Joseph Costello, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 Third Street, #471
San Francisco CA 94158
Phone415-514-1183
PronounsHe/Him/His
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    3-D spatial approach to discover genomic effectors of immunosuppression during malignant transformation
    NIH R01CA244838Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Global Analyses of the Placental Epigenome in Preeclampsia
    NIH R01HD092419Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Antigens for Molecularly Targeted Vaccines for Progressive Glioma
    NIH R21NS093654Jul 1, 2015 - Jun 30, 2018
    Role: Co-Principal Investigator
    Imaging Guided Genomics of Malignant Transformation
    NIH R01CA169316Apr 8, 2013 - Mar 31, 2019
    Role: Principal Investigator
    Training Program in Translational Brain Tumor Research
    NIH T32CA151022Sep 1, 2010 - Aug 31, 2025
    Role: Principal Investigator
    Integrated Epigenetic Maps of Human Embryonic and Adult Cells
    NIH U01ES017154Sep 30, 2008 - Jun 30, 2014
    Role: Principal Investigator
    Noninvasive Metabolic Signatures to Improve Management of Molecular Subtypes of Glioma
    NIH P01CA118816Dec 1, 2005 - Jul 31, 2024
    Role: Co-Investigator
    CONVERGENT MECHANISMS CONTRIBUTING TO CANCER
    NIH R01CA094971Apr 1, 2002 - Sep 30, 2007
    Role: Principal Investigator
    Center Core Grant for Vision Research
    NIH P30EY005722Mar 1, 1985 - Aug 31, 2021
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR002172Jan 1, 1983 - Mar 31, 2009
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses. Neuro Oncol. 2024 Nov 19. Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA. PMID: 39560080.
      View in: PubMed   Mentions:    Fields:    
    2. Activating the dark genome to illuminate cancer vaccine targets. Nat Genet. 2024 Sep; 56(9):1770-1771. Kwok DW, Okada H, Costello JF. PMID: 39223317; PMCID: PMC11456370.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Functional Electrical Stimulation and Brain-Machine Interfaces for Simultaneous Control of Wrist and Finger Flexion. bioRxiv. 2024 Aug 12. Mender MJ, Ward AL, Cubillos LH, Kelberman MM, Costello JT, Temmar H, Wallace DM, Lin ET, Lam JLW, Willsey MS, Ganesh Kumar N, Kung TA, Patil PG, Chestek CA. PMID: 39211094; PMCID: PMC11361090.
      View in: PubMed   Mentions:
    4. Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections. Cancers (Basel). 2024 Jul 01; 16(13). Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC. PMID: 39001492; PMCID: PMC11240479.
      View in: PubMed   Mentions:
    5. Telomeres in glioma: Maintenance mechanisms to therapeutic potential. Neuro Oncol. 2024 Jun 03; 26(6):1025-1026. Stevers NO, Costello JF. PMID: 38466631; PMCID: PMC11145438.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma. Mod Pathol. 2024 Jun; 37(6):100488. Beccari S, Mohamed E, Voong V, Hilz S, Lafontaine M, Shai A, Lim Y, Martinez J, Switzman B, Yu RL, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Costello JF, Phillips JJ. PMID: 38588881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Whole tumor analysis reveals early origin of the TERT promoter mutation and intercellular heterogeneity in TERT expression. Neuro Oncol. 2024 04 05; 26(4):640-652. Appin CL, Hong C, Suwala AK, Hilz S, Mathur R, Solomon DA, Smirnov IV, Stevers NO, Shai A, Wang A, Berger MS, Chang SM, Phillips JJ, Costello JF. PMID: 38141254; PMCID: PMC10995505.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections. bioRxiv. 2024 Mar 18. Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC. PMID: 37645893; PMCID: PMC10461981.
      View in: PubMed   Mentions:
    9. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Sci Rep. 2024 03 16; 14(1):6362. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 38493204; PMCID: PMC10944514.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Artificial neural network for brain-machine interface consistently produces more naturalistic finger movements than linear methods. bioRxiv. 2024 Mar 05. Temmar H, Willsey MS, Costello JT, Mender MJ, Cubillos LH, Lam JL, Wallace DM, Kelberman MM, Patil PG, Chestek CA. PMID: 38496403; PMCID: PMC10942378.
      View in: PubMed   Mentions:
    11. Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective. Cell. 2024 01 18; 187(2):446-463.e16. Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF. PMID: 38242087; PMCID: PMC10832360.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    12. "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade. Acta Neuropathol. 2023 12 11; 147(1):3. Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA. PMID: 38079020; PMCID: PMC10713691.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs. Neuro Oncol. 2023 12 08; 25(12):2221-2236. Williams EA, Ravindranathan A, Gupta R, Stevers NO, Suwala AK, Hong C, Kim S, Yuan JB, Wu J, Barreto J, Lucas CG, Chan E, Pekmezci M, LeBoit PE, Mully T, Perry A, Bollen A, Van Ziffle J, Devine WP, Reddy AT, Gupta N, Basnet KM, Macaulay RJB, Malafronte P, Lee H, Yong WH, Williams KJ, Juratli TA, Mata DA, Huang RSP, Hiemenz MC, Pavlick DC, Frampton GM, Janovitz T, Ross JS, Chang SM, Berger MS, Jacques L, Song JS, Costello JF, Solomon DA. PMID: 37436963; PMCID: PMC10708934.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. bioRxiv. 2023 Nov 02. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 37961484; PMCID: PMC10634890.
      View in: PubMed   Mentions: 2  
    15. Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens. bioRxiv. 2023 Oct 20. Kwok DW, Stevers NO, Nejo T, Chen LH, Etxeberria I, Jung J, Okada K, Cove MC, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Wu SH, Ramos E, Yamamichi A, Liu J, Watchmaker P, Ogino H, Saijo A, Du A, Grishanina N, Woo J, Diaz A, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. PMID: 37904942; PMCID: PMC10614978.
      View in: PubMed   Mentions:
    16. Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review. J Physiol Sci. 2023 Oct 17; 73(1):26. Corbett J, Young JS, Tipton MJ, Costello JT, Williams TB, Walker EF, Lee BJ, Stevens CE. PMID: 37848829; PMCID: PMC10717221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Balancing Memorization and Generalization in RNNs for High Performance Brain-Machine Interfaces. bioRxiv. 2023 May 28. Costello JT, Temmar H, Cubillos LH, Mender MJ, Wallace DM, Willsey MS, Patil PG, Chestek CA. PMID: 37292755; PMCID: PMC10245969.
      View in: PubMed   Mentions:
    18. Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance. Clin Cancer Res. 2023 05 01; 29(9):1763-1782. Carney SV, Banerjee K, Mujeeb A, Zhu B, Haase S, Varela ML, Kadiyala P, Tronrud CE, Zhu Z, Mukherji D, Gorla P, Sun Y, Tagett R, Núñez FJ, Luo M, Luo W, Ljungman M, Liu Y, Xia Z, Schwendeman A, Qin T, Sartor MA, Costello JF, Cahill DP, Lowenstein PR, Castro MG. PMID: 36692427; PMCID: PMC10159884.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Hyperpolarized δ-[1- 13C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma. Sci Rep. 2023 03 30; 13(1):5190. Minami N, Hong D, Taglang C, Batsios G, Gillespie AM, Viswanath P, Stevers N, Barger CJ, Costello JF, Ronen SM. PMID: 36997627; PMCID: PMC10063634.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects. J Clin Invest. 2023 03 01; 133(5). Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK. PMID: 36856115; PMCID: PMC9974099.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    21. Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro Oncol. 2023 01 05; 25(1):4-25. Miller JJ, Gonzalez Castro LN, McBrayer S, Weller M, Cloughesy T, Portnow J, Andronesi O, Barnholtz-Sloan JS, Baumert BG, Berger MS, Bi WL, Bindra R, Cahill DP, Chang SM, Costello JF, Horbinski C, Huang RY, Jenkins RB, Ligon KL, Mellinghoff IK, Nabors LB, Platten M, Reardon DA, Shi DD, Schiff D, Wick W, Yan H, von Deimling A, van den Bent M, Kaelin WG, Wen PY. PMID: 36239925; PMCID: PMC9825337.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    22. TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022 12 01; 24(12):2063-2075. Miki S, Koga T, Mckinney AM, Parisian AD, Tadokoro T, Vadla R, Marsala M, Hevner RF, Costello JF, Furnari F. PMID: 35325218; PMCID: PMC9713509.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Real-time brain-machine interface in non-human primates achieves high-velocity prosthetic finger movements using a shallow feedforward neural network decoder. Nat Commun. 2022 11 12; 13(1):6899. Willsey MS, Nason-Tomaszewski SR, Ensel SR, Temmar H, Mender MJ, Costello JT, Patil PG, Chestek CA. PMID: 36371498; PMCID: PMC9653378.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    24. Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma. Neuro Oncol. 2022 11 02; 24(11):1898-1910. Minami N, Hong D, Stevers N, Barger CJ, Radoul M, Hong C, Chen L, Kim Y, Batsios G, Gillespie AM, Pieper RO, Costello JF, Viswanath P, Ronen SM. PMID: 35460557; PMCID: PMC9629440.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. Cell Rep. 2022 09 20; 40(12):111344. McKinney AM, Mathur R, Stevers NO, Molinaro AM, Chang SM, Phillips JJ, Costello JF. PMID: 36130485; PMCID: PMC9534059.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer. Nat Commun. 2022 09 16; 13(1):5430. Barger CJ, Suwala AK, Soczek KM, Wang AS, Kim MY, Hong C, Doudna JA, Chang SM, Phillips JJ, Solomon DA, Costello JF. PMID: 36114166; PMCID: PMC9481613.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications. Neuro Oncol. 2022 09 01; 24(9):1471-1481. Mohamed E, Kumar A, Zhang Y, Wang AS, Chen K, Lim Y, Shai A, Taylor JW, Clarke J, Hilz S, Berger MS, Solomon DA, Costello JF, Molinaro AM, Phillips JJ. PMID: 35287169; PMCID: PMC9435510.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer. Clin Cancer Res. 2022 08 15; 28(16):3526-3536. Batsios G, Taglang C, Tran M, Stevers N, Barger C, Gillespie AM, Ronen SM, Costello JF, Viswanath P. PMID: 35679032; PMCID: PMC9378519.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    29. Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1. Acta Neuropathol. 2022 10; 144(4):747-765. Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA. PMID: 35945463; PMCID: PMC9468105.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. PMID: 35534562; PMCID: PMC9374001.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    31. Spatial concordance of DNA methylation classification in diffuse glioma. Neuro Oncol. 2021 12 01; 23(12):2054-2065. Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, Hoekstra OS, Lammertsma AA, Barkhof F, Pouwels PJW, Reijneveld JC, Rozemuller AJM, Beliën JAM, Boellaard R, Taylor MD, Das S, Costello JF, Vandertop WP, Wesseling P, de Witt Hamer PC, Verhaak RGW. PMID: 34049406; PMCID: PMC8643482.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    32. Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas. Neuro Oncol. 2021 11 02; 23(11):1872-1884. Yu Y, Villanueva-Meyer J, Grimmer MR, Hilz S, Solomon DA, Choi S, Wahl M, Mazor T, Hong C, Shai A, Phillips JJ, Wainer BH, McDermott M, Haas-Kogan D, Taylor JW, Butowski N, Clarke JL, Berger MS, Molinaro AM, Chang SM, Costello JF, Oberheim Bush NA. PMID: 33823014; PMCID: PMC8563321.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    33. Publisher Correction: Epigenomic contributions to tumor cell heterogeneity and plasticity. Nat Genet. 2021 Nov; 53(11):1622. Mathur R, Costello JF. PMID: 34671124.
      View in: PubMed   Mentions:    Fields:    
    34. Epigenomic contributions to tumor cell heterogeneity and plasticity. Nat Genet. 2021 10; 53(10):1403-1404. Mathur R, Costello JF. PMID: 34608295.
      View in: PubMed   Mentions:    Fields:    
    35. Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas. Neuro Oncol. 2021 09 01; 23(9):1509-1522. Viswanath P, Batsios G, Ayyappan V, Taglang C, Gillespie AM, Larson PEZ, Luchman HA, Costello JF, Pieper RO, Ronen SM. PMID: 33864084; PMCID: PMC8408874.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    36. The Placenta - Fast, Loose, and in Control. N Engl J Med. 2021 Jul 01; 385(1):87-89. Costello JF, Fisher SJ. PMID: 34192437; PMCID: PMC9616101.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease. Dev Cell. 2021 05 03; 56(9):1238-1252.e5. Zhang B, Kim MY, Elliot G, Zhou Y, Zhao G, Li D, Lowdon RF, Gormley M, Kapidzic M, Robinson JF, McMaster MT, Hong C, Mazor T, Hamilton E, Sears RL, Pehrsson EC, Marra MA, Jones SJM, Bilenky M, Hirst M, Wang T, Costello JF, Fisher SJ. PMID: 33891899; PMCID: PMC8650129.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    38. Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors. Neuro Oncol. 2021 04 12; 23(4):638-649. Manjunath M, Yan J, Youn Y, Drucker KL, Kollmeyer TM, McKinney AM, Zazubovich V, Zhang Y, Costello JF, Eckel-Passow J, Selvin PR, Jenkins RB, Song JS. PMID: 33130899; PMCID: PMC8041333.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    39. miRNA-independent function of long noncoding pri-miRNA loci. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). He D, Wu D, Muller S, Wang L, Saha P, Ahanger SH, Liu SJ, Cui M, Hong SJ, Jain M, Olson HE, Akeson M, Costello JF, Diaz A, Lim DA. PMID: 33758101; PMCID: PMC8020771.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    40. Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF. PMID: 33758097; PMCID: PMC8020668.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    41. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. PMID: 33367885; PMCID: PMC7992879.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    42. Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma. Metabolites. 2021 Feb 13; 11(2). Radoul M, Hong D, Gillespie AM, Najac C, Viswanath P, Pieper RO, Costello JF, Luchman HA, Ronen SM. PMID: 33668509; PMCID: PMC7917625.
      View in: PubMed   Mentions: 13  
    43. Non-invasive assessment of telomere maintenance mechanisms in brain tumors. Nat Commun. 2021 01 04; 12(1):92. Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM. PMID: 33397920; PMCID: PMC7782549.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    44. Prostate Cancer Progression and the Epigenome. N Engl J Med. 2020 12 03; 383(23):2287-2290. Arap W, Pasqualini R, Costello JF. PMID: 33264551.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence. Neuro Oncol. 2020 11 26; 22(11):1580-1590. Mathur R, Zhang Y, Grimmer MR, Hong C, Zhang M, Bollam S, Petrecca K, Clarke J, Berger MS, Phillips JJ, Oberheim-Bush NA, Molinaro AM, Chang SM, Costello JF. PMID: 32166314; PMCID: PMC8444710.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    46. Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma. Nat Commun. 2020 09 23; 11(1):4803. Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR. PMID: 32968068; PMCID: PMC7511976.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    47. Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment. Cancer Res. 2020 11 15; 80(22):5098-5108. Subramani E, Radoul M, Najac C, Batsios G, Molloy AR, Hong D, Gillespie AM, Santos RD, Viswanath P, Costello JF, Pieper RO, Ronen SM. PMID: 32958546; PMCID: PMC7669718.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    48. Epigenomic programming in early fetal brain development. Epigenomics. 2020 06; 12(12):1053-1070. Li L, Maire CL, Bilenky M, Carles A, Heravi-Moussavi A, Hong C, Tam A, Kamoh B, Cho S, Cheung D, Li I, Wong T, Nagarajan RP, Mungall AJ, Moore R, Wang T, Kleinman CL, Jabado N, Jones SJ, Marra MA, Ligon KL, Costello JF, Hirst M. PMID: 32677466; PMCID: PMC7857341.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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    152. A broad band of silence. Nat Genet. 2006 May; 38(5):504-6. Smith JS, Costello JF. PMID: 16642011.
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    153. DNA motifs associated with aberrant CpG island methylation. Genomics. 2006 May; 87(5):572-9. Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM. PMID: 16487676.
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    154. Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer. Genet Test. 2006; 10(4):281-4. Chen Y, Toland AE, McLennan J, Fridlyand J, Crawford B, Costello JF, Ziegler JL. PMID: 17253935.
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    155. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res. 2005 Jun 15; 65(12):5070-5. Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW, Lal A. PMID: 15958550.
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    156. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005 Jun; 37(6):645-51. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. PMID: 15895082.
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    157. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 01; 65(9):3617-23. Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. PMID: 15867356.
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    158. Comparative epigenomics of leukemia. Nat Genet. 2005 Mar; 37(3):211-2. Costello JF. PMID: 15731751.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    159. Phosphatase and tensin homologue growth suppression without phosphatase. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2677-8. Stokoe D, Costello JF. PMID: 15710873; PMCID: PMC549471.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    160. The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. Cancer Res. 2003 Nov 15; 63(22):7600-5. Hong C, Bollen AW, Costello JF. PMID: 14633674.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    161. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14133-8. He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM. PMID: 14617776; PMCID: PMC283558.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansCells
    162. Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12253-8. Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM. PMID: 14519846; PMCID: PMC218745.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    163. DNA methylation in brain development and gliomagenesis. Front Biosci. 2003 Jan 01; 8:s175-84. Costello JF. PMID: 12456310.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    164. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet. 2002 Nov; 32(3):453-8. Zardo G, Tiirikainen MI, Hong C, Misra A, Feuerstein BG, Volik S, Collins CC, Lamborn KR, Bollen A, Pinkel D, Albertson DG, Costello JF. PMID: 12355068.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    165. Methylation matters: a new spin on maspin. Nat Genet. 2002 Jun; 31(2):123-4. Costello JF, Vertino PM. PMID: 12040372.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    166. Restriction landmark genome scanning. Methods. 2002 Jun; 27(2):144-9. Costello JF, Smiraglia DJ, Plass C. PMID: 12095273.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    167. Restriction landmark genome scanning. Methods Mol Biol. 2002; 200:53-70. Costello JF, Plass C, Cavenee WK. PMID: 11951655.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    168. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum Mol Genet. 2001 Jun 15; 10(13):1413-9. Smiraglia DJ, Rush LJ, Frühwald MC, Dai Z, Held WA, Costello JF, Lang JC, Eng C, Li B, Wright FA, Caligiuri MA, Plass C. PMID: 11440994.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    169. Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci. Blood. 2001 May 15; 97(10):3226-33. Rush LJ, Dai Z, Smiraglia DJ, Gao X, Wright FA, Frühwald M, Costello JF, Held WA, Yu L, Krahe R, Kolitz JE, Bloomfield CD, Caligiuri MA, Plass C. PMID: 11342453.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    170. Methylation matters. J Med Genet. 2001 May; 38(5):285-303. Costello JF, Plass C. PMID: 11333864; PMCID: PMC1734882.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    171. Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon. J Med Genet. 2000 Jul; 37(7):501-9. Frühwald MC, O'Dorisio MS, Rush LJ, Reiter JL, Smiraglia DJ, Wenger G, Costello JF, White PS, Krahe R, Brodeur GM, Plass C. PMID: 10882752; PMCID: PMC1734623.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    172. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet. 2000 Feb; 24(2):132-8. Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK, Plass C. PMID: 10655057.
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    173. Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathol. 2000; 17(2):49-56. Costello JF, Plass C, Cavenee WK. PMID: 11210171.
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    174. A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels. Genomics. 1999 Jun 15; 58(3):254-62. Smiraglia DJ, Frühwald MC, Costello JF, McCormick SP, Dai Z, Peltomäki P, O'Dorisio MS, Cavenee WK, Plass C. PMID: 10373323.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    175. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 1999 Feb 15; 59(4):798-802. Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. PMID: 10029065.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    176. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol. 1997 Sep; 17(9):5612-9. Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. PMID: 9271436; PMCID: PMC232409.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    177. An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis. DNA Res. 1997 Jun 30; 4(3):253-5. Plass C, Weichenhan D, Catanese J, Costello JF, Yu F, Yu L, Smiraglia D, Cavenee WK, Caligiuri MA, deJong P, Held WA. PMID: 9330914.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    178. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 1997 Apr 01; 57(7):1250-4. Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Su Huang HJ, Cavenee WK. PMID: 9102208.
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    179. Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene. J Biol Chem. 1996 Jun 07; 271(23):13916-24. Pieper RO, Patel S, Ting SA, Futscher BW, Costello JF. PMID: 8662860.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    180. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 1996 May 15; 56(10):2405-10. Costello JF, Berger MS, Huang HS, Cavenee WK. PMID: 8625319.
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    181. O6-methylguanine-DNA methyltransferase in tumors and cells of the oligodendrocyte lineage. Can J Neurol Sci. 1995 May; 22(2):111-5. Nutt CL, Costello JF, Bambrick LL, Yarosh DB, Swinnen LJ, Chambers AF, Cairncross JG. PMID: 7627911.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    182. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Mol Cell Biol. 1994 Oct; 14(10):6515-21. Costello JF, Futscher BW, Kroes RA, Pieper RO. PMID: 7523853; PMCID: PMC359181.
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    183. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem. 1994 Jun 24; 269(25):17228-37. Costello JF, Futscher BW, Tano K, Graunke DM, Pieper RO. PMID: 8006031.
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    184. Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene. Cancer Commun. 1991 Aug; 3(8):241-53. Pieper RO, Costello JF, Kroes RA, Futscher BW, Marathi U, Erickson LC. PMID: 1716139.
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    185. Bombesin immunoreactive neurons in the hypothalamic paraventricular nucleus innervate the dorsal vagal complex in the rat. Brain Res. 1991 Feb 22; 542(1):77-82. Costello JF, Brown MR, Gray TS. PMID: 2054661.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    186. Metropolitan forensic anthropology team (MFAT) case studies in identification: 3. Identification of John J. Sullivan, the missing journalist. J Forensic Sci. 1985 Jan; 30(1):221-31. Zugibe FT, Taylor J, Weg N, DiBennerdo R, Costello JT, DeForest P. PMID: 3981113.
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    187. Glucose utilization and production by the dog kidney in vivo in metabolic acidosis and alkalosis. J Clin Invest. 1973 Mar; 52(3):608-11. Costello J, Scott JM, Wilson P, Bourke E. PMID: 4685085; PMCID: PMC302299.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
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