Sergio Baranzini, PhD

InstitutionUniversity of California San Francisco
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of Buenos Aires, ArgentinaBS/MS1992Biochemistry/Biotechnology
    University of Buenos Aires, ArgentinaPhD1997Biochemistry
    University of California, San FranciscoPostdoctoral Fellow2001Neurogenetics
    Collapse Awards and Honors
    University of Buenos Aires, Argentina1992Undergraduate scholarship for research in Molecular Biology
    University of Buenos Aires, Argentina1993Graduate Fellowship for research in Molecular Biology
    University of Buenos Aires, Argentina1995Graduate Fellowship for research in Medical Genetics
    Argentine Society of Genetics1996Best Presentation Award. XXVII Genetics Annual Meeting
    National Academy of Medicine, Argentina1996Adolfo Noceti and Atilio Tiscornia Award for ophthalmology research
    University of Buenos Aires1996Advanced Graduate Fellowship for research in Molecular Biology
    University of Buenos Aires1997Advanced Graduate Fellowship for research in Molecular Biology
    National Multiple Sclerosis Society (US)2001Advanced Postdoctoral Fellowship
    National Multiple Sclerosis Society (US)2009  - 2014Harry Weaver Neuroscience Scholar Award
    Department of Neurology. UCSF2010Endowed Chair in Neurology
    National Multiple Sclerosis Society (US)2015Stephen C. Reingold award

    Collapse Overview 
    Collapse Overview
    Sergio E. Baranzini earned his degree in clinical biochemistry from the University of Buenos Aires, Argentina, in 1992. He graduated from the same institution in 1997 obtaining a PhD with honors in human molecular genetics. The subject of his PhD thesis was the characterization of genetic mutations leading to Duchenne’s muscular dystrophy. Dr. Baranzini then moved to the University of California at San Francisco to specialize in the analysis of complex hereditary diseases, in particular multiple sclerosis. During his postdoctoral stay in UCSF Dr. Baranzini employed state-of-the art methods to explore MS pathogenesis, including immunology, molecular biology, genomics and bioinformatics. Since 2003 Dr. Baranzini is faculty in the Department of Neurology at UCSF, where he currently holds the title of Associate Professor In-Residence. His research involves the large throughout analysis of samples from MS patients to characterize the activity of genes during: i) different stages of the disease (i.e. remission vs. relapse), ii) differential response to treatment (i.e. good responders vs. poor responders), and iii) disease progression (i.e. benign vs. severe). In addition Dr. Baranzini is collaborating with several interdisciplinary teams worldwide to integrate all the available knowledge obtained in different research domains in an approach known as systems biology. Dr Baranzini’s current research involves immunological studies using the EAE model, sequencing of whole genomes and transcriptomes from patients with multiple sclerosis and developing bioinformatics tools to integrate this information with that coming from other high throughput technologies. Dr Baranzini uses a combination of “wet lab” methods including DNA microarrays, proteomics, and laser capture microdissection, in combination with “dry lab” analytical approaches encompassing bioinformatics, complexity theory, and mathematical modeling.
    Dr. Baranzini has published his research on MS in several top-tier journals like Science, Nature, PNAS, J Immunol, and PLos Biol. He is a member of the American Association of Immunologists, and an elected member of the American Neurological Association. He also serves as an ad-hoc reviewer for many specialized journals.

    Collapse Research 
    Collapse Research Activities and Funding
    Post GWAS approach to identify cell-specific genetic pathways underlying MS risk
    NIH R01NS088155Sep 15, 2014 - Jul 31, 2019
    Role: Principal Investigator
    NIH F05NS010448Mar 1, 1998
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Thompson AJ, Baranzini S, Geurts J, Hemmer B, Ciccarelli O. Multiple sclerosis. Lancet. 2018 Mar 22. PMID: 29576504.
      View in: PubMed
    2. Sand IK, Baranzini S. The microbiome and MS: The influence of the microbiota on MS risk and progression-Session chair summary. Mult Scler. 2018 Feb 01; 1352458518761167. PMID: 29498302.
      View in: PubMed
    3. Damotte V, Lizée A, Tremblay M, Agrawal A, Khankhanian P, Santaniello A, Gomez R, Lincoln R, Tang W, Chen T, Lee N, Villoslada P, Hollenbach JA, Bevan CD, Graves J, Bove R, Goodin DS, Green AJ, Baranzini S, Cree BA, Henry RG, Hauser SL, Gelfand JM, Gourraud PA. Harnessing electronic medical records to advance research on multiple sclerosis. Mult Scler. 2018 Jan 01; 1352458517747407. PMID: 29310490.
      View in: PubMed
    4. Pröbstel AK, Baranzini S. The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the "MS Microbiome". Neurotherapeutics. 2018 Jan; 15(1):126-134. PMID: 29147991.
      View in: PubMed
    5. Zamvil SS, Spencer CM, Baranzini S, Cree BAC. The Gut Microbiome in Neuromyelitis Optica. Neurotherapeutics. 2018 Jan; 15(1):92-101. PMID: 29280091.
      View in: PubMed
    6. Baranzini S. The era of GWAS is over - Commentary. Mult Scler. 2018 Mar; 24(3):260-261. PMID: 29251183.
      View in: PubMed
    7. Baranzini S, Oksenberg JR. The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years. Trends Genet. 2017 Dec; 33(12):960-970. PMID: 28987266.
      View in: PubMed
    8. Himmelstein DS, Lizee A, Hessler C, Brueggeman L, Chen SL, Hadley D, Green A, Khankhanian P, Baranzini S. Systematic integration of biomedical knowledge prioritizes drugs for repurposing. Elife. 2017 Sep 22; 6. PMID: 28936969.
      View in: PubMed
    9. Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini S, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):10719-10724. PMID: 28893994.
      View in: PubMed
    10. Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y, Lee YK, Hauser SL, Crabtree-Hartman E, Sand IK, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R, Mazmanian SK, Baranzini S. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):10713-10718. PMID: 28893978.
      View in: PubMed
    11. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg JR, Matarese G, Diaspro A, Kerlero de Rosbo N, Uccelli A. IFN-? orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways. J Allergy Clin Immunol. 2017 May; 139(5):1667-1676. PMID: 27670240.
      View in: PubMed
    12. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini S. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603. PMID: 27546286.
      View in: PubMed
    13. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 Oct; 80(4):499-510. PMID: 27464262.
      View in: PubMed
    14. Cree BA, Spencer CM, Varrin-Doyer M, Baranzini S, Zamvil SS. Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens. Ann Neurol. 2016 Sep; 80(3):443-7. PMID: 27398819.
      View in: PubMed
    15. Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini S, Hollenbach J, Cree BA, Hauser SL, Oksenberg JR, Henry RG. Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol. 2016 Jul 01; 73(7):795-802. PMID: 27244296.
      View in: PubMed
    16. Khankhanian P, Cozen W, Himmelstein DS, Madireddy L, Din L, van den Berg A, Matsushita T, Glaser SL, Moré JM, Smedby KE, Baranzini S, Mack TM, Lizée A, de Sanjosé S, Gourraud PA, Nieters A, Hauser SL, Cocco P, Maynadié M, Foretová L, Staines A, Delahaye-Sourdeix M, Li D, Bhatia S, Melbye M, Onel K, Jarrett R, McKay JD, Oksenberg JR, Hjalgrim H. Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis. Int J Epidemiol. 2016 06; 45(3):728-40. PMID: 26971321; PMCID: PMC5005944.
    17. Gustafsson M, Gawel DR, Alfredsson L, Baranzini S, Björkander J, Blomgran R, Hellberg S, Eklund D, Ernerudh J, Kockum I, Konstantinell A, Lahesmaa R, Lentini A, Liljenström HR, Mattson L, Matussek A, Mellergård J, Mendez M, Olsson T, Pujana MA, Rasool O, Serra-Musach J, Stenmarker M, Tripathi S, Viitala M, Wang H, Zhang H, Nestor CE, Benson M. A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases. Sci Transl Med. 2015 Nov 11; 7(313):313ra178. PMID: 26560356.
      View in: PubMed
    18. Page CM, Baranzini S, Mevik BH, Bos SD, Harbo HF, Andreassen BK. Assessing the Power of Exome Chips. PLoS One. 2015; 10(10):e0139642. PMID: 26437075; PMCID: PMC4593624.
    19. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini S, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934; PMCID: PMC5007634 [Available on 12/15/16].
    20. Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini S, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet. 2015 Oct; 47(10):1107-1113. PMID: 26343388.
      View in: PubMed
    21. Wang L, Himmelstein DS, Santaniello A, Parvin M, Baranzini S. iCTNet2: integrating heterogeneous biological interactions to understand complex traits. F1000Res. 2015; 4:485. PMID: 26834985; PMCID: PMC4706053.
    22. Khankhanian P, Matsushita T, Madireddy L, Lizée A, Din L, Moré JM, Gourraud PA, Hauser SL, Baranzini S, Oksenberg JR. Genetic contribution to multiple sclerosis risk among Ashkenazi Jews. BMC Med Genet. 2015 Jul 28; 16:55. PMID: 26212423; PMCID: PMC4557862.
    23. Himmelstein DS, Baranzini S. Heterogeneous Network Edge Prediction: A Data Integration Approach to Prioritize Disease-Associated Genes. PLoS Comput Biol. 2015 Jul; 11(7):e1004259. PMID: 26158728; PMCID: PMC4497619.
    24. Harari D, Orr I, Rotkopf R, Baranzini S, Schreiber G. A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFNß drugs in the treatment of multiple sclerosis. Hum Mol Genet. 2015 Jun 01; 24(11):3192-205. PMID: 25721402.
      View in: PubMed
    25. Khankhanian P, Din L, Caillier SJ, Gourraud PA, Baranzini S. SNP imputation bias reduces effect size determination. Front Genet. 2015; 6:30. PMID: 25709616; PMCID: PMC4321633.
    26. Wang L, Mousavi P, Baranzini S. iPINBPA: an integrative network-based functional module discovery tool for genome-wide association studies. Pac Symp Biocomput. 2015; 255-66. PMID: 25592586.
      View in: PubMed
    27. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini S, Kramer JH, Oksenberg JR. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8. PMID: 25618617; PMCID: PMC4346472.
    28. Haghikia A, Faissner S, Pappas D, Pula B, Akkad DA, Arning L, Ruhrmann S, Duscha A, Gold R, Baranzini S, Malhotra S, Montalban X, Comabella M, Chan A. Interferon-beta affects mitochondrial activity in CD4+ lymphocytes: Implications for mechanism of action in multiple sclerosis. Mult Scler. 2015 Sep; 21(10):1262-70. PMID: 25480861.
      View in: PubMed
    29. Baranzini S, Madireddy LR, Cromer A, D'Antonio M, Lehr L, Beelke M, Farmer P, Battaglini M, Caillier SJ, Stromillo ML, De Stefano N, Monnet E, Cree BA. Prognostic biomarkers of IFNb therapy in multiple sclerosis patients. Mult Scler. 2015 Jun; 21(7):894-904. PMID: 25392319.
      View in: PubMed
    30. Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82. PMID: 25473422.
      View in: PubMed
    31. Gourraud PA, Henry RG, Cree BA, Crane JC, Lizee A, Olson MP, Santaniello AV, Datta E, Zhu AH, Bevan CJ, Gelfand JM, Graves JS, Goodin DS, Green AJ, von Büdingen HC, Waubant E, Zamvil SS, Crabtree-Hartman E, Nelson S, Baranzini S, Hauser SL. Precision medicine in chronic disease management: The multiple sclerosis BioScreen. Ann Neurol. 2014 Nov; 76(5):633-42. PMID: 25263997; PMCID: PMC4214886.
    32. Wang L, Matsushita T, Madireddy L, Mousavi P, Baranzini S. PINBPA: cytoscape app for network analysis of GWAS data. Bioinformatics. 2015 Jan 15; 31(2):262-4. PMID: 25260698.
      View in: PubMed
    33. Palanichamy A, Jahn S, Nickles D, Derstine M, Abounasr A, Hauser SL, Baranzini S, Leppert D, von Büdingen HC. Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients. J Immunol. 2014 Jul 15; 193(2):580-586. PMID: 24928997; PMCID: PMC4082756.
    34. Baranzini S. The role of antiproliferative gene Tob1 in the immune system. Clin Exp Neuroimmunol. 2014 Jun 01; 5(2):132-136. PMID: 25071870.
      View in: PubMed
    35. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini S, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. PMID: 24776795; PMCID: PMC4057936.
    36. Fancy SP, Harrington EP, Baranzini S, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH. Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci. 2014 Apr; 17(4):506-12. PMID: 24609463; PMCID: PMC3975168.
    37. Zastepa E, Fitz-Gerald L, Hallett M, Antel J, Bar-Or A, Baranzini S, Lapierre Y, Haegert DG. Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS. Neurology. 2014 Feb 25; 82(8):681-90. PMID: 24453076; PMCID: PMC3945666.
    38. Parnell GP, Gatt PN, Krupa M, Nickles D, McKay FC, Schibeci SD, Batten M, Baranzini S, Henderson A, Barnett M, Slee M, Vucic S, Stewart GJ, Booth DR. The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clin Immunol. 2014 Mar; 151(1):16-24. PMID: 24495857.
      View in: PubMed
    39. Baranzini S. Symposium 2-1  The autoimmunome: Similarities and differences among genetic susceptibility to common immune-related diseases. Nihon Rinsho Meneki Gakkai Kaishi. 2014; 37(4):261. PMID: 25297131.
      View in: PubMed
    40. Khankhanian P, Baranzini S, Johnson BA, Madireddy L, Nickles D, Croen LA, Wu YW. Sequencing of the IL6 gene in a case-control study of cerebral palsy in children. BMC Med Genet. 2013 Dec 07; 14:126. PMID: 24314052; PMCID: PMC3881497.
    41. Baranzini S. Gene expression profiling in MS: a fulfilled promise? Mult Scler. 2013 Dec; 19(14):1813-4. PMID: 24277731.
      View in: PubMed
    42. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Nov; 45(11):1353-60. PMID: 24076602.
      View in: PubMed
    43. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. PMID: 23840004; PMCID: PMC3909648.
    44. Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini S. Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med. 2013 Jul 01; 210(7):1301-9. PMID: 23797093; PMCID: PMC3698524.
    45. Rossi S, Studer V, Moscatelli A, Motta C, Coghe G, Fenu G, Caillier S, Buttari F, Mori F, Barbieri F, Castelli M, De Chiara V, Monteleone F, Mancino R, Bernardi G, Baranzini S, Marrosu MG, Oksenberg JR, Centonze D. Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One. 2013; 8(6):e67357. PMID: 23840674; PMCID: PMC3696106.
    46. Nickles D, Chen HP, Li MM, Khankhanian P, Madireddy L, Caillier SJ, Santaniello A, Cree BA, Pelletier D, Hauser SL, Oksenberg JR, Baranzini S. Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls. Hum Mol Genet. 2013 Oct 15; 22(20):4194-205. PMID: 23748426; PMCID: PMC3781642.
    47. Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. Am J Hum Genet. 2013 Jun 06; 92(6):854-65. PMID: 23731539; PMCID: PMC3958952.
    48. Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini S, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol. 2013 May; 73(5):637-45. PMID: 23595422; PMCID: PMC3679350.
    49. Gourraud PA, Sdika M, Khankhanian P, Henry RG, Beheshtian A, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D, Baranzini S. A genome-wide association study of brain lesion distribution in multiple sclerosis. Brain. 2013 Apr; 136(Pt 4):1012-24. PMID: 23412934; PMCID: PMC3613709.
    50. Nickles D, Madireddy L, Yang S, Khankhanian P, Lincoln S, Hauser SL, Oksenberg JR, Baranzini S. In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing. BMC Genomics. 2012 Sep 14; 13:477. PMID: 22974163; PMCID: PMC3473256.
    51. Gourraud PA, Harbo HF, Hauser SL, Baranzini S. The genetics of multiple sclerosis: an up-to-date review. Immunol Rev. 2012 Jul; 248(1):87-103. PMID: 22725956.
      View in: PubMed
    52. Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini S, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012 Jul 02; 209(7):1325-34. PMID: 22734047; PMCID: PMC3405500.
    53. Su SY, Kasberger J, Baranzini S, Byerley W, Liao W, Oksenberg J, Sherr E, Jorgenson E. Detection of identity by descent using next-generation whole genome sequencing data. BMC Bioinformatics. 2012 Jun 06; 13:121. PMID: 22672699; PMCID: PMC3403908.
    54. Baranzini S, Nickles D. Genetics of multiple sclerosis: swimming in an ocean of data. Curr Opin Neurol. 2012 Jun; 25(3):239-45. PMID: 22516854.
      View in: PubMed
    55. Villoslada P, Baranzini S. Data integration and systems biology approaches for biomarker discovery: challenges and opportunities for multiple sclerosis. J Neuroimmunol. 2012 Jul 15; 248(1-2):58-65. PMID: 22281286.
      View in: PubMed
    56. Wang L, Khankhanian P, Baranzini S, Mousavi P. iCTNet: a Cytoscape plugin to produce and analyze integrative complex traits networks. BMC Bioinformatics. 2011 Sep 26; 12:380. PMID: 21943367; PMCID: PMC3190406.
    57. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011 Aug 10; 476(7359):214-9. PMID: 21833088.
      View in: PubMed
    58. Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini S, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci. 2011 Jun 26; 14(8):1009-16. PMID: 21706018; PMCID: PMC3145042.
    59. Slavotinek AM, Baranzini S, Schanze D, Labelle-Dumais C, Short KM, Chao R, Yahyavi M, Bijlsma EK, Chu C, Musone S, Wheatley A, Kwok PY, Marles S, Fryns JP, Maga AM, Hassan MG, Gould DB, Madireddy L, Li C, Cox TC, Smyth I, Chudley AE, Zenker M. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. J Med Genet. 2011 Jun; 48(6):375-82. PMID: 21507892; PMCID: PMC4294942.
    60. Haghikia A, Perrech M, Pula B, Ruhrmann S, Potthoff A, Brockmeyer NH, Goelz S, Wiendl H, Lindå H, Ziemssen T, Baranzini S, Käll TB, Bengel D, Olsson T, Gold R, Chan A. Functional energetics of CD4+-cellular immunity in monoclonal antibody-associated progressive multifocal leukoencephalopathy in autoimmune disorders. PLoS One. 2011 Apr 20; 6(4):e18506. PMID: 21533133; PMCID: PMC3080364.
    61. Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med. 2011 Jan 18; 3(1):3. PMID: 21244703; PMCID: PMC3092088.
    62. Baranzini S. Revealing the genetic basis of multiple sclerosis: are we there yet? Curr Opin Genet Dev. 2011 Jun; 21(3):317-24. PMID: 21247752; PMCID: PMC3105160.
    63. Sorani MD, Manley GT, Claude Hemphill J, Baranzini S. Dynamic, multi-level network models of clinical trials. Pac Symp Biocomput. 2011; 38-49. PMID: 21121031.
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    64. Fancy SP, Chan JR, Baranzini S, Franklin RJ, Rowitch DH. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43. PMID: 21692657.
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    65. Khankhanian P, Gourraud PA, Caillier SJ, Santaniello A, Hauser SL, Baranzini S, Oksenberg JR. Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset. BMC Genomics. 2010 Nov 10; 11:626. PMID: 21067613; PMCID: PMC3091764.
    66. Baranzini S, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain. 2010 Sep; 133(9):2603-11. PMID: 20802204; PMCID: PMC2929334.
    67. Oksenberg JR, Baranzini S. Multiple sclerosis genetics--is the glass half full, or half empty? Nat Rev Neurol. 2010 Aug; 6(8):429-37. PMID: 20625377.
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    68. Baranzini S, Mudge J, van Velkinburgh JC, Khankhanian P, Khrebtukova I, Miller NA, Zhang L, Farmer AD, Bell CJ, Kim RW, May GD, Woodward JE, Caillier SJ, McElroy JP, Gomez R, Pando MJ, Clendenen LE, Ganusova EE, Schilkey FD, Ramaraj T, Khan OA, Huntley JJ, Luo S, Kwok PY, Wu TD, Schroth GP, Oksenberg JR, Hauser SL, Kingsmore SF. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature. 2010 Apr 29; 464(7293):1351-6. PMID: 20428171; PMCID: PMC2862593.
    69. Baranzini S. The genetics of autoimmune diseases: a networked perspective. Curr Opin Immunol. 2009 Dec; 21(6):596-605. PMID: 19896815.
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    70. Otaegui D, Baranzini S, Armañanzas R, Calvo B, Muñoz-Culla M, Khankhanian P, Inza I, Lozano JA, Castillo-Triviño T, Asensio A, Olaskoaga J, López de Munain A. Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One. 2009 Jul 20; 4(7):e6309. PMID: 19617918; PMCID: PMC2708922.
    71. De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul; 41(7):776-82. PMID: 19525953; PMCID: PMC2757648.
    72. Fancy SP, Baranzini S, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 2009 Jul 01; 23(13):1571-85. PMID: 19515974; PMCID: PMC2704469.
    73. Baranzini S, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BM, Kappos L. Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet. 2009 Jun 01; 18(11):2078-90. PMID: 19286671; PMCID: PMC2678928.
    74. Villoslada P, Steinman L, Baranzini S. Systems biology and its application to the understanding of neurological diseases. Ann Neurol. 2009 Feb; 65(2):124-39. PMID: 19260029.
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