Claire Brett, MD

Title(s)Professor Emeritus, Anesthesia
SchoolSchool of Medicine
Address550 16th Street, #5141
San Francisco CA 94158
Phone415-476-6461
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    University of California, San FranciscoResidency School of Medicine

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2). Clin Pharmacol Ther. 2025 Apr 01. Riselli AM, Yee SW, Yang J, Brett CM, Trumbach K, Zhou X, Liu R, Liang X, Lai Y, Huo R, Xue Y, Shen H, Zhang L, Yang X, Liu Q, Huang SM, Giacomini KM. PMID: 40170495.
      View in: PubMed   Mentions:    Fields:    
    2. Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat. J Vet Pharmacol Ther. 2023 Nov; 46(6):401-412. Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM. PMID: 37198956.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 06; 55(6):711-21. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. PMID: 26597253; PMCID: PMC4876051.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    4. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet. 2016 Apr; 55(4):495-506. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. PMID: 26507723; PMCID: PMC4792735.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    5. Outcomes for extremely premature infants. Anesth Analg. 2015 Jun; 120(6):1337-51. Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ. PMID: 25988638; PMCID: PMC4438860.
      View in: PubMed   Mentions: 225     Fields:    Translation:Humans
    6. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. PMID: 24853734; PMCID: PMC4171106.
      View in: PubMed   Mentions: 35     Fields:    
    7. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. PMID: 23649425; PMCID: PMC4151246.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    8. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2013 Feb; 93(2):186-94. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. PMID: 23267855; PMCID: PMC3671611.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    9. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics. 2009 Jul; 19(7):497-504. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. PMID: 19483665; PMCID: PMC3104496.
      View in: PubMed   Mentions: 75     Fields:    Translation:CTClinical Trials
    10. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar; 83(3):416-21. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. PMID: 17609685.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    11. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther. 2008 Feb; 83(2):273-80. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. PMID: 17609683; PMCID: PMC2976713.
      View in: PubMed   Mentions: 163     Fields:    Translation:CTClinical Trials
    12. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007 May; 117(5):1422-31. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM. PMID: 17476361; PMCID: PMC1857259.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimalsCells
    13. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007 Mar; 81(3):328-45. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I, Pharmacogenetics Research Network. PMID: 17339863; PMCID: PMC5006950.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    14. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Mol Pharmacol. 2006 Nov; 70(5):1602-11. Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM. PMID: 16931768.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    15. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug; 318(2):521-9. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. PMID: 16702441.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    16. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacol Rev. 2006 Mar; 58(1):3-4. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507878.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F905-12. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM. PMID: 16291576.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    18. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr; 15(4):201-9. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. PMID: 15864112.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005; 5(3):157-65. Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. PMID: 15738947.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. PMID: 14586389.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    21. Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Pharm Res. 1998 Jul; 15(7):1145-7. Washington CB, Giacomini KM, Brett CM. PMID: 9688074.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    22. Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol. 1998; 38:431-60. Zhang L, Brett CM, Giacomini KM. PMID: 9597162.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    23. Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Biochim Biophys Acta. 1997 Nov 13; 1330(1):94-102. Ramanathan VK, Brett CM, Giacomini KM. PMID: 9375816.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    24. Taurine transport in cultured choroid plexus. Pharm Res. 1997 Apr; 14(4):406-9. Ramanathan VK, Chung SJ, Giacomini KM, Brett CM. PMID: 9144722.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Pharm Res. 1996 Jun; 13(6):952-6. Ramanathan VK, Hui AC, Brett CM, Giacomini KM. PMID: 8792439.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. Saturable disposition of taurine in the rat cerebrospinal fluid. J Pharmacol Exp Ther. 1996 Feb; 276(2):676-82. Chung SJ, Ramanathan VK, Brett CM, Giacomini KM. PMID: 8632336.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    27. Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Pharm Biotechnol. 1996; 8:259-83. Washington CB, Giacomini KM, Brett CM. PMID: 8791814.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Pharm Biotechnol. 1996; 8:193-210. Gutierrez MM, Brett CM, Giacomini KM. PMID: 8791811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    29. The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. J Pharmacol Exp Ther. 1995 Jul; 274(1):110-4. Washington CB, Brett CM, Wu X, Giacomini KM. PMID: 7616386.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    30. Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Biochim Biophys Acta. 1994 Jul 13; 1193(1):10-6. Chung SJ, Ramanathan V, Giacomini KM, Brett CM. PMID: 8038178.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    31. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Drug Metab Dispos. 1993 Jul-Aug; 21(4):587-97. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM. PMID: 8104117.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    32. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm Res. 1993 Mar; 10(3):423-6. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. PMID: 8464817.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. J Biol Chem. 1992 May 05; 267(13):8813-8. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM. PMID: 1315741.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    34. Nucleoside transport in brush border membrane vesicles from human kidney. Biochim Biophys Acta. 1992 Mar 23; 1105(1):1-9. Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. PMID: 1567888.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. The young lamb can increase cardiovascular performance during isoflurane anesthesia. Anesthesiology. 1989 Nov; 71(5):751-6. Brett CM, Teitel DF, Heymann MA, Rudolph AM. PMID: 2817470.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    36. Pre-induction of anesthesia in pediatric patients with nasally administered sufentanil. Anesthesiology. 1988 May; 68(5):671-5. Henderson JM, Brodsky DA, Fisher DM, Brett CM, Hertzka RE. PMID: 2897172.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    37. Short-term hemodynamic effects of captopril in infants with congestive heart failure. Am J Dis Child. 1988 Jan; 142(1):100-5. Shaddy RE, Teitel DF, Brett C. PMID: 3277384.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    38. Thiopental dose-response relations in unpremedicated infants, children, and adults. Anesth Analg. 1987 Oct; 66(10):1024-7. Brett CM, Fisher DM. PMID: 3631563.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. The cardiovascular effects of isoflurane in lambs. Anesthesiology. 1987 Jul; 67(1):60-5. Brett CM, Teitel DF, Heymann MA, Rudolph AM. PMID: 3605737.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    40. Comparison of enflurane, halothane, and isoflurane for diagnostic and therapeutic procedures in children with malignancies. Anesthesiology. 1985 Dec; 63(6):647-50. Fisher DM, Robinson S, Brett CM, Perin G, Gregory GA. PMID: 3840660.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
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