Kevin Leung, PhD

Title(s)Full Researcher, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th Street, #503E
San Francisco CA 94158
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-2087-4974 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines. J Proteome Res. 2025 May 01. Lui I, Schaefer K, Kirkemo LL, Zhou J, Perera RM, Leung KK, Wells JA. PMID: 40312771.
      View in: PubMed   Mentions:    Fields:    
    2. Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome. Chem Rev. 2025 Apr 23; 125(8):4069-4110. Leung KK, Schaefer K, Lin Z, Yao Z, Wells JA. PMID: 40178992; PMCID: PMC12022999.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity. bioRxiv. 2025 Feb 25. Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA. PMID: 40060520; PMCID: PMC11888210.
      View in: PubMed   Mentions:
    4. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Sci Rep. 2024 03 16; 14(1):6362. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 38493204; PMCID: PMC10944514.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Nat Chem Biol. 2024 06; 20(6):742-750. Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA. PMID: 38308046; PMCID: PMC11142921.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells. ACS Cent Sci. 2024 Jan 24; 10(1):199-208. Bartholow TG, Burroughs PWW, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA. PMID: 38292613; PMCID: PMC10823516.
      View in: PubMed   Mentions: 2  
    7. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. bioRxiv. 2023 Nov 02. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 37961484; PMCID: PMC10634890.
      View in: PubMed   Mentions: 2  
    8. Site-specific proximity labeling at single residue resolution for identification of protein partners in vitro and on cells. bioRxiv. 2023 Jul 27. Bartholow TG, Burroughs P, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA. PMID: 37546992; PMCID: PMC10402114.
      View in: PubMed   Mentions:
    9. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J Am Chem Soc. 2023 05 10; 145(18):10015-10021. Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. PMID: 37104712; PMCID: PMC10176470.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer. Clin Cancer Res. 2023 04 03; 29(7):1232-1242. Chopra S, Trepka K, Sakhamuri S, Carretero-González A, Zhu J, Egusa E, Zhou J, Leung K, Zhao N, Hooshdaran N, Feng FY, Wells JA, Chou J, Evans MJ. PMID: 36648492; PMCID: PMC10073270.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure. 2023 03 02; 31(3):253-264.e6. Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural Biology Consortium, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA. PMID: 36805129; PMCID: PMC9936628.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. Using Split Luminescent Biosensors for SARS-CoV-2 Antibody Detection in Serum, Plasma, and Blood Samples. Curr Protoc. 2022 Oct; 2(10):e521. Elledge SK, Eigl I, Phelps M, McClinton K, Zhou XX, Leung KK, Tato CM, Wells JA. PMID: 36200787; PMCID: PMC9793882.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    13. Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. bioRxiv. 2022 Aug 10. Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural Biology Consortium, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA. PMID: 35982665; PMCID: PMC9387132.
      View in: PubMed   Mentions:
    14. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nat Commun. 2022 07 15; 13(1):4121. Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD, Mullins RD, Eyquem J, Wells JA, Wiita AP. PMID: 35840578; PMCID: PMC9287322.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    15. CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease. Clin Cancer Res. 2022 07 15; 28(14):3066-3075. Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Lim SA, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, Aggarwal R, Evans MJ. PMID: 35604681; PMCID: PMC9288514.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    16. Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation. Mol Cell Proteomics. 2022 07; 21(7):100247. Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA. PMID: 35594991; PMCID: PMC9212846.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. The Unusual Cosubstrate Specificity of NQO2: Conservation Throughout the Amniotes and Implications for Cellular Function. Front Pharmacol. 2022; 13:838500. Islam F, Leung KK, Walker MD, Al Massri S, Shilton BH. PMID: 35517822; PMCID: PMC9065289.
      View in: PubMed   Mentions: 3  
    18. Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. J Clin Invest. 2022 02 15; 132(4). Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA. PMID: 35166238; PMCID: PMC8843743.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    19. CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma. Sci Rep. 2022 01 27; 12(1):1464. Safaee MM, Wang EJ, Jain S, Chen JS, Gill S, Zheng AC, Garcia JH, Beniwal AS, Tran Y, Nguyen AT, Trieu M, Leung K, Wells J, Maclean JM, Wycoff K, Aghi MK. PMID: 35087132; PMCID: PMC8795421.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance. Front Immunol. 2021; 12:686439. Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, Zhou Y, Lee K, Leung KK, Skartsis N, Kaul AM, Mulder A, Claas FHJ, Wells JA, Bluestone JA, Tang Q. PMID: 34616392; PMCID: PMC8488356.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    21. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nat Biotechnol. 2021 08; 39(8):928-935. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. PMID: 33767397; PMCID: PMC8355051.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    22. Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA. PMID: 33483421; PMCID: PMC7848737.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2. MAbs. 2021 Jan-Dec; 13(1):1893426. Lim SA, Gramespacher JA, Pance K, Rettko NJ, Solomon P, Jin J, Lui I, Elledge SK, Liu J, Bracken CJ, Simmons G, Zhou XX, Leung KK, Wells JA. PMID: 33666135; PMCID: PMC7939556.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    24. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 33093202; PMCID: PMC7668070.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    25. Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nat Chem Biol. 2021 01; 17(1):113-121. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA. PMID: 33082574; PMCID: PMC8356808.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    26. Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps. J Am Chem Soc. 2020 10 14; 142(41):17703-17713. Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA. PMID: 32924468; PMCID: PMC8168474.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    27. Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25464-25475. Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA. PMID: 32973096; PMCID: PMC7568340.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    28. Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding. mSphere. 2020 09 16; 5(5). Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk RP, Chiu CY, Wang TT, Wilson MR, Leung KK, Wells JA. PMID: 32938700; PMCID: PMC7494835.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCellsPHPublic Health
    29. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer. Clin Cancer Res. 2020 07 15; 26(14):3608-3615. Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. PMID: 32341034; PMCID: PMC7367754.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    30. Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7764-7775. Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA. PMID: 32205440; PMCID: PMC7148585.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    31. Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. Mol Cell Proteomics. 2020 02; 19(2):294-307. Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. PMID: 31792071; PMCID: PMC7000124.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):695-700. Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA. PMID: 30584089; PMCID: PMC6329958.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    33. Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. J Am Chem Soc. 2018 12 05; 140(48):16615-16624. Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. PMID: 30398859.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    34. Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2. Biochemistry. 2015 Dec 29; 54(51):7438-48. Leung KK, Shilton BH. PMID: 26636353.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Quinone reductase 2 is an adventitious target of protein kinase CK2 inhibitors TBBz (TBI) and DMAT. Biochemistry. 2015 Jan 13; 54(1):47-59. Leung KK, Shilton BH. PMID: 25379648.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Chloroquine binding reveals flavin redox switch function of quinone reductase 2. J Biol Chem. 2013 Apr 19; 288(16):11242-51. Leung KK, Shilton BH. PMID: 23471972; PMCID: PMC3630856.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. Flavin adenine dinucleotide content of quinone reductase 2: analysis and optimization for structure-function studies. Anal Biochem. 2012 Jan 01; 420(1):84-9. Leung KK, Litchfield DW, Shilton BH. PMID: 21971443.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
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