Coldren C, Schey K, Nesvizhskii A, Geraci M. PMID: 24316330.
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    61. S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241. Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron. .
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    62. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290.
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    63. Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium. Clin Exp Allergy. 2013 Aug; 43(8):914-27. Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS. PMID: 23889245.
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    64. Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-ß1. Cardiovasc Res. 2013 Sep 01; 99(4):769-79. Rahmutula D, Marcus GM, Wilson EE, Ding CH, Xiao Y, Paquet AC, Barbeau R, Barczak AJ, Erle DJ, Olgin JE. PMID: 23612580.
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    65. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. The Journal of Cell Biology. 2013 Feb 18; 200(4):i9-i9. Yelena Bronevetsky, Alejandro V. Villarino, Christopher J. Eisley, Rebecca Barbeau, Andrea J. Barczak, Gitta A. Heinz, Elisabeth Kremmer, Vigo Heissmeyer, Michael T. McManus, David J. Erle, Anjana Rao, K. Mark Ansel. .
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    66. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32. Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. PMID: 23382546.
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    67. Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013 Mar; 131(3):894-903. Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM. PMID: 23333113.
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    68. An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89. Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. PMID: 23304658.
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    69. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. PMID: 22955319.
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    70. Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. BMC Med Genomics. 2012 Jun 19; 5:27. Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE. PMID: 22713245.
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    71. AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):178-85. Schroeder BW, Verhaeghe C, Park SW, Nguyenvu LT, Huang X, Zhen G, Erle DJ. PMID: 22403803.
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    72. The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58. Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. PMID: 22232213.
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    73. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15201-6. Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM. PMID: 21876130.
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    74. Toward a systematic understanding of mRNA 3' untranslated regions. Proc Am Thorac Soc. 2011 May; 8(2):163-6. Zhao W, Blagev D, Pollack JL, Erle DJ. PMID: 21543795.
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    75. An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PLoS One. 2011 Jan 04; 6(1):e16004. Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS. PMID: 21245908.
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    76. Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. J Allergy Clin Immunol. 2010 Aug; 126(2):347-54. Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F. PMID: 20579713.
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    77. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11489-94. Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. PMID: 20534524.
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    78. Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation. . 2010 Mar; 298(3):L290-6. Gu N, Kang G, Jin C, Xu Y, Zhang Z, Erle DJ, Zhen G. PMID: 19965981.
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    79. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One. 2009 Aug 11; 4(8):e6580. Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N. PMID: 19668367.
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    80. Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):603-10. Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. PMID: 19628779.
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    81. Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol. 2009 Apr 15; 182(8):4581-9. Klinger M, Kim JK, Chmura SA, Barczak A, Erle DJ, Killeen N. PMID: 19342632.
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    82. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6950-5. Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ. PMID: 19359471.
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    83. CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol. 2009 Jan 01; 182(1):623-35. Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD. PMID: 19109196.
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    84. The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model. J Immunol. 2008 Aug 01; 181(3):2203-10. Nakagami Y, Favoreto S, Zhen G, Park SW, Nguyenvu LT, Kuperman DA, Dolganov GM, Huang X, Boushey HA, Avila PC, Erle DJ. PMID: 18641360.
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    85. Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):376-87. Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ. PMID: 18029791.
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    86. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. PMID: 17965775.
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    87. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15858-63. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. PMID: 17898169.
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    88. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. PMID: 17641300.
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    89. Progress toward a systems biology approach to acute lung injury. . 2007 Aug; 293(2):L290-1. Frank JA, Erle DJ. PMID: 17575007.
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    90. Genomics and proteomics of lung disease: conference summary. . 2007 Jul; 293(1):L45-51. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. PMID: 17468134.
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    91. Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals. J Immunol. 2007 Feb 01; 178(3):1457-67. Chang WL, Coro ES, Rau FC, Xiao Y, Erle DJ, Baumgarth N. PMID: 17237394.
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    92. Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog. 2007 Jan; 3(1):e1. Horsnell WG, Cutler AJ, Hoving JC, Hoving CJ, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F. PMID: 17222057.
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    93. Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines. The FASEB Journal. 2007 Jan 1; 21(6):a1202-a1202. Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay. .
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    94. IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):244-53. Zhen G, Park SW, Nguyenvu LT, Rodriguez MW, Barbeau R, Paquet AC, Erle DJ. PMID: 16980555.
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    95. The asthma channel? Stay tuned . . . Am J Respir Crit Care Med. 2006 Jun 01; 173(11):1181-2. Erle DJ, Zhen G. PMID: 16738260.
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    96. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec 01; 172(11):1383-92. Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. PMID: 16166618.
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    97. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol. 2005 Sep 15; 175(6):3746-52. Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ. PMID: 16148120.
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    98. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug; 116(2):305-11. Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. PMID: 16083784.
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    99. Increased DNA microarray hybridization specificity using sscDNA targets. BMC Genomics. 2005 Apr 22; 6:57. Barker CS, Griffin C, Dolganov GM, Hanspers K, Yang JY, Erle DJ. PMID: 15847692.
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    100. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy. 2005 Jan; 35(1):82-8. Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH. PMID: 15649271.
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    101. Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respir Res. 2004 Sep 15; 5:12. Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ. PMID: 15377395.
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    102. Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells. BMC Immunol. 2004 Jul 05; 5:13. Rodriguez MW, Paquet AC, Yang YH, Erle DJ. PMID: 15236665.
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    103. Asthma investigators begin to reap the fruits of genomics. Genome Biol. 2003; 4(11):232. Erle DJ, Yang YH. PMID: 14611649.
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    104. Abnormal alveolar development associated with elevated adenine nucleosides. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):38-50. Banerjee SK, Young HW, Barczak A, Erle DJ, Blackburn MR. PMID: 12855405.
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    105. Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res. 2003 Jul; 13(7):1775-85. Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ. PMID: 12805270.
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    106. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. PMID: 12091879.
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    107. Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells. Dev Immunol. 2002 Jun; 9(2):73-84. Shu F, Holzmann B, Seibold F, Erle D, Kearney JF. PMID: 12739784.
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    108. Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression. Chest. 2002 Mar; 121(3 Suppl):80S. Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A. PMID: 11893700.
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    109. The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol. 2002 Feb; 26(2):202-8. Venkayya R, Lam M, Willkom M, Grünig G, Corry DB, Erle DJ. PMID: 11804871.
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    110. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. PMID: 11694453.
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    111. Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7. Immunology. 2001 Jun; 103(2):155-63. Abramson O, Qiu S, Erle DJ. PMID: 11412302.
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    112. Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. Eur Respir J. 2000 May; 15(5):922-8. Solomon C, Christian DL, Chen LL, Welch BS, Kleinman MT, Dunham E, Erle DJ, Balmes JR. PMID: 10853860.
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    113. Recent advances in molecular biological techniques and their relevance to pulmonary research. Thorax. 2000 Apr; 55(4):329-39. Robinson BW, Erle DJ, Jones DA, Shapiro S, Metzger WJ, Albelda SM, Parks WC, Boylan A. PMID: 10722774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    114. Intraepithelial lymphocytes in the lung: a neglected lymphocyte population. Am J Respir Cell Mol Biol. 2000 Apr; 22(4):398-400. Erle DJ, Pabst R. PMID: 10745019.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    115. Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J Immunol. 1998 Jul 15; 161(2):952-6. Pachynski RK, Wu SW, Gunn MD, Erle DJ. PMID: 9670974.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    116. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol Chem. 1998 Mar 13; 273(11):6104-9. Pfaff M, Liu S, Erle DJ, Ginsberg MH. PMID: 9497328.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    117. Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization. J Cell Biol. 1997 Oct 20; 139(2):563-71. Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ. PMID: 9334357.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    118. Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. J Immunol. 1997 Aug 01; 159(3):1497-505. Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ. PMID: 9233649.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    119. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. PMID: 8666675.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    120. Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph. J Immunol. 1996 May 01; 156(9):3111-7. Abitorabi MA, Mackay CR, Jerome EH, Osorio O, Butcher EC, Erle DJ. PMID: 8617931.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    121. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 01; 183(1):109-17. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. PMID: 8551213.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    122. Intraepithelial lymphocytes. Scratching the surface. Curr Biol. 1995 Mar 01; 5(3):252-4. Erle DJ. PMID: 7780732.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    123. Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol. 1994 Jul 15; 153(2):517-28. Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. PMID: 7517418.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    124. Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression. Am J Respir Cell Mol Biol. 1994 Mar; 10(3):237-44. Erle DJ, Brown T, Christian D, Aris R. PMID: 7509610.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    125. Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules. Methods Enzymol. 1994; 245:420-51. Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D. PMID: 7760745.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    126. Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism. J Immunol. 1993 Jul 15; 151(2):717-29. Schweighoffer T, Tanaka Y, Tidswell M, Erle DJ, Horgan KJ, Luce GE, Lazarovits AI, Buck D, Shaw S. PMID: 7687621.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    127. Characterization of the leukocyte integrin subunit beta 7. Chest. 1993 Feb; 103(2 Suppl):86S. Rüegg C, Pytela R, Erle DJ. PMID: 8428547.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    128. How do integrins integrate? The role of cell adhesion receptors in differentiation and development. Am J Respir Cell Mol Biol. 1992 May; 6(5):459-60. Erle DJ, Pytela R. PMID: 1581071.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    129. Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol. 1992 Apr; 117(1):179-89. Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ. PMID: 1372909.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    130. Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction. Chest. 1992 Mar; 101(3 Suppl):49S. Sheppard D, Erle D, Busk M, Pytela R. PMID: 1541204.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    131. Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):170-7. Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R. PMID: 1892648.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    132. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J Biol Chem. 1991 Jun 15; 266(17):11009-16. Erle DJ, Rüegg C, Sheppard D, Pytela R. PMID: 2040616.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    133. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem. 1990 Jul 15; 265(20):11502-7. Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R. PMID: 2365683.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    134. Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1983 Oct; 128(4):592-6. Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA. PMID: 6354021.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
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