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Caroline McCoach, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-885-3882
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, Stanford, CAPhD2005Biochemistry
    University of Colorado, Aurora, COMD2009
    University of California, Davis, Sacramento, CAResidency/ Chief Residency2013
    University of California, Davis, Sacramento, CAResearch Fellowship2014
    University of Colorado, Aurora, COClinical Fellowship2017

    Collapse Overview 
    Collapse Overview
    Caroline McCoach is a thoracic oncologist who focuses on the treatment of patients with lung cancer as well as other thoracic malignancies. Her goal is to provide a personalized approach to treatment, based on each patient’s cancer type in combination with their individual treatment goals.

    Her primary research focus is on treatment of cancers driven by genetic mutations or alterations such as ALK, ROS1, EGFR, and others. She is also working to find treatments to prevent or delay the development of resistance to targeted therapies as well as increase the efficacy of standard targeted therapies by using rational combination treatments. She works closely with laboratory based researchers to develop new and improved treatments for lung cancer patients.

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular landscape of BRAF-mutant NSCLC reveals an association between clonality and driver mutations and identifies targetable non-V600 driver mutations. J Thorac Oncol. 2020 Jun 12. Negrao MV, Raymond VM, Lanman RB, Robichaux JP, He J, Nilsson MB, Ng PKS, Amador BE, Roarty EB, Nagy RJ, Banks KC, Zhu VW, Ng C, Chae YK, Clarke JM, Crawford JA, Meric-Bernstam F, Ou SH, Gandara DR, Heymach JV, Bivona TG, McCoach CE. PMID: 32540409.
      View in: PubMed   Mentions:    Fields:    
    2. Role of MPR as an early signal for efficacy in neoadjuvant studies. Clin Cancer Res. 2020 May 04. Blakely CM, McCoach CE. PMID: 32366673.
      View in: PubMed   Mentions:    Fields:    
    3. Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. Clin Cancer Res. 2020 Jan 15; 26(2):439-449. Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas VR, Wolff AM, Fraser JS, Collisson EA, McCoach CE, Camidge DR, Pacheco J, Bazhenova L, Li T, Bivona TG, Blakely CM. PMID: 31548343.
      View in: PubMed   Mentions:    Fields:    
    4. Engineering Multidimensional Evolutionary Forces to Combat Cancer. Cancer Discov. 2019 05; 9(5):587-604. McCoach CE, Bivona TG. PMID: 30992280.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    5. Exploratory analysis of the association of depth of response and survival in patients with metastatic non-small-cell lung cancer treated with a targeted therapy or immunotherapy. Ann Oncol. 2019 03 01; 30(3):492. McCoach CE, Blumenthal GM, Zhang L, Myers A, Tang S, Sridhara R, Keegan P, Pazdur R, Doebele RC, Kazandjian D. PMID: 29529128.
      View in: PubMed   Mentions:    Fields:    
    6. A Cautionary Analysis of Immunotherapy Prior to Targeted Therapy. J Thorac Oncol. 2019 01; 14(1):8-10. McCoach CE. PMID: 30579546.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019 02 01; 79(3):546-556. Neel DS, Allegakoen DV, Olivas V, Mayekar MK, Hemmati G, Chatterjee N, Blakely CM, McCoach CE, Rotow JK, Le A, Karachaliou N, Rosell R, Riess JW, Nichols R, Doebele RC, Bivona TG. PMID: 30538120.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation. Clin Lung Cancer. 2019 03; 20(2):e137-e141. Rotow JK, Woodard GA, Urisman A, McCoach CE, Bivona TG, Elicker BM, Jablons DM, Blakely CM. PMID: 30553716.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Current Status and Future Perspectives on Neoadjuvant Therapy in Lung Cancer. J Thorac Oncol. 2018 Dec; 13(12):1818-1831. Blumenthal GM, Bunn PA, Chaft JE, McCoach CE, Perez EA, Scagliotti GV, Carbone DP, Aerts HJWL, Aisner DL, Bergh J, Berry DA, Jarkowski A, Botwood N, Cross DAE, Diehn M, Drezner NL, Doebele RC, Blakely CM, Eberhardt WEE, Felip E, Gianni L, Keller SP, Leavey PJ, Malik S, Pignatti F, Prowell TM, Redman MW, Rizvi NA, Rosell R, Rusch V, de Ruysscher D, Schwartz LH, Sridhara R, Stahel RA, Swisher S, Taube JM, Travis WD, Keegan P, Wiens JR, Wistuba II, Wynes MW, Hirsch FR, Kris MG. PMID: 30268698.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. First-line Chemotherapy Responsiveness and Patterns of Metastatic Spread Identify Clinical Syndromes Present Within Advanced KRAS Mutant Non-Small-cell Lung Cancer With Different Prognostic Significance. Clin Lung Cancer. 2018 11; 19(6):531-543. Iams WT, Yu H, Shyr Y, Patil T, Horn L, McCoach C, Kelly K, Doebele RC, Camidge DR. PMID: 30197261.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 09; 20(9):1064-1073. Nichols RJ, Haderk F, Stahlhut C, Schulze CJ, Hemmati G, Wildes D, Tzitzilonis C, Mordec K, Marquez A, Romero J, Hsieh T, Zaman A, Olivas V, McCoach C, Blakely CM, Wang Z, Kiss G, Koltun ES, Gill AL, Singh M, Goldsmith MA, Smith JAM, Bivona TG. PMID: 30104724.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Resistance Mechanisms to Targeted Therapies in ROS1+ and ALK+ Non-small Cell Lung Cancer. Clin Cancer Res. 2018 07 15; 24(14):3334-3347. McCoach CE, Le AT, Gowan K, Jones K, Schubert L, Doak A, Estrada-Bernal A, Davies KD, Merrick DT, Bunn PA, Purcell WT, Dziadziuszko R, Varella-Garcia M, Aisner DL, Camidge DR, Doebele RC. PMID: 29636358.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer. Clin Cancer Res. 2018 06 15; 24(12):2758-2770. McCoach CE, Blakely CM, Banks KC, Levy B, Chue BM, Raymond VM, Le AT, Lee CE, Diaz J, Waqar SN, Purcell WT, Aisner DL, Davies KD, Lanman RB, Shaw AT, Doebele RC. PMID: 29599410.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. The evolving understanding of immunoediting and the clinical impact of immune escape. J Thorac Dis. 2018 Mar; 10(3):1248-1252. McCoach CE, Bivona TG. PMID: 29708132.
      View in: PubMed   Mentions:
    15. The importance of the initial response to cancer treatment in predicting longer overall survival. Expert Rev Clin Pharmacol. 2018 02; 11(2):109-111. McCoach CE, Doebele RC. PMID: 29251525.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017 Dec; 49(12):1693-1704. Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. PMID: 29106415.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    17. Exploratory analysis of the association of depth of response and survival in patients with metastatic non-small-cell lung cancer treated with a targeted therapy or immunotherapy. Ann Oncol. 2017 Nov 01; 28(11):2707-2714. McCoach CE, Blumenthal GM, Zhang L, Myers A, Tang S, Sridhara R, Keegan P, Pazdur R, Doebele RC, Kazandjian D. PMID: 29045514.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. PS01.68: Heterogeneous Clinical Syndromes Existing Within Patients with Stage IV KRAS Mutant Non-Small Cell Lung Cancer: Topic: Medical Oncology. J Thorac Oncol. 2016 Nov; 11(11S):S313. Iams WT, Yu H, Shyr Y, Patil T, Horn L, McCoach C, Kelly K, Doebele R, Camidge DR. PMID: 27969535.
      View in: PubMed   Mentions:
    19. Osimertinib, a third-generation tyrosine kinase inhibitor targeting non-small cell lung cancer with EGFR T790M mutations. Drugs Today (Barc). 2016 Oct; 52(10):561-568. McCoach CE, Jimeno A. PMID: 27910964.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance. Clin Lung Cancer. 2016 09; 17(5):466-469. McCoach CE, Bivona TG, Blakely CM, Doebele RC. PMID: 27378174.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. A Brief Report of the Status of Central Nervous System Metastasis Enrollment Criteria for Advanced Non-Small Cell Lung Cancer Clinical Trials: A Review of the ClinicalTrials.gov Trial Registry. J Thorac Oncol. 2016 Mar; 11(3):407-13. McCoach CE, Berge EM, Lu X, BarĂ³n AE, Camidge DR. PMID: 26725180.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Paraneoplastic Leukemoid Reaction as a Marker of Tumor Progression in Non-Small Cell Lung Cancer. Cancer Treat Commun. 2015; 4:15-18. McCoach CE, Rogers JG, Dwyre DM, Jonas BA. PMID: 25932381.
      View in: PubMed   Mentions:
    23. The minority report: targeting the rare oncogenes in NSCLC. Curr Treat Options Oncol. 2014 Dec; 15(4):644-57. McCoach CE, Doebele RC. PMID: 25228144.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease. J Am Heart Assoc. 2014 Apr 10; 3(2):e000697. Armstrong EJ, Chen DC, Westin GG, Singh S, McCoach CE, Bang H, Yeo KK, Anderson D, Amsterdam EA, Laird JR. PMID: 24721799.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    25. Treatment paradigms in advanced non-small-cell lung cancer. Clin Adv Hematol Oncol. 2013 Oct; 11(10):629-39. McCoach CE, Kelly K. PMID: 24518373.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Fungating mass as first presentation of advanced breast cancer. J Gen Intern Med. 2014 Apr; 29(4):685. McCoach CE, Aronowitz P. PMID: 24065379.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Gender-related variation in the clinical presentation and outcomes of critical limb ischemia. Vasc Med. 2013 Feb; 18(1):19-26. McCoach CE, Armstrong EJ, Singh S, Javed U, Anderson D, Yeo KK, Westin GG, Hedayati N, Amsterdam EA, Laird JR. PMID: 23439776.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Systematic identification of balanced transposition polymorphisms in Saccharomyces cerevisiae. PLoS Genet. 2009 Jun; 5(6):e1000502. Faddah DA, Ganko EW, McCoach C, Pickrell JK, Hanlon SE, Mann FG, Mieczkowska JO, Jones CD, Lieb JD, Vision TJ. PMID: 19503594.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with vandetanib sensitizes bladder cancer cells to cisplatin in a dose- and sequence-dependent manner. BJU Int. 2009 Jun; 103(12):1729-37. Flaig TW, Su LJ, McCoach C, Li Y, Raben D, Varella-Garcia M, Bemis LT. PMID: 19220256.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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