Iwei Yeh, MD, PhD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
Address1701 Divisadero
San Francisco CA 94115
Phone415-353-7989
ORCID ORCID Icon0000-0002-3941-3561 Additional info
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    The unifying theme of my research is to understand the genetic mechanisms involved in the development and progression of melanocytic skin tumors and harness our understanding to improve melanoma treatment. I am well positioned to accomplish this goal since I am an expert dermatopathologist and a scientist with expertise in cancer genetics and bioinformatics. My efforts have been focused on identifying oncogenic drivers in melanocytic tumors, with the goal to identify and move new knowledge from the laboratory directly to patient care. By combining the histopathologic classification with a better understanding of the biology of melanocytic tumors gained in the laboratory I seek to make a significant impact on patient care.

    My work has contributed to our understanding of the initiating oncogenic events in melanocytic tumors. In 2013 I was the lead author of an article in the Journal of the National Cancer Institute definitively showing that BRAF mutations are both clonal and heterozygous in melanocytic nevi, thereby establishing that they are initiating events. Subsequently, I worked to identify an array of kinase gene fusions in Spitz tumors, with lead author publications in Nature Communications and the Journal of Pathology describing the discovery of MET and NTRK3 gene fusions as initiating events in Spitz tumors.

    In a 2015 New England Journal of Medicine paper, I was a member of the team that identified multiple pathways of genetic progression in melanocytic tumors and showed that the diagnostically controversial entity "dysplastic nevus" has more oncogenic drivers than benign nevi and fewer than melanoma. This work demonstrated for the very first time that the step-wise progression model of cancer also applies to melanocytic tumors and forms the groundwork for future studies further delineating the diverse pathways of melanoma progression and potential targets for therapeutic intervention. In 2017 I was the lead author of an article in Nature Communications demonstrating that activating mutations of beta-catenin lead to progression of conventional nevus to deep penetrating nevus.

    A particular area of interest is the genetics of acral and mucosal melanomas. These melanomas arise in sun-protected sites and typically do not harbor a large number of ultraviolet light induced mutations but instead have highly rearranged genomes with many amplifications and deletions. Our group has developed new methodologies for genomically profiling small archival tissue samples and used this technique to identify SPRED1 as a tumor suppressor in mucosal melanoma. In a publication in Science, we demonstrated that loss of SPRED1 cooperates with KIT mutation and that dual inhibition of KIT and MEK is synergistic against KIT mutant melanomas with SPRED1 loss. These findings are currently being translated to the clinic through an investigator-initated clinical trial in collaboration with UCSF melanoma oncology.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Primary Cilia Are Preserved in Cellular Blue and Atypical Blue Nevi and Lost in Blue Nevus-like Melanoma. Am J Surg Pathol. 2021 Jul 15. Sheahon KM, Jankowski T, Yeh I, North JP, Pincus LB, LeBoit PE, McCalmont TH, Lang UE. PMID: 34265802.
      View in: PubMed   Mentions:    Fields:    
    2. Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids. Genome Med. 2021 Jun 01; 13(1):98. Gu W, Talevich E, Hsu E, Qi Z, Urisman A, Federman S, Gopez A, Arevalo S, Gottschall M, Liao L, Tung J, Chen L, Lim H, Ho C, Kasowski M, Oak J, Holmes BJ, Yeh I, Yu J, Wang L, Miller S, DeRisi JL, Prakash S, Simko J, Chiu CY. PMID: 34074327.
      View in: PubMed   Mentions:    Fields:    
    3. Response To: Feasibility of a Tumor Progression Model in PRKAR1A-inactivated Melanomas. Am J Surg Pathol. 2021 Apr 14. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH. PMID: 33859070.
      View in: PubMed   Mentions:    Fields:    
    4. Segmental overgrowth and aneurysms due to mosaic PDGFRB p.(Tyr562Cys). Am J Med Genet A. 2021 05; 185(5):1430-1436. Chenbhanich J, Hu Y, Hetts S, Cooke D, Dowd C, Devine P, UCLA Clinical Genomics Center , Russell B, Kang SHL, Chang VY, Abla AA, Cornett P, Yeh I, Lee H, Martinez-Agosto JA, Frieden IJ, Shieh JT. PMID: 33683022.
      View in: PubMed   Mentions:    Fields:    
    5. Melanoma models for the next generation of therapies. Cancer Cell. 2021 May 10; 39(5):610-631. Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. PMID: 33545064.
      View in: PubMed   Mentions: 1     Fields:    
    6. Expanding the Spectrum of Microscopic and Cytogenetic Findings Associated With Spitz Tumors With 11p Gains. Am J Surg Pathol. 2021 02 01; 45(2):277-285. Lezcano CM, Yeh I, Eslamdoost N, Fang Y, LeBoit PE, McCalmont TH, Moy AP, Zhang Y, Busam KJ. PMID: 33428338.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Publisher Correction: The genomic landscapes of individual melanocytes from human skin. Nature. 2021 Feb; 590(7844):E20. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. PMID: 33469220.
      View in: PubMed   Mentions:    Fields:    
    8. Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome. Pigment Cell Melanoma Res. 2021 Feb 01. Roy SF, Bastian BC, Maguiness S, Giubellino A, Vemula SS, McCalmont TH, Yeh I. PMID: 33522711.
      View in: PubMed   Mentions:    Fields:    
    9. The genomic landscapes of individual melanocytes from human skin. Nature. 2020 10; 586(7830):600-605. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. PMID: 33029006.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Eruptive Spitz nevus, a striking example of benign metastasis. Sci Rep. 2020 10 01; 10(1):16216. Raghavan SS, Kapler ES, Dinges MM, Bastian BC, Yeh I. PMID: 33004920.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes. Mod Pathol. 2021 04; 34(4):735-747. de la Fouchardière A, Tee MK, Peternel S, Valdebran M, Pissaloux D, Tirode F, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. PMID: 32968185.
      View in: PubMed   Mentions:    Fields:    
    12. Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma. Am J Surg Pathol. 2020 06; 44(6):805-816. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH. PMID: 32118628.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Spitz melanoma is a distinct subset of spitzoid melanoma. Mod Pathol. 2020 06; 33(6):1122-1134. Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. PMID: 31900433.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature. Am J Dermatopathol. 2020 Jan; 42(1):46-51. Cohen JN, Yeh I, LeBoit PE. PMID: 31268928.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. GNAQQ209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. Pigment Cell Melanoma Res. 2020 01; 33(1):96-111. Urtatiz O, Cook C, Huang JL, Yeh I, Van Raamsdonk CD. PMID: 31680437.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations. Mod Pathol. 2020 05; 33(5):846-857. Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A. PMID: 31719662.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. New and evolving concepts of melanocytic nevi and melanocytomas. Mod Pathol. 2020 01; 33(Suppl 1):1-14. Yeh I. PMID: 31659277.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7. Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC. PMID: 31618628.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Targeted Genomic Profiling of Acral Melanoma. J Natl Cancer Inst. 2019 10 01; 111(10):1068-1077. Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. PMID: 30657954.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. MicroRNA Ratios Distinguish Melanomas from Nevi. J Invest Dermatol. 2020 01; 140(1):164-173.e7. Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL. PMID: 31580842.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. Clin Cancer Res. 2020 01 15; 26(2):439-449. Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas VR, Wolff AM, Fraser JS, Collisson EA, McCoach CE, Camidge DR, Pacheco J, Bazhenova L, Li T, Bivona TG, Blakely CM. PMID: 31548343.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets. Nat Commun. 2019 07 18; 10(1):3163. Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, Xu Q, Rawson RV, Mukhopadhyay P, Dummer R, Levesque MP, Jönsson G, Wang X, Yeh I, Wu H, Joseph N, Bastian BC, Long GV, Spillane AJ, Shannon KF, Thompson JF, Saw RPM, Adams DJ, Si L, Pearson JV, Hayward NK, Waddell N, Mann GJ, Guo J, Scolyer RA. PMID: 31320640.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    23. PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change. J Natl Compr Canc Netw. 2019 07 01; 17(7):778-783. Tsai KK, Khurana N, McCalmont T, Daud A, Bastian B, Yeh I. PMID: 31319387.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion. Am J Surg Pathol. 2019 06; 43(6):737-746. Yeh I, Busam KJ, McCalmont TH, LeBoit PE, Pissaloux D, Alberti L, de la Fouchardière A, Bastian BC. PMID: 30844834.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma. Nat Commun. 2019 01 21; 10(1):353. Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V, Kuijjer ML, Arends MJ, Brenn T, Harms PW, Wood GA, Adams DJ. PMID: 30664638.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    26. Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site. Head Neck. 2019 06; 41(6):E82-E85. Chan JW, Yeh I, El-Sayed IH, Algazi AP, Glastonbury CM, Ha PK, Yom SS, van Zante A. PMID: 30633411.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018 11 30; 362(6418):1055-1060. Ablain J, Xu M, Rothschild H, Jordan RC, Mito JK, Daniels BH, Bell CF, Joseph NM, Wu H, Bastian BC, Zon LI, Yeh I. PMID: 30385465.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    28. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol. 2019 01; 137(1):139-150. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. PMID: 30196423.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    29. Cutaneous Non-Neural Granular Cell Tumors Harbor Recurrent ALK Gene Fusions. Am J Surg Pathol. 2018 09; 42(9):1133-1142. Cohen JN, Yeh I, Jordan RC, Wolsky RJ, Horvai AE, McCalmont TH, LeBoit PE. PMID: 30001233.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    30. Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42. Mod Pathol. 2019 01; 32(1):88-99. Stevers M, Rabban JT, Garg K, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Zaloudek C, Solomon DA. PMID: 30171198.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 07 09; 34(1):45-55.e4. Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC. PMID: 29990500.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    32. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 07 09; 34(1):56-68.e9. Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL. PMID: 29990501.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    33. Topical timolol: An effective treatment option for agminated pyogenic granuloma. Pediatr Dermatol. 2018 Sep; 35(5):e300-e303. McGinness A, Gillam A, Yeh I, Mathes EF. PMID: 29961974.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. PMID: 29476136.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    35. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 04; 31(4):660-673. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. PMID: 29148537.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. PMID: 28935960.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    37. Molecular Melanoma Diagnosis Update: Gene Fusion, Genomic Hybridization, and Massively Parallel Short-Read Sequencing. Clin Lab Med. 2017 09; 37(3):473-484. Lang UE, Yeh I, McCalmont TH. PMID: 28802496.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. Chronic Helicobacter cinaedi cellulitis diagnosed by microbial polymerase chain reaction. JAAD Case Rep. 2017 Sep; 3(5):398-400. Matsumoto A, Yeh I, Schwartz B, Rosenblum M, Schmidt TH. PMID: 28884138.
      View in: PubMed   Mentions:
    39. Prognostic factors and survival in acral lentiginous melanoma. Br J Dermatol. 2017 Aug; 177(2):428-435. Asgari MM, Shen L, Sokil MM, Yeh I, Jorgenson E. PMID: 28432682.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    40. Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. Mod Pathol. 2017 08; 30(8):1086-1099. Krings G, Joseph NM, Bean GR, Solomon D, Onodera C, Talevich E, Yeh I, Grenert JP, Hosfield E, Crawford ED, Jordan RC, van Zante A, Zaloudek C, Shin SJ, Chen YY. PMID: 28548128.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    41. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. PMID: 28453743.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    42. Eosinophilic Pustular Folliculitis in Children after Stem Cell Transplantation: An Eruption Distinct from Graft-Versus-Host Disease. Pediatr Dermatol. 2017 May; 34(3):326-330. Theiler M, Oza VS, Mathes EF, Dvorak CC, McCalmont TH, Yeh I, Sidbury R, Cordoro KM. PMID: 28317161.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2017 02; 30(2):246-254. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA. PMID: 27813512.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    44. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 11; 240(3):282-290. Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. PMID: 27477320.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    45. Recent advances in molecular genetics of melanoma progression: implications for diagnosis and treatment. F1000Res. 2016; 5. Yeh I. PMID: 27408703.
      View in: PubMed   Mentions: 1     Fields:    
    46. Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity. Mod Pathol. 2016 09; 29(9):1012-27. Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G. PMID: 27255162.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    47. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 05; 18(5):752-3. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. PMID: 26902849.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    48. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12; 373(20):1926-36. Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. PMID: 26559571.
      View in: PubMed   Mentions: 218     Fields:    Translation:Humans
    49. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. PMID: 26343386.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    50. Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion. Pigment Cell Melanoma Res. 2015 Sep; 28(5):607-10. Menzies AM, Yeh I, Botton T, Bastian BC, Scolyer RA, Long GV. PMID: 26072686.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    51. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015 May 27; 6:7174. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. PMID: 26013381.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    52. Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions. Am J Surg Pathol. 2015 May; 39(5):581-91. Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC. PMID: 25602801.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    53. Melanoma BRAF fusions--letter. Clin Cancer Res. 2014 Dec 15; 20(24):6631. Botton T, Yeh I, Bastian BC. PMID: 25512635.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    54. Ambiguous melanocytic tumors with loss of 3p21. Am J Surg Pathol. 2014 Aug; 38(8):1088-95. Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian BC, LeBoit PE. PMID: 24705312.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    55. Supraorbital cutaneous fetal rhabdomyoma of intermediate type: a case report. Am J Dermatopathol. 2014 May; 36(5):e93-6. Yang SH, McCalmont TH, Ahn GG, Yeh I. PMID: 24803069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. SOX-10 expression in cutaneous myoepitheliomas and mixed tumors. J Cutan Pathol. 2014 Apr; 41(4):353-63. Naujokas A, Charli-Joseph Y, Ruben BS, Yeh I, LeBoit PE, McCalmont TH, Pincus LB. PMID: 24329979.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    57. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014; 5:3116. Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC. PMID: 24445538.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    58. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 2013 Nov; 26(6):845-51. Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian BC. PMID: 23890088.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    59. UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):E3225-34. Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Yeh I, Ye I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB. PMID: 23929777.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    60. Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia. J Natl Cancer Inst. 2013 Jun 19; 105(12):917-9. Yeh I, von Deimling A, Bastian BC. PMID: 23690527.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    61. Melanoma ex blue nevus: two cases resembling large plaque-type blue nevus with subcutaneous cellular nodules. J Cutan Pathol. 2012 Dec; 39(12):1094-9. North JP, Yeh I, McCalmont TH, LeBoit PE. PMID: 23145498.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    62. Evaluation and management of a patient with chronic pruritus. J Allergy Clin Immunol. 2012 Oct; 130(4):1015-6.e7. Steinhoff M, Cevikbas F, Yeh I, Chong K, Buddenkotte J, Ikoma A. PMID: 23021147.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    63. Differential expression of PHLDA1 (TDAG51) in basal cell carcinoma and trichoepithelioma. Br J Dermatol. 2012 Nov; 167(5):1106-10. Yeh I, McCalmont TH, LeBoit PE. PMID: 22958125.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    64. Melanoma arising in a large plaque-type blue nevus with subcutaneous cellular nodules. Am J Surg Pathol. 2012 Aug; 36(8):1258-63. Yeh I, Fang Y, Busam KJ. PMID: 22790865.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    65. Neurofibroma-like spindle cell melanoma: CD34 fingerprint and CGH for diagnosis. Am J Dermatopathol. 2012 Aug; 34(6):668-70. Yeh I, Vemula SS, Mirza SA, McCalmont TH. PMID: 22456515.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    66. Hypomelanotic blue nevi lack fingerprint CD34 immunopositivity. Am J Dermatopathol. 2012 May; 34(3):342-3. Panse G, Yeh I, McCalmont TH. PMID: 22277788.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. Plexiform melanocytic schwannoma: a mimic of melanoma. J Cutan Pathol. 2012 May; 39(5):521-5. Yeh I, Argenyi Z, Vemula SS, Furmanczyk PS, Bouffard D, McCalmont TH. PMID: 22416678.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    68. Eccrine hidradenitis sine neutrophils: a toxic response to chemotherapy. J Cutan Pathol. 2011 Nov; 38(11):905-10. Yeh I, George E, Fleckman P. PMID: 21955315.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    69. Cutaneous mycobacterial spindle cell pseudotumor: a potential mimic of soft tissue neoplasms. Am J Dermatopathol. 2011 Aug; 33(6):e66-9. Yeh I, Evan G, Jokinen CH. PMID: 21712686.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    70. Diffuse infantile hepatic hemangiomas: a report of four cases successfully managed with medical therapy. Pediatr Dermatol. 2011 May-Jun; 28(3):267-75. Yeh I, Bruckner AL, Sanchez R, Jeng MR, Newell BD, Frieden IJ. PMID: 21517953.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    71. Distinguishing neurofibroma from desmoplastic melanoma: the value of the CD34 fingerprint. J Cutan Pathol. 2011 Aug; 38(8):625-30. Yeh I, McCalmont TH. PMID: 21457155.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    72. Fingerprint CD34 immunopositivity. J Cutan Pathol. 2010 Nov; 37(11):1127-9. Yeh I, McCalmont TH. PMID: 20849453.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    73. Madura foot caused by Actinomadura madurae in a pregnant woman. Arch Dermatol. 2010 Oct; 146(10):1189-90. Yeh I, Dhanireddy S. PMID: 20956671.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    74. An infiltrative variant of non-neural granular cell tumor: a case report. J Cutan Pathol. 2009 Oct; 36 Suppl 1:46-51. Yeh I, Tran DT, Davis TL, Argenyi ZB. PMID: 19187104.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    75. Genome-wide associations studies for melanoma and nevi. Pigment Cell Melanoma Res. 2009 Oct; 22(5):527-8. Yeh I, Bastian BC. PMID: 19686382.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    76. Drug Targets for Plasmodium falciparum: a post-genomic review/survey. Mini Rev Med Chem. 2006 Feb; 6(2):177-202. Yeh I, Altman RB. PMID: 16472186.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    77. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004 May; 14(5):917-24. Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. PMID: 15078855.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    78. Knowledge acquisition, consistency checking and concurrency control for Gene Ontology (GO). Bioinformatics. 2003 Jan 22; 19(2):241-8. Yeh I, Karp PD, Noy NF, Altman RB. PMID: 12538245.
      View in: PubMed   Mentions: 16     Fields:    
    79. Modelling biological processes using workflow and Petri Net models. Bioinformatics. 2002 Jun; 18(6):825-37. Peleg M, Yeh I, Altman RB. PMID: 12075018.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
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