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Jayanta Debnath, MD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Phone415-514-0681
ORCID ORCID Icon0000-0002-8745-4069 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.1998School of Medicine
    Brigham and Women's HospitalResidency2000Pathology
    Harvard Medical SchoolPost-doc 2005Cell Biology

    Collapse Overview 
    Collapse Overview
    Autophagy In Cell Survival and Cancer Progression

    Autophagy is a fundamental catabolic process in which a cell literally “eats itself”. During autophagy, the cytoplasm and organelles of a cell are sequestered within double membrane vacuoles, called autophagosomes, and subsequently delivered to the lysosome for degradation. In eukaryotic cells, autophagy primarily functions as a critical survival response during nutrient deprivation or stress; as a result, interest in manipulating this tightly controlled self-eating process to treat human diseases, such as cancer, has rapidly intensified.

    My laboratory focuses how autophagy contributes to cell survival and cancer progression using both in vitro and in vivo models. Our three main goals are: 1) determine the role of autophagy in cancer metabolism, cell survival and oncogenic transformation; 2) delineate the role of autophagy in cancer progression and metastasis in vivo; and 3) dissect the biological and biochemical functions of the molecules that control autophagy (called ATGs) to ultimately exploit this process for therapeutic benefit.

    Ongoing Research:

    Autophagy, metabolic fitness, and oncogenic transformation: Cancer cells are resistant to anoikis, a form of apoptosis observed in epithelial cells deprived of extracellular matrix (ECM) contact. Several years ago, we discovered that autophagy serves as a mechanism of anoikis resistance. In follow-up work, we have discovered that autophagy also facilitates glycolytic metabolism during oncogenic transformation. Based on these findings, we are dissecting how autophagy contributes to the metabolic fitness of oncogene-transformed cells, allowing them to survive and expand in response to ECM deprivation and other microenvironmental stresses.

    Autophagy in cancer progression and metastases: My laboratory is also delineating how autophagy impacts breast cancer progression in vivo using mouse cancer models. We have created mice containing conditional null mutant alleles that allow us to delete autophagy in a tissue specific manner. We are now crossing with established mouse models of metastatic breast cancer to define the role of autophagy in cancer progression in vivo. Our studies focus on dissecting the functional requirements for autophagy in both tumor cells as well as key stromal constituents of the larger tumor microenvironment during primary tumor growth and metastasis.

    Novel biochemical and biological functions of ATGs: Despite widespread interest in exploiting autophagy for therapeutic purposes, we have much to learn about how this process works in mammalian cells and tissues. Autophagy is a tightly regulated by highly conserved gene products called ATGs. However, our recent results implicate these ATGs in diverse cellular functions that are distinct from their long-established roles in classical autophagy. Using cell biological, biochemical and yeast genetic approaches, we are: 1) dissecting new roles for ATGs in the control of secretion and adhesion; 2) probing genetic interactions between autophagy and mitochondrial protein quality control pathways; 3) elucidating the cellular functions of ATG12-ATG3, a novel complex between two autophagy regulators discovered in my laboratory, in the control of endocytosis and exosome biogenesis; and 4) determining how autophagy impacts protein translation during starvation.

    Collapse Research 
    Collapse Research Activities and Funding
    Stromal Fibroblast Autophagy In Tumor Progression and Desmoplasia
    NIH/NCI R01CA213775Dec 13, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Autophagy-dependent exosome loading and biogenesis in AD and FTD
    NIH/NIA R01AG057462Sep 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Deciphering Autophagy-Dependent Secretion In Cancer Via Proximity-Based Biotinylation
    NIH/NCI R21CA201849Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Autophagy as a microenvironmental regulator of tumorigenesis and resistance
    NIH/NCI R01CA188404Sep 1, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Autophagy in Adhesion and Metastasis
    NIH/NCI R01CA126792Jun 1, 2007 - Jan 31, 2020
    Role: Principal Investigator
    Oncogenes and Luminal Apoptosis Within Mammary Acini
    NIH/NCI K08CA098419Aug 1, 2003 - Jan 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Amaravadi RK, Kimmelman AC, Debnath J. Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discov. 2019 Sep; 9(9):1167-1181. PMID: 31434711.
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    2. Jayanta Debnath, Anup Saha, Pradip Kumar Da, Niladri Sekhar Das, Pranjal Tripathi. Prevalence and antibiotic susceptibility pattern of multidrug resistant gram negative bacilli in lower respiratory tract Infections in a tertiary care hospital of Tripura. Indian Journal of Microbiology Research. 2018 Dec 30; 5(4):538-542.
      View in: Publisher Site
    3. Leidal AM, Levine B, Debnath J. Autophagy and the cell biology of age-related disease. Nat Cell Biol. 2018 12; 20(12):1338-1348. PMID: 30482941.
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    4. Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018 12; 3(12):1472-1485. PMID: 30478389.
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    5. Marsh T, Debnath J. WIPIng the Brakes off Autophagy Induction. Mol Cell. 2018 10 18; 72(2):203-204. PMID: 30340019.
      View in: PubMed
    6. Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18). PMID: 30166453.
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    7. Commisso C, Debnath J. Macropinocytosis Fuels Prostate Cancer. Cancer Discov. 2018 07; 8(7):800-802. PMID: 29967075.
      View in: PubMed
    8. Murrow L, Debnath J. Atg12-Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release. Mol Cell Oncol. 2018; 5(5):e1039191. PMID: 30263931.
      View in: PubMed
    9. Cadwell K, Debnath J. Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. J Cell Biol. 2018 03 05; 217(3):813-822. PMID: 29237720.
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    10. Roy S, Debnath J. Autophagy enables retromer-dependent plasma membrane translocation of SLC2A1/GLUT1 to enhance glucose uptake. Autophagy. 2017; 13(11):2013-2014. PMID: 28933603.
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    11. Monkkonen T, Debnath J. Inflammatory signaling cascades and autophagy in cancer. Autophagy. 2018; 14(2):190-198. PMID: 28813180.
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    12. Roy S, Leidal AM, Ye J, Ronen SM, Debnath J. Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake. Mol Cell. 2017 Jul 06; 67(1):84-95.e5. PMID: 28602638.
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    13. Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 07 03; 36(13):1811-1836. PMID: 28596378.
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    14. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420. PMID: 28314591.
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    15. U Bhunia, Z A Naser, T Ghosh, Pankaj Kumar, C Nandi, A Agarwal, C Das, J Pradhan, J Debnath, M K Dey, G Pal, A Chakrabarti. Design of cryo-refrigerator assisted HTS steering magnet for K500 cyclotron beam line. Indian Journal of Cryogenics. 2017 Jan 1; 42(1):110.
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    16. Vlahakis A, Debnath J. The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion. J Mol Biol. 2017 02 17; 429(4):515-530. PMID: 27932295.
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    17. Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol. 2017 Jan; 13(1):119-126. PMID: 27870838.
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    18. Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 12 01; 126(12):4417-4429. PMID: 27775547.
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    19. Vlahakis A, Debnath J. Triggering Selective Autophagy at the Right Place and the Right Time. Mol Cell. 2016 10 20; 64(2):215-216. PMID: 27768868.
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    20. Kenific CM, Wittmann T, Debnath J. Autophagy in adhesion and migration. J Cell Sci. 2016 10 15; 129(20):3685-3693. PMID: 27672021.
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    21. Solvik T, Debnath J. At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication. J Cell Biol. 2016 08 29; 214(5):503-5. PMID: 27573461.
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    22. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. PMID: 27568548.
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    23. Kenific CM, Debnath J. NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly. Autophagy. 2016 10 02; 12(10):1958-1959. PMID: 27484104.
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    24. Liu J, Debnath J. The Evolving, Multifaceted Roles of Autophagy in Cancer. Adv Cancer Res. 2016; 130:1-53. PMID: 27037750.
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    25. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016 Feb 29; 212(5):577-90. PMID: 26903539.
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    26. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
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    27. Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL. Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015 Dec 24; 528(7583):565-9. PMID: 26649827.
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    28. Leidal AM, Debnath J. Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress. Dev Cell. 2015 Dec 07; 35(5):529-530. PMID: 26651287.
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    29. Salas E, Roy S, Marsh T, Rubin B, Debnath J. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2016 06 02; 35(22):2913-22. PMID: 26434592.
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    30. Vinay Singh, A. Dutta, A. Agarwal, C. Das, B. Naik, Z.A. Naser, S. Paul, U. Bhunia, J. Pradhan, J. Debnath. Beam Behaviour and Magnetic Field of K500 SCC. Journal of Nuclear Physics Material Sciences Radiation and Applications. 2015 Aug 3; 3(1):127-134.
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    31. Kaur J, Debnath J. Autophagy at the crossroads of catabolism and anabolism. Nat Rev Mol Cell Biol. 2015 Aug; 16(8):461-72. PMID: 26177004.
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    32. Lyndsay Murrow, Jayanta Debnath. Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release. Molecular & Cellular Oncology. 2015 May 1; 00-00.
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    33. Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. Autophagy in malignant transformation and cancer progression. EMBO J. 2015 Apr 01; 34(7):856-80. PMID: 25712477.
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    34. Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015 Mar; 17(3):300-10. PMID: 25686249.
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    35. Murrow L, Debnath J. A nuclear option that initiates autophagy. Mol Cell. 2015 Feb 05; 57(3):393-5. PMID: 25658203.
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    36. Mar FA, Debnath J, Stohr BA. Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction. Autophagy. 2015; 11(3):527-37. PMID: 25751002.
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    37. Marsh T, Debnath J. Ironing out VPS34 inhibition. Nat Cell Biol. 2015 Jan; 17(1):1-3. PMID: 25679028.
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    38. Murrow L, Debnath J. ATG12-ATG3 connects basal autophagy and late endosome function. Autophagy. 2015; 11(6):961-2. PMID: 25998418.
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    39. Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015; 11(1):145-54. PMID: 25585051.
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    40. Jayanta Debnath, Pradip Kumar Das. Bacteriological profile and antibiotic susceptibility pattern of neonatal septicemia in a tertiary care hospital of Tripura. Indian Journal of Microbiology Research. 2015 Jan 1; 2(4):238.
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    41. Kenific CM, Debnath J. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015 Jan; 25(1):37-45. PMID: 25278333.
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    42. Amaravadi R, Debnath J. Mouse models address key concerns regarding autophagy inhibition in cancer therapy. Cancer Discov. 2014 Aug; 4(8):873-5. PMID: 25092744.
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    43. Leidal AM, Debnath J. 'Doubling down' on the autophagy pathway to suppress tumor growth. Genes Dev. 2014 Jun 01; 28(11):1137-9. PMID: 24888584.
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    44. Lock R, Kenific CM, Leidal AM, Salas E, Debnath J. Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discov. 2014 Apr; 4(4):466-79. PMID: 24513958.
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    45. Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW. Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 2014; 10(12):2269-78. PMID: 25629932.
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    46. Goldsmith J, Levine B, Debnath J. Autophagy and cancer metabolism. Methods Enzymol. 2014; 542:25-57. PMID: 24862259.
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    47. Starobinets H, Debnath J. Cancer: A suppression switch. Nature. 2013 Dec 12; 504(7479):225-6. PMID: 24305045.
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    48. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 08; 33(19):2441-53. PMID: 23770848.
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    49. Chen N, Debnath J. I?B kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy. 2013 Aug; 9(8):1214-27. PMID: 23778976.
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    50. Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7. PMID: 23389440.
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    51. Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso JA. Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol. 2013; 734:73-89. PMID: 23143976.
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    52. Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene. 2013 Oct 10; 32(41):4932-40. PMID: 23160380.
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    53. Murrow L, Debnath J. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol. 2013 Jan 24; 8:105-37. PMID: 23072311.
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    54. Chen N, Eritja N, Lock R, Debnath J. Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture. Oncogene. 2013 May 16; 32(20):2543-54. PMID: 22777351.
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    55. Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81. PMID: 22675028.
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    56. Lee HS, Daniels BH, Salas E, Bollen AW, Debnath J, Margeta M. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study. PLoS One. 2012; 7(4):e36221. PMID: 22558391.
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