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Joseph Costello, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 Third Street, #471
San Francisco CA 94158
Phone415-514-1183
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    Other Positions
    Title(s)Karen Osney Brownstein Chair in Molecular Neuro-Oncology

    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    3-D spatial approach to discover genomic effectors of immunosuppression during malignant transformation
    NIH R01CA244838Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Global Analyses of the Placental Epigenome in Preeclampsia
    NIH R01HD092419Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Antigens for Molecularly Targeted Vaccines for Progressive Glioma
    NIH R21NS093654Jul 1, 2015 - Jun 30, 2018
    Role: Co-Principal Investigator
    Imaging Guided Genomics of Malignant Transformation
    NIH R01CA169316Apr 8, 2013 - Mar 31, 2019
    Role: Principal Investigator
    Training Program in Translational Brain Tumor Research
    NIH T32CA151022Sep 1, 2010 - Aug 31, 2025
    Role: Principal Investigator
    Integrated Epigenetic Maps of Human Embryonic and Adult Cells
    NIH U01ES017154Sep 30, 2008 - Jun 30, 2014
    Role: Principal Investigator
    Noninvasive Metabolic Signatures to Improve Management of Molecular Subtypes of Glioma
    NIH P01CA118816Dec 1, 2005 - Jul 31, 2024
    Role: Co-Investigator
    CONVERGENT MECHANISMS CONTRIBUTING TO CANCER
    NIH R01CA094971Apr 1, 2002 - Sep 30, 2007
    Role: Principal Investigator
    Center Core Grant for Vision Research
    NIH P30EY005722Mar 1, 1985 - Aug 31, 2021
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR002172Jan 1, 1983 - Mar 31, 2009
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 3D spatial sampling to quantify morphologic heterogeneity in isocitrate dehydrogenase-wildtype glioblastoma. J Neuropathol Exp Neurol. 2025 Sep 03. Voong V, Beccari S, Hashemi E, Kriener B, Mathur R, Lafontaine M, Shai A, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Waszak SM, Costello JF, Phillips JJ. PMID: 40901714.
      View in: PubMed   Mentions:    Fields:    
    2. Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas. bioRxiv. 2025 Jul 15. Chowdhury T, Tesileanu CMS, Kocakavuk E, Johnson KC, Lee J, Erson-Omay Z, Heo C, Aldape K, Amin SB, Anderson KJ, Ashley DM, Barnholtz-Sloan JS, Brat DJ, Brodbelt AR, Castro AV, Claus EB, Connelly JM, Costello J, Datta I, Elliott C, Finocchiaro G, French PJ, Gan HK, Garofano L, Ghospurkar PL, Golebiewska A, Gundla PS, Hermes B, Hong C, Hoogstrate Y, Horbinski C, Huse JT, Iavarone A, Karadag C, Khasraw M, Kouwenhoven MC, LaViolette PS, Li K, Lowman A, McCortney K, Moon HE, Nader S, Nasrallah MP, Ng HK, Ormond DR, Padovan M, Paek SH, Poisson LM, Puri S, Shen E, Shwetal M, Sloan AE, Vallentgoed WR, Van Meir EG, Vaubel R, Wade T, Walenkamp AM, Watts C, Weiss T, Weller M, Wesseling P, Westcott K, Westerman B, Ye GY, Yung WKA, GLASS Consortium, Varn FS, Verhaak RG. PMID: 40791422; PMCID: PMC12338597.
      View in: PubMed   Mentions:
    3. The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible. Mol Cell. 2025 Jun 19; 85(12):2337-2354.e9. Stevers NO, Kim S, Yuan JB, Barger CJ, Hong C, Lenzo O, McKinney AM, Wu SH, Lee YJ, Kwok DW, Suwala AK, Appin CL, Gordan JD, Molinaro AM, Song JS, Costello JF. PMID: 40513567; PMCID: PMC12302846.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies. Nat Commun. 2025 Mar 14; 16(1):2543. Meade RD, Akerman AP, Notley SR, McGarr GW, McCourt ER, Kirby NV, Costello JT, Cotter JD, Crandall CG, Zanobetti A, Kenny GP. PMID: 40087302; PMCID: PMC11909281.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples. Sci Adv. 2025 Mar 14; 11(11):eadn2830. Wang Q, Wang J, Mathur R, Youngblood MW, Jin Q, Hou Y, Stasiak LA, Luan Y, Zhao H, Hilz S, Hong C, Chang SM, Lupo JM, Phillips JJ, Costello JF, Yue F. PMID: 40073147; PMCID: PMC11900876.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Tumour-wide RNA splicing aberrations generate actionable public neoantigens. Nature. 2025 Mar; 639(8054):463-473. Kwok DW, Stevers NO, Etxeberria I, Nejo T, Colton Cove M, Chen LH, Jung J, Okada K, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. PMID: 39972144; PMCID: PMC11903331.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    7. Leveraging passive exercise to support brain health. Br J Sports Med. 2025 Feb 03; 59(3):143-145. Tari B, Heath M, Herold F, Cheval B, Ronca F, Etnier JL, Costello JT, Logan NE, Cully M, Zou L. PMID: 39653430.
      View in: PubMed   Mentions: 1     Fields:    
    8. Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf024. Rodriguez Almaraz E, Guerra GA, Al-Adli NN, Young JS, Dada A, Quintana D, Taylor JW, Oberheim Bush NA, Clarke JL, Butowski NA, de Groot J, Pekmezci M, Perry A, Bollen AW, Scheffler AW, Glidden DV, Phillips JJ, Costello JF, Chang EF, Hervey-Jumper S, Berger MS, Francis SS, Chang SM, Solomon DA. PMID: 40051658; PMCID: PMC11883348.
      View in: PubMed   Mentions:
    9. Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses. Neuro Oncol. 2025 Jan 12; 27(1):89-105. Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA. PMID: 39560080; PMCID: PMC11726253.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Caring for Post-9/11 Veterans in the Civilian Sector: Knowledge and Readiness of Registered and Advance Practice Nurse Providers. J Mil Veterans Health. 2024 Oct; 32(4):18-36. Simoni C, Costello J, Blanchette L, Ratliff J, Bith-Melander P, Jindal C, Cassidy KJ, Choi YM, Kronsteadt S, Efird J. PMID: 39777140; PMCID: PMC11706512.
      View in: PubMed   Mentions:
    11. Activating the dark genome to illuminate cancer vaccine targets. Nat Genet. 2024 Sep; 56(9):1770-1771. Kwok DW, Okada H, Costello JF. PMID: 39223317; PMCID: PMC11456370.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Functional Electrical Stimulation and Brain-Machine Interfaces for Simultaneous Control of Wrist and Finger Flexion. bioRxiv. 2024 Aug 12. Mender MJ, Ward AL, Cubillos LH, Kelberman MM, Costello JT, Temmar H, Wallace DM, Lin ET, Lam JLW, Willsey MS, Ganesh Kumar N, Kung TA, Patil PG, Chestek CA. PMID: 39211094; PMCID: PMC11361090.
      View in: PubMed   Mentions:
    13. Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections. Cancers (Basel). 2024 Jul 01; 16(13). Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC. PMID: 39001492; PMCID: PMC11240479.
      View in: PubMed   Mentions: 2  
    14. Telomeres in glioma: Maintenance mechanisms to therapeutic potential. Neuro Oncol. 2024 06 03; 26(6):1025-1026. Stevers NO, Costello JF. PMID: 38466631; PMCID: PMC11145438.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. Human dopaminergic system in the exercise-cognition link. Trends Mol Med. 2024 Aug; 30(8):708-712. Hou M, Herold F, Zhang Z, Ando S, Cheval B, Ludyga S, Erickson KI, Hillman CH, Yu Q, Liu-Ambrose T, Kuang J, Kramer AF, Chen Y, Costello JT, Chen C, Dupuy O, Pindus DM, McMorris T, Stiernman L, Zou L. PMID: 38719712.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    16. Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma. Mod Pathol. 2024 Jun; 37(6):100488. Beccari S, Mohamed E, Voong V, Hilz S, Lafontaine M, Shai A, Lim Y, Martinez J, Switzman B, Yu RL, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Costello JF, Phillips JJ. PMID: 38588881.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Whole tumor analysis reveals early origin of the TERT promoter mutation and intercellular heterogeneity in TERT expression. Neuro Oncol. 2024 04 05; 26(4):640-652. Appin CL, Hong C, Suwala AK, Hilz S, Mathur R, Solomon DA, Smirnov IV, Stevers NO, Shai A, Wang A, Berger MS, Chang SM, Phillips JJ, Costello JF. PMID: 38141254; PMCID: PMC10995505.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections. bioRxiv. 2024 Mar 18. Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC. PMID: 37645893; PMCID: PMC10461981.
      View in: PubMed   Mentions:
    19. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Sci Rep. 2024 03 16; 14(1):6362. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 38493204; PMCID: PMC10944514.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Artificial neural network for brain-machine interface consistently produces more naturalistic finger movements than linear methods. bioRxiv. 2024 Mar 05. Temmar H, Willsey MS, Costello JT, Mender MJ, Cubillos LH, Lam JL, Wallace DM, Kelberman MM, Patil PG, Chestek CA. PMID: 38496403; PMCID: PMC10942378.
      View in: PubMed   Mentions:
    21. Striking up a Conversation: Exploring Advising in Graduate Programs in Health Professions Education. Mil Med. 2024 Jan 23; 189(1-2):e21-e26. Elliott SA, Schermerhorn J, Durning S, Costello J, Norton C, Meyer H. PMID: 37074123.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective. Cell. 2024 01 18; 187(2):446-463.e16. Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF. PMID: 38242087; PMCID: PMC10832360.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    23. "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade. Acta Neuropathol. 2023 12 11; 147(1):3. Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA. PMID: 38079020; PMCID: PMC10713691.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    24. Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs. Neuro Oncol. 2023 12 08; 25(12):2221-2236. Williams EA, Ravindranathan A, Gupta R, Stevers NO, Suwala AK, Hong C, Kim S, Yuan JB, Wu J, Barreto J, Lucas CG, Chan E, Pekmezci M, LeBoit PE, Mully T, Perry A, Bollen A, Van Ziffle J, Devine WP, Reddy AT, Gupta N, Basnet KM, Macaulay RJB, Malafronte P, Lee H, Yong WH, Williams KJ, Juratli TA, Mata DA, Huang RSP, Hiemenz MC, Pavlick DC, Frampton GM, Janovitz T, Ross JS, Chang SM, Berger MS, Jacques L, Song JS, Costello JF, Solomon DA. PMID: 37436963; PMCID: PMC10708934.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. The effects of sleep deprivation, acute hypoxia, and exercise on cognitive performance: A multi-experiment combined stressors study. Physiol Behav. 2024 Feb 01; 274:114409. Williams TB, Badariotti JI, Corbett J, Miller-Dicks M, Neupert E, McMorris T, Ando S, Parker MO, Thelwell RC, Causer AJ, Young JS, Mayes HS, White DK, de Carvalho FA, Tipton MJ, Costello JT. PMID: 37977251.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. bioRxiv. 2023 Nov 02. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 37961484; PMCID: PMC10634890.
      View in: PubMed   Mentions: 2  
    27. Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens. bioRxiv. 2023 Oct 20. Kwok DW, Stevers NO, Nejo T, Chen LH, Etxeberria I, Jung J, Okada K, Cove MC, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Wu SH, Ramos E, Yamamichi A, Liu J, Watchmaker P, Ogino H, Saijo A, Du A, Grishanina N, Woo J, Diaz A, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. PMID: 37904942; PMCID: PMC10614978.
      View in: PubMed   Mentions:
    28. Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review. J Physiol Sci. 2023 10 17; 73(1):26. Corbett J, Young JS, Tipton MJ, Costello JT, Williams TB, Walker EF, Lee BJ, Stevens CE. PMID: 37848829; PMCID: PMC10717221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Balancing Memorization and Generalization in RNNs for High Performance Brain-Machine Interfaces. bioRxiv. 2023 May 28. Costello JT, Temmar H, Cubillos LH, Mender MJ, Wallace DM, Willsey MS, Patil PG, Chestek CA. PMID: 37292755; PMCID: PMC10245969.
      View in: PubMed   Mentions: 1  
    30. Peroxisomes : novel findings and future directions. Histochem Cell Biol. 2023 May; 159(5):379-387. Pedrosa AG, Reglinski K, Lismont C, Kors S, Costello J, Rodrigues TA, Marques M, Linka N, Argyriou C, Weinhofer I, Kocherlakota S, Riccio V, Ferreira V, Di Cara F, Ferreira AR, Francisco T, Azevedo JE, Ribeiro D. PMID: 37160800; PMCID: PMC10170047.
      View in: PubMed   Mentions: 1     Fields:    
    31. Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance. Clin Cancer Res. 2023 05 01; 29(9):1763-1782. Carney SV, Banerjee K, Mujeeb A, Zhu B, Haase S, Varela ML, Kadiyala P, Tronrud CE, Zhu Z, Mukherji D, Gorla P, Sun Y, Tagett R, Núñez FJ, Luo M, Luo W, Ljungman M, Liu Y, Xia Z, Schwendeman A, Qin T, Sartor MA, Costello JF, Cahill DP, Lowenstein PR, Castro MG. PMID: 36692427; PMCID: PMC10159884.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Hyperpolarized δ-[1- 13C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma. Sci Rep. 2023 03 30; 13(1):5190. Minami N, Hong D, Taglang C, Batsios G, Gillespie AM, Viswanath P, Stevers N, Barger CJ, Costello JF, Ronen SM. PMID: 36997627; PMCID: PMC10063634.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects. J Clin Invest. 2023 03 01; 133(5). Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK. PMID: 36856115; PMCID: PMC9974099.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    34. Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro Oncol. 2023 01 05; 25(1):4-25. Miller JJ, Gonzalez Castro LN, McBrayer S, Weller M, Cloughesy T, Portnow J, Andronesi O, Barnholtz-Sloan JS, Baumert BG, Berger MS, Bi WL, Bindra R, Cahill DP, Chang SM, Costello JF, Horbinski C, Huang RY, Jenkins RB, Ligon KL, Mellinghoff IK, Nabors LB, Platten M, Reardon DA, Shi DD, Schiff D, Wick W, Yan H, von Deimling A, van den Bent M, Kaelin WG, Wen PY. PMID: 36239925; PMCID: PMC9825337.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    35. TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022 12 01; 24(12):2063-2075. Miki S, Koga T, Mckinney AM, Parisian AD, Tadokoro T, Vadla R, Marsala M, Hevner RF, Costello JF, Furnari F. PMID: 35325218; PMCID: PMC9713509.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. Real-time brain-machine interface in non-human primates achieves high-velocity prosthetic finger movements using a shallow feedforward neural network decoder. Nat Commun. 2022 11 12; 13(1):6899. Willsey MS, Nason-Tomaszewski SR, Ensel SR, Temmar H, Mender MJ, Costello JT, Patil PG, Chestek CA. PMID: 36371498; PMCID: PMC9653378.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    37. Editorial: "Molecular mechanisms and physiological significance of organelle interactions and cooperation-Volume II". Front Cell Dev Biol. 2022; 10:1076670. Costello J, Islinger M, Schrader M. PMID: 36425529; PMCID: PMC9679776.
      View in: PubMed   Mentions:
    38. Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma. Neuro Oncol. 2022 11 02; 24(11):1898-1910. Minami N, Hong D, Stevers N, Barger CJ, Radoul M, Hong C, Chen L, Kim Y, Batsios G, Gillespie AM, Pieper RO, Costello JF, Viswanath P, Ronen SM. PMID: 35460557; PMCID: PMC9629440.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    39. GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. Cell Rep. 2022 09 20; 40(12):111344. McKinney AM, Mathur R, Stevers NO, Molinaro AM, Chang SM, Phillips JJ, Costello JF. PMID: 36130485; PMCID: PMC9534059.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    40. Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer. Nat Commun. 2022 09 16; 13(1):5430. Barger CJ, Suwala AK, Soczek KM, Wang AS, Kim MY, Hong C, Doudna JA, Chang SM, Phillips JJ, Solomon DA, Costello JF. PMID: 36114166; PMCID: PMC9481613.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    41. PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications. Neuro Oncol. 2022 09 01; 24(9):1471-1481. Mohamed E, Kumar A, Zhang Y, Wang AS, Chen K, Lim Y, Shai A, Taylor JW, Clarke J, Hilz S, Berger MS, Solomon DA, Costello JF, Molinaro AM, Phillips JJ. PMID: 35287169; PMCID: PMC9435510.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    42. Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer. Clin Cancer Res. 2022 08 15; 28(16):3526-3536. Batsios G, Taglang C, Tran M, Stevers N, Barger C, Gillespie AM, Ronen SM, Costello JF, Viswanath P. PMID: 35679032; PMCID: PMC9378519.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    43. Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1. Acta Neuropathol. 2022 10; 144(4):747-765. Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA. PMID: 35945463; PMCID: PMC9468105.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    44. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. PMID: 35534562; PMCID: PMC9374001.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    45. Cognitive Improvement After Aerobic and Resistance Exercise Is Not Associated With Peripheral Biomarkers. Front Behav Neurosci. 2022; 16:853150. Ando S, Komiyama T, Tanoue Y, Sudo M, Costello JT, Uehara Y, Higaki Y. PMID: 35368295; PMCID: PMC8967356.
      View in: PubMed   Mentions: 7  
    46. Spatial concordance of DNA methylation classification in diffuse glioma. Neuro Oncol. 2021 12 01; 23(12):2054-2065. Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, Hoekstra OS, Lammertsma AA, Barkhof F, Pouwels PJW, Reijneveld JC, Rozemuller AJM, Beliën JAM, Boellaard R, Taylor MD, Das S, Costello JF, Vandertop WP, Wesseling P, de Witt Hamer PC, Verhaak RGW. PMID: 34049406; PMCID: PMC8643482.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
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    48. Publisher Correction: Epigenomic contributions to tumor cell heterogeneity and plasticity. Nat Genet. 2021 Nov; 53(11):1622. Mathur R, Costello JF. PMID: 34671124.
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    52. Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease. Dev Cell. 2021 05 03; 56(9):1238-1252.e5. Zhang B, Kim MY, Elliot G, Zhou Y, Zhao G, Li D, Lowdon RF, Gormley M, Kapidzic M, Robinson JF, McMaster MT, Hong C, Mazor T, Hamilton E, Sears RL, Pehrsson EC, Marra MA, Jones SJM, Bilenky M, Hirst M, Wang T, Costello JF, Fisher SJ. PMID: 33891899; PMCID: PMC8650129.
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    147. The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res. 2011 Apr 01; 17(7):2014-23. Leng S, Bernauer AM, Hong C, Do KC, Yingling CM, Flores KG, Tessema M, Tellez CS, Willink RP, Burki EA, Picchi MA, Stidley CA, Prados MD, Costello JF, Gilliland FD, Crowell RE, Belinsky SA. PMID: 21355081; PMCID: PMC3070839.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    148. Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes. PLoS One. 2011 Feb 15; 6(2):e17121. Blahnik KR, Dou L, Echipare L, Iyengar S, O'Geen H, Sanchez E, Zhao Y, Marra MA, Hirst M, Costello JF, Korf I, Farnham PJ. PMID: 21347206; PMCID: PMC3039671.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    149. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol. 2010 Oct; 28(10):1045-8. Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A, Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, Farnham PJ, Hirst M, Lander ES, Mikkelsen TS, Thomson JA. PMID: 20944595; PMCID: PMC3607281.
      View in: PubMed   Mentions: 1096     Fields:    Translation:HumansCells
    150. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010 Oct; 28(10):1097-105. Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, Johnson BE, Fouse SD, Delaney A, Zhao Y, Olshen A, Ballinger T, Zhou X, Forsberg KJ, Gu J, Echipare L, O'Geen H, Lister R, Pelizzola M, Xi Y, Epstein CB, Bernstein BE, Hawkins RD, Ren B, Chung WY, Gu H, Bock C, Gnirke A, Zhang MQ, Haussler D, Ecker JR, Li W, Farnham PJ, Waterland RA, Meissner A, Marra MA, Hirst M, Milosavljevic A, Costello JF. PMID: 20852635; PMCID: PMC2955169.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansCells
    151. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature. 2010 Jul 08; 466(7303):253-7. Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF. PMID: 20613842; PMCID: PMC3998662.
      View in: PubMed   Mentions: 910     Fields:    Translation:HumansAnimalsCells
    152. A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell. 2010 Apr 13; 17(4):362-75. Chen R, Nishimura MC, Bumbaca SM, Kharbanda S, Forrest WF, Kasman IM, Greve JM, Soriano RH, Gilmour LL, Rivers CS, Modrusan Z, Nacu S, Guerrero S, Edgar KA, Wallin JJ, Lamszus K, Westphal M, Heim S, James CD, VandenBerg SR, Costello JF, Moorefield S, Cowdrey CJ, Prados M, Phillips HS. PMID: 20385361.
      View in: PubMed   Mentions: 292     Fields:    Translation:HumansCells
    153. Genome-scale DNA methylation analysis. Epigenomics. 2010 Feb; 2(1):105-17. Fouse SD, Nagarajan RO, Costello JF. PMID: 20657796; PMCID: PMC2907108.
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    154. Epigenetic inactivation of the miR-34a in hematological malignancies. Carcinogenesis. 2010 Apr; 31(4):745-50. Chim CS, Wong KY, Qi Y, Loong F, Lam WL, Wong LG, Jin DY, Costello JF, Liang R. PMID: 20118199.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    155. Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res. 2010 Jan 15; 70(2):453-62. Costa BM, Smith JS, Chen Y, Chen J, Phillips HS, Aldape KD, Zardo G, Nigro J, James CD, Fridlyand J, Reis RM, Costello JF. PMID: 20068170; PMCID: PMC2849935.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    156. Epigenetics of neurological cancers. Future Oncol. 2009 Dec; 5(10):1615-29. Fouse SD, Costello JF. PMID: 20001799; PMCID: PMC4018230.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    157. A first look at entire human methylomes. Nat Biotechnol. 2009 Dec; 27(12):1130-2. Costello JF, Krzywinski M, Marra MA. PMID: 20010593.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    158. The transversus abdominis plane block, when used as part of a multimodal regimen inclusive of intrathecal morphine, does not improve analgesia after cesarean delivery. Reg Anesth Pain Med. 2009 Nov-Dec; 34(6):586-9. Costello JF, Moore AR, Wieczorek PM, Macarthur AJ, Balki M, Carvalho JC. PMID: 19916252.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    159. Molecular epigenetics and genetics in neuro-oncology. Neurotherapeutics. 2009 Jul; 6(3):436-46. Nagarajan RP, Costello JF. PMID: 19560734; PMCID: PMC3981537.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    160. Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol. 2009 Jun; 19(3):188-97. Nagarajan RP, Costello JF. PMID: 19429483.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    161. Food allergy is associated with an increased risk of asthma. Clin Exp Allergy. 2009 Feb; 39(2):261-70. Schroeder A, Kumar R, Pongracic JA, Sullivan CL, Caruso DM, Costello J, Meyer KE, Vucic Y, Gupta R, Kim JS, Fuleihan R, Wang X. PMID: 19187334; PMCID: PMC2922978.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    162. Restriction landmark genomic scanning: analysis of CpG islands in genomes by 2D gel electrophoresis. Methods Mol Biol. 2009; 507:131-48. Costello JF, Hong C, Plass C, Smiraglia DJ. PMID: 18987812.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    163. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. Neuro Oncol. 2009 Aug; 11(4):414-22. Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF. PMID: 19001526; PMCID: PMC2743221.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    164. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy. 2009 Jan; 39(1):101-9. Tsai HJ, Kumar R, Pongracic J, Liu X, Story R, Yu Y, Caruso D, Costello J, Schroeder A, Fang Y, Demirtas H, Meyer KE, O'Gorman MR, Wang X. PMID: 19016802; PMCID: PMC2729087.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    165. Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res. 2008 Oct 01; 68(19):8094-103. Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. PMID: 18829568; PMCID: PMC2744404.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    166. Cesarean delivery under ultrasound-guided spinal anesthesia [corrected] in a parturient with poliomyelitis and Harrington instrumentation. Can J Anaesth. 2008 Sep; 55(9):606-11. Costello JF, Balki M. PMID: 18840590.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    167. Stem cells: Tips for priming potency. Nature. 2008 Jul 03; 454(7200):45-6. Costello JF. PMID: 18596797.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    168. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. PMID: 18577219; PMCID: PMC2443372.
      View in: PubMed   Mentions: 495     Fields:    Translation:HumansAnimalsCells
    169. Transversus abdominis plane block in a patient with debilitating pain from an abdominal wall hematoma following cesarean delivery. Anesth Analg. 2008 Jun; 106(6):1928. Randall IM, Costello J, Carvalho JC. PMID: 18499643.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    170. A sequence-based survey of the complex structural organization of tumor genomes. Genome Biol. 2008; 9(3):R59. Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta KJ, Mills GB, Bajsarowicz K, Kobayashi Y, Sridharan S, Paris PL, Tao Q, Aerni SJ, Brown RP, Bashir A, Gray JW, Cheng JF, de Jong P, Nefedov M, Ried T, Padilla-Nash HM, Collins CC. PMID: 18364049; PMCID: PMC2397511.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    171. Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations. BMC Genomics. 2007 Nov 30; 8:446. Smiraglia DJ, Kazhiyur-Mannar R, Oakes CC, Wu YZ, Liang P, Ansari T, Su J, Rush LJ, Smith LT, Yu L, Liu C, Dai Z, Chen SS, Wang SH, Costello J, Ioshikhes I, Dawson DW, Hong JS, Teitell MA, Szafranek A, Camoriano M, Song F, Elliott R, Held W, Trasler JM, Plass C, Wenger R. PMID: 18053125; PMCID: PMC2235865.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    172. Molecular signatures define two main classes of meningiomas. Mol Cancer. 2007 Oct 15; 6:64. Carvalho LH, Smirnov I, Baia GS, Modrusan Z, Smith JS, Jun P, Costello JF, McDermott MW, Vandenberg SR, Lal A. PMID: 17937814; PMCID: PMC2173907.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    173. Identification of DNA methylation in 3' genomic regions that are associated with upregulation of gene expression in colorectal cancer. Epigenetics. 2007 Sep; 2(3):161-72. Smith JF, Mahmood S, Song F, Morrow A, Smiraglia D, Zhang X, Rajput A, Higgins MJ, Krumm A, Petrelli NJ, Costello JF, Nagase H, Plass C, Held WA. PMID: 17965620.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    174. Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10974-9. Hong C, Moorefield KS, Jun P, Aldape KD, Kharbanda S, Phillips HS, Costello JF. PMID: 17578925; PMCID: PMC1904113.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    175. Genome-epigenome interactions in cancer. Hum Mol Genet. 2007 Apr 15; 16 Spec No 1:R96-105. Brena RM, Costello JF. PMID: 17613554.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    176. Mining methylation for early detection of common cancers. PLoS Med. 2006 Dec; 3(12):e479. Brena RM, Plass C, Costello JF. PMID: 17194184; PMCID: PMC1762083.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    177. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res. 2006 Sep 01; 66(17):8469-76. Cadieux B, Ching TT, VandenBerg SR, Costello JF. PMID: 16951158.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    178. Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem. 2006 Aug 25; 281(34):24790-802. Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. PMID: 16766534.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    179. A broad band of silence. Nat Genet. 2006 May; 38(5):504-6. Smith JS, Costello JF. PMID: 16642011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    180. DNA motifs associated with aberrant CpG island methylation. Genomics. 2006 May; 87(5):572-9. Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM. PMID: 16487676.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    181. Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer. Genet Test. 2006; 10(4):281-4. Chen Y, Toland AE, McLennan J, Fridlyand J, Crawford B, Costello JF, Ziegler JL. PMID: 17253935.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    182. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res. 2005 Jun 15; 65(12):5070-5. Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW, Lal A. PMID: 15958550.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    183. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005 Jun; 37(6):645-51. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. PMID: 15895082.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    184. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 01; 65(9):3617-23. Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. PMID: 15867356.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    185. Comparative epigenomics of leukemia. Nat Genet. 2005 Mar; 37(3):211-2. Costello JF. PMID: 15731751.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    186. Phosphatase and tensin homologue growth suppression without phosphatase. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2677-8. Stokoe D, Costello JF. PMID: 15710873; PMCID: PMC549471.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    187. The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. Cancer Res. 2003 Nov 15; 63(22):7600-5. Hong C, Bollen AW, Costello JF. PMID: 14633674.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    188. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14133-8. He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM. PMID: 14617776; PMCID: PMC283558.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCells
    189. Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12253-8. Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM. PMID: 14519846; PMCID: PMC218745.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    190. DNA methylation in brain development and gliomagenesis. Front Biosci. 2003 Jan 01; 8:s175-84. Costello JF. PMID: 12456310.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    191. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet. 2002 Nov; 32(3):453-8. Zardo G, Tiirikainen MI, Hong C, Misra A, Feuerstein BG, Volik S, Collins CC, Lamborn KR, Bollen A, Pinkel D, Albertson DG, Costello JF. PMID: 12355068.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    192. Methylation matters: a new spin on maspin. Nat Genet. 2002 Jun; 31(2):123-4. Costello JF, Vertino PM. PMID: 12040372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    193. Restriction landmark genome scanning. Methods. 2002 Jun; 27(2):144-9. Costello JF, Smiraglia DJ, Plass C. PMID: 12095273.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    194. Restriction landmark genome scanning. Methods Mol Biol. 2002; 200:53-70. Costello JF, Plass C, Cavenee WK. PMID: 11951655.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    195. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum Mol Genet. 2001 Jun 15; 10(13):1413-9. Smiraglia DJ, Rush LJ, Frühwald MC, Dai Z, Held WA, Costello JF, Lang JC, Eng C, Li B, Wright FA, Caligiuri MA, Plass C. PMID: 11440994.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    196. Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci. Blood. 2001 May 15; 97(10):3226-33. Rush LJ, Dai Z, Smiraglia DJ, Gao X, Wright FA, Frühwald M, Costello JF, Held WA, Yu L, Krahe R, Kolitz JE, Bloomfield CD, Caligiuri MA, Plass C. PMID: 11342453.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    197. Methylation matters. J Med Genet. 2001 May; 38(5):285-303. Costello JF, Plass C. PMID: 11333864; PMCID: PMC1734882.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    198. Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon. J Med Genet. 2000 Jul; 37(7):501-9. Frühwald MC, O'Dorisio MS, Rush LJ, Reiter JL, Smiraglia DJ, Wenger G, Costello JF, White PS, Krahe R, Brodeur GM, Plass C. PMID: 10882752; PMCID: PMC1734623.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    199. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet. 2000 Feb; 24(2):132-8. Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK, Plass C. PMID: 10655057.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansCells
    200. Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathol. 2000; 17(2):49-56. Costello JF, Plass C, Cavenee WK. PMID: 11210171.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    201. A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels. Genomics. 1999 Jun 15; 58(3):254-62. Smiraglia DJ, Frühwald MC, Costello JF, McCormick SP, Dai Z, Peltomäki P, O'Dorisio MS, Cavenee WK, Plass C. PMID: 10373323.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    202. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 1999 Feb 15; 59(4):798-802. Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. PMID: 10029065.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    203. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol. 1997 Sep; 17(9):5612-9. Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. PMID: 9271436; PMCID: PMC232409.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    204. An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis. DNA Res. 1997 Jun 30; 4(3):253-5. Plass C, Weichenhan D, Catanese J, Costello JF, Yu F, Yu L, Smiraglia D, Cavenee WK, Caligiuri MA, deJong P, Held WA. PMID: 9330914.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    205. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 1997 Apr 01; 57(7):1250-4. Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Su Huang HJ, Cavenee WK. PMID: 9102208.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    206. Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene. J Biol Chem. 1996 Jun 07; 271(23):13916-24. Pieper RO, Patel S, Ting SA, Futscher BW, Costello JF. PMID: 8662860.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    207. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 1996 May 15; 56(10):2405-10. Costello JF, Berger MS, Huang HS, Cavenee WK. PMID: 8625319.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    208. O6-methylguanine-DNA methyltransferase in tumors and cells of the oligodendrocyte lineage. Can J Neurol Sci. 1995 May; 22(2):111-5. Nutt CL, Costello JF, Bambrick LL, Yarosh DB, Swinnen LJ, Chambers AF, Cairncross JG. PMID: 7627911.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    209. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Mol Cell Biol. 1994 Oct; 14(10):6515-21. Costello JF, Futscher BW, Kroes RA, Pieper RO. PMID: 7523853; PMCID: PMC359181.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    210. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem. 1994 Jun 24; 269(25):17228-37. Costello JF, Futscher BW, Tano K, Graunke DM, Pieper RO. PMID: 8006031.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    211. Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene. Cancer Commun. 1991 Aug; 3(8):241-53. Pieper RO, Costello JF, Kroes RA, Futscher BW, Marathi U, Erickson LC. PMID: 1716139.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    212. Bombesin immunoreactive neurons in the hypothalamic paraventricular nucleus innervate the dorsal vagal complex in the rat. Brain Res. 1991 Feb 22; 542(1):77-82. Costello JF, Brown MR, Gray TS. PMID: 2054661.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    213. Metropolitan forensic anthropology team (MFAT) case studies in identification: 3. Identification of John J. Sullivan, the missing journalist. J Forensic Sci. 1985 Jan; 30(1):221-31. Zugibe FT, Taylor J, Weg N, DiBennerdo R, Costello JT, DeForest P. PMID: 3981113.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    214. Glucose utilization and production by the dog kidney in vivo in metabolic acidosis and alkalosis. J Clin Invest. 1973 Mar; 52(3):608-11. Costello J, Scott JM, Wilson P, Bourke E. PMID: 4685085; PMCID: PMC302299.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
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