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Philip Ballard

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-4193
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Proteomic Profile Associated with Chronic Lung Disease of Premature Infants
    NIH/NHLBI R21HL129910Sep 15, 2015 - Jun 30, 2017
    Role: Principal Investigator
    UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
    NIH/NHLBI U01HL101798May 1, 2010 - Apr 30, 2015
    Role: Co-Principal Investigator
    Regulation and role of CEACAM6 in the lung alveolus
    NIH/NHLBI R01HL088193Dec 10, 2007 - Nov 30, 2011
    Role: Principal Investigator
    SCOR in Pathobiology of Lung Development
    NIH/NHLBI P50HL056401Sep 1, 1996 - Jul 31, 2007
    Role: Principal Investigator
    Molecular Therapy for Cystic Fibrosis
    NIH P30DK047757Sep 30, 1993 - Mar 31, 2018
    Role: Co-Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Co-Investigator
    Cellular and molecular biology of lung surfactant
    NIH P01HL019737Dec 1, 1976 - Jun 30, 2014
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000240Dec 1, 1976 - Sep 29, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wai KC, Hibbs AM, Steurer MA, Black DM, Asselin JM, Eichenwald EC, Ballard P, Ballard RA, Keller RL. Maternal Black Race and Persistent Wheezing Illness in Former Extremely Low Gestational Age Newborns: Secondary Analysis of a Randomized Trial. J Pediatr. 2018 Apr 04. PMID: 29627188.
      View in: PubMed
    2. Ballard P. Commentary on the identity of fibroblast pneumocyte factor: rat vs. human. Pediatr Res. 2017 07; 82(1):4-5. PMID: 28355199.
      View in: PubMed
    3. Keller RL, Eichenwald EC, Hibbs AM, Rogers EE, Wai KC, Black DM, Ballard P, Asselin JM, Truog WE, Merrill JD, Mammel MC, Steinhorn RH, Ryan RM, Durand DJ, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, Helderman J, Porta NF, Wadhawan R, Palermo L, Ballard RA. The Randomized, Controlled Trial of Late Surfactant: Effects on Respiratory Outcomes at 1-Year Corrected Age. J Pediatr. 2017 Apr; 183:19-25.e2. PMID: 28100402.
      View in: PubMed
    4. Barrette AM, Roberts JK, Chapin C, Egan EA, Segal MR, Oses-Prieto JA, Chand S, Burlingame AL, Ballard P. Antiinflammatory Effects of Budesonide in Human Fetal Lung. Am J Respir Cell Mol Biol. 2016 11; 55(5):623-632. PMID: 27281349.
      View in: PubMed
    5. Wai KC, Kohn MA, Ballard RA, Truog WE, Black DM, Asselin JM, Ballard P, Rogers EE, Keller RL. Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns. J Pediatr. 2016 Oct; 177:97-102.e2. PMID: 27470692; PMCID: PMC5037007 [Available on 10/01/17].
    6. Roberts JK, Stockmann C, Dahl MJ, Albertine KH, Egan E, Lin Z, Reilly CA, Ballard P, Ballard RA, Ward RM. Pharmacokinetics of Budesonide Administered with Surfactant in Premature Lambs: Implications for Neonatal Clinical Trials. Curr Clin Pharmacol. 2016; 11(1):53-61. PMID: 26416605.
      View in: PubMed
    7. Lin SE, Barrette AM, Chapin C, Gonzales LW, Gonzalez RF, Dobbs LG, Ballard P. Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice. Physiol Rep. 2015 Dec; 3(12). PMID: 26702074; PMCID: PMC4760449.
    8. Ballard RA, Keller RL, Black DM, Ballard P, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn RH, Rogers EE, Ryan RM, Durand DJ, Asselin JM, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, O'Shea TM, Porta NF, Wadhawan R, Palermo L. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr. 2016 Jan; 168:23-9.e4. PMID: 26500107; PMCID: PMC4698022 [Available on 01/01/17].
    9. Gonzales LW, Gonzalez R, Barrette AM, Wang P, Dobbs L, Ballard P. Expression of Carcinoembryonic Cell Adhesion Molecule 6 and Alveolar Epithelial Cell Markers in Lungs of Human Infants with Chronic Lung Disease. J Histochem Cytochem. 2015 12; 63(12):908-21. PMID: 26374831; PMCID: PMC4823795 [Available on 12/01/16].
    10. Danhaive O, Chapin C, Horneman H, Cogo PE, Ballard P. Surface film formation in vitro by infant and therapeutic surfactants: role of surfactant protein B. Pediatr Res. 2015 Feb; 77(2):340-6. PMID: 25360829; PMCID: PMC4391810.
    11. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard P, Frank JA. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):550-8. PMID: 24787463; PMCID: PMC4189483.
    12. Ballard P, Keller RL, Black DM, Durand DJ, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn R, Ryan RM, Courtney SE, Horneman H, Ballard RA. Inhaled nitric oxide increases urinary nitric oxide metabolites and cyclic guanosine monophosphate in premature infants: relationship to pulmonary outcome. Am J Perinatol. 2015 Feb; 32(3):225-32. PMID: 24968129; PMCID: PMC5032843.
    13. Keller RL, Merrill JD, Black DM, Steinhorn RH, Eichenwald EC, Durand DJ, Ryan RM, Truog WE, Courtney SE, Ballard P, Ballard RA. Late administration of surfactant replacement therapy increases surfactant protein-B content: a randomized pilot study. Pediatr Res. 2012 Dec; 72(6):613-9. PMID: 23037875; PMCID: PMC3548137.
    14. Chapin C, Bailey NA, Gonzales LW, Lee JW, Gonzalez RF, Ballard P. Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lung. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 15; 302(2):L216-25. PMID: 22037359; PMCID: PMC3349363.
    15. Heine VM, Griveau A, Chapin C, Ballard P, Chen JK, Rowitch DH. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med. 2011 Oct 19; 3(105):105ra104. PMID: 22013124; PMCID: PMC3694585.
    16. Golombek SG, Truog WE, Ballard RA, Ballard P. Re: 'The use of iNO in the newborn period: results from the European iNO registry'. Acta Paediatr. 2010 Sep; 99(9):1283. PMID: 20456263.
      View in: PubMed
    17. Gonzalez RF, Allen L, Gonzales L, Ballard P, Dobbs LG. HTII-280, a biomarker specific to the apical plasma membrane of human lung alveolar type II cells. J Histochem Cytochem. 2010 Oct; 58(10):891-901. PMID: 20566753; PMCID: PMC2942742.
    18. Ballard P, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA. Regulated gene expression in cultured type II cells of adult human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L36-50. PMID: 20382749; PMCID: PMC2904098.
    19. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ, Truog WE, Ballard P, Zadell A, Wadlinger SR, Coburn CE, Ballard RA. Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxide. J Pediatr. 2010 Apr; 156(4):556-61.e1. PMID: 20138299; PMCID: PMC2843768.
    20. Zupancic JA, Hibbs AM, Palermo L, Truog WE, Cnaan A, Black DM, Ballard P, Wadlinger SR, Ballard RA. Economic evaluation of inhaled nitric oxide in preterm infants undergoing mechanical ventilation. Pediatrics. 2009 Nov; 124(5):1325-32. PMID: 19841125.
      View in: PubMed
    21. Kolla V, Gonzales LW, Bailey NA, Wang P, Angampalli S, Godinez MH, Madesh M, Ballard P. Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1019-30. PMID: 19329538; PMCID: PMC2692808.
    22. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard P, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500. PMID: 19151197; PMCID: PMC2654978.
    23. Davis CW, Gonzales LW, Ballard RA, Ballard P, Guo C, Gow AJ. Expression of nitric oxide synthases and endogenous NO metabolism in bronchopulmonary dysplasia. Pediatr Pulmonol. 2008 Jul; 43(7):703-9. PMID: 18500734; PMCID: PMC4015107.
    24. Hibbs AM, Walsh MC, Martin RJ, Truog WE, Lorch SA, Alessandrini E, Cnaan A, Palermo L, Wadlinger SR, Coburn CE, Ballard P, Ballard RA. One-year respiratory outcomes of preterm infants enrolled in the Nitric Oxide (to prevent) Chronic Lung Disease trial. J Pediatr. 2008 Oct; 153(4):525-9. PMID: 18534620; PMCID: PMC2745607.
    25. Ballard P, Truog WE, Merrill JD, Gow A, Posencheg M, Golombek SG, Parton LA, Luan X, Cnaan A, Ballard RA. Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infants. Pediatrics. 2008 Mar; 121(3):555-61. PMID: 18310205.
      View in: PubMed
    26. Ballard P, Merrill JD, Truog WE, Godinez RI, Godinez MH, McDevitt TM, Ning Y, Golombek SG, Parton LA, Luan X, Cnaan A, Ballard RA. Surfactant function and composition in premature infants treated with inhaled nitric oxide. Pediatrics. 2007 Aug; 120(2):346-53. PMID: 17671061.
      View in: PubMed
    27. Truog WE, Ballard P, Norberg M, Golombek S, Savani RC, Merrill JD, Parton LA, Cnaan A, Luan X, Ballard RA. Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxide. Pediatrics. 2007 Apr; 119(4):670-8. PMID: 17403837.
      View in: PubMed
    28. Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard P. Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1506-14. PMID: 17337509.
      View in: PubMed
    29. McDevitt TM, Gonzales LW, Savani RC, Ballard P. Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L249-57. PMID: 16997883.
      View in: PubMed
    30. Kolla V, Gonzales LW, Gonzales J, Wang P, Angampalli S, Feinstein SI, Ballard P. Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):213-25. PMID: 16960125; PMCID: PMC1899316.
    31. Ballard RA, Truog WE, Cnaan A, Martin RJ, Ballard P, Merrill JD, Walsh MC, Durand DJ, Mayock DE, Eichenwald EC, Null DR, Hudak ML, Puri AR, Golombek SG, Courtney SE, Stewart DL, Welty SE, Phibbs RH, Hibbs AM, Luan X, Wadlinger SR, Asselin JM, Coburn CE. Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med. 2006 Jul 27; 355(4):343-53. PMID: 16870913.
      View in: PubMed
    32. Postle AD, Gonzales LW, Bernhard W, Clark GT, Godinez MH, Godinez RI, Ballard P. Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells. J Lipid Res. 2006 Jun; 47(6):1322-31. PMID: 16513897.
      View in: PubMed
    33. Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu MM, Kimura S, Ballard P, Beers MF, Epstein JA, Morrisey EE. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L191-9. PMID: 16510470.
      View in: PubMed
    34. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard P. Gene induction during differentiation of human pulmonary type II cells in vitro. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):727-37. PMID: 16474099; PMCID: PMC2644235.
    35. Cheong N, Madesh M, Gonzales LW, Zhao M, Yu K, Ballard P, Shuman H. Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. J Biol Chem. 2006 Apr 07; 281(14):9791-800. PMID: 16415354.
      View in: PubMed
    36. Ballard P, Gonzales LW, Godinez RI, Godinez MH, Savani RC, McCurnin DC, Gibson LL, Yoder BA, Kerecman JD, Grubb PH, Shaul PW. Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide. Pediatr Res. 2006 Jan; 59(1):157-62. PMID: 16326985.
      View in: PubMed
    37. Shu W, Guttentag S, Wang Z, Andl T, Ballard P, Lu MM, Piccolo S, Birchmeier W, Whitsett JA, Millar SE, Morrisey EE. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol. 2005 Jul 01; 283(1):226-39. PMID: 15907834.
      View in: PubMed
    38. Koo HC, Davis JM, Li Y, Hatzis D, Opsimos H, Pollack S, Strayer MS, Ballard P, Kazzaz JA. Effects of transgene expression of superoxide dismutase and glutathione peroxidase on pulmonary epithelial cell growth in hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L718-26. PMID: 15579623.
      View in: PubMed
    39. Merrill JD, Ballard RA, Cnaan A, Hibbs AM, Godinez RI, Godinez MH, Truog WE, Ballard P. Dysfunction of pulmonary surfactant in chronically ventilated premature infants. Pediatr Res. 2004 Dec; 56(6):918-26. PMID: 15496605.
      View in: PubMed
    40. Daugherty BL, Mateescu M, Patel AS, Wade K, Kimura S, Gonzales LW, Guttentag S, Ballard P, Koval M. Developmental regulation of claudin localization by fetal alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1266-73. PMID: 15347569.
      View in: PubMed
    41. Ekekezie II, Thibeault DW, Simon SD, Norberg M, Merrill JD, Ballard RA, Ballard P, Truog WE. Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease. Pediatrics. 2004 Jun; 113(6):1709-14. PMID: 15173495.
      View in: PubMed
    42. Hamvas A, Nogee LM, White FV, Schuler P, Hackett BP, Huddleston CB, Mendeloff EN, Hsu FF, Wert SE, Gonzales LW, Beers MF, Ballard P. Progressive lung disease and surfactant dysfunction with a deletion in surfactant protein C gene. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):771-6. PMID: 14656744.
      View in: PubMed
    43. Ballard P, Merrill JD, Godinez RI, Godinez MH, Truog WE, Ballard RA. Surfactant protein profile of pulmonary surfactant in premature infants. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1123-8. PMID: 12904326.
      View in: PubMed
    44. Lorch SA, Banks BA, Christie J, Merrill JD, Althaus J, Schmidt K, Ballard P, Ischiropoulos H, Ballard RA. Plasma 3-nitrotyrosine and outcome in neonates with severe bronchopulmonary dysplasia after inhaled nitric oxide. Free Radic Biol Med. 2003 May 01; 34(9):1146-52. PMID: 12706495.
      View in: PubMed
    45. Berry GT, Wu S, Buccafusca R, Ren J, Gonzales LW, Ballard P, Golden JA, Stevens MJ, Greer JJ. Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea. J Biol Chem. 2003 May 16; 278(20):18297-302. PMID: 12582158.
      View in: PubMed
    46. Pepe GJ, Ballard P, Albrecht ED. Fetal lung maturation in estrogen-deprived baboons. J Clin Endocrinol Metab. 2003 Jan; 88(1):471-7. PMID: 12519892.
      View in: PubMed
    47. Gonzales LW, Guttentag SH, Wade KC, Postle AD, Ballard P. Differentiation of human pulmonary type II cells in vitro by glucocorticoid plus cAMP. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L940-51. PMID: 12376347.
      View in: PubMed
    48. Li C, Zhu NL, Tan RC, Ballard P, Derynck R, Minoo P. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. PMID: 12161428.
      View in: PubMed
    49. Rosenberg E, Li F, Reisher SR, Wang M, Gonzales LW, Ewing JR, Malek S, Ballard P, Notarfrancesco K, Shuman H, Feinstein SI. Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. Biochim Biophys Acta. 2002 May 03; 1575(1-3):82-90. PMID: 12020822.
      View in: PubMed
    50. Mulugeta S, Gray JM, Notarfrancesco KL, Gonzales LW, Koval M, Feinstein SI, Ballard P, Fisher AB, Shuman H. Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3. J Biol Chem. 2002 Jun 21; 277(25):22147-55. PMID: 11940594.
      View in: PubMed
    51. Banks BA, Macones G, Cnaan A, Merrill JD, Ballard P, Ballard RA. Multiple courses of antenatal corticosteroids are associated with early severe lung disease in preterm neonates. J Perinatol. 2002 Mar; 22(2):101-7. PMID: 11896513.
      View in: PubMed
    52. Strayer M, Savani RC, Gonzales LW, Zaman A, Cui Z, Veszelovszky E, Wood E, Ho YS, Ballard P. Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L394-404. PMID: 11839532.
      View in: PubMed
    53. Bates SR, Gonzales LW, Tao JQ, Rueckert P, Ballard P, Fisher AB. Recovery of rat type II cell surfactant components during primary cell culture. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L267-76. PMID: 11792631.
      View in: PubMed