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Boris Bastian, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentDermatology
Address1701 Divisadero
San Francisco CA 94115
Phone415-502-0267
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    Collapse Biography 
    Collapse Awards and Honors
    National Cancer Institute2017NCI Outstanding Investigatory Award
    American Academy of Dermatology2017Lila and Murray Gruber Memorial Cancer Research Award
    American Skin Association2016Research Achievement Award
    Society of Melanoma Research2014Lifetime Achievement Award
    Melanoma Research Foundation2012Scientific Leadership Award
    German National Academy of Science Leopoldina2012Elected Member
    Society of Melanoma Research2010  - 2013President
    European Association of Dermatologic Oncology2010Honorary Member
    American Society of Dermatopathology2012Helwig Award
    American Skin Association2008Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research
    American Society of Dermatopathology2005Hermann Pinkus Lectureship and Award

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular and immunologic evolution of melanomas from pre-neoplastic lesions
    NIH/NCI R35CA220481Sep 15, 2017 - Aug 31, 2024
    Role: Principal Investigator
    Molecular Pathology of Cancer
    NIH/NCI T32CA177555Sep 12, 2013 - Aug 31, 2018
    Role: Co-Principal Investigator
    The GNAQ pathway as a therapeutic target in uveal melanoma
    NIH/NCI R01CA142873Dec 1, 2009 - May 31, 2021
    Role: Principal Investigator
    Biomarker Discovery for the Classification of Melanoma
    NIH/NCI R01CA131524Jul 15, 2008 - May 31, 2013
    Role: Principal Investigator
    Program Project Grant
    NIH/NIAMS P01AR050440Sep 26, 2003 - Aug 31, 2010
    Role: Co-Investigator
    Classification of ambiguous melanocytic tumors
    NIH/NCI R33CA095300Sep 25, 2002 - Jul 31, 2006
    Role: Principal Investigator
    Human Melanoma: Etiology, Progression and Therapy
    NIH P01CA025874Jan 1, 1980 - Mar 31, 2016
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian B, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2018 Jul 27. PMID: 30051528.
      View in: PubMed
    2. Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Johnston J, Cham E, Cooney T, Sun PP, Oberheim Bush NA, McDermott M, Van Ziffle J, Onodera C, Grenert JP, Bastian B, Villanueva-Meyer JE, Pekmezci M, Bollen AW, Perry A. Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile. Acta Neuropathol. 2018 Jul 13. PMID: 30006677.
      View in: PubMed
    3. Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian B. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 Jul 09; 34(1):45-55.e4. PMID: 29990500.
      View in: PubMed
    4. Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian B, Judson RL. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 Jul 09; 34(1):56-68.e9. PMID: 29990501.
      View in: PubMed
    5. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian B, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 Jun 07; 6(1):47. PMID: 29880043.
      View in: PubMed
    6. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian B, Perry A, Solomon DA. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. PMID: 29476136.
      View in: PubMed
    7. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian B, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 Apr; 135(4):635-638. PMID: 29435664.
      View in: PubMed
    8. Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian B, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 Mar; 135(3):485-488. PMID: 29428973.
      View in: PubMed
    9. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian B, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 Apr; 31(4):660-673. PMID: 29148537.
      View in: PubMed
    10. Shain AH, Bastian B. Filling the gaps in the genomic catalogue of melanoma subtypes. Pigment Cell Melanoma Res. 2017 Jan; 30(6):508-509. PMID: 28656717.
      View in: PubMed
    11. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian B, de la Fouchardière A. Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644. PMID: 28935960.
      View in: PubMed
    12. Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian B, Hockemeyer D. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science. 2017 09 29; 357(6358):1416-1420. PMID: 28818973.
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    13. Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN. Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation? Cancer Genet. 2017 Oct; 216-217:74-78. PMID: 29025598.
      View in: PubMed
    14. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian B. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017 05 08; 31(5):685-696.e6. PMID: 28486107.
      View in: PubMed
    15. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian B, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. PMID: 28453743.
      View in: PubMed
    16. Eluri M, Feneran A, Bordeaux JS, Ruben B, Ostrowski S, Bastian B, Honda K. Multiple Merkel cell carcinomas: Late metastasis or multiple primary tumors? A molecular study. JAAD Case Rep. 2017 Mar; 3(2):131-134. PMID: 28367486.
      View in: PubMed
    17. Jonsson VD, Blakely CM, Lin L, Asthana S, Matni N, Olivas V, Pazarentzos E, Gubens MA, Bastian B, Taylor BS, Doyle JC, Bivona TG. Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution. Sci Rep. 2017 Mar 13; 7:44206. PMID: 28287179.
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    18. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian B, Rabban JT, Garg K, Zaloudek C, Solomon DA. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2017 Feb; 30(2):246-254. PMID: 27813512.
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    19. Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian B. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 11; 240(3):282-290. PMID: 27477320.
      View in: PubMed
    20. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian B, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 11; 132(5):757-760. PMID: 27624885.
      View in: PubMed
    21. Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian B, Chen YY, Krings G. Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity. Mod Pathol. 2016 09; 29(9):1012-27. PMID: 27255162.
      View in: PubMed
    22. Shain AH, Bastian B. From melanocytes to melanomas. Nat Rev Cancer. 2016 06; 16(6):345-58. PMID: 27125352.
      View in: PubMed
    23. Talevich E, Shain AH, Botton T, Bastian B. CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing. PLoS Comput Biol. 2016 Apr; 12(4):e1004873. PMID: 27100738; PMCID: PMC4839673.
    24. Merlino G, Herlyn M, Fisher DE, Bastian B, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA. The state of melanoma: challenges and opportunities. Pigment Cell Melanoma Res. 2016 07; 29(4):404-16. PMID: 27087480.
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    25. Shain AH, Bastian B. The Genetic Evolution of Melanoma. N Engl J Med. 2016 03 10; 374(10):995-6. PMID: 26962740.
      View in: PubMed
    26. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian B, Mueller S, Solomon DA. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 05; 18(5):752-3. PMID: 26902849; PMCID: PMC4827050 [Available on 05/01/17].
    27. Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian B. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12; 373(20):1926-36. PMID: 26559571.
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    28. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian B. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9. PMID: 26343386; PMCID: PMC4589486.
    29. Conde-Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, Viros A, Gesbert F, Delmas V, Rambow F, Bastian B, Campbell AD, Colombo S, Puig I, Bellacosa A, Sansom O, Marais R, Van Kempen LC, Larue L. A caveolin-dependent and PI3K/AKT-independent role of PTEN in ß-catenin transcriptional activity. Nat Commun. 2015 Aug 26; 6:8093. PMID: 26307673; PMCID: PMC4560817.
    30. Sanborn JZ, Chung J, Purdom E, Wang NJ, Kakavand H, Wilmott JS, Butler T, Thompson JF, Mann GJ, Haydu LE, Saw RP, Busam KJ, Lo RS, Collisson EA, Hur JS, Spellman PT, Cleaver JE, Gray JW, Huh N, Murali R, Scolyer RA, Bastian B, Cho RJ. Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10995-1000. PMID: 26286987; PMCID: PMC4568214.
    31. Singh AD, Schoenfield LA, Bastian B, Aziz HA, Marino MJ, Biscotti CV. Congenital uveal melanoma? Surv Ophthalmol. 2016 Jan-Feb; 61(1):59-64. PMID: 26277063.
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    32. Menzies AM, Yeh I, Botton T, Bastian B, Scolyer RA, Long GV. Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion. Pigment Cell Melanoma Res. 2015 Sep; 28(5):607-10. PMID: 26072686; PMCID: PMC4539279.
    33. Machan S, Molina-Ruiz AM, Fernández-Aceñero MJ, Encabo B, LeBoit P, Bastian B, Requena L. Metastatic melanoma in association with a giant congenital melanocytic nevus in an adult: controversial CGH findings. Am J Dermatopathol. 2015 Jun; 37(6):487-94. PMID: 25062263.
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    34. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian B. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015 May 27; 6:7174. PMID: 26013381; PMCID: PMC4446791.
    35. Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, Busam KJ, LeBoit PE, McCalmont TH, Bastian B. Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions. Am J Surg Pathol. 2015 May; 39(5):581-91. PMID: 25602801; PMCID: PMC4398593.
    36. Carvajal RD, Lawrence DP, Weber JS, Gajewski TF, Gonzalez R, Lutzky J, O'Day SJ, Hamid O, Wolchok JD, Chapman PB, Sullivan RJ, Teitcher JB, Ramaiya N, Giobbie-Hurder A, Antonescu CR, Heinrich MC, Bastian B, Corless CL, Fletcher JA, Hodi FS. Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition. Clin Cancer Res. 2015 May 15; 21(10):2289-96. PMID: 25695690; PMCID: PMC5013827.
    37. Botton T, Yeh I, Bastian B. Melanoma BRAF fusions--letter. Clin Cancer Res. 2014 Dec 15; 20(24):6631. PMID: 25512635; PMCID: PMC4270079.
    38. Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian B, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB. Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nat Commun. 2014 Nov 25; 5:5442. PMID: 25421844; PMCID: PMC4385735.
    39. Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, García-Patos V, Recio JÁ. A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS Genet. 2014 Oct; 10(10):e1004721. PMID: 25329316; PMCID: PMC4199501.
    40. Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian B, Gutkind JS, Bowcock AM, Streicher HZ, Patel PM, Sato T, Sossman JA, Sznol M, Welch J, Thurin M, Selig S, Flaherty KT, Carvajal RD. Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res. 2015 Mar; 28(2):135-47. PMID: 25113308; PMCID: PMC4326637.
    41. Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian B, LeBoit PE. Ambiguous melanocytic tumors with loss of 3p21. Am J Surg Pathol. 2014 Aug; 38(8):1088-95. PMID: 24705312; PMCID: PMC4101029.
    42. North JP, Garrido MC, Kolaitis NA, LeBoit PE, McCalmont TH, Bastian B. Fluorescence in situ hybridization as an ancillary tool in the diagnosis of ambiguous melanocytic neoplasms: a review of 804 cases. Am J Surg Pathol. 2014 Jun; 38(6):824-31. PMID: 24618603.
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    43. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian B, Zhang K, Guan KL. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. PMID: 24882516; PMCID: PMC4075337.
    44. Menzel M, Meckbach D, Weide B, Toussaint NC, Schilbach K, Noor S, Eigentler T, Ikenberg K, Busch C, Quintanilla-Martinez L, Kohlhofer U, Göke A, Göke F, Handgretinger R, Ottmann C, Bastian B, Garbe C, Röcken M, Perner S, Kohlbacher O, Bauer J. In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival. Pigment Cell Melanoma Res. 2014 Jul; 27(4):671-3. PMID: 24703331.
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    45. North JP, Vemula SS, Bastian B. Chromosomal copy number analysis in melanoma diagnostics. Methods Mol Biol. 2014; 1102:199-226. PMID: 24258981.
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    46. Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian B. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014; 5:3116. PMID: 24445538; PMCID: PMC4084638.
    47. Bastian B. The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol. 2014; 9:239-71. PMID: 24460190; PMCID: PMC4831647.
    48. Simpson RM, Bastian B, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):37-47. PMID: 24128326.
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    49. Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian B. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 2013 Nov; 26(6):845-51. PMID: 23890088; PMCID: PMC3808507.
    50. Bastian B, Esteve-Puig R. Targeting activated KIT signaling for melanoma therapy. J Clin Oncol. 2013 Sep 10; 31(26):3288-90. PMID: 23940224.
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    51. Cronin JC, Watkins-Chow DE, Incao A, Hasskamp JH, Schönewolf N, Aoude LG, Hayward NK, Bastian B, Dummer R, Loftus SK, Pavan WJ. SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Res. 2013 Sep 15; 73(18):5709-18. PMID: 23913827.
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    52. Lyons J, Bastian B, McCormick F. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13845-50. PMID: 23908401; PMCID: PMC3752210.
    53. Fleming JL, Dworkin AM, Allain DC, Fernandez S, Wei L, Peters SB, Iwenofu OH, Ridd K, Bastian B, Toland AE. Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma. Int J Cancer. 2014 Jan 01; 134(1):244-8. PMID: 23784969; PMCID: PMC3831612.
    54. Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian B, Vogt T, Herlyn M. Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell. 2013 Jun 10; 23(6):811-25. PMID: 23764003; PMCID: PMC3810180.
    55. Yeh I, von Deimling A, Bastian B. Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia. J Natl Cancer Inst. 2013 Jun 19; 105(12):917-9. PMID: 23690527; PMCID: PMC3687371.
    56. Wiesner T, Murali R, Fried I, Cerroni L, Busam K, Kutzner H, Bastian B. A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression. Am J Surg Pathol. 2012 Jun; 36(6):818-30. PMID: 22367297; PMCID: PMC3354018.
    57. Murali R, Wiesner T, Rosenblum MK, Bastian B. GNAQ and GNA11 mutations in melanocytomas of the central nervous system. Acta Neuropathol. 2012 Mar; 123(3):457-9. PMID: 22307269; PMCID: PMC3495609.
    58. Minor DR, Kashani-Sabet M, Garrido M, O'Day SJ, Hamid O, Bastian B. Sunitinib therapy for melanoma patients with KIT mutations. Clin Cancer Res. 2012 Mar 01; 18(5):1457-63. PMID: 22261812.
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    59. Daud A, Bastian B. Beyond BRAF in melanoma. Curr Top Microbiol Immunol. 2012; 355:99-117. PMID: 21826607.
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    60. McCalmont TH, Bastian B. An unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes. J Cutan Pathol. 2012 Jan; 39(1):25-8. PMID: 22211333.
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    61. Jalas JR, Vemula S, Bezrookove V, Leboit PE, Simko JP, Bastian B. Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma. Am J Surg Pathol. 2011 Sep; 35(9):1413-8. PMID: 21836492; PMCID: PMC3319763.
    62. Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P, Windpassinger C, Wackernagel W, Loy S, Wolf I, Viale A, Lash AE, Pirun M, Socci ND, Rütten A, Palmedo G, Abramson D, Offit K, Ott A, Becker JC, Cerroni L, Kutzner H, Bastian B, Speicher MR. Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet. 2011 Aug 28; 43(10):1018-21. PMID: 21874003; PMCID: PMC3328403.
    63. Ahronowitz IZ, Daud AI, Leong SP, Shue EH, Bastian B, McCalmont TH, Yu SS. An isolated Merkel cell carcinoma metastasis at a distant cutaneous site presenting as a second 'primary' tumor. J Cutan Pathol. 2011 Oct; 38(10):801-7. PMID: 21883364.
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    64. Whiteman DC, Pavan WJ, Bastian B. The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res. 2011 Oct; 24(5):879-97. PMID: 21707960.
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    65. North JP, Vetto JT, Murali R, White KP, White CR, Bastian B. Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma. Am J Surg Pathol. 2011 Aug; 35(8):1146-50. PMID: 21716079; PMCID: PMC4153784.
    66. Carvajal RD, Antonescu CR, Wolchok JD, Chapman PB, Roman RA, Teitcher J, Panageas KS, Busam KJ, Chmielowski B, Lutzky J, Pavlick AC, Fusco A, Cane L, Takebe N, Vemula S, Bouvier N, Bastian B, Schwartz GK. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011 Jun 08; 305(22):2327-34. PMID: 21642685; PMCID: PMC3986039.
    67. Bauer J, Büttner P, Murali R, Okamoto I, Kolaitis NA, Landi MT, Scolyer RA, Bastian B. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res. 2011 Apr; 24(2):345-51. PMID: 21324100; PMCID: PMC3107974.
    68. McCalmont TH, Vemula S, Sands P, Bastian B. Molecular-microscopical correlation in dermatopathology. J Cutan Pathol. 2011 Apr; 38(4):324-6, 323. PMID: 21323719; PMCID: PMC3339263.
    69. Broekaert SM, Roy R, Okamoto I, van den Oord J, Bauer J, Garbe C, Barnhill RL, Busam KJ, Cochran AJ, Cook MG, Elder DE, McCarthy SW, Mihm MC, Schadendorf D, Scolyer RA, Spatz A, Bastian B. Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res. 2010 Dec; 23(6):763-70. PMID: 20874733; PMCID: PMC3107973.
    70. Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian B. Mutations in GNA11 in uveal melanoma. N Engl J Med. 2010 Dec 02; 363(23):2191-9. PMID: 21083380; PMCID: PMC3107972.
    71. Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian B, Attardi LD. Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet. 2010 Oct 21; 6(10):e1001168. PMID: 20975948; PMCID: PMC2958815.
    72. Dworkin AM, Ridd K, Bautista D, Allain DC, Iwenofu OH, Roy R, Bastian B, Toland AE. Germline variation controls the architecture of somatic alterations in tumors. PLoS Genet. 2010 Sep 23; 6(9):e1001136. PMID: 20885788; PMCID: PMC2944791.
    73. Griewank KG, Bastian B. Comment on "Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT". J Invest Dermatol. 2010 Sep; 130(9):2330-1; author reply 2331-2. PMID: 20711207.
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    74. Gerami P, Pouryazdanparast P, Vemula S, Bastian B. Molecular analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus. Am J Dermatopathol. 2010 May; 32(3):301-5. PMID: 20110797.
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    75. Flaherty KT, Hodi FS, Bastian B. Mutation-driven drug development in melanoma. Curr Opin Oncol. 2010 May; 22(3):178-83. PMID: 20401974; PMCID: PMC3107971.
    76. Dalton SR, Gerami P, Kolaitis NA, Charzan S, Werling R, LeBoit PE, Bastian B. Use of fluorescence in situ hybridization (FISH) to distinguish intranodal nevus from metastatic melanoma. Am J Surg Pathol. 2010 Feb; 34(2):231-7. PMID: 20087158; PMCID: PMC2831773.
    77. Garrido MC, Bastian B. KIT as a therapeutic target in melanoma. J Invest Dermatol. 2010 Jan; 130(1):20-7. PMID: 19847190; PMCID: PMC2831053.
    78. Ridd K, Bastian B. Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma. J Invest Dermatol. 2010 Mar; 130(3):901-3. PMID: 19812598; PMCID: PMC2825112.
    79. Yeh I, Bastian B. Genome-wide associations studies for melanoma and nevi. Pigment Cell Melanoma Res. 2009 Oct; 22(5):527-8. PMID: 19686382; PMCID: PMC2841523.
    80. Harradine KA, Ridd K, Saunier EF, Clermont FF, Perez-Losada J, Moore DH, Epstein EH, Bastian B, Akhurst RJ. Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients. Clin Cancer Res. 2009 Aug 15; 15(16):5101-7. PMID: 19671862; PMCID: PMC2812428.
    81. Gerami P, Jewell SS, Morrison LE, Blondin B, Schulz J, Ruffalo T, Matushek P, Legator M, Jacobson K, Dalton SR, Charzan S, Kolaitis NA, Guitart J, Lertsbarapa T, Boone S, LeBoit PE, Bastian B. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009 Aug; 33(8):1146-56. PMID: 19561450.
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    82. Bauer J, Weng J, Kebebew E, Soares P, Trovisco V, Bastian B. Germline variation of the melanocortin-1 receptor does not explain shared risk for melanoma and thyroid cancer. Exp Dermatol. 2009 Jun; 18(6):548-52. PMID: 19493000; PMCID: PMC2862686.
    83. Ridd K, Vemula S, Bastian B. Absence of somatic mutations of NEMO in keratoacanthoma. J Invest Dermatol. 2009 Oct; 129(10):2518-20. PMID: 19404319; PMCID: PMC2823812.
    84. Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian B, Pavan WJ, Samuels Y. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res. 2009 Aug; 22(4):435-44. PMID: 19422606.
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    85. Gartside MG, Chen H, Ibrahimi OA, Byron SA, Curtis AV, Wellens CL, Bengston A, Yudt LM, Eliseenkova AV, Ma J, Curtin JA, Hyder P, Harper UL, Riedesel E, Mann GJ, Trent JM, Bastian B, Meltzer PS, Mohammadi M, Pollock PM. Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma. Mol Cancer Res. 2009 Jan; 7(1):41-54. PMID: 19147536; PMCID: PMC4233648.
    86. Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian B. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature. 2009 Jan 29; 457(7229):599-602. PMID: 19078957; PMCID: PMC2696133.
    87. Ridd K, Yu S, Bastian B. The presence of polyomavirus in non-melanoma skin cancer in organ transplant recipients is rare. J Invest Dermatol. 2009 Jan; 129(1):250-2. PMID: 18650847; PMCID: PMC2837873.
    88. Viros A, Fridlyand J, Bauer J, Lasithiotakis K, Garbe C, Pinkel D, Bastian B. Improving melanoma classification by integrating genetic and morphologic features. PLoS Med. 2008 Jun 03; 5(6):e120. PMID: 18532874; PMCID: PMC2408611.
    89. Lutzky J, Bauer J, Bastian B. Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res. 2008 Aug; 21(4):492-3. PMID: 18510589.
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    90. Freedberg DE, Rigas SH, Russak J, Gai W, Kaplow M, Osman I, Turner F, Randerson-Moor JA, Houghton A, Busam K, Timothy Bishop D, Bastian B, Newton-Bishop JA, Polsky D. Frequent p16-independent inactivation of p14ARF in human melanoma. J Natl Cancer Inst. 2008 Jun 04; 100(11):784-95. PMID: 18505964; PMCID: PMC4410798.
    91. Fargnoli MC, Fargnoli MC, Pike K, Pfeiffer RM, Tsang S, Rozenblum E, Munroe DJ, Golubeva Y, Calista D, Seidenari S, Massi D, Carli P, Bauer J, Elder DE, Bastian B, Peris K, Landi MT. MC1R variants increase risk of melanomas harboring BRAF mutations. J Invest Dermatol. 2008 Oct; 128(10):2485-90. PMID: 18368129; PMCID: PMC2835495.
    92. North JP, Kageshita T, Pinkel D, LeBoit PE, Bastian B. Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma. J Invest Dermatol. 2008 Aug; 128(8):2024-30. PMID: 18323782; PMCID: PMC2825251.
    93. Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, Kumasaka M, Denat L, Goodall J, Luciani F, Viros A, Demirkan N, Bastian B, Goding CR, Larue L. Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev. 2007 Nov 15; 21(22):2923-35. PMID: 18006687; PMCID: PMC2049194.
    94. Kebebew E, Weng J, Bauer J, Ranvier G, Clark OH, Duh QY, Shibru D, Bastian B, Griffin A. The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg. 2007 Sep; 246(3):466-70; discussion 470-1. PMID: 17717450; PMCID: PMC1959359.
    95. Curtin JA, Pinkel D, Bastian B. Absence of PDGFRA mutations in primary melanoma. J Invest Dermatol. 2008 Feb; 128(2):488-9. PMID: 17762857.
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    96. Bastian B, Pinkel D. Expanding the genetic spectrum of pigmentation. Pigment Cell Melanoma Res. 2008 Oct; 21(5):507-8. PMID: 18721233.
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    97. Kim RD, Curtin JA, Bastian B. Lack of somatic alterations of MC1R in primary melanoma. Pigment Cell Melanoma Res. 2008 Oct; 21(5):579-82. PMID: 18761657; PMCID: PMC2825252.
    98. Murata H, Ashida A, Takata M, Yamaura M, Bastian B, Saida T. Establishment of a novel melanoma cell line SMYM-PRGP showing cytogenetic and biological characteristics of the radial growth phase of acral melanomas. Cancer Sci. 2007 Jul; 98(7):958-63. PMID: 17488338.
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    99. Thorns C, Bastian B, Pinkel D, Roydasgupta R, Fridlyand J, Merz H, Krokowski M, Bernd HW, Feller AC. Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach. Genes Chromosomes Cancer. 2007 Jan; 46(1):37-44. PMID: 17044049.
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    100. Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA, Bastian B, Springer C, Marais R. In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res. 2006 Oct 01; 66(19):9483-91. PMID: 17018604.
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    101. Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian B, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol. 2006 Oct; 8(10):1053-63. PMID: 16964246.
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    102. Curtin JA, Busam K, Pinkel D, Bastian B. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006 Sep 10; 24(26):4340-6. PMID: 16908931.
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    103. Bauer J, Curtin JA, Pinkel D, Bastian B. Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J Invest Dermatol. 2007 Jan; 127(1):179-82. PMID: 16888631.
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    104. Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Kanetsky PA, Pinkel D, Bastian B. MC1R germline variants confer risk for BRAF-mutant melanoma. Science. 2006 Jul 28; 313(5786):521-2. PMID: 16809487.
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    105. Curtin JA, Stark MS, Pinkel D, Hayward NK, Bastian B. PI3-kinase subunits are infrequent somatic targets in melanoma. J Invest Dermatol. 2006 Jul; 126(7):1660-3. PMID: 16614723.
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    106. Bauer J, Bastian B. Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool. Dermatol Ther. 2006 Jan-Feb; 19(1):40-9. PMID: 16405569.
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    107. Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian B. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005 Nov 17; 353(20):2135-47. PMID: 16291983.
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    108. Maize JC, McCalmont TH, Carlson JA, Busam KJ, Kutzner H, Bastian B. Genomic analysis of blue nevi and related dermal melanocytic proliferations. Am J Surg Pathol. 2005 Sep; 29(9):1214-20. PMID: 16096412.
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    109. Sahara LY, Bastian B, Bruckner AL. Coalescing, nevoid papules in an infant. Arch Dermatol. 2005 Jul; 141(7):897-902. PMID: 16027310.
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    110. Bauer J, Bastian B. Genomic analysis of melanocytic neoplasia. Adv Dermatol. 2005; 21:81-99. PMID: 16350439.
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    111. Hantschke M, Bastian B, LeBoit PE. Consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and Spitz nevus. Am J Surg Pathol. 2004 Dec; 28(12):1621-5. PMID: 15577682.
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    112. Bastian B. Molecular genetics of melanocytic neoplasia: practical applications for diagnosis. Pathology. 2004 Oct; 36(5):458-61. PMID: 15370116.
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    113. Maldonado JL, Timmerman L, Fridlyand J, Bastian B. Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway. Am J Pathol. 2004 May; 164(5):1783-7. PMID: 15111324; PMCID: PMC1615645.
    114. Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, Kageshita T, Ono T, Albertson DG, Pinkel D, Bastian B. Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst. 2003 Dec 17; 95(24):1878-90. PMID: 14679157.
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    115. Bastian B, Olshen AB, LeBoit PE, Pinkel D. Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003 Nov; 163(5):1765-70. PMID: 14578177; PMCID: PMC1892437.
    116. Dalton SR, Fillman EP, Altman CE, Gardner TL, Davis TL, Bastian B, Libow LF, Elston DM. Atypical junctional melanocytic proliferations in benign lichenoid keratosis. Hum Pathol. 2003 Jul; 34(7):706-9. PMID: 12874767.
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    117. Bastian B. Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer. Oncogene. 2003 May 19; 22(20):3081-6. PMID: 12789284.
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    118. Bastian B. Hypothesis: a role for telomere crisis in spontaneous regression of melanoma. Arch Dermatol. 2003 May; 139(5):667-8. PMID: 12756110.
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    119. Bastian B. The longer your telomeres, the larger your nevus? Am J Dermatopathol. 2003 Feb; 25(1):83-4. PMID: 12544108.
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    120. Takata M, Maruo K, Kageshita T, Ikeda S, Ono T, Shirasaki F, Takehara K, Bastian B. Two cases of unusual acral melanocytic tumors: illustration of molecular cytogenetics as a diagnostic tool. Hum Pathol. 2003 Jan; 34(1):89-92. PMID: 12605371.
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    121. Buckley PG, Mantripragada KK, Benetkiewicz M, Tapia-Páez I, Diaz De Ståhl T, Rosenquist M, Ali H, Jarbo C, De Bustos C, Hirvelä C, Sinder Wilén B, Fransson I, Thyr C, Johnsson BI, Bruder CE, Menzel U, Hergersberg M, Mandahl N, Blennow E, Wedell A, Beare DM, Collins JE, Dunham I, Albertson D, Pinkel D, Bastian B, Faruqi AF, Lasken RS, Ichimura K, Collins VP, Dumanski JP. A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications. Hum Mol Genet. 2002 Dec 01; 11(25):3221-9. PMID: 12444106.
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    122. Bastian B, Xiong J, Frieden IJ, Williams ML, Chou P, Busam K, Pinkel D, LeBoit PE. Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas. Am J Pathol. 2002 Oct; 161(4):1163-9. PMID: 12368190; PMCID: PMC1867277.
    123. Sauter ER, Yeo UC, von Stemm A, Zhu W, Litwin S, Tichansky DS, Pistritto G, Nesbit M, Pinkel D, Herlyn M, Bastian B. Cyclin D1 is a candidate oncogene in cutaneous melanoma. Cancer Res. 2002 Jun 01; 62(11):3200-6. PMID: 12036934.
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    124. Harvell JD, Bastian B, LeBoit PE. Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases. Am J Surg Pathol. 2002 May; 26(5):654-61. PMID: 11979096.
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    125. You MJ, Castrillon DH, Bastian B, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1455-60. PMID: 11818530; PMCID: PMC122212.
    126. Bastian B. Molecular cytogenetics as a diagnostic tool for typing melanocytic tumors. Recent Results Cancer Res. 2002; 160:92-9. PMID: 12079244.
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