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Johannes Kratz, MD

Title(s)Assistant Professor, Surgery
SchoolSchool of Medicine
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-353-7502
ORCID ORCID Icon0000-0003-0696-4073 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, Palo Alto, CAB.A. (with Distinction)1999Philosophy
    Stanford University, Palo Alto, CAB.S. (with Honors with Distinction)1999Biological Sciences
    Stanford University, Palo Alto, CAM.A.2000Philosophy
    Harvard Medical School, Boston, MAM.D. (Magna Cum Laude)2006
    Massachusetts General Hospital, Boston, MAResidency2014General Surgery
    University of California, San Francisco, CAFellowship2017Cardiothoracic Surgery
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    American Association for Thoracic Surgery2019Michael DeBakey Research Scholarship
    University of California, San Francisco2019Haile T. Debas Academy of Medical Educators Excellence in Teaching Award
    Bakar ImmunoX Initiative2019Hellman Family Clinical-Translational Research Development Award
    University of California, San Francisco2018Van Auken Endowed Chair in Thoracic Oncology
    University of California, San Francisco2017UCSF Health Exceptional Physician Award
    Partners HealthCare2012Partners HealthCare Resident/Fellow as Teacher Award
    Harvard Medical School2012First Place, Oral Presentation, Harvard Medical School Surgery Research Conference
    International Association for the Study of Lung Cancer2011President's Conference Selection, World Conference on Lung Cancer
    Massachusetts General Hospital2010Willard M. Daggett Award
    Massachusetts General Hospital2008Wyeth Scholarship of the American College of Surgeons for the Study of Inflammation
    Harvard Medical School2006John E. Thayer Scholarship Award
    Harvard Medical School2006Aesculapian Club
    Harvard Medical School2005Soma Weiss Scholar Award
    Harvard Medical School2004Howard Hughes Research Training Fellowship

    Collapse Overview 
    Collapse Overview
    Johannes R. Kratz, M.D. is Director of Minimally Invasive and Robotic Thoracic Surgery and holds the Van Auken Endowed Chair in Thoracic Oncology. Kratz graduated magna cum laude from Harvard Medical School and holds a Masters in Philosophy from Stanford.

    Kratz worked as research fellow in the Thoracic Oncology Lab from 2008-2011 where he played a pivotal role in the development of a prognostic assay for early-stage lung cancer patients. The novel assay was validated in an international clinical trial led by thoracic surgeons David M. Jablons, M.D. and Michael Mann, M.D. The assay better predicted risk of death in early-stage lung cancer patients versus conventional staging guidelines and later successfully identified Stage 1A lung cancer patients who had a very high likelihood of mortality after surgery. Kratz finished his clinical training as a clinical fellow in Thoracic Surgery at UCSF from 2014 - 2017.

    Kratz has published numerous papers and has been the recipient of numerous awards and honors including the Partners Healthcare Resident/Fellow as Teacher Award, Willard M. Daggett Award, Edward Churchill Surgical Research Fellowship, Wyeth Scholarship of the American College of Surgeons, John E. Thayer Scholarship Award, Howard Hughes Medical Fellows Program Continued Support Award, Howard Hughes Medical Student Research Fellowship, and designation as a Soma Weiss Scholar.

    Collapse Research 
    Collapse Research Activities and Funding
    Immune Phenotypes of High-Risk Early Stage Lung Adenocarcinoma
    American Association of Thoracic Surgery Jul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Role Description: This project aims to define the immune phenotype of high-risk lung adenocarcinoma through immune profiling, nucleic acid sequencing, and 3D organoid cell culture.
    COVID-19 Related Rapid Research Pilot Initiative
    University of California, San Francisco Jun 3, 2020 - Jun 2, 2021
    Role: Principal Investigator
    Role Description: This project investigates the epidemiological and institutional impacts of resuming elective surgery at UCSF during COVID-19 pandemic
    Lung Cancer Tumor Immune Microenvironments
    Helen Diller Family Comprehensive Cancer Center Oct 19, 2019 - Sep 30, 2020
    Role: Principal Investigator
    Role Description: This project seeks to define the tumor immune microenvironments of early-stage lung adenocarcinomas.
    CoProject Pilot in Early-Stage Lung Cancer
    Bakar ImmunoX Foundation Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Role Description: This project aims to profile immune populations of low- vs. high-risk lung adenocarcinomas through the use of several high-dimensional assays, nucleic acid sequencing, and 3D organoid cell culture.

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Websites
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. Cell. 2020 Aug 07. Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG. PMID: 32822576.
      View in: PubMed   Mentions:    Fields:    
    2. Perioperative Lung Resection Outcomes After Implementation of a Multidisciplinary, Evidence-based Thoracic ERAS Program. Ann Surg. 2019 Dec 05. Haro GJ, Sheu B, Marcus SG, Sarin A, Campbell L, Jablons DM, Kratz JR. PMID: 31851005.
      View in: PubMed   Mentions:    Fields:    
    3. Comparison of Conventional TNM and Novel TNMB Staging Systems for Non-Small Cell Lung Cancer. JAMA Netw Open. 2019 12 02; 2(12):e1917062. Haro GJ, Sheu B, Cook NR, Woodard GA, Mann MJ, Kratz JR. PMID: 31808928.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. MA06.09 Timing of Driver Mutation Development and the Genetic Evolution of Semi-Solid Lung Nodules into Early NSCLC. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s271-s272. G. Woodard, V. Ding, I. Kim, K. Jones, G. Chavez, G. Haro, J. Kratz, M. Mann, J. Rotow, C. Blakely, D. Jablons. .
      View in: Publisher Site   Mentions:
    5. Esophagectomy Outcomes after Implementation of an Enhanced Recovery after Surgery Program. Journal of the American College of Surgeons. 2019 Oct 1; 229(4):s277. Greg J. Haro, Fang Yu Sheu, Stanley J. Rogers, David M. Jablons, Johannes R. Kratz. .
      View in: Publisher Site   Mentions:
    6. P1.14-58 A Phase II Study to Evaluate Neoadjuvant Osimertinib for Surgically Resectable, EGFR-Mutant Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s578. J. Rotow, A. Urisman, C. Mccoach, T. Jahan, T. Bivona, K. Jones, A. Gupta, H. Do, J. Riess, D. Aisner, R. Doebele, D. Jablons, J. Kratz, C. Blakely. .
      View in: Publisher Site   Mentions:
    7. Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma. Cancer Manag Res. 2019; 11:8209-8218. Jiang L, Tolani B, Yeh CC, Fan Y, Reza JA, Horvai AE, Xia E, Kratz JR, Jablons DM, Mann MJ. PMID: 31686913.
      View in: PubMed   Mentions:
    8. Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. J Thorac Oncol. 2019 07; 14(7):1223-1232. Kratz JR, Haro GJ, Cook NR, He J, Van Den Eeden SK, Woodard GA, Gubens MA, Jahan TM, Jones KD, Kim IJ, He B, Jablons DM, Mann MJ. PMID: 30959120.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development. Genet Test Mol Biomarkers. 2020 Feb; 24(2):59-66. Lancaster EM, Jablons D, Kratz JR. PMID: 30907630.
      View in: PubMed   Mentions: 2     Fields:    
    10. Central Airway Obstruction Due to Tracheal Glomus Tumor. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1):e43-e45. Haro GJ, Seeley EJ, Jablons DM, Kratz JR. PMID: 30464882.
      View in: PubMed   Mentions:
    11. Giant right coronary artery aneurysm presenting as cardiac tamponade. Interact Cardiovasc Thorac Surg. 2018 11 01; 27(5):787-789. Ramirez JL, Kratz JR, Wieselthaler GM. PMID: 29800339.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. P2.16-12 Expanded Data Confirm Molecular Testing Identifies Lung Adenocarcinoma Patients, Including Stage IA, Who Benefit from Adjuvant Chemotherapy. Journal of Thoracic Oncology. 2018 Oct 1; 13(10):s835. G. Woodard, S. Wang, J. Kratz, G. Haro, M. Gubens, C. Blakely, T. Jahan, K. Jones, M. Mann, D. Jablons. .
      View in: Publisher Site   Mentions:
    13. Propensity Matched Analysis of Perioperative Outcomes in Robotic-Assisted Thoracic Surgery, Video Assisted Thoracic Surgery, and Open Lung Resections. Journal of the American College of Surgeons. 2018 Oct 1; 227(4):s53. Greg J. Haro, Johannes R. Kratz, David M. Jablons, Michael J. Mann, Jasleen Kukreja. .
      View in: Publisher Site   Mentions:
    14. P3.03-24 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. Journal of Thoracic Oncology. 2018 Oct 1; 13(10):s919. G. Haro, J. Kratz, N. Cook, J. He, S. Van Den Eeden, G. Woodard, M. Gubens, T. Jahan, K. Jones, I. Kim, B. He, D. Jablons, M. Mann. .
      View in: Publisher Site   Mentions:
    15. Intraoperative identification and treatment of a giant right coronary artery aneurysm. Multimed Man Cardiothorac Surg. 2018 Jul 24; 2018. Ramirez J, Wieselthaler G, Kratz J. PMID: 30070779.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Surgical Management of Pulmonary Mucormycosis in Third-Trimester Pregnancy. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1):e27-e29. Ramirez JL, Urisman A, Kukreja J, Kratz JR. PMID: 29977735.
      View in: PubMed   Mentions:
    17. Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2018 01; 19(1):58-64. Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons DM. PMID: 28645632.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Management of Lung Cancer Invading the Superior Sulcus. Thorac Surg Clin. 2017 May; 27(2):149-157. Kratz JR, Woodard G, Jablons DM. PMID: 28363369.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. P1.03-066 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer TNM Staging Topic: Staging. Journal of Thoracic Oncology. 2017 Jan 1; 12(1):s584-s585. Johannes Kratz, Nancy Cook, Gavitt Woodard, Kirk Jones, Matthew Gubens, Thierry Jahan, Il-Jin Kim, Biao He, David Jablons, Michael Mann. .
      View in: Publisher Site   Mentions:
    20. OA19.06 Adjuvant Chemotherapy Decisions Based on Molecular Risk Status Improves Outcomes in Early Stage, Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2017 Jan 1; 12(1):s320. Gavitt Woodard, Jane Crockard, Clara Zoon-Besselink, Johannes Kratz, Matthew Gubens, Thierry Jahan, Collin Blakely, Kirk Jones, Michael Mann, David Jablons. .
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    21. High risk, high reward: An analysis of outcomes for candidates awaiting hepatic re-transplantation. Ann Hepatol. 2016 Nov - Dec; 15(6):888-894. Shah JA, Patel MS, Kratz JR, Markmann JF, Vagefi PA. PMID: 31208661.
      View in: PubMed   Mentions:
    22.  High risk, high reward: An analysis of outcomes for candidates awaiting hepatic re-transplantation. Ann Hepatol. 2016 Nov-Dec 2016; 15(6):888-894. Shah JA, Patel MS, Kratz JR, Markmann JF, Vagefi PA. PMID: 27740522.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma. Oncol Rep. 2015 Apr; 33(4):2052-60. Hirata T, Zheng Q, Chen Z, Kinoshita H, Okamoto J, Kratz J, Li H, Lui N, Do H, Cheng T, Tseng HH, Koizumi K, Shimizu K, Zhou HM, Jablons D, He B. PMID: 25632963.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. The race to liver transplantation: a comparison of patients with and without hepatocellular carcinoma from listing to post-transplantation. J Am Coll Surg. 2015 Jun; 220(6):1001-7. Patel MS, Kohn R, Kratz JR, Shah JA, Markmann JF, Vagefi PA. PMID: 25868408.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Prognostic and Predictive Biomarker Signatures. Lung Cancer. 2014 May 12; 564-571. Johannes R. Kratz, David M. Jablons. .
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    26. The migrated liver transplantation candidate: insight into geographic disparities in liver distribution. J Am Coll Surg. 2014 Jun; 218(6):1113-8. Kohn R, Kratz JR, Markmann JF, Vagefi PA. PMID: 24680570.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature. Transl Lung Cancer Res. 2013 Jun; 2(3):222-5. Kratz JR, Mann MJ, Jablons DM. PMID: 25806235.
      View in: PubMed   Mentions:
    28. Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. Diagn Mol Pathol. 2013 Jun; 22(2):65-9. Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ. PMID: 23628816.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Prognostic assay in small, node-negative non-small cell lung cancer--reply. JAMA. 2013 Feb 27; 309(8):769-70. Mann MJ, Jablons DM, Kratz JR. PMID: 23443437.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. The role of stem cells in airway repair: implications for the origins of lung cancer. Chin J Cancer. 2013 Feb; 32(2):71-4. Mulvihill MS, Kratz JR, Pham P, Jablons DM, He B. PMID: 23114089.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    31. A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors. JAMA. 2012 Oct 24; 308(16):1629-31. Kratz JR, Van den Eeden SK, He J, Jablons DM, Mann MJ. PMID: 23093159.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    32. Development of a rapid and practical mutation screening assay for human lung adenocarcinoma. Int J Oncol. 2012 Jun; 40(6):1900-6. Choi H, Kratz J, Pham P, Lee S, Ray R, Kwon YW, Mao JH, Kang HC, Jablons D, Kim IJ. PMID: 22407457.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 2012 Mar 03; 379(9818):823-32. Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons DM. PMID: 22285053.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    34. IL11 is prognostic of survival in lung adenocarcinoma. Journal of the American College of Surgeons. 2011 Sep 1; 213(3):s38-s39. Johannes R. Kratz, Patrick T. Pham, Michael S. Mulvihill, M. Roshni Ray, Michael J. Mann, David M. Jablons. .
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    35. Child neurology: Brachial plexus birth injury: what every neurologist needs to know. Neurology. 2011 Aug 16; 77(7):695-7. Pham CB, Kratz JR, Jelin AC, Gelfand AA. PMID: 21844527.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients. Clin Lung Cancer. 2011 Jul; 12(4):237-44. Okamoto J, Kratz JR, Hirata T, Mikami I, Raz D, Segal M, Chen Z, Zhou HM, Pham P, Li H, Yagui-Beltran A, Beltran A, Ray MR, Koizumi K, Shimizu K, Jablons D, He B. PMID: 21726823.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Cancer stem cells in lung tumorigenesis. Ann Thorac Surg. 2010 Jun; 89(6):S2090-5. Kratz JR, Yagui-Beltrán A, Jablons DM. PMID: 20493987.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    38. Genomic prognostic models in early-stage lung cancer. Clin Lung Cancer. 2009 May; 10(3):151-7. Kratz JR, Jablons DM. PMID: 19443334.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    39. Anal canal duplication associated with presacral cyst. J Pediatr Surg. 2008 Sep; 43(9):1749-52. Kratz JR, Deshpande V, Ryan DP, Goldstein AM. PMID: 18779021.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest. 2006 Jan; 116(1):49-58. Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA, García-Cardeña G. PMID: 16341264.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansCells
    41. Fluid Mechanical Forces as Extrinsic Modifiers of Endothelial Function. Endothelial Cells in Health and Disease. 2005 Feb 28; 189-202. Johannes Kratz, Kush Parmar, Sripriya Natarajan, Guillermo García-Cardeña. .
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    42. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg. 2004 Oct; 128(4):552-61. Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ. PMID: 15457156.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    43. Catalysis of peptide dissociation from class II MHC-peptide complexes. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6581-6. Schmitt L, Kratz JR, Davis MM, McConnell HM. PMID: 10359754.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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