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Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading. bioRxiv. 2024 Jul 31.
Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M. PMID: 39211079; PMCID: PMC11360891.
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Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: A Phase II Multicenter Study. J Clin Oncol. 2024 Sep 10; 42(26):3105-3114.
Blakely CM, Urisman A, Gubens MA, Mulvey CK, Allen GM, Shiboski SC, Rotow JK, Chakrabarti T, Kerr DL, Aredo JV, Bacaltos B, Gee M, Tan L, Jones KD, Devine WP, Doebele RC, Aisner DL, Patil T, Schenk EL, Bivona TG, Riess JW, Coleman M, Kratz JR, Jablons DM. PMID: 39028931; PMCID: PMC11379363.
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PubMed Mentions: Fields:
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Current Trial Report: A Multicenter Phase I/Ib study of Capmatinib Plus Trametinib in Patients With Metastatic Nonsmall Cell Lung Center Harboring MET Exon 14 Skipping Mutations and Other MET-Alterations. Clin Lung Cancer. 2024 Jul 05.
Lara MS, Riess JW, Goldman JW, Jiang F, Bivona TG, Blakely CM. PMID: 39089913.
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PubMed Mentions: Fields:
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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nat Commun. 2024 Jun 13; 15(1):4871.
Hobor S, Al Bakir M, Hiley CT, Skrzypski M, Frankell AM, Bakker B, Watkins TBK, Markovets A, Dry JR, Brown AP, van der Aart J, van den Bos H, Spierings D, Oukrif D, Novelli M, Chakrabarti T, Rabinowitz AH, Ait Hassou L, Litière S, Kerr DL, Tan L, Kelly G, Moore DA, Renshaw MJ, Venkatesan S, Hill W, Huebner A, Martínez-Ruiz C, Black JRM, Wu W, Angelova M, McGranahan N, Downward J, Chmielecki J, Barrett C, Litchfield K, Chew SK, Blakely CM, de Bruin EC, Foijer F, Vousden KH, Bivona TG, TRACERx consortium, Hynds RE, Kanu N, Zaccaria S, Grönroos E, Swanton C. PMID: 38871738; PMCID: PMC11176322.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Quantification of cerebrospinal fluid tumor DNA in lung cancer patients with suspected leptomeningeal carcinomatosis. NPJ Precis Oncol. 2024 May 28; 8(1):121.
Azad TD, Nanjo S, Jin MC, Chabon JJ, Kurtz DM, Chaudhuri AA, Connolly ID, Hui AB, Liu CL, Merriott D, Ko R, Yoo C, Carter J, Chen E, Bonilla R, Hata A, Katakami N, Irie K, Yano S, Okimoto R, Bivona TG, Newman AM, Iv M, Nagpal S, Gephart MH, Alizadeh AA, Diehn M. PMID: 38806586; PMCID: PMC11133465.
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PubMed Mentions:
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Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nat Commun. 2024 May 03; 15(1):3741.
Haderk F, Chou YT, Cech L, Fernández-Méndez C, Yu J, Olivas V, Meraz IM, Barbosa Rabago D, Kerr DL, Gomez C, Allegakoen DV, Guan J, Shah KN, Herrington KA, Gbenedio OM, Nanjo S, Majidi M, Tamaki W, Pourmoghadam YK, Rotow JK, McCoach CE, Riess JW, Gutkind JS, Tang TT, Post L, Huang B, Santisteban P, Goodarzi H, Bandyopadhyay S, Kuo CJ, Roose JP, Wu W, Blakely CM, Roth JA, Bivona TG. PMID: 38702301; PMCID: PMC11068778.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors. Nat Cancer. 2024 Jun; 5(6):938-952.
Sinha S, Vegesna R, Mukherjee S, Kammula AV, Dhruba SR, Wu W, Kerr DL, Nair NU, Jones MG, Yosef N, Stroganov OV, Grishagin I, Aldape KD, Blakely CM, Jiang P, Thomas CJ, Benes CH, Bivona TG, Schäffer AA, Ruppin E. PMID: 38637658.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers. Cancer Discov. 2024 Apr 04; 14(4):630-634.
Bivona TG. PMID: 38571428.
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PubMed Mentions: Fields:
Translation:
Humans
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Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies. Mol Cell. 2023 12 07; 83(23):4199-4201.
Gencel-Augusto J, Bivona TG. PMID: 38065059.
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PubMed Mentions: Fields:
Translation:
Humans
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The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. Nat Genet. 2024 Jan; 56(1):60-73.
Caswell DR, Gui P, Mayekar MK, Law EK, Pich O, Bailey C, Boumelha J, Kerr DL, Blakely CM, Manabe T, Martinez-Ruiz C, Bakker B, De Dios Palomino Villcas J, I Vokes N, Dietzen M, Angelova M, Gini B, Tamaki W, Allegakoen P, Wu W, Humpton TJ, Hill W, Tomaschko M, Lu WT, Haderk F, Al Bakir M, Nagano A, Gimeno-Valiente F, de Carné Trécesson S, Vendramin R, Barbè V, Mugabo M, Weeden CE, Rowan A, McCoach CE, Almeida B, Green M, Gomez C, Nanjo S, Barbosa D, Moore C, Przewrocka J, Black JRM, Grönroos E, Suarez-Bonnet A, Priestnall SL, Zverev C, Lighterness S, Cormack J, Olivas V, Cech L, Andrews T, Rule B, Jiao Y, Zhang X, Ashford P, Durfee C, Venkatesan S, Temiz NA, Tan L, Larson LK, Argyris PP, Brown WL, Yu EA, Rotow JK, Guha U, Roper N, Yu J, Vogel RI, Thomas NJ, Marra A, Selenica P, Yu H, Bakhoum SF, Chew SK, Reis-Filho JS, Jamal-Hanjani M, Vousden KH, McGranahan N, Van Allen EM, Kanu N, Harris RS, Downward J, Bivona TG, Swanton C. PMID: 38049664; PMCID: PMC10786726.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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The essential chaperone DNAJC17 activates HSP70 to coordinate RNA splicing and G2-M progression. bioRxiv. 2023 Oct 26.
Allegakoen DV, Kwong K, Morales J, Bivona TG, Sabnis AJ. PMID: 37961102; PMCID: PMC10634838.
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PubMed Mentions:
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Long Non-Coding RNAs as Emerging Targets in Lung Cancer. Cancers (Basel). 2023 Jun 10; 15(12).
Gencel-Augusto J, Wu W, Bivona TG. PMID: 37370745; PMCID: PMC10295998.
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PubMed Mentions:
5
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Author Correction: 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib. Commun Biol. 2023 Jun 06; 6(1):608.
Meraz IM, Majidi M, Fang B, Meng F, Gao L, Shao R, Song R, Li F, Lissanu Y, Chen H, Ha MJ, Wang Q, Wang J, Shpall E, Jung SY, Haderk F, Gui P, Riess JW, Olivas V, Bivona TG, Roth JA. PMID: 37280434; PMCID: PMC10244399.
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PubMed Mentions:
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FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. Res Sq. 2023 May 29.
Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. PMID: 37398210; PMCID: PMC10312925.
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PubMed Mentions:
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FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer. bioRxiv. 2023 May 16.
Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. PMID: 37205599; PMCID: PMC10187251.
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PubMed Mentions:
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3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib. Commun Biol. 2023 05 11; 6(1):509.
Meraz IM, Majidi M, Fang B, Meng F, Gao L, Shao R, Song R, Li F, Lissanu Y, Chen H, Ha MJ, Wang Q, Wang J, Shpall E, Jung SY, Haderk F, Gui P, Riess JW, Olivas V, Bivona TG, Roth JA. PMID: 37169941; PMCID: PMC10175489.
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PubMed Mentions: Translation:
HumansAnimals
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GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma. JCI Insight. 2022 12 08; 7(23).
Morales J, Allegakoen DV, Garcia JA, Kwong K, Sahu PK, Fajardo DA, Pan Y, Horlbeck MA, Weissman JS, Gustafson WC, Bivona TG, Sabnis AJ. PMID: 36282590; PMCID: PMC9746907.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Phase 1 Study of Ceritinib Combined With Trametinib in Patients With Advanced ALK- or ROS1-Positive NSCLC. JTO Clin Res Rep. 2022 Dec; 3(12):100436.
Lara MS, Gubens MA, Bacaltos B, Daran L, Lim SL, Li T, Gandara DR, Bivona TG, Riess JW, Blakely CM. PMID: 36545322; PMCID: PMC9761844.
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PubMed Mentions:
4
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AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer. Cancer Discov. 2022 11 02; 12(11):2666-2683.
Noronha A, Belugali Nataraj N, Lee JS, Zhitomirsky B, Oren Y, Oster S, Lindzen M, Mukherjee S, Will R, Ghosh S, Simoni-Nieves A, Verma A, Chatterjee R, Borgoni S, Robinson W, Sinha S, Brandis A, Kerr DL, Wu W, Sekar A, Giri S, Chung Y, Drago-Garcia D, Danysh BP, Lauriola M, Fiorentino M, Ardizzoni A, Oren M, Blakely CM, Ezike J, Wiemann S, Parida L, Bivona TG, Aqeilan RI, Brugge JS, Regev A, Getz G, Ruppin E, Yarden Y. PMID: 35895872; PMCID: PMC9627128.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Quantitative Framework for Bench-to-Bedside Cancer Research. Cancers (Basel). 2022 Oct 26; 14(21).
Zaman A, Bivona TG. PMID: 36358671; PMCID: PMC9658824.
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PubMed Mentions:
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Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function. PLoS Biol. 2022 09; 20(9):e3001753.
Bennett NK, Nakaoka HJ, Laurent D, Okimoto RA, Sei Y, Horvai AE, Bivona TG, Ten Hoeve J, Graeber TG, Nakamura K, Nakamura JL. PMID: 36137002; PMCID: PMC9498964.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. J Clin Invest. 2022 07 01; 132(13).
Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O, Hosomichi K, Nishiyama A, Yano S, Kirichok Y, Tan DS, Rosell R, Okimoto RA, Bivona TG. PMID: 35579943; PMCID: PMC9246391.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022 05 26; 185(11):1905-1923.e25.
Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS. PMID: 35523183; PMCID: PMC9452598.
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PubMed Mentions:
64 Fields:
Translation:
Animals
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Understanding Drug Sensitivity and Tackling Resistance in Cancer. Cancer Res. 2022 04 15; 82(8):1448-1460.
Tyner JW, Haderk F, Kumaraswamy A, Baughn LB, Van Ness B, Liu S, Marathe H, Alumkal JJ, Bivona TG, Chan KS, Druker BJ, Hutson AD, Nelson PS, Sawyers CL, Willey CD. PMID: 35195258; PMCID: PMC9018544.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells. Sci Transl Med. 2022 03 30; 14(638):eabc7480.
Ali M, Lu M, Ang HX, Soderquist RS, Eyler CE, Hutchinson HM, Glass C, Bassil CF, Lopez OM, Kerr DL, Falcon CJ, Yu HA, Hata AN, Blakely CM, McCoach CE, Bivona TG, Wood KC. PMID: 35353542; PMCID: PMC9516479.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Remodeling of the tumor/tumor microenvironment ecosystem during KRAS G12C inhibitor clinical resistance in lung cancer. J Clin Invest. 2022 02 15; 132(4).
Manabe T, Bivona TG. PMID: 35166243; PMCID: PMC8843703.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens. Mol Oncol. 2022 06; 16(12):2367-2383.
Pedraz-Valdunciel C, Giannoukakos S, Potie N, Giménez-Capitán A, Huang CY, Hackenberg M, Fernandez-Hilario A, Bracht J, Filipska M, Aldeguer E, Rodríguez S, Bivona TG, Warren S, Aguado C, Ito M, Aguilar-Hernández A, Molina-Vila MA, Rosell R. PMID: 35060299; PMCID: PMC9208080.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Evolution of metastasis: new tools and insights. Trends Cancer. 2022 02; 8(2):98-109.
Gui P, Bivona TG. PMID: 34872888.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids. J Vis Exp. 2021 11 22; (177).
Barbosa Rabago D, Blakely CM, Haderk F, Bivona TG. PMID: 34866626.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma. Mol Cancer. 2021 08 26; 20(1):108.
Wu Q, Luo X, Terp MG, Li Q, Li Y, Shen L, Chen Y, Jacobsen K, Bivona TG, Chen H, Zeng R, Ditzel HJ. PMID: 34446021; PMCID: PMC8393456.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Targeting AXL in NSCLC. Lung Cancer (Auckl). 2021; 12:67-79.
Zaman A, Bivona TG. PMID: 34408519; PMCID: PMC8364399.
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PubMed Mentions:
5
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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer. Cell Rep. 2021 08 03; 36(5):109491.
Zaman A, Wu X, Lemoff A, Yadavalli S, Lee J, Wang C, Cooper J, McMillan EA, Yeaman C, Mirzaei H, White MA, Bivona TG. PMID: 34348154; PMCID: PMC8383154.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Inhibition of SHP2 as an approach to block RAS-driven cancers. Adv Cancer Res. 2022; 153:205-236.
Chou YT, Bivona TG. PMID: 35101231.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer. J Thorac Oncol. 2021 10; 16(10):1647-1662.
Rolfo C, Mack P, Scagliotti GV, Aggarwal C, Arcila ME, Barlesi F, Bivona T, Diehn M, Dive C, Dziadziuszko R, Leighl N, Malapelle U, Mok T, Peled N, Raez LE, Sequist L, Sholl L, Swanton C, Abbosh C, Tan D, Wakelee H, Wistuba I, Bunn R, Freeman-Daily J, Wynes M, Belani C, Mitsudomi T, Gandara D. PMID: 34246791.
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PubMed Mentions:
168 Fields:
Translation:
Humans
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Stepwise evolution of therapy resistance in AML. Cancer Cell. 2021 07 12; 39(7):904-906.
Gui P, Bivona TG. PMID: 34171262.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell. 2021 05 13; 184(10):2649-2664.e18.
Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG. PMID: 33848463; PMCID: PMC8127962.
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PubMed Mentions:
70 Fields:
Translation:
HumansCells
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Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021 02 26; 371(6532).
Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, Bivona TG, Weissman JS. PMID: 33479121; PMCID: PMC7983364.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment. Curr Opin Chem Biol. 2021 06; 62:1-12.
Kerr DL, Haderk F, Bivona TG. PMID: 33418513.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis. Oncogenesis. 2020 Nov 19; 9(11):102.
Nothdurft S, Thumser-Henner C, Breitenbücher F, Okimoto RA, Dorsch M, Opitz CA, Sadik A, Esser C, Hölzel M, Asthana S, Forster J, Beisser D, Kalmbach S, Grüner BM, Bivona TG, Schramm A, Schuler M. PMID: 33214553; PMCID: PMC7677369.
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PubMed Mentions:
21
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Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G. Cancer Lett. 2020 11 28; 493:217-227.
Liu J, Mayekar MK, Wu W, Yan M, Guan H, Wang J, Zaman A, Cui Y, Bivona TG, Choudhry H, Xing Q, Cao W. PMID: 32905814.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. Cell. 2020 09 03; 182(5):1232-1251.e22.
Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG. PMID: 32822576; PMCID: PMC7484178.
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PubMed Mentions:
253 Fields:
Translation:
HumansCells
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Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma. Nat Commun. 2020 07 22; 11(1):3675.
Cao W, Lee H, Wu W, Zaman A, McCorkle S, Yan M, Chen J, Xing Q, Sinnott-Armstrong N, Xu H, Sailani MR, Tang W, Cui Y, Liu J, Guan H, Lv P, Sun X, Sun L, Han P, Lou Y, Chang J, Wang J, Gao Y, Guo J, Schenk G, Shain AH, Biddle FG, Collisson E, Snyder M, Bivona TG. PMID: 32699215; PMCID: PMC7376194.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations. J Thorac Oncol. 2020 10; 15(10):1611-1623.
Negrao MV, Raymond VM, Lanman RB, Robichaux JP, He J, Nilsson MB, Ng PKS, Amador BE, Roarty EB, Nagy RJ, Banks KC, Zhu VW, Ng C, Chae YK, Clarke JM, Crawford JA, Meric-Bernstam F, Ignatius Ou SH, Gandara DR, Heymach JV, Bivona TG, McCoach CE. PMID: 32540409; PMCID: PMC7529990.
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PubMed Mentions:
28 Fields:
Translation:
Humans
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EGFR targeted therapy resistance: current status, challenges, and future outlook. J Thorac Dis. 2020 May; 12(5):2849-2850.
Bivona TG. PMID: 32642197; PMCID: PMC7330318.
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PubMed Mentions:
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Betacellulin drives therapy resistance in glioblastoma. Neuro Oncol. 2020 04 15; 22(4):457-469.
Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA. PMID: 31678994; PMCID: PMC7158663.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. J Thorac Oncol. 2020 06; 15(6):973-999.
Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr OK, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST. PMID: 32018052; PMCID: PMC7397559.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy. Chronic Dis Transl Med. 2019 Dec; 5(4):258-266.
Zargar A, Chang S, Kothari A, Snijders AM, Mao JH, Wang J, Hernández AC, Keasling JD, Bivona TG. PMID: 32055785; PMCID: PMC7004931.
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PubMed Mentions:
12
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Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. Clin Cancer Res. 2020 01 15; 26(2):439-449.
Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas VR, Wolff AM, Fraser JS, Collisson EA, McCoach CE, Camidge DR, Pacheco J, Bazhenova L, Li T, Bivona TG, Blakely CM. PMID: 31548343; PMCID: PMC6980768.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale. Cancers (Basel). 2019 Sep 17; 11(9).
Bracht JWP, Karachaliou N, Bivona T, Lanman RB, Faull I, Nagy RJ, Drozdowskyj A, Berenguer J, Fernandez-Bruno M, Molina-Vila MA, Rosell R. PMID: 31533235; PMCID: PMC6770188.
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PubMed Mentions:
26
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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep. 2019 08 27; 28(9):2317-2330.e8.
Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG. PMID: 31461649; PMCID: PMC6728083.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Targeting Oncogenic BRAF: Past, Present, and Future. Cancers (Basel). 2019 Aug 16; 11(8).
Zaman A, Wu W, Bivona TG. PMID: 31426419; PMCID: PMC6721448.
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PubMed Mentions:
88
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CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs. J Clin Invest. 2019 07 22; 129(8):3401-3406.
Okimoto RA, Wu W, Nanjo S, Olivas V, Lin YK, Ponce RK, Oyama R, Kondo T, Bivona TG. PMID: 31329165; PMCID: PMC6668665.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Engineering Multidimensional Evolutionary Forces to Combat Cancer. Cancer Discov. 2019 05; 9(5):587-604.
McCoach CE, Bivona TG. PMID: 30992280; PMCID: PMC6497542.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Dampening oncogenic RAS signaling. Science. 2019 03 22; 363(6433):1280-1281.
Bivona TG. PMID: 30898918.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Polytherapy and Targeted Cancer Drug Resistance. Trends Cancer. 2019 03; 5(3):170-182.
Chatterjee N, Bivona TG. PMID: 30898264; PMCID: PMC6446041.
View in:
PubMed Mentions:
98 Fields:
Translation:
Humans
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Emerging Targeted Therapies for the Treatment of Non-small Cell Lung Cancer. Curr Oncol Rep. 2019 02 26; 21(3):21.
Halliday PR, Blakely CM, Bivona TG. PMID: 30806814.
View in:
PubMed Mentions:
44 Fields:
Translation:
Humans
-
Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 02 04; 216(2):419-427.
Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. PMID: 30683736; PMCID: PMC6363423.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCTClinical Trials
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Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology. Trends Mol Med. 2019 03; 25(3):185-197.
Sabnis AJ, Bivona TG. PMID: 30686761; PMCID: PMC6401263.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Immunohistochemistry to Study YAP in Human Tissue Samples. Methods Mol Biol. 2019; 1893:89-95.
Haderk F, Olivas V, Bivona TG. PMID: 30565127.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019 02 01; 79(3):546-556.
Neel DS, Allegakoen DV, Olivas V, Mayekar MK, Hemmati G, Chatterjee N, Blakely CM, McCoach CE, Rotow JK, Le A, Karachaliou N, Rosell R, Riess JW, Nichols R, Doebele RC, Bivona TG. PMID: 30538120; PMCID: PMC6359944.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118.
Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. PMID: 30478424; PMCID: PMC6324945.
View in:
PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
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Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation. Clin Lung Cancer. 2019 03; 20(2):e137-e141.
Rotow JK, Woodard GA, Urisman A, McCoach CE, Bivona TG, Elicker BM, Jablons DM, Blakely CM. PMID: 30553716.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
-
Circulating tumor DNA analysis in patients with EGFR mutant lung cancer. J Thorac Dis. 2018 Nov; 10(Suppl 33):S4061-S4064.
Nanjo S, Bivona TG. PMID: 30631555; PMCID: PMC6297447.
View in:
PubMed Mentions:
1
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Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. J Cell Sci. 2018 09 05; 131(17).
Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL. PMID: 30131440; PMCID: PMC6140321.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science. 2018 08 31; 361(6405).
Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. PMID: 30166458; PMCID: PMC6430110.
View in:
PubMed Mentions:
75 Fields:
Translation:
HumansCells
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RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 09; 20(9):1064-1073.
Nichols RJ, Haderk F, Stahlhut C, Schulze CJ, Hemmati G, Wildes D, Tzitzilonis C, Mordec K, Marquez A, Romero J, Hsieh T, Zaman A, Olivas V, McCoach C, Blakely CM, Wang Z, Kiss G, Koltun ES, Gill AL, Singh M, Goldsmith MA, Smith JAM, Bivona TG. PMID: 30104724; PMCID: PMC6115280.
View in:
PubMed Mentions:
168 Fields:
Translation:
HumansAnimalsCells
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Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC. J Thorac Oncol. 2018 09; 13(9):1248-1268.
Rolfo C, Mack PC, Scagliotti GV, Baas P, Barlesi F, Bivona TG, Herbst RS, Mok TS, Peled N, Pirker R, Raez LE, Reck M, Riess JW, Sequist LV, Shepherd FA, Sholl LM, Tan DSW, Wakelee HA, Wistuba II, Wynes MW, Carbone DP, Hirsch FR, Gandara DR. PMID: 29885479.
View in:
PubMed Mentions:
264 Fields:
Translation:
Humans
-
TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer. J Clin Invest. 2018 06 01; 128(6):2500-2518.
Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA. PMID: 29613856; PMCID: PMC5983340.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Emerging application of genomics-guided therapeutics in personalized lung cancer treatment. Ann Transl Med. 2018 May; 6(9):160.
Zaman A, Bivona TG. PMID: 29911108; PMCID: PMC5985272.
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PubMed Mentions:
18
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BRAF in Lung Cancers: Analysis of Patient Cases Reveals Recurrent BRAF Mutations, Fusions, Kinase Duplications, and Concurrent Alterations. JCO Precis Oncol. 2018; 2.
Sheikine Y, Pavlick D, Klempner SJ, Trabucco SE, Chung JH, Rosenzweig M, Wang K, Velcheti V, Frampton GM, Peled N, Murray M, Chae YK, Albacker LA, Gay L, Husain H, Suh JH, Millis SZ, Reddy VP, Elvin JA, Hartmaier RJ, Dowlati A, Stephens P, Ross JS, Bivona TG, Miller VA, Ganesan S, Schrock AB, Ou SI, Ali SM. PMID: 32913992; PMCID: PMC7446447.
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PubMed Mentions:
21 Fields:
-
Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 04 05; 173(2):321-337.e10.
Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N. PMID: 29625050; PMCID: PMC6070353.
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PubMed Mentions:
1328 Fields:
Translation:
HumansCells
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The evolving understanding of immunoediting and the clinical impact of immune escape. J Thorac Dis. 2018 Mar; 10(3):1248-1252.
McCoach CE, Bivona TG. PMID: 29708132; PMCID: PMC5906217.
View in:
PubMed Mentions:
10
-
Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis. EBioMedicine. 2018 03; 29:112-127.
Karachaliou N, Chaib I, Cardona AF, Berenguer J, Bracht JWP, Yang J, Cai X, Wang Z, Hu C, Drozdowskyj A, Servat CC, Servat JC, Ito M, Attili I, Aldeguer E, Capitan AG, Rodriguez J, Rojas L, Viteri S, Molina-Vila MA, Ou SI, Okada M, Mok TS, Bivona TG, Ono M, Cui J, Ramón Y Cajal S, Frias A, Cao P, Rosell R. PMID: 29433983; PMCID: PMC5925453.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. Cancers (Basel). 2017 Nov 30; 9(12).
Wu W, Haderk F, Bivona TG. PMID: 29189709; PMCID: PMC5742812.
View in:
PubMed Mentions:
14
-
Imaging PD-L1 Expression with ImmunoPET. Bioconjug Chem. 2018 01 17; 29(1):96-103.
Truillet C, Oh HLJ, Yeo SP, Lee CY, Huynh LT, Wei J, Parker MFL, Blakely C, Sevillano N, Wang YH, Shen YS, Olivas V, Jami KM, Moroz A, Jego B, Jaumain E, Fong L, Craik CS, Chang AJ, Bivona TG, Wang CI, Evans MJ. PMID: 29125731; PMCID: PMC5773933.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017 Dec; 49(12):1693-1704.
Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. PMID: 29106415; PMCID: PMC5709185.
View in:
PubMed Mentions:
254 Fields:
Translation:
HumansCells
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Understanding and targeting resistance mechanisms in NSCLC. Nat Rev Cancer. 2017 10 25; 17(11):637-658.
Rotow J, Bivona TG. PMID: 29068003.
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PubMed Mentions:
396 Fields:
Translation:
HumansAnimals
-
Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. Nat Commun. 2017 10 10; 8(1):823.
Ma P, Fu Y, Cai MC, Yan Y, Jing Y, Zhang S, Chen M, Wu J, Shen Y, Zhu L, Chen HZ, Gao WQ, Wang M, Gu Z, Bivona TG, Zhao X, Zhuang G. PMID: 29018192; PMCID: PMC5634994.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Current Landscape of Targeted Therapy in Lung Cancer. Clin Pharmacol Ther. 2017 Nov; 102(5):757-764.
Mayekar MK, Bivona TG. PMID: 28786099.
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PubMed Mentions:
82 Fields:
Translation:
Humans
-
Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer. Nat Commun. 2017 09 04; 8(1):410.
Jacobsen K, Bertran-Alamillo J, Molina MA, Teixidó C, Karachaliou N, Pedersen MH, Castellví J, Garzón M, Codony-Servat C, Codony-Servat J, Giménez-Capitán A, Drozdowskyj A, Viteri S, Larsen MR, Lassen U, Felip E, Bivona TG, Ditzel HJ, Rosell R. PMID: 28871105; PMCID: PMC5583255.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC. J Natl Cancer Inst. 2017 09 01; 109(9).
Chaib I, Karachaliou N, Pilotto S, Codony Servat J, Cai X, Li X, Drozdowskyj A, Servat CC, Yang J, Hu C, Cardona AF, Vivanco GL, Vergnenegre A, Sanchez JM, Provencio M, de Marinis F, Passaro A, Carcereny E, Reguart N, Campelo CG, Teixido C, Sperduti I, Rodriguez S, Lazzari C, Verlicchi A, de Aguirre I, Queralt C, Wei J, Estrada R, Puig de la Bellacasa R, Ramirez JL, Jacobson K, Ditzel HJ, Santarpia M, Viteri S, Molina MA, Zhou C, Cao P, Ma PC, Bivona TG, Rosell R. PMID: 28376152; PMCID: PMC5409000.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC). Oncotarget. 2017 Jul 18; 8(29):47305-47316.
Codony-Servat C, Codony-Servat J, Karachaliou N, Molina MA, Chaib I, Ramirez JL, de Los Llanos Gil M, Solca F, Bivona TG, Rosell R. PMID: 28521301; PMCID: PMC5564566.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
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A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases. Oncologist. 2017 07; 22(7):768-773.
Wang VE, Young L, Ali S, Miller VA, Urisman A, Wolfe J, Bivona TG, Damato B, Fogh S, Bergsland EK. PMID: 28507205; PMCID: PMC5507651.
View in:
PubMed Mentions:
18 Fields:
Translation:
Humans
-
Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma. NPJ Precis Oncol. 2017; 1.
Neel DS, Bivona TG. PMID: 29152593; PMCID: PMC5687582.
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PubMed Mentions:
48
-
Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution. Sci Rep. 2017 03 13; 7:44206.
Jonsson VD, Blakely CM, Lin L, Asthana S, Matni N, Olivas V, Pazarentzos E, Gubens MA, Bastian BC, Taylor BS, Doyle JC, Bivona TG. PMID: 28287179; PMCID: PMC5347024.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Dividing and conquering the variation among variants in EML4-ALK lung cancer. Transl Cancer Res. 2017 Mar; 6(Suppl 2):S369-S370.
Bivona TG. PMID: 30613480; PMCID: PMC6319928.
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PubMed Mentions:
-
CD74-ROS1 Fusion in NSCLC Detected by Hybrid Capture-Based Tissue Genomic Profiling and ctDNA Assays. J Thorac Oncol. 2017 02; 12(2):e19-e20.
Wang V, Bivona T, Ali SM, Schrock AB, Miller VA. PMID: 28115114.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer. Cancer Res. 2017 03 01; 77(5):1200-1211.
Rho JK, Lee IY, Choi YJ, Choi CM, Hur JY, Koh JS, Lee J, Suh BC, Song HJ, Salgaonkar P, Lee J, Lee J, Jung DS, Kim SY, Woo DC, Baek IJ, Lee JY, Ha CH, Sung YH, Kim JK, Kim WS, Song JS, Kim CH, Bivona TG, Lee JC. PMID: 28082405; PMCID: PMC5334209.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Metastasis: From head to tail. Cell Cycle. 2017 03 19; 16(6):487-488.
Okimoto RA, Bivona TG. PMID: 28055306; PMCID: PMC5384580.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. Oncotarget. 2016 Dec 13; 7(50):82013-82027.
Thiagarajan PS, Wu X, Zhang W, Shi I, Bagai R, Leahy P, Feng Y, Veigl M, Lindner D, Danielpour D, Yin L, Rosell R, Bivona TG, Zhang Z, Ma PC. PMID: 27852038; PMCID: PMC5347670.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Inactivation of Capicua drives cancer metastasis. Nat Genet. 2017 01; 49(1):87-96.
Okimoto RA, Breitenbuecher F, Olivas VR, Wu W, Gini B, Hofree M, Asthana S, Hrustanovic G, Flanagan J, Tulpule A, Blakely CM, Haringsma HJ, Simmons AD, Gowen K, Suh J, Miller VA, Ali S, Schuler M, Bivona TG. PMID: 27869830; PMCID: PMC5195898.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):13456-13461.
Okimoto RA, Lin L, Olivas V, Chan E, Markegard E, Rymar A, Neel D, Chen X, Hemmati G, Bollag G, Bivona TG. PMID: 27834212; PMCID: PMC5127364.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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HSP70 dependence in rhabdomyosarcoma: Seed or soil? Cell Cycle. 2017 01 17; 16(2):147-148.
Sabnis AJ, Bivona TG. PMID: 27686974; PMCID: PMC5283818.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):9015-20.
Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. PMID: 27450084; PMCID: PMC4987817.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer. Cancer Lett. 2016 09 28; 380(1):144-52.
Premasekharan G, Gilbert E, Okimoto RA, Hamirani A, Lindquist KJ, Ngo VT, Roy R, Hough J, Edwards M, Paz R, Foye A, Sood R, Copren KA, Gubens M, Small EJ, Bivona TG, Collisson EA, Friedlander TW, Paris PL. PMID: 27343980.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance. Clin Lung Cancer. 2016 09; 17(5):466-469.
McCoach CE, Bivona TG, Blakely CM, Doebele RC. PMID: 27378174; PMCID: PMC5378381.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Nat Med. 2016 05 05; 22(5):472-8.
Bivona TG, Doebele RC. PMID: 27149220; PMCID: PMC5384713.
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PubMed Mentions:
95 Fields:
Translation:
Humans
-
RAS signaling in ALK fusion lung cancer. Small GTPases. 2016; 7(1):32-3.
Hrustanovic G, Bivona TG. PMID: 26901483; PMCID: PMC4905280.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Tracking Down Response and Resistance to TRK Inhibitors. Cancer Discov. 2016 Jan; 6(1):14-6.
Okimoto RA, Bivona TG. PMID: 26747892; PMCID: PMC4709026.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
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RAS-MAPK signaling influences the efficacy of ALK-targeting agents in lung cancer. Mol Cell Oncol. 2016 Mar; 3(2):e1091061.
Hrustanovic G, Bivona TG. PMID: 27308613; PMCID: PMC4905399.
View in:
PubMed Mentions:
4
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RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat Med. 2015 Sep; 21(9):1038-47.
Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM, Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG. PMID: 26301689; PMCID: PMC4734742.
View in:
PubMed Mentions:
147 Fields:
Translation:
HumansCells
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Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas. Cancer Discov. 2015 Oct; 5(10):1040-8.
Zill OA, Greene C, Sebisanovic D, Siew LM, Leng J, Vu M, Hendifar AE, Wang Z, Atreya CE, Kelley RK, Van Loon K, Ko AH, Tempero MA, Bivona TG, Munster PN, Talasaz A, Collisson EA. PMID: 26109333; PMCID: PMC4592417.
View in:
PubMed Mentions:
129 Fields:
Translation:
Humans
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Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation. Oncogene. 2016 Mar 03; 35(9):1198-205.
Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas VR, Gubens MA, Balassanian R, Weissman J, Polkinghorn W, Bivona TG. PMID: 25982275.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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AXL receptor tyrosine kinase as a therapeutic target in NSCLC. Lung Cancer (Auckl). 2015; 6:27-34.
Okimoto RA, Bivona TG. PMID: 28210148; PMCID: PMC5217513.
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PubMed Mentions:
18
-
The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors. Mol Cell Oncol. 2016 Jan; 3(1):e1021441.
Lin L, Bivona TG. PMID: 27308535; PMCID: PMC4845171.
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PubMed Mentions:
16
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AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas. Cancer Cell. 2015 Apr 13; 27(4):533-46.
Elkabets M, Pazarentzos E, Juric D, Sheng Q, Pelossof RA, Brook S, Benzaken AO, Rodon J, Morse N, Yan JJ, Liu M, Das R, Chen Y, Tam A, Wang H, Liang J, Gurski JM, Kerr DA, Rosell R, Teixidó C, Huang A, Ghossein RA, Rosen N, Bivona TG, Scaltriti M, Baselga J. PMID: 25873175; PMCID: PMC4398915.
View in:
PubMed Mentions:
172 Fields:
Translation:
HumansAnimalsCells
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NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer. Cell Rep. 2015 Apr 07; 11(1):98-110.
Blakely CM, Pazarentzos E, Olivas V, Asthana S, Yan JJ, Tan I, Hrustanovic G, Chan E, Lin L, Neel DS, Newton W, Bobb KL, Fouts TR, Meshulam J, Gubens MA, Jablons DM, Johnson JR, Bandyopadhyay S, Krogan NJ, Bivona TG. PMID: 25843712; PMCID: PMC4394036.
View in:
PubMed Mentions:
111 Fields:
Translation:
HumansCells
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AUY922 effectively overcomes MET- and AXL-mediated resistance to EGFR-TKI in lung cancer cells. PLoS One. 2015; 10(3):e0119832.
Choi YJ, Kim SY, So KS, Baek IJ, Kim WS, Choi SH, Lee JC, Bivona TG, Rho JK, Choi CM. PMID: 25780909; PMCID: PMC4363657.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Adaptive stress signaling in targeted cancer therapy resistance. Oncogene. 2015 Nov 05; 34(45):5599-606.
Pazarentzos E, Bivona TG. PMID: 25703329; PMCID: PMC4546915.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet. 2015 Mar; 47(3):250-6.
Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson EA, Algazi A, Robinson E, Osman I, Muñoz-Couselo E, Cortes J, Frederick DT, Cooper ZA, McMahon M, Marchetti A, Rosell R, Flaherty KT, Wargo JA, Bivona TG. PMID: 25665005; PMCID: PMC4930244.
View in:
PubMed Mentions:
289 Fields:
Translation:
HumansAnimalsCells
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YAP in MAPK pathway targeted therapy resistance. Cell Cycle. 2015; 14(12):1765-6.
Flaherty KT, Wargo JA, Bivona TG. PMID: 26036142; PMCID: PMC4612653.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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RAS-MAPK in ALK targeted therapy resistance. Cell Cycle. 2015; 14(23):3661-2.
Hrustanovic G, Bivona TG. PMID: 26654768; PMCID: PMC4825705.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer. J Transl Med. 2014 Dec 14; 12:355.
Shen J, Wei J, Guan W, Wang H, Ding Y, Qian X, Yu L, Zou Z, Xie L, Costa C, Bivona T, Rosell R, Liu B. PMID: 25496700; PMCID: PMC4302091.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors. Cancer Treat Rev. 2014 Sep; 40(8):990-1004.
Rolfo C, Giovannetti E, Hong DS, Bivona T, Raez LE, Bronte G, Buffoni L, Reguart N, Santos ES, Germonpre P, Taron M, Passiglia F, Van Meerbeeck JP, Russo A, Peeters M, Gil-Bazo I, Pauwels P, Rosell R. PMID: 24953979.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimals
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The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial. Clin Cancer Res. 2014 Apr 01; 20(7):2001-10.
Costa C, Molina MA, Drozdowskyj A, Giménez-Capitán A, Bertran-Alamillo J, Karachaliou N, Gervais R, Massuti B, Wei J, Moran T, Majem M, Felip E, Carcereny E, Garcia-Campelo R, Viteri S, Taron M, Ono M, Giannikopoulos P, Bivona T, Rosell R. PMID: 24493829.
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PubMed Mentions:
114 Fields:
Translation:
HumansCTClinical Trials
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Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):E748-57.
Lin L, Asthana S, Chan E, Bandyopadhyay S, Martins MM, Olivas V, Yan JJ, Pham L, Wang MM, Bollag G, Solit DB, Collisson EA, Rudin CM, Taylor BS, Bivona TG. PMID: 24550319; PMCID: PMC3932924.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Activating mutations cluster in the "molecular brake" regions of protein kinases and do not associate with conserved or catalytic residues. Hum Mutat. 2014 Mar; 35(3):318-28.
Molina-Vila MA, Nabau-Moretó N, Tornador C, Sabnis AJ, Rosell R, Estivill X, Bivona TG, Marino-Buslje C. PMID: 24323975.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Recent advances in personalized lung cancer medicine. Per Med. 2014; 11(3):309-321.
Okimoto RA, Bivona TG. PMID: 25506379; PMCID: PMC4263209.
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PubMed Mentions:
12 Fields:
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Genetics and biomarkers in personalisation of lung cancer treatment. Lancet. 2013 Aug 24; 382(9893):720-31.
Rosell R, Bivona TG, Karachaliou N. PMID: 23972815.
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PubMed Mentions:
146 Fields:
Translation:
HumansCells
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FGFR fusions in the driver's seat. Cancer Discov. 2013 Jun; 3(6):607-9.
Sabnis AJ, Bivona TG. PMID: 23749526; PMCID: PMC4988530.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Mechanisms of resistance to EGFR targeted therapies. Cancer Biol Ther. 2013 Apr; 14(4):304-14.
Hrustanovic G, Lee BJ, Bivona TG. PMID: 23358468; PMCID: PMC3667869.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Secrets of drug resistance in NSCLC exposed by new molecular definition of EMT. Clin Cancer Res. 2013 Jan 01; 19(1):3-5.
Neel DS, Bivona TG. PMID: 23172883; PMCID: PMC3537879.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Resiliency of lung cancers to EGFR inhibitor treatment unveiled, offering opportunities to divide and conquer EGFR inhibitor resistance. Cancer Discov. 2012 Oct; 2(10):872-5.
Blakely CM, Bivona TG. PMID: 23071030; PMCID: PMC3475614.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients. Chemother Res Pract. 2012; 2012:817297.
Lin L, Bivona TG. PMID: 22970367; PMCID: PMC3437267.
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PubMed Mentions:
43
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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet. 2012 Jul 01; 44(8):852-60.
Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, Abdel-Rahman M, Wang X, Levine AD, Rho JK, Choi YJ, Choi CM, Kim SW, Jang SJ, Park YS, Kim WS, Lee DH, Lee JS, Miller VA, Arcila M, Ladanyi M, Moonsamy P, Sawyers C, Boggon TJ, Ma PC, Costa C, Taron M, Rosell R, Halmos B, Bivona TG. PMID: 22751098; PMCID: PMC3408577.
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PubMed Mentions:
636 Fields:
Translation:
HumansAnimalsCells
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Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):19024-9.
Morris LG, Taylor BS, Bivona TG, Gong Y, Eng S, Brennan CW, Kaufman A, Kastenhuber ER, Banuchi VE, Singh B, Heguy A, Viale A, Mellinghoff IK, Huse J, Ganly I, Chan TA. PMID: 22065749; PMCID: PMC3223475.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR. Nature. 2011 Mar 24; 471(7339):523-6.
Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL. PMID: 21430781; PMCID: PMC3541675.
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PubMed Mentions:
219 Fields:
Translation:
HumansCells
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Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res. 2011 Mar 01; 17(5):1160-8.
Rosell R, Molina MA, Costa C, Simonetti S, Gimenez-Capitan A, Bertran-Alamillo J, Mayo C, Moran T, Mendez P, Cardenal F, Isla D, Provencio M, Cobo M, Insa A, Garcia-Campelo R, Reguart N, Majem M, Viteri S, Carcereny E, Porta R, Massuti B, Queralt C, de Aguirre I, Sanchez JM, Sanchez-Ronco M, Mate JL, Ariza A, Benlloch S, Sanchez JJ, Bivona TG, Sawyers CL, Taron M. PMID: 21233402.
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PubMed Mentions:
132 Fields:
Translation:
HumansCells
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Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis. Methods Enzymol. 2008; 439:87-102.
Quatela SE, Sung PJ, Ahearn IM, Bivona TG, Philips MR. PMID: 18374158.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell. 2006 Feb 17; 21(4):481-93.
Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, Cox AD, Philips MR. PMID: 16483930.
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PubMed Mentions:
219 Fields:
Translation:
HumansAnimalsCells
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Analysis of Ras activation in living cells with GFP-RBD. Methods Enzymol. 2006; 407:128-43.
Bivona TG, Quatela S, Philips MR. PMID: 16757320.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains. Methods. 2005 Oct; 37(2):138-45.
Bivona TG, Philips MR. PMID: 16289969.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 2005 Mar 25; 280(12):11413-21.
Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. PMID: 15657046.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J. 2004 Apr 21; 23(8):1749-60.
Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona TG, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ. PMID: 15057271; PMCID: PMC394250.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Membranes as messengers in T cell adhesion signaling. Nat Immunol. 2004 Apr; 5(4):363-72.
Dustin ML, Bivona TG, Philips MR. PMID: 15052266.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol. 2004 Apr; 24(8):3485-96.
Perez de Castro I, Bivona TG, Philips MR, Pellicer A. PMID: 15060167; PMCID: PMC381594.
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PubMed Mentions:
69 Fields:
Translation:
HumansCells
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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell. 2004 Feb 13; 13(3):341-55.
Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. PMID: 14967142.
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PubMed Mentions:
185 Fields:
Translation:
AnimalsCells
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Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 02; 164(3):461-70.
Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR. PMID: 14757755; PMCID: PMC2172240.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem. 2003 Nov 21; 278(47):47038-45.
Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, Philips MR, O'Bryan JP. PMID: 12970366.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 07; 424(6949):694-8.
Bivona TG, Pérez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR. PMID: 12845332.
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PubMed Mentions:
162 Fields:
Translation:
HumansAnimalsCells
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Ras pathway signaling on endomembranes. Curr Opin Cell Biol. 2003 Apr; 15(2):136-42.
Bivona TG, Philips MR. PMID: 12648668.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol. 2002 May; 4(5):343-50.
Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL, Cox AD, Philips MR. PMID: 11988737.
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PubMed Mentions:
265 Fields:
Translation:
HumansAnimalsCells
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Toxoplasma gondii Rab5 enhances cholesterol acquisition from host cells. Cell Microbiol. 2002 Mar; 4(3):139-52.
Robibaro B, Stedman TT, Coppens I, Ngô HM, Pypaert M, Bivona T, Nam HW, Joiner KA. PMID: 11906451.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells