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Tumour-wide RNA splicing aberrations generate actionable public neoantigens. Nature. 2025 Mar; 639(8054):463-473.
Kwok DW, Stevers NO, Etxeberria I, Nejo T, Colton Cove M, Chen LH, Jung J, Okada K, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. PMID: 39972144; PMCID: PMC11903331.
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Interferon regulatory factor 8-driven reprogramming of the immune microenvironment enhances antitumor adaptive immunity and reduces immunosuppression in murine glioblastoma. Neuro Oncol. 2024 Dec 05; 26(12):2272-2287.
Montoya M, Collins SA, Chuntova P, Patel TS, Nejo T, Yamamichi A, Kasahara N, Okada H. PMID: 39115195; PMCID: PMC11630541.
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AnimalsCells
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Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier. Nat Commun. 2024 Sep 13; 15(1):8021.
Guo Y, Lee H, Kim C, Park C, Yamamichi A, Chuntova P, Gallus M, Bernabeu MO, Okada H, Jo H, Arvanitis C. PMID: 39271721; PMCID: PMC11399249.
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Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment. JCI Insight. 2024 Apr 08; 9(7).
Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H. PMID: 38386420; PMCID: PMC11128202.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma. bioRxiv. 2024 Apr 03.
Montoya M, Collins SA, Chuntova P, Patel TS, Nejo T, Yamamichi A, Kasahara N, Okada H. PMID: 38617245; PMCID: PMC11014587.
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Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Sci Rep. 2024 03 16; 14(1):6362.
Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 38493204; PMCID: PMC10944514.
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3 Fields:
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HumansCells
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Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. Cancers 2023, 15, 3726. Cancers (Basel). 2023 Dec 26; 16(1).
Gallus M, Kwok D, Lakshmanachetty S, Yamamichi A, Okada H. PMID: 38201665; PMCID: PMC10778241.
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Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment. bioRxiv. 2023 Nov 15.
Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H. PMID: 38014236; PMCID: PMC10680638.
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Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. bioRxiv. 2023 Nov 02.
Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 37961484; PMCID: PMC10634890.
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1
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Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens. bioRxiv. 2023 Oct 20.
Kwok DW, Stevers NO, Nejo T, Chen LH, Etxeberria I, Jung J, Okada K, Cove MC, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Wu SH, Ramos E, Yamamichi A, Liu J, Watchmaker P, Ogino H, Saijo A, Du A, Grishanina N, Woo J, Diaz A, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. PMID: 37904942; PMCID: PMC10614978.
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Glioma-neuronal circuit remodeling induces regional immunosuppression. bioRxiv. 2023 Aug 06.
Nejo T, Krishna S, Jimenez C, Yamamichi A, Young JS, Lakshmanachetty S, Chen T, Phyu SSS, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel AGS, Raleigh DR, Hervey-Jumper SL, Okada H. PMID: 37577659; PMCID: PMC10418167.
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Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. Cancers (Basel). 2023 Jul 22; 15(14).
Gallus M, Kwok D, Lakshmanachetty S, Yamamichi A, Okada H. PMID: 37509387; PMCID: PMC10378701.
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5
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Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Immisch et al. J Immunother Cancer. 2023 03; 11(3).
Chheda ZS, Mueller S, Hegde B, Yamamichi A, Butterfield LH, Okada H. PMID: 36944450; PMCID: PMC10032395.
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1 Fields:
Translation:
Humans
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Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma. Mol Ther Oncolytics. 2022 Sep 15; 26:265-274.
Chalise L, Kato A, Ohno M, Maeda S, Yamamichi A, Kuramitsu S, Shiina S, Takahashi H, Ozone S, Yamaguchi J, Kato Y, Rockenbach Y, Natsume A, Todo T. PMID: 35991754; PMCID: PMC9364057.
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28
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Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma. J Immunother Cancer. 2022 05; 10(5).
Chuntova P, Yamamichi A, Chen T, Narayanaswamy R, Ronseaux S, Hudson C, Tron AE, Hyer ML, Montoya M, Mende AL, Nejo T, Downey KM, Diebold D, Lu M, Nicolay B, Okada H. PMID: 35606087; PMCID: PMC9174833.
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11 Fields:
Translation:
HumansAnimalsCells
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Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice. Neuro Oncol. 2022 02 01; 24(2):259-272.
Chuntova P, Hou Y, Naka R, Yamamichi A, Chen T, Goretsky Y, Hatae R, Nejo T, Kohanbash G, Mende AL, Montoya M, Downey KM, Diebold D, Skinner J, Liang HE, Schwer B, Okada H. PMID: 34347086; PMCID: PMC8804899.
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5 Fields:
Translation:
AnimalsCells
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Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas. Brain Tumor Pathol. 2022 Jan; 39(1):14-24.
Nishikawa T, Watanabe R, Kitano Y, Yamamichi A, Motomura K, Ohka F, Aoki K, Hirano M, Kato A, Yamaguchi J, Maeda S, Kibe Y, Saito R, Wakabayashi T, Kato Y, Sato S, Ogino T, Natsume A, Ito I. PMID: 34826036.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Tumor antigens in glioma. Semin Immunol. 2020 02; 47:101385.
Nejo T, Yamamichi A, Almeida ND, Goretsky YE, Okada H. PMID: 32037183.
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26 Fields:
Translation:
HumansAnimals
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Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas. Cancer Res. 2019 Oct 01; 79(19):4814-4827.
Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y. PMID: 31431463.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma. Cell Rep. 2019 02 26; 26(9):2274-2281.e5.
Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A. PMID: 30811978.
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4 Fields:
Translation:
HumansAnimalsCells
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Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion. Brain Tumor Pathol. 2018 Apr; 35(2):106-113.
Yamamichi A, Ohka F, Aoki K, Suzuki H, Kato A, Hirano M, Motomura K, Tanahashi K, Chalise L, Maeda S, Wakabayashi T, Kato Y, Natsume A. PMID: 29550880.
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6 Fields:
Translation:
Humans
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A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR. Brain Tumor Pathol. 2018 Apr; 35(2):97-105.
Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A. PMID: 29460200.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Remote ischemic preconditioning protects human neural stem cells from oxidative stress. Apoptosis. 2017 Nov; 22(11):1353-1361.
Motomura A, Shimizu M, Kato A, Motomura K, Yamamichi A, Koyama H, Ohka F, Nishikawa T, Nishimura Y, Hara M, Fukuda T, Bando Y, Nishimura T, Wakabayashi T, Natsume A. PMID: 28951984.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma. Brain Tumor Pathol. 2017 Apr; 34(2):91-97.
Ohka F, Yamamichi A, Kurimoto M, Motomura K, Tanahashi K, Suzuki H, Aoki K, Deguchi S, Chalise L, Hirano M, Kato A, Nishimura Y, Hara M, Kato Y, Wakabayashi T, Natsume A. PMID: 28353033.
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5 Fields:
Translation:
Humans
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Adoptive immunotherapy for the treatment of glioblastoma: progress and possibilities. Immunotherapy. 2016 12; 8(12):1393-1404.
Kuramitsu S, Yamamichi A, Ohka F, Motomura K, Hara M, Natsume A. PMID: 28000534.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas. Sci Technol Adv Mater. 2016; 17(1):618-625.
Yamamichi A, Kasama T, Ohka F, Suzuki H, Kato A, Motomura K, Hirano M, Ranjit M, Chalise L, Kurimoto M, Kondo G, Aoki K, Kaji N, Tokeshi M, Matsubara T, Senga T, Kaneko MK, Suzuki H, Hara M, Wakabayashi T, Baba Y, Kato Y, Natsume A. PMID: 27877908; PMCID: PMC5101859.
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PubMed Mentions:
5
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CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains. Cancer Immunol Res. 2016 Mar; 4(3):259-68.
Shiina S, Ohno M, Ohka F, Kuramitsu S, Yamamichi A, Kato A, Motomura K, Tanahashi K, Yamamoto T, Watanabe R, Ito I, Senga T, Hamaguchi M, Wakabayashi T, Kaneko MK, Kato Y, Chandramohan V, Bigner DD, Natsume A. PMID: 26822025.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Rapid sensitive analysis of IDH1 mutation in lower-grade gliomas by automated genetic typing involving a quenching probe. Cancer Invest. 2016; 34(1):12-5.
Kurimoto M, Suzuki H, Aoki K, Ohka F, Kondo G, Motomura K, Iijima K, Yamamichi A, Ranjit M, Wakabayashi T, Kimura S, Natsume A. PMID: 26695622.
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PubMed Mentions:
2 Fields:
Translation:
Humans