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Jayanta Debnath, MD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-514-0681
ORCID ORCID Icon0000-0002-8745-4069 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.1998School of Medicine
    Brigham and Women's HospitalResidency2000Pathology
    Harvard Medical SchoolPost-doc 2005Cell Biology

    Collapse Overview 
    Collapse Overview
    Autophagy In Cell Survival and Cancer Progression

    Autophagy is a fundamental catabolic process in which a cell literally “eats itself”. During autophagy, the cytoplasm and organelles of a cell are sequestered within double membrane vacuoles, called autophagosomes, and subsequently delivered to the lysosome for degradation. In eukaryotic cells, autophagy primarily functions as a critical survival response during nutrient deprivation or stress; as a result, interest in manipulating this tightly controlled self-eating process to treat human diseases, such as cancer, has rapidly intensified.

    My laboratory focuses how autophagy contributes to cell survival and cancer progression using both in vitro and in vivo models. Our three main goals are: 1) determine the role of autophagy in cancer metabolism, cell survival and oncogenic transformation; 2) delineate the role of autophagy in cancer progression and metastasis in vivo; and 3) dissect the biological and biochemical functions of the molecules that control autophagy (called ATGs) to ultimately exploit this process for therapeutic benefit.

    Ongoing Research:

    Autophagy, metabolic fitness, and oncogenic transformation: Cancer cells are resistant to anoikis, a form of apoptosis observed in epithelial cells deprived of extracellular matrix (ECM) contact. Several years ago, we discovered that autophagy serves as a mechanism of anoikis resistance. In follow-up work, we have discovered that autophagy also facilitates glycolytic metabolism during oncogenic transformation. Based on these findings, we are dissecting how autophagy contributes to the metabolic fitness of oncogene-transformed cells, allowing them to survive and expand in response to ECM deprivation and other microenvironmental stresses.

    Autophagy in cancer progression and metastases: My laboratory is also delineating how autophagy impacts breast cancer progression in vivo using mouse cancer models. We have created mice containing conditional null mutant alleles that allow us to delete autophagy in a tissue specific manner. We are now crossing with established mouse models of metastatic breast cancer to define the role of autophagy in cancer progression in vivo. Our studies focus on dissecting the functional requirements for autophagy in both tumor cells as well as key stromal constituents of the larger tumor microenvironment during primary tumor growth and metastasis.

    Novel biochemical and biological functions of ATGs: Despite widespread interest in exploiting autophagy for therapeutic purposes, we have much to learn about how this process works in mammalian cells and tissues. Autophagy is a tightly regulated by highly conserved gene products called ATGs. However, our recent results implicate these ATGs in diverse cellular functions that are distinct from their long-established roles in classical autophagy. Using cell biological, biochemical and yeast genetic approaches, we are: 1) dissecting new roles for ATGs in the control of secretion and adhesion; 2) probing genetic interactions between autophagy and mitochondrial protein quality control pathways; 3) elucidating the cellular functions of ATG12-ATG3, a novel complex between two autophagy regulators discovered in my laboratory, in the control of endocytosis and exosome biogenesis; and 4) determining how autophagy impacts protein translation during starvation.

    Collapse Research 
    Collapse Research Activities and Funding
    Stromal Fibroblast Autophagy In Tumor Progression and Desmoplasia
    NIH R01CA213775Sep 1, 2018 - Nov 30, 2022
    Role: Principal Investigator
    Autophagy-dependent exosome loading and biogenesis in AD and FTD
    NIH R01AG057462Sep 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Deciphering Autophagy-Dependent Secretion In Cancer Via Proximity-Based Biotinylation
    NIH R21CA201849Jun 1, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Autophagy as a microenvironmental regulator of tumorigenesis and resistance
    NIH R01CA188404Sep 1, 2014 - Aug 31, 2020
    Role: Principal Investigator
    Autophagy and Pro-metastatic Differentiation
    NIH R01CA126792Feb 1, 2009 - Sep 29, 2011
    Role: Principal Investigator
    Oncogenes and Luminal Apoptosis Within Mammary Acini
    NIH K08CA098419Aug 1, 2003 - Jul 31, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Feb 08; 1-382. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. PMID: 33634751.
      View in: PubMed   Mentions:    Fields:    
    2. Beyond Autophagy: The Expanding Roles of ATG8 Proteins. Trends Biochem Sci. 2021 Feb 05. Nieto-Torres JL, Leidal AM, Debnath J, Hansen M. PMID: 33558127.
      View in: PubMed   Mentions:    Fields:    
    3. The pleiotropic functions of autophagy in metastasis. J Cell Sci. 2021 Jan 22; 134(2). Marsh T, Tolani B, Debnath J. PMID: 33483365.
      View in: PubMed   Mentions:    Fields:    
    4. Unconventional secretion: cargo channeling by TMED10. Cell Res. 2020 Sep; 30(9):713-714. Nguyen TA, Debnath J. PMID: 32728197.
      View in: PubMed   Mentions:    Fields:    
    5. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Dec; 588(7838):459-465. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962.
      View in: PubMed   Mentions:    Fields:    
    6. Ribosome profiling reveals a functional role for autophagy in mRNA translational control. Commun Biol. 2020 Jul 17; 3(1):388. Goldsmith J, Marsh T, Asthana S, Leidal AM, Suresh D, Olshen A, Debnath J. PMID: 32681145.
      View in: PubMed   Mentions:
    7. LC3-dependent extracellular vesicle loading and secretion (LDELS). Autophagy. 2020 06; 16(6):1162-1163. Leidal AM, Debnath J. PMID: 32330402.
      View in: PubMed   Mentions: 2     Fields:    
    8. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 05; 581(7806):100-105. Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. PMID: 32376951.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    9. Autophagy suppresses breast cancer metastasis by degrading NBR1. Autophagy. 2020 06; 16(6):1164-1165. Marsh T, Debnath J. PMID: 32267786.
      View in: PubMed   Mentions:    Fields:    
    10. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Dev Cell. 2020 03 09; 52(5):591-604.e6. Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. PMID: 32084360.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Unraveling the mechanisms that specify molecules for secretion in extracellular vesicles. Methods. 2020 05 01; 177:15-26. Leidal AM, Debnath J. PMID: 31978536.
      View in: PubMed   Mentions: 7     Fields:    
    12. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    13. Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discov. 2019 09; 9(9):1167-1181. Amaravadi RK, Kimmelman AC, Debnath J. PMID: 31434711.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    14. Autophagy and the cell biology of age-related disease. Nat Cell Biol. 2018 12; 20(12):1338-1348. Leidal AM, Levine B, Debnath J. PMID: 30482941.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    15. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018 12; 3(12):1472-1485. Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH. PMID: 30478389.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. WIPIng the Brakes off Autophagy Induction. Mol Cell. 2018 10 18; 72(2):203-204. Marsh T, Debnath J. PMID: 30340019.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    17. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18). Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Macropinocytosis Fuels Prostate Cancer. Cancer Discov. 2018 07; 8(7):800-802. Commisso C, Debnath J. PMID: 29967075.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Atg12-Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release. Mol Cell Oncol. 2018; 5(5):e1039191. Murrow L, Debnath J. PMID: 30263931.
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    20. Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. J Cell Biol. 2018 03 05; 217(3):813-822. Cadwell K, Debnath J. PMID: 29237720.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. Autophagy enables retromer-dependent plasma membrane translocation of SLC2A1/GLUT1 to enhance glucose uptake. Autophagy. 2017; 13(11):2013-2014. Roy S, Debnath J. PMID: 28933603.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    22. Inflammatory signaling cascades and autophagy in cancer. Autophagy. 2018; 14(2):190-198. Monkkonen T, Debnath J. PMID: 28813180.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    23. Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake. Mol Cell. 2017 Jul 06; 67(1):84-95.e5. Roy S, Leidal AM, Ye J, Ronen SM, Debnath J. PMID: 28602638.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    24. Molecular definitions of autophagy and related processes. EMBO J. 2017 07 03; 36(13):1811-1836. Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. PMID: 28596378.
      View in: PubMed   Mentions: 286     Fields:    Translation:Animals
    25. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. PMID: 28314591.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion. J Mol Biol. 2017 02 17; 429(4):515-530. Vlahakis A, Debnath J. PMID: 27932295.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol. 2017 Jan; 13(1):119-126. Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. PMID: 27870838.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 12 01; 126(12):4417-4429. Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J. PMID: 27775547.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. Triggering Selective Autophagy at the Right Place and the Right Time. Mol Cell. 2016 10 20; 64(2):215-216. Vlahakis A, Debnath J. PMID: 27768868.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Autophagy in adhesion and migration. J Cell Sci. 2016 10 15; 129(20):3685-3693. Kenific CM, Wittmann T, Debnath J. PMID: 27672021.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    31. At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication. J Cell Biol. 2016 08 29; 214(5):503-5. Solvik T, Debnath J. PMID: 27573461.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    32. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. PMID: 27568548.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    33. NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly. Autophagy. 2016 10 02; 12(10):1958-1959. Kenific CM, Debnath J. PMID: 27484104.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. The Evolving, Multifaceted Roles of Autophagy in Cancer. Adv Cancer Res. 2016; 130:1-53. Liu J, Debnath J. PMID: 27037750.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016 Feb 29; 212(5):577-90. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. PMID: 26903539.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
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    94. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy. 2008 Jan; 4(1):37-45. Chen GC, Lee JY, Tang HW, Debnath J, Thomas SM, Settleman J. PMID: 17952025.
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    95. The Dual Roles for Autophagy in Cell Death and Survival. Autophagy in Immunity and Infection. 2006 Jun 20; 105-126. Jayanta Debnath, Christopher Fung. .
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    98. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004 Apr 26; 165(2):263-73. Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS. PMID: 15117969.
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    100. Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol. 2003 Oct 27; 163(2):315-26. Debnath J, Walker SJ, Brugge JS. PMID: 14568991.
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    101. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 2003 Aug; 5(8):733-40. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. PMID: 12844146.
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    102. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003 Jul; 30(3):256-68. Debnath J, Muthuswamy SK, Brugge JS. PMID: 12798140.
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    104. Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk. Biochem Soc Trans. 2001 Nov; 29(Pt 6):863-7. Czar MJ, Debnath J, Schaeffer EM, Lewis CM, Schwartzberg PL. PMID: 11709089.
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    105. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2001; 2:3. Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL. PMID: 11353545.
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    108. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol. 1999 Feb; 19(2):1498-507. Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. PMID: 9891083.
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    109. Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro. Oncogene. 1995 May 18; 10(10):1977-88. Van Etten RA, Debnath J, Zhou H, Casasnovas JM. PMID: 7539119.
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    110. HPLC-based method for determination of absolute configuration of alpha-chiral amines. Anal Chem. 1993 May 15; 65(10):1456-61. Husain PA, Debnath J, May SW. PMID: 8517551.
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