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Jayanta Debnath, MD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-514-0681
ORCID ORCID Icon0000-0002-8745-4069 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.1998School of Medicine
    Brigham and Women's HospitalResidency2000Pathology
    Harvard Medical SchoolPost-doc 2005Cell Biology

    Collapse Overview 
    Collapse Overview
    Autophagy In Cell Survival and Cancer Progression

    Autophagy is a fundamental catabolic process in which a cell literally “eats itself”. During autophagy, the cytoplasm and organelles of a cell are sequestered within double membrane vacuoles, called autophagosomes, and subsequently delivered to the lysosome for degradation. In eukaryotic cells, autophagy primarily functions as a critical survival response during nutrient deprivation or stress; as a result, interest in manipulating this tightly controlled self-eating process to treat human diseases, such as cancer, has rapidly intensified.

    My laboratory focuses how autophagy contributes to cell survival and cancer progression using both in vitro and in vivo models. Our three main goals are: 1) determine the role of autophagy in cancer metabolism, cell survival and oncogenic transformation; 2) delineate the role of autophagy in cancer progression and metastasis in vivo; and 3) dissect the biological and biochemical functions of the molecules that control autophagy (called ATGs) to ultimately exploit this process for therapeutic benefit.

    Ongoing Research:

    Autophagy, metabolic fitness, and oncogenic transformation: Cancer cells are resistant to anoikis, a form of apoptosis observed in epithelial cells deprived of extracellular matrix (ECM) contact. Several years ago, we discovered that autophagy serves as a mechanism of anoikis resistance. In follow-up work, we have discovered that autophagy also facilitates glycolytic metabolism during oncogenic transformation. Based on these findings, we are dissecting how autophagy contributes to the metabolic fitness of oncogene-transformed cells, allowing them to survive and expand in response to ECM deprivation and other microenvironmental stresses.

    Autophagy in cancer progression and metastases: My laboratory is also delineating how autophagy impacts breast cancer progression in vivo using mouse cancer models. We have created mice containing conditional null mutant alleles that allow us to delete autophagy in a tissue specific manner. We are now crossing with established mouse models of metastatic breast cancer to define the role of autophagy in cancer progression in vivo. Our studies focus on dissecting the functional requirements for autophagy in both tumor cells as well as key stromal constituents of the larger tumor microenvironment during primary tumor growth and metastasis.

    Novel biochemical and biological functions of ATGs: Despite widespread interest in exploiting autophagy for therapeutic purposes, we have much to learn about how this process works in mammalian cells and tissues. Autophagy is a tightly regulated by highly conserved gene products called ATGs. However, our recent results implicate these ATGs in diverse cellular functions that are distinct from their long-established roles in classical autophagy. Using cell biological, biochemical and yeast genetic approaches, we are: 1) dissecting new roles for ATGs in the control of secretion and adhesion; 2) probing genetic interactions between autophagy and mitochondrial protein quality control pathways; 3) elucidating the cellular functions of ATG12-ATG3, a novel complex between two autophagy regulators discovered in my laboratory, in the control of endocytosis and exosome biogenesis; and 4) determining how autophagy impacts protein translation during starvation.

    Collapse Research 
    Collapse Research Activities and Funding
    Stromal Fibroblast Autophagy In Tumor Progression and Desmoplasia
    NIH/NCI R01CA213775Dec 13, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Autophagy-dependent exosome loading and biogenesis in AD and FTD
    NIH/NIA R01AG057462Sep 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Deciphering Autophagy-Dependent Secretion In Cancer Via Proximity-Based Biotinylation
    NIH/NCI R21CA201849Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Autophagy as a microenvironmental regulator of tumorigenesis and resistance
    NIH/NCI R01CA188404Sep 1, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Autophagy in Adhesion and Metastasis
    NIH/NCI R01CA126792Feb 1, 2009 - Sep 29, 2011
    Role: Principal Investigator
    Oncogenes and Luminal Apoptosis Within Mammary Acini
    NIH/NCI K08CA098419Aug 1, 2003 - May 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Aug 31. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962.
      View in: PubMed   Mentions:    Fields:    
    2. Unconventional secretion: cargo channeling by TMED10. Cell Res. 2020 Jul 29. Nguyen TA, Debnath J. PMID: 32728197.
      View in: PubMed   Mentions:    Fields:    
    3. Ribosome profiling reveals a functional role for autophagy in mRNA translational control. Commun Biol. 2020 Jul 17; 3(1):388. Goldsmith J, Marsh T, Asthana S, Leidal AM, Suresh D, Olshen A, Debnath J. PMID: 32681145.
      View in: PubMed   Mentions:
    4. LC3-dependent extracellular vesicle loading and secretion (LDELS). Autophagy. 2020 06; 16(6):1162-1163. Leidal AM, Debnath J. PMID: 32330402.
      View in: PubMed   Mentions:    Fields:    
    5. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 05; 581(7806):100-105. Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. PMID: 32376951.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    6. Autophagy suppresses breast cancer metastasis by degrading NBR1. Autophagy. 2020 06; 16(6):1164-1165. Marsh T, Debnath J. PMID: 32267786.
      View in: PubMed   Mentions:    Fields:    
    7. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Dev Cell. 2020 Mar 09; 52(5):591-604.e6. Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. PMID: 32084360.
      View in: PubMed   Mentions: 2     Fields:    
    8. Unraveling the mechanisms that specify molecules for secretion in extracellular vesicles. Methods. 2020 05 01; 177:15-26. Leidal AM, Debnath J. PMID: 31978536.
      View in: PubMed   Mentions: 6     Fields:    
    9. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    10. Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discov. 2019 09; 9(9):1167-1181. Amaravadi RK, Kimmelman AC, Debnath J. PMID: 31434711.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    11. Autophagy and the cell biology of age-related disease. Nat Cell Biol. 2018 12; 20(12):1338-1348. Leidal AM, Levine B, Debnath J. PMID: 30482941.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018 12; 3(12):1472-1485. Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH. PMID: 30478389.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. WIPIng the Brakes off Autophagy Induction. Mol Cell. 2018 10 18; 72(2):203-204. Marsh T, Debnath J. PMID: 30340019.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    14. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18). Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Macropinocytosis Fuels Prostate Cancer. Cancer Discov. 2018 07; 8(7):800-802. Commisso C, Debnath J. PMID: 29967075.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Atg12-Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release. Mol Cell Oncol. 2018; 5(5):e1039191. Murrow L, Debnath J. PMID: 30263931.
      View in: PubMed   Mentions:
    17. Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. J Cell Biol. 2018 03 05; 217(3):813-822. Cadwell K, Debnath J. PMID: 29237720.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Autophagy enables retromer-dependent plasma membrane translocation of SLC2A1/GLUT1 to enhance glucose uptake. Autophagy. 2017; 13(11):2013-2014. Roy S, Debnath J. PMID: 28933603.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    19. Inflammatory signaling cascades and autophagy in cancer. Autophagy. 2018; 14(2):190-198. Monkkonen T, Debnath J. PMID: 28813180.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    20. Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake. Mol Cell. 2017 Jul 06; 67(1):84-95.e5. Roy S, Leidal AM, Ye J, Ronen SM, Debnath J. PMID: 28602638.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Molecular definitions of autophagy and related processes. EMBO J. 2017 07 03; 36(13):1811-1836. Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. PMID: 28596378.
      View in: PubMed   Mentions: 193     Fields:    Translation:Animals
    22. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. PMID: 28314591.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion. J Mol Biol. 2017 02 17; 429(4):515-530. Vlahakis A, Debnath J. PMID: 27932295.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol. 2017 Jan; 13(1):119-126. Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. PMID: 27870838.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 12 01; 126(12):4417-4429. Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J. PMID: 27775547.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    26. Triggering Selective Autophagy at the Right Place and the Right Time. Mol Cell. 2016 10 20; 64(2):215-216. Vlahakis A, Debnath J. PMID: 27768868.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Autophagy in adhesion and migration. J Cell Sci. 2016 10 15; 129(20):3685-3693. Kenific CM, Wittmann T, Debnath J. PMID: 27672021.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication. J Cell Biol. 2016 08 29; 214(5):503-5. Solvik T, Debnath J. PMID: 27573461.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    29. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. PMID: 27568548.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    30. NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly. Autophagy. 2016 10 02; 12(10):1958-1959. Kenific CM, Debnath J. PMID: 27484104.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    31. The Evolving, Multifaceted Roles of Autophagy in Cancer. Adv Cancer Res. 2016; 130:1-53. Liu J, Debnath J. PMID: 27037750.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    32. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016 Feb 29; 212(5):577-90. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. PMID: 26903539.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    33. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. PMID: 26799652.
      View in: PubMed   Mentions: 1304     Fields:    Translation:HumansAnimals
    34. Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015 Dec 24; 528(7583):565-9. Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL. PMID: 26649827.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    35. Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress. Dev Cell. 2015 Dec 07; 35(5):529-530. Leidal AM, Debnath J. PMID: 26651287.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    36. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2016 06 02; 35(22):2913-22. Salas E, Roy S, Marsh T, Rubin B, Debnath J. PMID: 26434592.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    37. Autophagy at the crossroads of catabolism and anabolism. Nat Rev Mol Cell Biol. 2015 Aug; 16(8):461-72. Kaur J, Debnath J. PMID: 26177004.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    38. Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release. Molecular & Cellular Oncology. 2015 May 1; 00-00. Lyndsay Murrow, Jayanta Debnath. .
      View in: Publisher Site   Mentions:
    39. Autophagy in malignant transformation and cancer progression. EMBO J. 2015 Apr 01; 34(7):856-80. Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. PMID: 25712477.
      View in: PubMed   Mentions: 294     Fields:    Translation:HumansAnimals
    40. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015 Mar; 17(3):300-10. Murrow L, Malhotra R, Debnath J. PMID: 25686249.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    41. A nuclear option that initiates autophagy. Mol Cell. 2015 Feb 05; 57(3):393-5. Murrow L, Debnath J. PMID: 25658203.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    42. Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction. Autophagy. 2015; 11(3):527-37. Mar FA, Debnath J, Stohr BA. PMID: 25751002.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015; 11(1):145-54. Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. PMID: 25585051.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    44. ATG12-ATG3 connects basal autophagy and late endosome function. Autophagy. 2015; 11(6):961-2. Murrow L, Debnath J. PMID: 25998418.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    45. Ironing out VPS34 inhibition. Nat Cell Biol. 2015 Jan; 17(1):1-3. Marsh T, Debnath J. PMID: 25679028.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015 Jan; 25(1):37-45. Kenific CM, Debnath J. PMID: 25278333.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    47. Mouse models address key concerns regarding autophagy inhibition in cancer therapy. Cancer Discov. 2014 Aug; 4(8):873-5. Amaravadi R, Debnath J. PMID: 25092744.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    48. 'Doubling down' on the autophagy pathway to suppress tumor growth. Genes Dev. 2014 Jun 01; 28(11):1137-9. Leidal AM, Debnath J. PMID: 24888584.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    49. Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discov. 2014 Apr; 4(4):466-79. Lock R, Kenific CM, Leidal AM, Salas E, Debnath J. PMID: 24513958.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    50. Autophagy and cancer metabolism. Methods Enzymol. 2014; 542:25-57. Goldsmith J, Levine B, Debnath J. PMID: 24862259.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    51. Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 2014; 10(12):2269-78. Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW. PMID: 25629932.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    52. Cancer: A suppression switch. Nature. 2013 Dec 12; 504(7479):225-6. Starobinets H, Debnath J. PMID: 24305045.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    53. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 08; 33(19):2441-53. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. PMID: 23770848.
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    54. I?B kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy. 2013 Aug; 9(8):1214-27. Chen N, Debnath J. PMID: 23778976.
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    55. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7. Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. PMID: 23389440.
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    56. Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol. 2013; 734:73-89. Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso JA. PMID: 23143976.
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    57. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene. 2013 Oct 10; 32(41):4932-40. Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA. PMID: 23160380.
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    58. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol. 2013 Jan 24; 8:105-37. Murrow L, Debnath J. PMID: 23072311.
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    59. Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture. Oncogene. 2013 May 16; 32(20):2543-54. Chen N, Eritja N, Lock R, Debnath J. PMID: 22777351.
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    60. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81. Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. PMID: 22675028.
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    61. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study. PLoS One. 2012; 7(4):e36221. Lee HS, Daniels BH, Salas E, Bollen AW, Debnath J, Margeta M. PMID: 22558391.
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    62. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. PMID: 22966490.
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    63. Targeting chaperone-mediated autophagy in cancer. Sci Transl Med. 2011 Nov 16; 3(109):109ps45. Thorburn A, Debnath J. PMID: 22089450.
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    64. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov; 7(11):1273-94. Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. PMID: 21997368.
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    65. The multifaceted roles of autophagy in tumors-implications for breast cancer. J Mammary Gland Biol Neoplasia. 2011 Sep; 16(3):173-87. Debnath J. PMID: 21779879.
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    66. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol. 2011 Sep; 31(17):3616-29. Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA. PMID: 21709020.
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    67. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 2011 Sep; 89(9):877-89. Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. PMID: 21678117.
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    68. Ras, autophagy and glycolysis. Cell Cycle. 2011 May 15; 10(10):1516-7. Lock R, Debnath J. PMID: 21467842.
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    69. ATG12-ATG3 and mitochondria. Autophagy. 2011 Jan; 7(1):109-11. Radoshevich L, Debnath J. PMID: 21068544.
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    70. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell. 2011 Jan 15; 22(2):165-78. Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, Debnath J. PMID: 21119005.
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    71. Therapeutic implications of autophagy-mediated cell survival in gastrointestinal stromal tumor after treatment with imatinib mesylate. Autophagy. 2010 Nov; 6(8):1190-1. Rubin BP, Debnath J. PMID: 20930540.
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    72. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. PMID: 21062993.
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    73. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell. 2010 Aug 20; 142(4):590-600. Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J. PMID: 20723759.
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    74. p66(Shc) and Ras: controlling anoikis from the inside-out. Oncogene. 2010 Oct 14; 29(41):5556-8. Debnath J. PMID: 20711240.
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    75. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14333-8. Gupta A, Roy S, Lazar AJ, Wang WL, McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G, Debiec-Rychter M, Schoffski P, Trent JA, Debnath J, Rubin BP. PMID: 20660757.
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    76. Autophagy and tumorigenesis. Semin Immunopathol. 2010 Dec; 32(4):383-96. Roy S, Debnath J. PMID: 20589500.
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    77. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 01; 5(4):e9979. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. PMID: 20376313.
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    78. A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst Biol. 2009 Dec 31; 3:122. Kim SH, Debnath J, Mostov K, Park S, Hunt CA. PMID: 20043854.
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    79. Autophagy and tumorigenesis. FEBS Lett. 2010 Apr 02; 584(7):1427-35. Chen N, Debnath J. PMID: 20035753.
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    80. Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol. 2010 Apr; 22(2):241-5. Kenific CM, Thorburn A, Debnath J. PMID: 19945838.
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    81. Computational investigation of epithelial cell dynamic phenotype in vitro. Theor Biol Med Model. 2009 May 28; 6:8. Kim SH, Park S, Mostov K, Debnath J, Hunt CA. PMID: 19476639.
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    82. Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation. Autophagy. 2009 May; 5(4):573-5. N'Diaye EN, Debnath J, Brown EJ. PMID: 19398896.
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    83. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep. 2009 Feb; 10(2):173-9. N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, Brown EJ. PMID: 19148225.
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    84. Detachment-induced autophagy in three-dimensional epithelial cell cultures. Methods Enzymol. 2009; 452:423-39. Debnath J. PMID: 19200896.
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    85. Extracellular matrix regulation of autophagy. Curr Opin Cell Biol. 2008 Oct; 20(5):583-8. Lock R, Debnath J. PMID: 18573652.
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    86. Detachment-induced autophagy during anoikis and lumen formation in epithelial acini. Autophagy. 2008 Apr; 4(3):351-3. Debnath J. PMID: 18196957.
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    87. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol. 2008; 3:313-39. Hebner C, Weaver VM, Debnath J. PMID: 18039125.
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    88. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell. 2008 Mar; 19(3):797-806. Fung C, Lock R, Gao S, Salas E, Debnath J. PMID: 18094039.
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    89. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. PMID: 18188003.
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    90. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy. 2008 Jan; 4(1):37-45. Chen GC, Lee JY, Tang HW, Debnath J, Thomas SM, Settleman J. PMID: 17952025.
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    91. The Dual Roles for Autophagy in Cell Death and Survival. Autophagy in Immunity and Infection. 2006 Jun 20; 105-126. Jayanta Debnath, Christopher Fung. .
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    92. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer. 2005 Sep; 5(9):675-88. Debnath J, Brugge JS. PMID: 16148884.
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    93. Does autophagy contribute to cell death? Autophagy. 2005 Jul; 1(2):66-74. Debnath J, Baehrecke EH, Kroemer G. PMID: 16874022.
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    94. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004 Apr 26; 165(2):263-73. Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS. PMID: 15117969.
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    95. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3438-43. Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS. PMID: 14993595.
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    96. Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol. 2003 Oct 27; 163(2):315-26. Debnath J, Walker SJ, Brugge JS. PMID: 14568991.
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    97. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 2003 Aug; 5(8):733-40. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. PMID: 12844146.
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    98. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003 Jul; 30(3):256-68. Debnath J, Muthuswamy SK, Brugge JS. PMID: 12798140.
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    99. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 2002 Oct 04; 111(1):29-40. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. PMID: 12372298.
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    100. Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk. Biochem Soc Trans. 2001 Nov; 29(Pt 6):863-7. Czar MJ, Debnath J, Schaeffer EM, Lewis CM, Schwartzberg PL. PMID: 11709089.
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    101. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2001; 2:3. Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL. PMID: 11353545.
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    102. Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med. 2000 Oct 02; 192(7):987-1000. Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL. PMID: 11015440.
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    104. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol. 1999 Feb; 19(2):1498-507. Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. PMID: 9891083.
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    105. Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro. Oncogene. 1995 May 18; 10(10):1977-88. Van Etten RA, Debnath J, Zhou H, Casasnovas JM. PMID: 7539119.
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    106. HPLC-based method for determination of absolute configuration of alpha-chiral amines. Anal Chem. 1993 May 15; 65(10):1456-61. Husain PA, Debnath J, May SW. PMID: 8517551.
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    107. Activation of an adrenergic pro-drug through sequential stereoselective action of tandem target enzymes. Biochem Biophys Res Commun. 1992 Nov 30; 189(1):33-9. Debnath J, Husain PA, May SW. PMID: 1449487.
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