C. Anthony Hunt, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address513 Parnassus Avenue, MSB, #840
San Francisco CA 94117
ORCID ORCID Icon0000-0001-9372-6860 Additional info
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    Collapse Biography 
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    Georgia Institute of Technology1970BS in Chemistry with Highest Honors
    1984American Association for the Advancement of Science

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    My research is motivated by this question. What are the causal mechanisms that link induced changes in molecular level events to emergent changes in phenotype at the organism level? We need new ways to explore and challenge plausible answers. So doing will facilitate moving away from empirical approaches to biomedical research and reliance on correlational methods toward new approaches based on improving mechanistic knowledge and insight.
    We need ways to build and challenge experimentally (falsify) many alternative, nested, networked mechanistic hypotheses. Doing so using established, bottom-up, computational mathematical models is problematic at best. New methods and new approaches are needed. My search started in earnest circa 1997. We have now developed and demonstrated the scientific power of a novel, fundamentally new class biomedical simulation models along with methods to challenge and iteratively improve plausible, explanatory mechanisms. We adapted concepts and advanced methods from several domains. I call the process the synthetic method of modeling and simulation (SM). I say synthetic because standalone biomimetic components are plugged together in specific ways to form hierarchical, multiscale biomimetic mechanisms in software. I refer to the models as analogues because even though they exist only in silico, their phenotypes can be made to increasingly overlap more of the referent, biological phenotype. They are designed to evolve to become embodiments of most of what we know (or think we know) about aspects of specific organisms and their components.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An exploration of knowledge-organizing technologies to advance transdisciplinary back pain research. JOR Spine. 2023 Dec; 6(4):e1300. Lotz JC, Ropella G, Anderson P, Yang Q, Hedderich MA, Bailey J, Hunt CA. PMID: 38156063; PMCID: PMC10751978.
      View in: PubMed   Mentions:
    2. Theoretical Schemas to Guide Back Pain Consortium (BACPAC) Chronic Low Back Pain Clinical Research. Pain Med. 2023 08 04; 24(Suppl 1):S13-S35. Chau A, Steib S, Whitaker E, Kohns D, Quinter A, Craig A, Chiodo A, Chandran S, Laidlaw A, Schott Z, Farlow N, Yarjanian J, Omwanghe A, Wasserman R, O'Neill C, Clauw D, Bowden A, Marras W, Carey T, Mehling W, Hunt CA, Lotz J. PMID: 36562563; PMCID: PMC10403312.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance. PLoS One. 2022; 17(7):e0269775. Krishnan P, Smith AK, Ropella GEP, Dutta L, Kennedy RC, Hunt CA. PMID: 35867653; PMCID: PMC9307204.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms. PLoS Comput Biol. 2020 06; 16(6):e1007622. Smith AK, Ropella GEP, McGill MR, Krishnan P, Dutta L, Kennedy RC, Jaeschke H, Hunt CA. PMID: 32484845; PMCID: PMC7292418.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. Toxicol Sci. 2019 05 01; 169(1):151-166. Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA. PMID: 30698817; PMCID: PMC6484890.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. The Spectrum of Mechanism-Oriented Models and Methods for Explanations of Biological Phenomena. Processes (Basel). 2018 May; 6(5). Hunt CA, Erdemir A, Lytton WW, Gabhann FM, Sander EA, Transtrum MK, Mulugeta L. PMID: 34262852; PMCID: PMC8277120.
      View in: PubMed   Mentions: 9  
    7. A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation. J Pharmacol Exp Ther. 2018 04; 365(1):127-138. Smith AK, Xu Y, Ropella GEP, Hunt CA. PMID: 29434053.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Simulation enabled search for explanatory mechanisms of the fracture healing process. PLoS Comput Biol. 2018 02; 14(2):e1005980. Kennedy RC, Marmor M, Marcucio R, Hunt CA. PMID: 29394245; PMCID: PMC5812655.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    9. Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments. PLoS Comput Biol. 2016 12; 12(12):e1005253. Smith AK, Petersen BK, Ropella GE, Kennedy RC, Kaplowitz N, Ookhtens M, Hunt CA. PMID: 27984590; PMCID: PMC5161305.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    10. Virtual Experiments Enable Exploring and Challenging Explanatory Mechanisms of Immune-Mediated P450 Down-Regulation. PLoS One. 2016; 11(5):e0155855. Petersen BK, Ropella GE, Hunt CA. PMID: 27227433; PMCID: PMC4881988.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. A cell-centered, agent-based framework that enables flexible environment granularities. Theor Biol Med Model. 2016 Feb 02; 13:4. Kennedy RC, Ropella GE, Hunt CA. PMID: 26839017; PMCID: PMC4736144.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. In silico, experimental, mechanistic model for extended-release felodipine disposition exhibiting complex absorption and a highly variable food interaction. PLoS One. 2014; 9(9):e108392. Kim SH, Jackson AJ, Hunt CA. PMID: 25268237; PMCID: PMC4182452.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Toward modular biological models: defining analog modules based on referent physiological mechanisms. BMC Syst Biol. 2014 Aug 16; 8:95. Petersen BK, Ropella GE, Hunt CA. PMID: 25123169; PMCID: PMC4236728.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    14. Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models. Wiley Interdiscip Rev Syst Biol Med. 2014 Jul-Aug; 6(4):289-309. Kirschner DE, Hunt CA, Marino S, Fallahi-Sichani M, Linderman JJ. PMID: 24810243; PMCID: PMC4102180.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    15. Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity. Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug; 5(4):461-80. Hunt CA, Kennedy RC, Kim SH, Ropella GE. PMID: 23737142; PMCID: PMC3739932.
      View in: PubMed   Mentions: 19     Fields:    
    16. Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products. Theor Biol Med Model. 2012 Aug 31; 9:39. Kim SH, Jackson AJ, Hur R, Hunt CA. PMID: 22938185; PMCID: PMC3563477.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Relational grounding facilitates development of scientifically useful multiscale models. Theor Biol Med Model. 2011 Sep 27; 8:35. Hunt CA, Ropella GE, Lam Tn, Gewitz AD. PMID: 21951817; PMCID: PMC3200146.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    18. Enabling clearance predictions to emerge from in silico actions of quasi-autonomous hepatocyte components. Drug Metab Dispos. 2011 Oct; 39(10):1910-20. Sheikh-Bahaei S, Hunt CA. PMID: 21768275.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol. 2011 Apr; 7(4):e1002030. Engelberg JA, Datta A, Mostov KE, Hunt CA. PMID: 21490722; PMCID: PMC3072361.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    20. Cloud computing and validation of expandable in silico livers. BMC Syst Biol. 2010 Dec 03; 4:168. Ropella GE, Hunt CA. PMID: 21129207; PMCID: PMC3016276.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    21. Tracing multiscale mechanisms of drug disposition in normal and diseased livers. J Pharmacol Exp Ther. 2010 Jul; 334(1):124-36. Park S, Kim SH, Ropella GE, Roberts MS, Hunt CA. PMID: 20406856.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    22. Simulation of lung alveolar epithelial wound healing in vitro. J R Soc Interface. 2010 Aug 06; 7(49):1157-70. Kim SH, Matthay MA, Mostov K, Hunt CA. PMID: 20236957; PMCID: PMC2894878.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    23. Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion. PLoS Comput Biol. 2010 Feb 19; 6(2):e1000681. Tang J, Hunt CA. PMID: 20174606; PMCID: PMC2824748.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst Biol. 2009 Dec 31; 3:122. Kim SH, Debnath J, Mostov K, Park S, Hunt CA. PMID: 20043854; PMCID: PMC2814811.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    25. Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments. J Pharmacol Exp Ther. 2010 Feb; 332(2):398-412. Lam TN, Hunt CA. PMID: 19864617.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. At the biological modeling and simulation frontier. Pharm Res. 2009 Nov; 26(11):2369-400. Hunt CA, Ropella GE, Lam TN, Tang J, Kim SH, Engelberg JA, Sheikh-Bahaei S. PMID: 19756975; PMCID: PMC2763179.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    27. Computational investigation of epithelial cell dynamic phenotype in vitro. Theor Biol Med Model. 2009 May 28; 6:8. Kim SH, Park S, Mostov K, Debnath J, Hunt CA. PMID: 19476639; PMCID: PMC2696420.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. A computational approach to understand in vitro alveolar morphogenesis. PLoS One. 2009; 4(3):e4819. Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA. PMID: 19283073; PMCID: PMC2653231.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    29. Essential operating principles for tumor spheroid growth. BMC Syst Biol. 2008 Dec 23; 2:110. Engelberg JA, Ropella GE, Hunt CA. PMID: 19105850; PMCID: PMC2667182.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Computational strategies unravel and trace how liver disease changes hepatic drug disposition. J Pharmacol Exp Ther. 2009 Jan; 328(1):294-305. Park S, Ropella GE, Kim SH, Roberts MS, Hunt CA. PMID: 18948498.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    31. Discovering plausible mechanistic details of hepatic drug interactions. Drug Metab Dispos. 2009 Jan; 37(1):237-46. Lam TN, Hunt CA. PMID: 18936110.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    32. Dichotomies between computational and mathematical models. Nat Biotechnol. 2008 Jul; 26(7):737-8; author reply 738-9. Hunt CA, Ropella GE, Park S, Engelberg J. PMID: 18612289.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    33. In silico methods for unraveling the mechanistic complexities of intestinal absorption: metabolism-efflux transport interactions. Drug Metab Dispos. 2008 Jul; 36(7):1414-24. Garmire LX, Hunt CA. PMID: 18436618.
      View in: PubMed   Mentions: 1     Fields:    
    34. A framework and mechanistically focused, in silico method for enabling rational translational research. Summit Transl Bioinform. 2008 Mar 01; 2008:46-50. Hunt CA, Baranzini S, Matthay MA, Park S. PMID: 21347126; PMCID: PMC3041517.
      View in: PubMed   Mentions:
    35. Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model. Drug Metab Dispos. 2008 Apr; 36(4):759-68. Yan L, Sheihk-Bahaei S, Park S, Ropella GE, Hunt CA. PMID: 18227144.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    36. Mechanistic simulations explain paradoxical saquinavir metabolism during in vitro vectorial transport study. Annu Int Conf IEEE Eng Med Biol Soc. 2008; 2008:5462-5. Lam TN, Hunt CA. PMID: 19163953.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    37. In silico simulation of epithelial cell tubulogenesis. Annu Int Conf IEEE Eng Med Biol Soc. 2008; 2008:1036-9. Engelberg JA, Kim M, Mostov KE, Hunt CA. PMID: 19162839.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. Using an in silico liver to evaluate a hepatic enzyme induction mechanism. Annu Int Conf IEEE Eng Med Biol Soc. 2008; 2008:2415-8. Hunt C, Ropella GE. PMID: 19163189.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver. Pharm Res. 2008 May; 25(5):1023-36. Yan L, Ropella GE, Park S, Roberts MS, Hunt CA. PMID: 18044012.
      View in: PubMed   Mentions: 18     Fields:    
    40. Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme. J Control Release. 2007 Dec 20; 124(3):163-71. Nikanjam M, Gibbs AR, Hunt CA, Budinger TF, Forte TM. PMID: 17964677.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    41. An in silico transwell device for the study of drug transport and drug-drug interactions. Pharm Res. 2007 Dec; 24(12):2171-86. Garmire LX, Garmire DG, Hunt CA. PMID: 17703347.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. PMID: 17332496; PMCID: PMC1855040.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    43. Dynamics of in silico leukocyte rolling, activation, and adhesion. BMC Syst Biol. 2007 Feb 19; 1:14. Tang J, Ley KF, Hunt CA. PMID: 17408504; PMCID: PMC1839892.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    44. Physiologically based synthetic models of hepatic disposition. J Pharmacokinet Pharmacodyn. 2006 Dec; 33(6):737-72. Hunt CA, Ropella GE, Yan L, Hung DY, Roberts MS. PMID: 17051440.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    45. Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol. 2006 Oct 06; 2(10):e129. Grant MR, Mostov KE, Tlsty TD, Hunt CA. PMID: 17029556; PMCID: PMC1592363.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    46. Mechanistic study of the cellular interplay of transport and metabolism using the synthetic modeling method. Pharm Res. 2006 Mar; 23(3):493-505. Liu Y, Hunt CA. PMID: 16435171.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Simulating in vitro epithelial morphogenesis in multiple environments. Comput Syst Bioinformatics Conf. 2006; 381-4. Grant MR, Kim SH, Hunt CA. PMID: 17369657.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    48. Studies of intestinal drug transport using an in silico epithelio-mimetic device. Biosystems. 2005 Nov; 82(2):154-67. Liu Y, Hunt CA. PMID: 16135397.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    49. Glucose transport to the brain: a systems model. Brain Res Brain Res Rev. 2005 Nov; 49(3):595-617. Qutub AA, Hunt CA. PMID: 16269321.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    50. Plasticity of gene expression in injured human dorsal root ganglia revealed by GeneChip oligonucleotide microarrays. J Clin Neurosci. 2004 Apr; 11(3):289-99. Rabert D, Xiao Y, Yiangou Y, Kreder D, Sangameswaran L, Segal MR, Hunt CA, Birch R, Anand P. PMID: 14975420.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Novel stepwise normalization method for two-channel cDNA microarrays. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2921-4. Xiao Y, Hunt CA, Segal MR, Yang YH. PMID: 17270889.
      View in: PubMed   Mentions:    Fields:    
    52. Modeling liver physiology: combining fractals, imaging and animation. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:3120-3. Lin DW, Johnson S, Hunt CA. PMID: 17270940.
      View in: PubMed   Mentions: 3     Fields:    
    53. Applying models of targeted drug delivery to gene delivery. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:3535-8. Lam TN, Hunt CA. PMID: 17271053.
      View in: PubMed   Mentions:    Fields:    
    54. Modeling mammary gland morphogenesis as a reaction-diffusion process. Conf Proc IEEE Eng Med Biol Soc. 2004; 2006:679-82. Grant MR, Hunt CA, Xia L, Fata JE, Bissell MJ. PMID: 17271768.
      View in: PubMed   Mentions: 4     Fields:    
    55. Representing intestinal drug transport in silico: an agent-oriented approach. Conf Proc IEEE Eng Med Biol Soc. 2004; 2006:770-3. Liu Y, Hunt CA. PMID: 17271791.
      View in: PubMed   Mentions:    Fields:    
    56. In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:853-6. Yan L, Hunt CA, Ropella GE, Roberts MS. PMID: 17271811.
      View in: PubMed   Mentions: 4     Fields:    
    57. The necessity of a theory of biology for tissue engineering: metabolism-repair systems. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:5031-4. Ganguli S, Hunt CA. PMID: 17271446.
      View in: PubMed   Mentions:    Fields:    
    58. An agent-based computational approach for representing aspects of in vitro multi-cellular tumor spheroid growth. Conf Proc IEEE Eng Med Biol Soc. 2004; 2006:691-4. Chen S, Ganguli S, Hunt CA. PMID: 17271771.
      View in: PubMed   Mentions: 4     Fields:    
    59. Assessment of differential gene expression in human peripheral nerve injury. BMC Genomics. 2002 Sep 27; 3(1):28. Xiao Y, Segal MR, Rabert D, Ahn AH, Anand P, Sangameswaran L, Hu D, Hunt CA. PMID: 12354329; PMCID: PMC137578.
      View in: PubMed   Mentions: 6     Fields:    
    60. A forecasting approach to accelerate drug development. Stat Med. 1998 Aug 15-30; 17(15-16):1725-40; discussion 1741-3. Hunt CA, Guzy S, Weiner DL. PMID: 9749443.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    61. Bootstrapping for pharmacokinetic models: visualization of predictive and parameter uncertainty. Pharm Res. 1998 May; 15(5):690-7. Hunt CA, Givens GH, Guzy S. PMID: 9619776.
      View in: PubMed   Mentions: 3     Fields:    
    62. Validation of a decision support system for use in drug development: pharmacokinetic data. Pharm Res. 1997 Oct; 14(10):1287-97. Guzy S, Hunt CA. PMID: 9358539.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    63. Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys. Nucleic Acids Res. 1997 Feb 01; 25(3):575-81. Lim CS, Jabrane-Ferrat N, Fontes JD, Okamoto H, Garovoy MR, Peterlin BM, Hunt CA. PMID: 9016598; PMCID: PMC146464.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    64. Measures of uncertainty of pharmacokinetic and pharmacodynamic parameter estimates: a new computerized algorithm. Comput Biomed Res. 1996 Dec; 29(6):466-81. Guzy S, Hunt CA. PMID: 9012569.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    65. An oligonucleotide blocks interferon-gamma signal transduction. Transplantation. 1996 Nov 15; 62(9):1297-301. Lee PP, Ramanathan M, Hunt CA, Garovoy MR. PMID: 8932275.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    66. Screening and characterization of estrogenic activity from a hydroxystilbene library. Chem Biol. 1995 Jan; 2(1):45-51. Williard R, Jammalamadaka V, Zava D, Benz CC, Hunt CA, Kushner PJ, Scanlan TS. PMID: 9383402.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    67. Suppression of interferon-gamma induction of MHC class II and ICAM-1 by a 26-base oligonucleotide composed of deoxyguanosine and deoxythymidine. Transpl Immunol. 1994 Dec; 2(4):285-92. Tam S, Huey B, Li Y, Lui GM, Hwang DG, Lantz M, Weiss TL, Hunt CA, Garovoy MR. PMID: 7704538.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    68. Inhibition of transcription factor binding to the HER2 promoter by triplex-forming oligodeoxyribonucleotides. Gene. 1994 Nov 04; 149(1):123-6. Noonberg SB, Scott GK, Hunt CA, Hogan ME, Benz CC. PMID: 7958975.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    69. Paradoxical production of target protein using antisense RNA expression vectors. Gene. 1994 Nov 04; 149(1):21-4. Williard R, Benz CC, Baxter JD, Kushner P, Hunt CA. PMID: 7958984.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    70. Characterization of the oligodeoxynucleotide-mediated inhibition of interferon-gamma-induced major histocompatibility complex class I and intercellular adhesion molecule-1. J Biol Chem. 1994 Oct 07; 269(40):24564-74. Ramanathan M, Lantz M, MacGregor RD, Garovoy MR, Hunt CA. PMID: 7929128.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    71. Sequential staining of short oligonucleotides in polyacrylamide gels with ethidium bromide and methylene blue. Biotechniques. 1994 Oct; 17(4):626, 628. Lim CS, Hunt CA. PMID: 7530455.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    72. Characterization of apocytochrome C binding to human erythrocytes. Am J Hematol. 1994 Oct; 47(2):132-4. Krishnan G, MacGregor RD, Shohet SB, Hunt CA. PMID: 8092129.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    73. Calcium dependent cellular uptake of a c-myc antisense oligonucleotide. Cell Mol Biol (Noisy-le-grand). 1994 Sep; 40(6):843-50. Wu-Pong S, Weiss TL, Hunt CA. PMID: 7812192.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    74. In vivo generation of highly abundant sequence-specific oligonucleotides for antisense and triplex gene regulation. Nucleic Acids Res. 1994 Jul 25; 22(14):2830-6. Noonberg SB, Scott GK, Garovoy MR, Benz CC, Hunt CA. PMID: 8052538; PMCID: PMC308254.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    75. Detection of triplex-forming RNA oligonucleotides by triplex blotting. Biotechniques. 1994 Jun; 16(6):1070-2, 1074. Noonberg SB, Scott GK, Hunt CA, Benz CC. PMID: 7521186.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Biological availability and nuclease resistance extend the in vitro activity of a phosphorothioate-3'hydroxypropylamine oligonucleotide. Nucleic Acids Res. 1994 Mar 25; 22(6):977-86. Tam RC, Li Y, Noonberg S, Hwang DG, Lui G, Hunt CA, Garovoy MR. PMID: 8152930; PMCID: PMC307918.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    77. Inhibition of interferon-gamma-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides. Transplantation. 1994 Feb 27; 57(4):612-5. Ramanathan M, Lantz M, MacGregor RD, Huey B, Tam S, Li Y, Garovoy MR, Hunt CA. PMID: 7906905.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    78. Inhibition of interferon-gamma-mediated immune functions by oligonucleotides. Suppression of human T cell proliferation by downregulation of IFN-gamma-induced ICAM-1 and Fc-receptor on accessory cells. Transplantation. 1994 Feb 27; 57(4):606-12. Fedoseyeva EV, Li Y, Huey B, Tam S, Hunt CA, Benichou G, Garovoy MR. PMID: 7906904.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    79. Antisense c-myc oligonucleotide cellular uptake and activity. Antisense Res Dev. 1994; 4(3):155-63. Wu-Pong S, Weiss TL, Hunt CA. PMID: 7849486.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    80. Characteristics of oligonucleotide uptake in human keratinocyte cultures. J Invest Dermatol. 1993 Nov; 101(5):727-31. Noonberg SB, Garovoy MR, Hunt CA. PMID: 8228335.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    81. Predictions of effect for intracellular antisense oligodeoxyribonucleotides from a kinetic model. Antisense Res Dev. 1993; 3(1):3-18. Ramanathan M, MacGregor RD, Hunt CA. PMID: 8388278.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    82. Antisense c-myc oligodeoxyribonucleotide cellular uptake. Pharm Res. 1992 Aug; 9(8):1010-7. Wu-Pong S, Weiss TL, Hunt CA. PMID: 1384028.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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