Chad Christine, MD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address400 Parnassus Avenue, #A891
San Francisco CA 94117
ORCID ORCID Icon0000-0003-4166-9432 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    Cornell University Medical College, New York, New YorkM.D.1991School of Medicine
    Cornell University, Ithaca, New YorkBA1985Physics and English
    Collapse Awards and Honors
    American Academy of Neurology (AAN)2018Elected as Fellow of AAN
    American Neurological Association (ANA)2013Elected as Fellow of the ANA
    International Movement Disorder Society2006William Koller Memorial Fund Award
    UCSF Academy of Medical Educators2006Innovative Curricular Design and Program Development
    Cornell University Medical College1991Kean-Haas Fellowship for International Study
    Stanford University School of Medicine1988Walton Foundation Scholarship

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    Relationship of B12 status measures with outcomes in SURE-PD2, SURE-PD3 and STEADY-PD III
    Michael J Fox Foundation for Parkinson's Research 18462Sep 30, 2020 - Aug 30, 2022
    Role: PI
    Description: To determine whether vitamin B12 and other B12 status measures are associated with PD progression using plasma specimens from recently performed clinical trial of early PD progression
    Open-Label Safety Study of Glial cell Line derived neurotrophic factor Gene transfer (AAV2-GDNF) in Parkinson’s disease
    Brain Neurotherapy Bio, Inc Aug 1, 2020 - Apr 30, 2026
    Role: Site Co-PI
    Description: To determine the safety and possible clinical benefits of this treatment in PD.
    NLY01-PD-1Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment with NLY01 in Early-stage Parkinson’s Disease
    Neuraly, Inc Apr 1, 2020 - Dec 31, 2021
    Role: Site Investigator
    Description: To determine the safety and possible benefit of NLY01-PD in early PD
    PD 1105: A Randomized, Sham Surgery Controlled, Double-blind, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Moderate to Advanced Parkinson’s Disease Patients with Motor Fluctuations
    Neurocrine Biosciences, Inc Nov 1, 2018 - Dec 31, 2023
    Role: Site PI
    Description: To determine the safty and efficacy of VY-AADC02 in subjects with advanced PD
    PD 1104: An Observational, Long-Term Extension Study for Participants of Prior VY-AADC01 or VY-AADC02 Clinical Studies
    Neurocrine Biosciences, Inc Apr 1, 2018 - Dec 31, 2029
    Role: Site PI
    Description: To provide long term observational follow-up of subjects treated with AADC gene therapy
    PD 1102: An Open-label Safety and Efficacy Study of VY-AADC01 Administered by MRI-Guided Convective Infusion using a Posterior Trajectory into the Putamen of Participants with Parkinson’s Disease with fluctuating Responses to Levodopa.
    Voyager Therapeutics Jan 1, 2017 - Apr 30, 2021
    Role: Site Co-PI
    Description: To determine the safety and possible clinical benefit of VY-AADC01 in moderately advanced Parkinson's disease
    Relationship of cerebrospinal markers of B12 status to baseline status and outcomes in the DATATOP study
    NIH and Michael J Fox Foundation for Parkinson's Research 11951May 1, 2016 - Jun 30, 2019
    Role: PI
    Description: To determine whether cerebrospinal markers of B12 status are associated with PD progression.
    “A Phase 3 double-blind placebo-controlled parallel group study of isradipine as a disease modifying agent in patients with early Parkinson disease.”
    NIH Jul 1, 2014 - Nov 30, 2015
    Role: Site PI
    Description: To determine whether isradipine haa a disease modifying effect on PD progression
    The Relationship of Vitamin B12 status and Parkinson’s disease
    Michael J Fox Foundation for Parkinson's Research 8646Jan 1, 2014 - Mar 30, 2015
    Role: PI
    Description: To Study the association of vitamin B12 and homocysteine levels with PD progression using serum samples from the DATATOP study of early Parkinson's disease.
    Parkinson's Disease Neuroprotection Clinical Trial
    NIH U10NS044460Sep 15, 2002 - Nov 30, 2015
    Role: Co-PI
    Description: To determine the safety and possible clinical benefit of AADC gene therapy in moderately advance PD.
    NIH K08NS001813Jul 1, 1995 - May 31, 2000
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nat Commun. 2023 Dec 19; 14(1):8368. Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakamura K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF. PMID: 38114471; PMCID: PMC10730909.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Long-Term Intake of Folate, Vitamin B6, and Vitamin B12 and the Incidence of Parkinson's Disease in a Sample of U.S. Women and Men. Mov Disord. 2023 05; 38(5):866-879. Flores-Torres MH, Christine CW, Bjornevik K, Molsberry SA, Hung AY, Healy BC, Blacker D, Schwarzschild MA, Ascherio A. PMID: 36938854.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling. Life Sci Alliance. 2023 04; 6(4). Goel S, Oliva R, Jeganathan S, Bader V, Krause LJ, Kriegler S, Stender ID, Christine CW, Nakamura K, Hoffmann JE, Winter R, Tatzelt J, Winklhofer KF. PMID: 36720498; PMCID: PMC9889916.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    4. Author Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial. Neurology. 2022 08 09; 99(6):259. Christine CW, Richardson RM, Fine EM, Khwaja OS, Liang GS, Meier A, Roberts EW, Bankiewicz K, Larson PS. PMID: 35940891.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Author Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial. Neurology. 2022 08 09; 99(6):260-261. Christine CW, Richardson RM, Van Laar A, Fine EM, Khwaja OS, Liang GS, Bankiewicz K, Larson PS. PMID: 35940892.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Association of elevated blood homocysteine with cognitive decline in early, untreated Parkinson's disease. J Neurol Sci. 2022 Mar 15; 434:120185. Christine CW, Green R. PMID: 35180679.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial. Neurology. 2022 01 04; 98(1):e40-e50. Christine CW, Richardson RM, Van Laar AD, Thompson ME, Fine EM, Khwaja OS, Li C, Liang GS, Meier A, Roberts EW, Pfau ML, Rodman JR, Bankiewicz KS, Larson PS. PMID: 34649873; PMCID: PMC8726573.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    8. Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial. JAMA. 2021 09 14; 326(10):926-939. Parkinson Study Group SURE-PD3 Investigators, Schwarzschild MA, Ascherio A, Casaceli C, Curhan GC, Fitzgerald R, Kamp C, Lungu C, Macklin EA, Marek K, Mozaffarian D, Oakes D, Rudolph A, Shoulson I, Videnovic A, Scott B, Gauger L, Aldred J, Bixby M, Ciccarello J, Gunzler SA, Henchcliffe C, Brodsky M, Keith K, Hauser RA, Goetz C, LeDoux MS, Hinson V, Kumar R, Espay AJ, Jimenez-Shahed J, Hunter C, Christine C, Daley A, Leehey M, de Marcaida JA, Friedman JH, Hung A, Bwala G, Litvan I, Simon DK, Simuni T, Poon C, Schiess MC, Chou K, Park A, Bhatti D, Peterson C, Criswell SR, Rosenthal L, Durphy J, Shill HA, Mehta SH, Ahmed A, Deik AF, Fang JY, Stover N, Zhang L, Dewey RB, Gerald A, Boyd JT, Houston E, Suski V, Mosovsky S, Cloud L, Shah BB, Saint-Hilaire M, James R, Zauber SE, Reich S, Shprecher D, Pahwa R, Langhammer A, LaFaver K, LeWitt PA, Kaminski P, Goudreau J, Russell D, Houghton DJ, Laroche A, Thomas K, McGraw M, Mari Z, Serrano C, Blindauer K, Rabin M, Kurlan R, Morgan JC, Soileau M, Ainslie M, Bodis-Wollner I, Schneider RB, Waters C, Ratel AS, Beck CA, Bolger P, Callahan KF, Crotty GF, Klements D, Kostrzebski M, McMahon GM, Pothier L, Waikar SS, Lang A, Mestre T. PMID: 34519802; PMCID: PMC8441591.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCTClinical Trials
    9. Data-driven evolution of neurosurgical gene therapy delivery in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2020 11; 91(11):1210-1218. Richardson RM, Bankiewicz KS, Christine CW, Van Laar AD, Gross RE, Lonser R, Factor SA, Kostyk SK, Kells AP, Ravina B, Larson PS. PMID: 32732384; PMCID: PMC7569395.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression. Mov Disord. 2020 08; 35(8):1466-1471. Christine CW, Auinger P, Saleh N, Tian M, Bottiglieri T, Arning E, Tran NK, Ueland PM, Green R, Parkinson Study Group-DATATOP Investigators. PMID: 32407590; PMCID: PMC7496300.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    11. Vitamin B12 measurements across neurodegenerative disorders. J Clin Mov Disord. 2020; 7:3. Luthra NS, Marcus AH, Hills NK, Christine CW. PMID: 32257364; PMCID: PMC7066740.
      View in: PubMed   Mentions: 9  
    12. Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease. Mov Disord. 2020 05; 35(5):851-858. Nutt JG, Curtze C, Hiller A, Anderson S, Larson PS, Van Laar AD, Richardson RM, Thompson ME, Sedkov A, Leinonen M, Ravina B, Bankiewicz KS, Christine CW. PMID: 32149427; PMCID: PMC7318280.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    13. Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease. J Mov Disord. 2019 May; 12(2):91-96. Dietiker C, Kim S, Zhang Y, Christine CW. PMID: 31158942; PMCID: PMC6547038.
      View in: PubMed   Mentions: 6  
    14. Linking vitamin B12 and a trembling disorder. Cell Res. 2019 05; 29(5):343-344. Green R, Christine CW. PMID: 30976075; PMCID: PMC6796848.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease. Ann Neurol. 2019 05; 85(5):704-714. Christine CW, Bankiewicz KS, Van Laar AD, Richardson RM, Ravina B, Kells AP, Boot B, Martin AJ, Nutt J, Thompson ME, Larson PS. PMID: 30802998; PMCID: PMC6593762.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCTClinical Trials
    16. Characterization of vitamin D supplementation and clinical outcomes in a large cohort of early Parkinson's disease. J Clin Mov Disord. 2018; 5:7. Luthra NS, Kim S, Zhang Y, Christine CW, NINDS NET-PD Investigators. PMID: 30397507; PMCID: PMC6208018.
      View in: PubMed   Mentions: 9  
    17. Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's Disease. Mov Disord. 2018 05; 33(5):762-770. Christine CW, Auinger P, Joslin A, Yelpaala Y, Green R, Parkinson Study Group-DATATOP Investigators. PMID: 29508904.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    18. Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores. Neurology. 2017 Oct 24; 89(17):1789-1794. Leehey M, Luo S, Sharma S, Wills AA, Bainbridge JL, Wong PS, Simon DK, Schneider J, Zhang Y, Pérez A, Dhall R, Christine CW, Singer C, Cambi F, Boyd JT. PMID: 28972194; PMCID: PMC5664310.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    19. Precipitous Deterioration of Motor Function, Cognition, and Behavior. JAMA Neurol. 2017 05 01; 74(5):591-596. Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD. PMID: 28264087; PMCID: PMC5600817.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort. J Neurol Sci. 2017 Jun 15; 377:137-143. Chou KL, Elm JJ, Wielinski CL, Simon DK, Aminoff MJ, Christine CW, Liang GS, Hauser RA, Sudarsky L, Umeh CC, Voss T, Juncos J, Fang JY, Boyd JT, Bodis-Wollner I, Mari Z, Morgan JC, Wills AM, Lee SL, Parashos SA, NINDS NET-PD Investigators. PMID: 28477684; PMCID: PMC5518305.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. Longer Duration of MAO-B Inhibitor Exposure is Associated with Less Clinical Decline in Parkinson's Disease: An Analysis of NET-PD LS1. J Parkinsons Dis. 2017; 7(1):117-127. Hauser RA, Li R, Pérez A, Ren X, Weintraub D, Elm J, Goudreau JL, Morgan JC, Fang JY, Aminoff MJ, Christine CW, Dhall R, Umeh CC, Boyd JT, Stover N, Leehey M, Zweig RM, Nicholas AP, Bodis-Wollner I, Willis A, Kieburtz K, Tilley BC, NINDS NET-PD Investigators. PMID: 27911341.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    22. Cognitive function in 1736 participants in NINDS Exploratory Trials in PD Long-term Study-1. Parkinsonism Relat Disord. 2016 12; 33:127-133. Wills AA, Elm JJ, Ye R, Chou KL, Parashos SA, Hauser RA, Bodis-Wollner I, Hinson VK, Christine CW, Schneider JS, NINDS NET-PD Investigators. PMID: 27743701; PMCID: PMC6091572.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America. J Neurol Sci. 2016 Jul 15; 366:74-81. Goudreau JL, Pérez A, Aminoff MJ, Boyd JT, Burau KD, Christine CW, Leehey M, Morgan JC, NET-PD Investigators.. PMID: 27288780.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    24. Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease. Mov Disord Clin Pract. 2015 Dec; 2(4):371-378. Bega D, Luo S, Fernandez H, Chou K, Aminoff M, Parashos S, Walker H, Russell DS, Christine CW, Dhall R, Singer C, Bodis-Wollner I, Hamill R, Truong D, Mari Z, Glazmann S, Huang M, Houston E, Simuni T. PMID: 28393083; PMCID: PMC5381520.
      View in: PubMed   Mentions: 4  
    25. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. JAMA. 2015 Feb 10; 313(6):584-93. Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM. PMID: 25668262; PMCID: PMC4349346.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    26. Parkinson's disease severity and use of dopaminergic medications. Parkinsonism Relat Disord. 2015 Mar; 21(3):297-9. Fang JY, Pérez A, Christine CW, Leehey M, Aminoff MJ, Boyd JT, Morgan JC, Dhall R, Nicholas AP, Bodis-Wollner I, Zweig RM, Goudreau JL, NINDS NET-PD Investigators. PMID: 25541182; PMCID: PMC4340731.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial. PLoS One. 2014; 9(12):e112287. Umeh CC, Pérez A, Augustine EF, Dhall R, Dewey RB, Mari Z, Simon DK, Wills AM, Christine CW, Schneider JS, Suchowersky O. PMID: 25486269; PMCID: PMC4259292.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    28. Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease. Parkinsonism Relat Disord. 2014 Jun; 20(6):644-6. Moonen AJ, Wijers A, Leentjens AF, Christine CW, Factor SA, Juncos J, Lyness JM, Marsh L, Panisset M, Pfeiffer R, Rottenberg D, Serrano Ramos C, Shulman L, Singer C, Slevin J, McDonald W, Auinger P, Richard IH. PMID: 24679737.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    29. Changes in the thalamus in atypical parkinsonism detected using shape analysis and diffusion tensor imaging. AJNR Am J Neuroradiol. 2014 May; 35(5):897-903. Hess CP, Christine CW, Apple AC, Dillon WP, Aminoff MJ. PMID: 24356677; PMCID: PMC7964542.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Development of corticobasal syndrome in a patient with congenital erythropoietic porphyria. Parkinsonism Relat Disord. 2014 Mar; 20(3):349-50. Sidorsky TI, Christine CW, Epstein JH, Berger TG. PMID: 24388147.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. J Clin Invest. 2012 Sep; 122(9):3159-69. Fanara P, Wong PY, Husted KH, Liu S, Liu VM, Kohlstaedt LA, Riiff T, Protasio JC, Boban D, Killion S, Killian M, Epling L, Sinclair E, Peterson J, Price RW, Cabin DE, Nussbaum RL, Brühmann J, Brandt R, Christine CW, Aminoff MJ, Hellerstein MK. PMID: 22922254; PMCID: PMC3428100.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology. 2012 Apr 17; 78(16):1229-36. Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, Factor SA, Juncos J, Serrano Ramos C, Brodsky M, Manning C, Marsh L, Shulman L, Fernandez HH, Black KJ, Panisset M, Christine CW, Jiang W, Singer C, Horn S, Pfeiffer R, Rottenberg D, Slevin J, Elmer L, Press D, Hyson HC, McDonald W, SAD-PD Study Group. PMID: 22496199; PMCID: PMC3324323.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    33. Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease. Hum Gene Ther. 2012 Apr; 23(4):377-81. Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS. PMID: 22424171; PMCID: PMC4530392.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCellsCTClinical Trials
    34. Development of Parkinson's disease in patients with Narcolepsy. J Neural Transm (Vienna). 2012 Jun; 119(6):697-9. Christine CW, Marks WJ, Ostrem JL. PMID: 22231845.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. A case of slow orthostatic tremor, responsive to intravenous immunoglobulin. Mov Disord. 2011 Jul; 26(8):1563-5. Hegde M, Glass GA, Dalmau J, Christine CW. PMID: 21469203.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    36. Hospitalization in Parkinson disease: a survey of National Parkinson Foundation Centers. Parkinsonism Relat Disord. 2011 Jul; 17(6):440-5. Chou KL, Zamudio J, Schmidt P, Price CC, Parashos SA, Bloem BR, Lyons KE, Christine CW, Pahwa R, Bodis-Wollner I, Oertel WH, Suchowersky O, Aminoff MJ, Malaty IA, Friedman JH, Okun MS. PMID: 21458353; PMCID: PMC3895941.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    37. Management of the hospitalized patient with Parkinson's disease: current state of the field and need for guidelines. Parkinsonism Relat Disord. 2011 Mar; 17(3):139-45. Aminoff MJ, Christine CW, Friedman JH, Chou KL, Lyons KE, Pahwa R, Bloem BR, Parashos SA, Price CC, Malaty IA, Iansek R, Bodis-Wollner I, Suchowersky O, Oertel WH, Zamudio J, Oberdorf J, Schmidt P, Okun MS, National Parkinson Foundation Working Group on Hospitalization in Parkinson's Disease. PMID: 21159538; PMCID: PMC3070297.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    38. Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease. Neurosurgery. 2010 Nov; 67(5):1377-85. Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS. PMID: 20871425.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsCTClinical Trials
    39. Parkinsonism in patients with a history of amphetamine exposure. Mov Disord. 2010 Jan 30; 25(2):228-31. Christine CW, Garwood ER, Schrock LE, Austin DE, McCulloch CE. PMID: 20063432; PMCID: PMC2831101.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansPHPublic Health
    40. Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder. Stereotact Funct Neurosurg. 2010; 88(1):51-5. Ostrem JL, Christine CW, Glass GA, Schrock LE, Starr PA. PMID: 20051710.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    41. Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology. 2009 Nov 17; 73(20):1662-9. Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ. PMID: 19828868; PMCID: PMC2839805.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCTClinical Trials
    42. Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. Alzheimer Dis Assoc Disord. 2009 Oct-Dec; 23(4):365-70. Kao AW, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL. PMID: 19935145; PMCID: PMC2886667.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    43. The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism. J Neurosurg. 2009 Feb; 110(2):234-8. Christine CW, Langston JW, Turner RS, Starr PA. PMID: 19099380; PMCID: PMC2908499.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. Results from a phase I safety trial of hAADC gene therapy for Parkinson disease. Neurology. 2008 May 20; 70(21):1980-3. Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ. PMID: 18401019.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCTClinical Trials
    45. Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease. Mov Disord. 2007 Apr 15; 22(5):619-26. Nakamura K, Christine CW, Starr PA, Marks WJ. PMID: 17230483.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    46. Amphetamine exposure is elevated in Parkinson's disease. Neurotoxicology. 2006 Dec; 27(6):1003-6. Garwood ER, Bekele W, McCulloch CE, Christine CW. PMID: 16620991.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    47. Online support groups for Parkinson's patients: a pilot study of effectiveness. Soc Work Health Care. 2005; 42(2):23-38. Lieberman MA, Winzelberg A, Golant M, Wakahiro M, DiMinno M, Aminoff M, Christine C. PMID: 16390834.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. Clinical differentiation of parkinsonian syndromes: prognostic and therapeutic relevance. Am J Med. 2004 Sep 15; 117(6):412-9. Christine CW, Aminoff MJ. PMID: 15380498.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    49. Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease. Mov Disord. 2003 Jul; 18(7):791-8. Theodosopoulos PV, Marks WJ, Christine C, Starr PA. PMID: 12815658.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    50. Implantation of deep brain stimulators into the subthalamic nucleus: technical approach and magnetic resonance imaging-verified lead locations. J Neurosurg. 2002 Aug; 97(2):370-87. Starr PA, Christine CW, Theodosopoulos PV, Lindsey N, Byrd D, Mosley A, Marks WJ. PMID: 12186466.
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    51. Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7097-102. Lissin DV, Gomperts SN, Carroll RC, Christine CW, Kalman D, Kitamura M, Hardy S, Nicoll RA, Malenka RC, von Zastrow M. PMID: 9618545; PMCID: PMC22752.
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    52. Magnesium removal induces paroxysmal neuronal firing and NMDA receptor-mediated neuronal degeneration in cortical cultures. Neurosci Lett. 1990 Jul 31; 115(2-3):313-7. Rose K, Christine CW, Choi DW. PMID: 1978266.
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    53. Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res. 1990 Jan 08; 506(2):339-42. Giffard RG, Monyer H, Christine CW, Choi DW. PMID: 1967968.
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    54. Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons. J Neurosci. 1990 Jan; 10(1):108-16. Christine CW, Choi DW. PMID: 1688929; PMCID: PMC6570328.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    55. Cation channels in the apical membrane of collecting duct principal cell epithelium in culture. Ren Physiol Biochem. 1990 Jan-Apr; 13(1-2):70-81. Laskowski FH, Christine CW, Gitter AH, Beyenbach KW, Gross P, Frömter E. PMID: 1689863.
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    56. Acute brain injury, NMDA receptors, and hydrogen ions: observations in cortical cell cultures. Adv Exp Med Biol. 1990; 268:501-4. Choi DW, Monyer H, Giffard RG, Goldberg MP, Christine CW. PMID: 2150160.
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    57. Bicarbonate dependence of glutamate receptor activation by beta-N-methylamino-L-alanine: channel recording and study with related compounds. Neuron. 1989 Sep; 3(3):321-6. Weiss JH, Christine CW, Choi DW. PMID: 2561969.
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    58. Zinc and LTP. Nature. 1989 Mar 16; 338(6212):212. Weiss JH, Koh JY, Christine CW, Choi DW. PMID: 2537931.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    59. Glutamate neurotoxicity, calcium, and zinc. Ann N Y Acad Sci. 1989; 568:219-24. Choi DW, Weiss JH, Koh JY, Christine CW, Kurth MC. PMID: 2576505.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    60. High-conductance K+ channel in apical membranes of principal cells cultured from rabbit renal cortical collecting duct anlagen. Pflugers Arch. 1987 Mar; 408(3):282-90. Gitter AH, Beyenbach KW, Christine CW, Gross P, Minuth WW, Frömter E. PMID: 2437523.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
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