Lee Chen, PhD, MD

Title(s)Postdoctoral Scholar, Neurological Surgery
SchoolSchool of Medicine
Phone415-514-1183
ORCID ORCID Icon0000-0002-3176-0964 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells. Biomedicines. 2022 Mar 23; 10(4). Singh SX, Yang R, Roso K, Hansen LJ, Du C, Chen LH, Greer PK, Pirozzi CJ, He Y. PMID: 35453502; PMCID: PMC9025092.
      View in: PubMed   Mentions:
    2. MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization. Sci Rep. 2022 03 09; 12(1):4183. Hansen LJ, Yang R, Roso K, Wang W, Chen L, Yang Q, Pirozzi CJ, He Y. PMID: 35264604; PMCID: PMC8907307.
      View in: PubMed   Mentions:
    3. TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist. Acta Neuropathol Commun. 2021 11 03; 9(1):178. Xu C, Liu H, Pirozzi CJ, Chen LH, Greer PK, Diplas BH, Zhang L, Waitkus MS, He Y, Yan H. PMID: 34732238; PMCID: PMC8565061.
      View in: PubMed   Mentions:
    4. The integrated genomic and epigenomic landscape of brainstem glioma. Nat Commun. 2020 06 17; 11(1):3077. Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, Ashley DM, Yan H, Zhang L. PMID: 32555164; PMCID: PMC7299931.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib. Mol Cancer Res. 2020 07; 18(7):968-980. Wang Z, Xu C, Diplas BH, Moure CJ, Chen CJ, Chen LH, Du C, Zhu H, Greer PK, Zhang L, He Y, Waitkus MS, Yan H. PMID: 32229503.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP. Mol Cancer Res. 2019 10; 17(10):2042-2050. Moure CJ, Diplas BH, Chen LH, Yang R, Pirozzi CJ, Wang Z, Spasojevic I, Waitkus MS, He Y, Yan H. PMID: 31292202; PMCID: PMC6774824.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation. Cancer Res. 2019 07 01; 79(13):3383-3394. Hansen LJ, Sun R, Yang R, Singh SX, Chen LH, Pirozzi CJ, Moure CJ, Hemphill C, Carpenter AB, Healy P, Ruger RC, Chen CJ, Greer PK, Zhao F, Spasojevic I, Grenier C, Huang Z, Murphy SK, McLendon RE, Friedman HS, Friedman AH, Herndon JE, Sampson JH, Keir ST, Bigner DD, Yan H, He Y. PMID: 31040154; PMCID: PMC6810595.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. Sci Rep. 2018 08 21; 8(1):12507. Lei K, Sun R, Chen LH, Diplas BH, Moure CJ, Wang W, Hansen LJ, Tao Y, Chen X, Chen CJ, Greer PK, Zhao F, Yan H, Bigner DD, Huang J, He Y. PMID: 30131529; PMCID: PMC6104024.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Nat Commun. 2018 05 25; 9(1):2087. Diplas BH, He X, Brosnan-Cashman JA, Liu H, Chen LH, Wang Z, Moure CJ, Killela PJ, Loriaux DB, Lipp ES, Greer PK, Yang R, Rizzo AJ, Rodriguez FJ, Friedman AH, Friedman HS, Wang S, He Y, McLendon RE, Bigner DD, Jiao Y, Waitkus MS, Meeker AK, Yan H. PMID: 29802247; PMCID: PMC5970234.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    10. Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. Cancer Res. 2017 11 15; 77(22):6097-6108. Yang R, Chen LH, Hansen LJ, Carpenter AB, Moure CJ, Liu H, Pirozzi CJ, Diplas BH, Waitkus MS, Greer PK, Zhu H, McLendon RE, Bigner DD, He Y, Yan H. PMID: 28939681; PMCID: PMC5690824.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression. Mol Cancer Res. 2017 05; 15(5):507-520. Pirozzi CJ, Carpenter AB, Waitkus MS, Wang CY, Zhu H, Hansen LJ, Chen LH, Greer PK, Feng J, Wang Y, Bock CB, Fan P, Spasojevic I, McLendon RE, Bigner DD, He Y, Yan H. PMID: 28148827; PMCID: PMC5415422.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    12. Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Nat Genet. 2014 Jul; 46(7):726-30. Zhang L, Chen LH, Wan H, Yang R, Wang Z, Feng J, Yang S, Jones S, Wang S, Zhou W, Zhu H, Killela PJ, Zhang J, Wu Z, Li G, Hao S, Wang Y, Webb JB, Friedman HS, Friedman AH, McLendon RE, He Y, Reitman ZJ, Bigner DD, Yan H. PMID: 24880341; PMCID: PMC4073211.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    13. SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women. J Biomed Sci. 2014 Mar 21; 21:24. Lai LC, Tsai MH, Chen PC, Chen LH, Hsiao JH, Chen SK, Lu TP, Lee JM, Hsu CP, Hsiao CK, Chuang EY. PMID: 24650256; PMCID: PMC3994426.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. Oncotarget. 2013 Nov; 4(11):2144-53. Guo C, Chen LH, Huang Y, Chang CC, Wang P, Pirozzi CJ, Qin X, Bao X, Greer PK, McLendon RE, Yan H, Keir ST, Bigner DD, He Y. PMID: 24240169; PMCID: PMC3875776.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    15. Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17603-8. Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. PMID: 23045699; PMCID: PMC3491484.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    16. Mutant IDH1 is required for IDH1 mutated tumor cell growth. Oncotarget. 2012 Aug; 3(8):774-82. Jin G, Pirozzi CJ, Chen LH, Lopez GY, Duncan CG, Feng J, Spasojevic I, Bigner DD, He Y, Yan H. PMID: 22885298; PMCID: PMC3478455.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    17. Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan. PLoS One. 2011; 6(11):e28222. Chen LH, Kuo WH, Tsai MH, Chen PC, Hsiao CK, Chuang EY, Chang LY, Hsieh FJ, Lai LC, Chang KJ. PMID: 22140552; PMCID: PMC3226667.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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