Kevin Leung • UCSF Profiles

Kevin Leung, PhD

Title(s)	Associate Researcher, Pharmaceutical Chemistry
School	School of Pharmacy
Address	1700 4th St San Francisco CA 94158
ORCID	0000-0002-2087-4974
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nat Biotechnol. 2021 08; 39(8):928-935. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. PMID: 33767397.

View in: PubMed Mentions: 6 Fields:
Bio Biotechnology
Translation:Humans
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA. PMID: 33483421.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Humans Cells
Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2. MAbs. 2021 Jan-Dec; 13(1):1893426. Lim SA, Gramespacher JA, Pance K, Rettko NJ, Solomon P, Jin J, Lui I, Elledge SK, Liu J, Bracken CJ, Simmons G, Zhou XX, Leung KK, Wells JA. PMID: 33666135.

View in: PubMed Mentions: 3 Fields:
All Allergy and Immunology
Translation:Humans Cells
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 33093202.

View in: PubMed Mentions: 45 Fields:
Sci Science
Translation:Humans Animals Cells
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nat Chem Biol. 2021 01; 17(1):113-121. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium , Zhou XX, Leung KK, Wells JA. PMID: 33082574.

View in: PubMed Mentions: 17 Fields:
Bio Biology Che Chemistry
Translation:Humans Animals Cells
Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps. J Am Chem Soc. 2020 10 14; 142(41):17703-17713. Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA. PMID: 32924468.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Cells
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25464-25475. Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA. PMID: 32973096.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Humans Cells
Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding. mSphere. 2020 09 16; 5(5). Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk RP, Chiu CY, Wang TT, Wilson MR, Leung KK, Wells JA. PMID: 32938700.

View in: PubMed Mentions: 12 Fields:
Mic Microbiology Par Parasitology
Translation:Humans Cells PHPublic Health
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. medRxiv. 2020 Aug 21. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer N, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. PMID: 32839788.

View in: PubMed Mentions:
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. bioRxiv. 2020 Aug 10. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium , Zhou XX, Leung KK, Wells JA. PMID: 32817948.

View in: PubMed Mentions:
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 04. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586.

View in: PubMed Mentions:
A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding. medRxiv. 2020 May 29. Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk R, Chiu CY, Wilson MR, Leung KK, Wells JA. PMID: 32511506.

View in: PubMed Mentions:
Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer. Clin Cancer Res. 2020 07 15; 26(14):3608-3615. Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. PMID: 32341034.

View in: PubMed Mentions: 4 Fields:
Neo Neoplasms
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7764-7775. Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA. PMID: 32205440.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Humans Cells
Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. Mol Cell Proteomics. 2020 02; 19(2):294-307. Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. PMID: 31792071.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):695-700. Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA. PMID: 30584089.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Cells
Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. J Am Chem Soc. 2018 12 05; 140(48):16615-16624. Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. PMID: 30398859.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Translation:Humans Animals Cells
Flavin adenine dinucleotide content of quinone reductase 2: analysis and optimization for structure-function studies. Anal Biochem. 2012 Jan 01; 420(1):84-9. Leung KK, Litchfield DW, Shilton BH. PMID: 21971443.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Cells