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Susan Chang, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address400 Parnassus Ave, UC Clinics
San Francisco CA 94158
Phone415-353-2383
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    Collapse Biography 
    Collapse Education and Training
    University of British ColumbiaM.D.1985School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Imaging and Tissue Correlates to Optimize Management of Glioblastoma
    NIH/NCI P01CA118816Dec 1, 2005 - Jul 31, 2018
    Role: Principal Investigator
    SPORE: Brain Tumore SPORE Grant
    NIH/NCI P50CA097257Sep 20, 2002 - Aug 31, 2018
    Role: Co-Investigator
    NABTC Member Intitution Grant (UCSF Project Leader)
    NIH/NCI U01CA062422Mar 25, 1994 - Dec 31, 2009
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang S, Nelson SJ, Woehrer A, Phillips JJ, Solomon DA, Costello JF. Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. Neuro Oncol. 2018 Apr 09; 20(5):632-641. PMID: 29077933.
      View in: PubMed
    2. Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang S, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR. Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation. Cell Rep. 2018 Mar 27; 22(13):3672-3683. PMID: 29590631.
      View in: PubMed
    3. Choi S, Yu Y, Grimmer MR, Wahl M, Chang S, Costello JF. Temozolomide-associated Hypermutation in Gliomas. Neuro Oncol. 2018 Feb 14. PMID: 29452419.
      View in: PubMed
    4. Camidge DR, Lee EQ, Lin NU, Margolin K, Ahluwalia MS, Bendszus M, Chang S, Dancey J, de Vries EGE, Harris GJ, Hodi FS, Lassman AB, Macdonald DR, Peereboom DM, Schiff D, Soffietti R, van den Bent MJ, Wefel JS, Wen PY. Clinical trial design for systemic agents in patients with brain metastases from solid tumours: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group. Lancet Oncol. 2018 Jan; 19(1):e20-e32. PMID: 29304358.
      View in: PubMed
    5. Alexander BM, Brown PD, Ahluwalia MS, Aoyama H, Baumert BG, Chang S, Gaspar LE, Kalkanis SN, Macdonald DR, Mehta MP, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Lee EQ, Wen PY. Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group. Lancet Oncol. 2018 Jan; 19(1):e33-e42. PMID: 29304360.
      View in: PubMed
    6. Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang S, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903. PMID: 28942218.
      View in: PubMed
    7. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang S, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):10743-10748. PMID: 28916733.
      View in: PubMed
    8. Nagueh SF, Chang S, Nabi F, Shah DJ, Estep JD. Cardiac Imaging in Patients With Heart Failure and Preserved Ejection Fraction. Circ Cardiovasc Imaging. 2017 Sep; 10(9). PMID: 28838962.
      View in: PubMed
    9. Wahl M, Anwar M, Hess CP, Chang S, Lupo JM. Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol. 2017 Aug 10; 12(1):126. PMID: 28797254.
      View in: PubMed
    10. van den Bent MJ, Smits M, Kros JM, Chang S. Diffuse Infiltrating Oligodendroglioma and Astrocytoma. J Clin Oncol. 2017 Jul 20; 35(21):2394-2401. PMID: 28640702.
      View in: PubMed
    11. Wen PY, Chang S, Van den Bent MJ, Vogelbaum MA, Macdonald DR, Lee EQ. Response Assessment in Neuro-Oncology Clinical Trials. J Clin Oncol. 2017 Jul 20; 35(21):2439-2449. PMID: 28640707.
      View in: PubMed
    12. Nagueh SF, Chang S, Nabi F, Shah DJ, Estep JD. Imaging to Diagnose and Manage Patients in Heart Failure With Reduced Ejection Fraction. Circ Cardiovasc Imaging. 2017 Apr; 10(4). PMID: 28400485.
      View in: PubMed
    13. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang S, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792. PMID: 28327577.
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    14. Clarke JL, Molinaro AM, Cabrera JR, DeSilva AA, Rabbitt JE, Prey J, Drummond DC, Kim J, Noble C, Fitzgerald JB, Chang S, Butowski NA, Taylor JW, Park JW, Prados MD. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017 Mar; 79(3):603-610. PMID: 28233053.
      View in: PubMed
    15. Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang S, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 03; 132(1):171-179. PMID: 28124178.
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    16. Nayak L, de Groot J, Wefel JS, Cloughesy TF, Lieberman F, Chang S, Omuro A, Drappatz J, Batchelor TT, DeAngelis LM, Gilbert MR, Aldape KD, Yung AW, Fisher J, Ye X, Chen A, Grossman S, Prados M, Wen PY. Phase I trial of aflibercept (VEGF trap) with radiation therapy and concomitant and adjuvant temozolomide in patients with high-grade gliomas. J Neurooncol. 2017 03; 132(1):181-188. PMID: 28116649.
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    17. Sulman EP, Ismaila N, Chang S. Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline. J Oncol Pract. 2017 Feb; 13(2):123-127. PMID: 27907278.
      View in: PubMed
    18. Sulman EP, Ismaila N, Armstrong TS, Tsien C, Batchelor TT, Cloughesy T, Galanis E, Gilbert M, Gondi V, Lovely M, Mehta M, Mumber MP, Sloan A, Chang S. Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline. J Clin Oncol. 2017 Jan 20; 35(3):361-369. PMID: 27893327.
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    19. Abudiab MM, McKay J, Deavers M, Zoghbi WA, Chang S. Pannus of Mitral Valve Prosthesis Causing Left Ventricular Outflow Tract Obstruction. Methodist Debakey Cardiovasc J. 2016 Sep; 12(3):183. PMID: 27826376.
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    20. Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang S, et al. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. J Neurooncol. 2016 10; 130(1):171-179. PMID: 27535746.
      View in: PubMed
    21. Han SJ, Chang S, Berger MS. Laser Ablation vs Open Resection for Deep-Seated Tumors: The Case for Open Resection. Neurosurgery. 2016 Aug; 63 Suppl 1:10-14. PMID: 27399358.
      View in: PubMed
    22. Bush NA, Chang S, Berger MS. Current and future strategies for treatment of glioma. Neurosurg Rev. 2017 Jan; 40(1):1-14. PMID: 27085859.
      View in: PubMed
    23. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang S, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 08; 18(8):1169-79. PMID: 26911151; PMCID: PMC4933480.
    24. Imber BS, Braunstein SE, Wu FY, Nabavizadeh N, Boehling N, Weinberg VK, Tihan T, Barnes M, Mueller S, Butowski NA, Clarke JL, Chang S, McDermott MM, Prados MD, Berger MS, Haas-Kogan DA. Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience. J Neurooncol. 2016 Jan; 126(1):193-200. PMID: 26493740; PMCID: PMC4826306 [Available on 01/01/17].
    25. Chang S, Cahill DP, Aldape KD, Mehta MP. Treatment of Adult Lower-Grade Glioma in the Era of Genomic Medicine. Am Soc Clin Oncol Educ Book. 2016; 35:75-81. PMID: 27249688.
      View in: PubMed
    26. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang S, Prados MD, Jenkins RB, Wiemels JL, Telomere Group EC, Samani NJ, Wiencke JK, Wrensch MR. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15; 6(40):42468-77. PMID: 26646793; PMCID: PMC4767445.
    27. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang S, Prados M, Butowski N, Clarke J, Nelson SJ. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55. PMID: 26692525; PMCID: PMC4700297.
    28. Mazor T, Pankov A, Johnson BE, Hong C, Hamilton EG, Bell RJ, Smirnov IV, Reis GF, Phillips JJ, Barnes MJ, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers ML, Bollen AW, Taylor BS, Molinaro AM, Olshen AB, Chang S, Song JS, Costello JF. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell. 2015 Sep 14; 28(3):307-317. PMID: 26373278; PMCID: PMC4573399.
    29. Wen Q, Kelley DA, Banerjee S, Lupo JM, Chang S, Xu D, Hess CP, Nelson SJ. Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T. Neuroimage Clin. 2015; 9:291-9. PMID: 26509116; PMCID: PMC4579286.
    30. Chaikriangkrai K, Chebrolu L, Bhatti S, Chang S. Diagnosis of ischemia in hypertrophic cardiomyopathy: role of computed tomography and nuclear stress testing. Curr Opin Cardiol. 2015 Sep; 30(5):483-92. PMID: 26165377.
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    31. Maragiannis D, Schutt RC, Gramze NL, Chaikriangkrai K, McGregor K, Chin K, Nabi F, Little SH, Nagueh SF, Chang S. Association of Left Ventricular Diastolic Dysfunction with Subclinical Coronary Atherosclerotic Disease Burden Using Coronary Artery Calcium Scoring. J Atheroscler Thromb. 2015 Dec 1; 22(12):1278-86. PMID: 26269148.
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    32. Han SJ, Englot DJ, Birk H, Molinaro AM, Chang S, Clarke JL, Prados MD, Taylor JW, Berger MS, Butowski NA. Impact of Timing of Concurrent Chemoradiation for Newly Diagnosed Glioblastoma: A Critical Review of Current Evidence. Neurosurgery. 2015 Aug; 62 Suppl 1:160-5. PMID: 26181937.
      View in: PubMed
    33. Han SJ, Rutledge WC, Molinaro AM, Chang S, Clarke JL, Prados MD, Taylor JW, Berger MS, Butowski NA. The Effect of Timing of Concurrent Chemoradiation in Patients With Newly Diagnosed Glioblastoma. Neurosurgery. 2015 Aug; 77(2):248-53; discussion 253. PMID: 25856113; PMCID: PMC4506198.
    34. Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy LS, Bracci PM, Marshall R, Zheng S, Reis GF, Pico AR, O'Neill BP, Buckner JC, Giannini C, Huse JT, Perry A, Tihan T, Berger MS, Chang S, Prados MD, Wiemels J, Wiencke JK, Wrensch MR, Jenkins RB. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015 Jun 25; 372(26):2499-508. PMID: 26061753; PMCID: PMC4489704.
    35. Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang S, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY. Response assessment criteria for brain metastases: proposal from the RANO group. Lancet Oncol. 2015 Jun; 16(6):e270-8. PMID: 26065612.
      View in: PubMed
    36. Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang S, Walsh KM, Myong S, Song JS, Costello JF. Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Science. 2015 May 29; 348(6238):1036-9. PMID: 25977370; PMCID: PMC4456397.
    37. Chang S. New initiatives for Neuro-Oncology Practice-building on the success of the first year. Neurooncol Pract. 2015 Mar; 2(1):1. PMID: 26034634.
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    38. van Thuijl HF, Mazor T, Johnson BE, Fouse SD, Aihara K, Hong C, Malmström A, Hallbeck M, Heimans JJ, Kloezeman JJ, Stenmark-Askmalm M, Lamfers ML, Saito N, Aburatani H, Mukasa A, Berger MS, Söderkvist P, Taylor BS, Molinaro AM, Wesseling P, Reijneveld JC, Chang S, Ylstra B, Costello JF. Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment. Acta Neuropathol. 2015 Apr; 129(4):597-607. PMID: 25724300; PMCID: PMC4482618.
    39. Barajas RF, Pampaloni MH, Clarke JL, Seo Y, Savic D, Hawkins RA, Behr SC, Chang S, Berger M, Dillon WP, Cha S. Assessing Biological Response to Bevacizumab Using 18F-Fluoromisonidazole PET/MR Imaging in a Patient with Recurrent Anaplastic Astrocytoma. Case Rep Radiol. 2015; 2015:731361. PMID: 25793136; PMCID: PMC4352456.
    40. Wen Q, Jalilian L, Lupo JM, Molinaro AM, Chang S, Clarke J, Prados M, Nelson SJ. Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab. J Neurooncol. 2015 Jan; 121(2):331-9. PMID: 25351579; PMCID: PMC4311062.
    41. Reardon DA, Ballman KV, Buckner JC, Chang S, Ellingson BM. Impact of imaging measurements on response assessment in glioblastoma clinical trials. Neuro Oncol. 2014 Oct; 16 Suppl 7:vii24-35. PMID: 25313236; PMCID: PMC4195531.
    42. Wen PY, Cloughesy TF, Ellingson BM, Reardon DA, Fine HA, Abrey L, Ballman K, Bendszuz M, Buckner J, Chang S, Prados MD, Pope WB, Gregory Sorensen A, van den Bent M, Yung WK. Report of the Jumpstarting Brain Tumor Drug Development Coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD). Neuro Oncol. 2014 Oct; 16 Suppl 7:vii36-47. PMID: 25313237; PMCID: PMC4195530.
    43. Ahluwalia MS, Chang S. Medical therapy of gliomas. J Neurooncol. 2014 Sep; 119(3):503-12. PMID: 24986089; PMCID: PMC4170021.
    44. Clarke JL, Molinaro AM, Phillips JJ, Butowski NA, Chang S, Perry A, Costello JF, DeSilva AA, Rabbitt JE, Prados MD. A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma. Neuro Oncol. 2014 Jul; 16(7):984-90. PMID: 24637230; PMCID: PMC4057142.
    45. Hakeem A, Bhatti S, Chang S. Screening and risk stratification of coronary artery disease in end-stage renal disease. JACC Cardiovasc Imaging. 2014 Jul; 7(7):715-28. PMID: 25034921.
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    46. Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang S, Nelson SJ. Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels. J Magn Reson Imaging. 2015 May; 41(5):1332-41. PMID: 24935758; PMCID: PMC4269580.
    47. Le DD, Orrego CM, Maragiannis D, Chang S. An unusual case of right-sided heart failure caused by giant sinus of Valsalva aneurysm obstructing right ventricular outflow tract. Eur Heart J. 2014 Oct 14; 35(39):2721. PMID: 24935920.
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    48. Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang S, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul; 46(7):731-5. PMID: 24908248; PMCID: PMC4074274.
    49. Han SJ, Rolston JD, Molinaro AM, Clarke JL, Prados MD, Chang S, Berger MS, DeSilva A, Butowski NA. Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma. Neuro Oncol. 2014 Sep; 16(9):1255-62. PMID: 24670608; PMCID: PMC4136897.
    50. Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips JJ, Molinaro AM, Chang S, Nelson SJ. Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy. NMR Biomed. 2014 May; 27(5):578-93. PMID: 24596146; PMCID: PMC3983568.
    51. Chang S. Launch of Neuro-Oncology Practice. Neurooncol Pract. 2014 Mar; 1(1):1-2. PMID: 26034607.
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    52. Wen PY, Chang S, Lamborn KR, Kuhn JG, Norden AD, Cloughesy TF, Robins HI, Lieberman FS, Gilbert MR, Mehta MP, Drappatz J, Groves MD, Santagata S, Ligon AH, Yung WK, Wright JJ, Dancey J, Aldape KD, Prados MD, Ligon KL. Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02. Neuro Oncol. 2014 Apr; 16(4):567-78. PMID: 24470557; PMCID: PMC3956354.
    53. Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS, Olshen AB, Cha S, Zhao Y, Moore RA, Mungall AJ, Jones SJ, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger MS, Chang S, Taylor BS, Costello JF. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014 Jan 10; 343(6167):189-193. PMID: 24336570; PMCID: PMC3998672.
    54. Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, Butowski NA, Chang S, Clarke JL, McDermott MW, Prados MD, Sloan AE, Bruce JN, Parsa AT. Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro Oncol. 2014 Jan; 16(2):274-9. PMID: 24335700; PMCID: PMC3895386.
    55. Hakeem A, Bhatti S, Chang S. Does hybrid imaging have a role in cardiac risk evaluation of the pre-renal transplant patient? J Nucl Cardiol. 2013 Dec; 20(6):963-5. PMID: 24092269.
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    56. Bian W, Hess CP, Chang S, Nelson SJ, Lupo JM. Susceptibility-weighted MR imaging of radiation therapy-induced cerebral microbleeds in patients with glioma: a comparison between 3T and 7T. Neuroradiology. 2014 Feb; 56(2):91-6. PMID: 24281386; PMCID: PMC4940363.
    57. Lin NU, Lee EQ, Aoyama H, Barani IJ, Baumert BG, Brown PD, Camidge DR, Chang S, Dancey J, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Lamborn KR, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Wen PY. Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group. Lancet Oncol. 2013 Sep; 14(10):e396-406. PMID: 23993384.
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    58. Lin NU, Wefel JS, Lee EQ, Schiff D, van den Bent MJ, Soffietti R, Suh JH, Vogelbaum MA, Mehta MP, Dancey J, Linskey ME, Camidge DR, Aoyama H, Brown PD, Chang S, Kalkanis SN, Barani IJ, Baumert BG, Gaspar LE, Hodi FS, Macdonald DR, Wen PY. Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group. Lancet Oncol. 2013 Sep; 14(10):e407-16. PMID: 23993385.
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    59. Walsh KM, Rice T, Decker PA, Kosel ML, Kollmeyer T, Hansen HM, Zheng S, McCoy LS, Bracci PM, Anderson E, Hsuang G, Wiemels JL, Pico AR, Smirnov I, Molinaro AM, Tihan T, Berger MS, Chang S, Prados MD, Lachance DH, Sicotte H, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR. Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. Neuro Oncol. 2013 Aug; 15(8):1041-7. PMID: 23733245; PMCID: PMC3714154.
    60. Bian W, Hess CP, Chang S, Nelson SJ, Lupo JM. Computer-aided detection of radiation-induced cerebral microbleeds on susceptibility-weighted MR images. Neuroimage Clin. 2013; 2:282-90. PMID: 24179783; PMCID: PMC3777794.
    61. Lupo JM, Essock-Burns E, Molinaro AM, Cha S, Chang S, Butowski N, Nelson SJ. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9. PMID: 23393208; PMCID: PMC3607266.
    62. Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang S, Nelson SJ. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17. PMID: 23393206; PMCID: PMC3635514.
    63. Rice T, Zheng S, Decker PA, Walsh KM, Bracci P, Xiao Y, McCoy LS, Smirnov I, Patoka JS, Hansen HM, Hsuang G, Wiemels JL, Tihan T, Pico AR, Prados MD, Chang S, Berger MS, Caron A, Fink S, Kollmeyer T, Rynearson A, Voss J, Kosel ML, Fridley BL, Lachance DH, Eckel-Passow JE, Sicotte H, O'Neill BP, Giannini C, Wiencke JK, Jenkins RB, Wrensch MR. Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology. Neuro Oncol. 2013 May; 15(5):535-41. PMID: 23361564; PMCID: PMC3635511.
    64. Huang T, Mueller S, Rutkowski MJ, Han SJ, Bloch O, Barani IJ, Parsa AT, Chang S. Multidisciplinary care of patients with brain tumors. Surg Oncol Clin N Am. 2013 Apr; 22(2):161-78. PMID: 23453330.
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    65. Butowski N, Chang S. Endpoints for clinical trials and revised assessment in neuro-oncology. Curr Opin Neurol. 2012 Dec; 25(6):780-5. PMID: 23007010.
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    66. Lee EQ, Puduvalli VK, Reid JM, Kuhn JG, Lamborn KR, Cloughesy TF, Chang S, Drappatz J, Yung WK, Gilbert MR, Robins HI, Lieberman FS, Lassman AB, McGovern RM, Xu J, Desideri S, Ye X, Ames MM, Espinoza-Delgado I, Prados MD, Wen PY. Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03. Clin Cancer Res. 2012 Nov 01; 18(21):6032-9. PMID: 22923449; PMCID: PMC3947570.
    67. Crane CA, Han SJ, Ahn B, Oehlke J, Kivett V, Fedoroff A, Butowski N, Chang S, Clarke J, Berger MS, McDermott MW, Prados MD, Parsa AT. Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein. Clin Cancer Res. 2013 Jan 01; 19(1):205-14. PMID: 22872572.
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    68. Barajas RF, Phillips JJ, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang S, Nelson SJ. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54. PMID: 22711606; PMCID: PMC3379808.
    69. Ozhinsky E, Vigneron DB, Chang S, Nelson SJ. Automated prescription of oblique brain 3D magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Apr; 69(4):920-30. PMID: 22692829; PMCID: PMC3443494.
    70. Estep JD, Chang S, Bhimaraj A, Torre-Amione G, Zoghbi WA, Nagueh SF. Imaging for ventricular function and myocardial recovery on nonpulsatile ventricular assist devices. Circulation. 2012 May 08; 125(18):2265-77. PMID: 22566350.
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    154. Parsa AT, Wachhorst S, Lamborn KR, Prados MD, McDermott MW, Berger MS, Chang S. Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults. J Neurosurg. 2005 Apr; 102(4):622-8. PMID: 15871503.
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    155. Butowski N, Chang S. Small molecule and monoclonal antibody therapies in neurooncology. Cancer Control. 2005 Apr; 12(2):116-24. PMID: 15855895.
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    156. Chang S, Parney IF, Huang W, Anderson FA, Asher AL, Bernstein M, Lillehei KO, Brem H, Berger MS, Laws ER. Patterns of care for adults with newly diagnosed malignant glioma. JAMA. 2005 Feb 02; 293(5):557-64. PMID: 15687310.
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    157. Parney IF, Kunwar S, McDermott M, Berger M, Prados M, Cha S, Croteau D, Puri RK, Chang S. Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma. J Neurosurg. 2005 Feb; 102(2):267-75. PMID: 15739554.
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    158. Chang S, Kuhn J, Wen P, Greenberg H, Schiff D, Conrad C, Fink K, Robins HI, Cloughesy T, De Angelis L, Razier J, Hess K, Dancey J, Prados MD. Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs. Invest New Drugs. 2004 Nov; 22(4):427-35. PMID: 15292713.
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    159. Chang S, Lamborn KR, Malec M, Larson D, Wara W, Sneed P, Rabbitt J, Page M, Nicholas MK, Prados MD. Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2004 Oct 01; 60(2):353-7. PMID: 15380566.
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    160. Chan AA, Lau A, Pirzkall A, Chang S, Verhey LJ, Larson D, McDermott MW, Dillon WP, Nelson SJ. Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma. J Neurosurg. 2004 Sep; 101(3):467-75. PMID: 15352605.
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    161. Shaffrey ME, Mut M, Asher AL, Burri SH, Chahlavi A, Chang S, Farace E, Fiveash JB, Lang FF, Lopes MB, Markert JM, Schiff D, Siomin V, Tatter SB, Vogelbaum MA. Brain metastases. Curr Probl Surg. 2004 Aug; 41(8):665-741. PMID: 15354117.
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    162. Chang S, Seiferheld W, Curran W, Share R, Atkins J, Choucair A, Kresl J, Thoron L, Cairncross G, Gilbert M, Bahary JP, Dolinskas C, Louis DN, Bushunow P, Buckner J, Barger G, Mehta M. Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1122-6. PMID: 15234047.
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    163. Lamborn KR, Chang S, Prados MD. Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis. Neuro Oncol. 2004 Jul; 6(3):227-35. PMID: 15279715; PMCID: PMC1871999.
    164. Chang S, Yazbek N, Lakkis NM. Use of statins prior to percutaneous coronary intervention reduces myonecrosis and improves clinical outcome. Catheter Cardiovasc Interv. 2004 Jun; 62(2):193-7. PMID: 15170709.
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    165. Chang S, Prados MD, Yung WK, Fine H, Junck L, Greenberg H, Robins HI, Mehta M, Fink KL, Jaeckle KA, Kuhn J, Hess K, Schold C. Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial. Cancer. 2004 Apr 15; 100(8):1712-6. PMID: 15073861.
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    166. Larson DA, Suplica JM, Chang S, Lamborn KR, McDermott MW, Sneed PK, Prados MD, Wara WM, Nicholas MK, Berger MS. Permanent iodine 125 brachytherapy in patients with progressive or recurrent glioblastoma multiforme. Neuro Oncol. 2004 Apr; 6(2):119-26. PMID: 15134626; PMCID: PMC1871978.
    167. Chang S, Lakkis NM, Franklin J, Spencer WH, Nagueh SF. Predictors of outcome after alcohol septal ablation therapy in patients with hypertrophic obstructive cardiomyopathy. Circulation. 2004 Feb 24; 109(7):824-7. PMID: 14967729.
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    168. Schmidt MH, Gottfried ON, von Koch CS, Chang S, McDermott MW. Central neurocytoma: a review. J Neurooncol. 2004 Feb; 66(3):377-84. PMID: 15015671.
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    169. Chang S, Theodosopoulos P, Lamborn K, Malec M, Rabbitt J, Page M, Prados MD. Temozolomide in the treatment of recurrent malignant glioma. Cancer. 2004 Feb 01; 100(3):605-11. PMID: 14745879.
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    170. Prados MD, Yung WK, Fine HA, Greenberg HS, Junck L, Chang S, Nicholas MK, Robins HI, Mehta MP, Fink KL, Jaeckle KA, Kuhn J, Hess KR, Schold SC. Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study. Neuro Oncol. 2004 Jan; 6(1):33-7. PMID: 14769138; PMCID: PMC1871975.
    171. Schold SC, Kokkinakis DM, Chang S, Berger MS, Hess KR, Schiff D, Robins HI, Mehta MP, Fink KL, Davis RL, Prados MD. O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas. Neuro Oncol. 2004 Jan; 6(1):28-32. PMID: 14769137; PMCID: PMC1871964.
    172. Keles GE, Lamborn KR, Chang S, Prados MD, Berger MS. Volume of residual disease as a predictor of outcome in adult patients with recurrent supratentorial glioblastomas multiforme who are undergoing chemotherapy. J Neurosurg. 2004 Jan; 100(1):41-6. PMID: 14743910.
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    173. Prados MD, Yung WK, Jaeckle KA, Robins HI, Mehta MP, Fine HA, Wen PY, Cloughesy TF, Chang S, Nicholas MK, Schiff D, Greenberg HS, Junck L, Fink KL, Hess KR, Kuhn J. Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. Neuro Oncol. 2004 Jan; 6(1):44-54. PMID: 14769140; PMCID: PMC1871968.
    174. Chang S, Sekandarzad MW, Jiang S, Nagueh S, Spencer W, Lakkis N. Impact of infarct size on clinical and echocardiographic outcome in patients undergoing nonsurgical septal reduction therapy. Am Heart J. 2003 Dec; 146(6):1112-4. PMID: 14661008.
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    175. Prados MD, McDermott M, Chang S, Wilson CB, Fick J, Culver KW, Van Gilder J, Keles GE, Spence A, Berger M. Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial. J Neurooncol. 2003 Dec; 65(3):269-78. PMID: 14682377.
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    176. von Koch CS, Schmidt MH, Uyehara-Lock JH, Berger MS, Chang S. The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature. Surg Neurol. 2003 Dec; 60(6):560-5. PMID: 14670681.
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    177. Chang S, Kuhn JG, Ian Robins H, Clifford Schold S, Spence AM, Berger MS, Mehta MP, Pollack I, Gilbert M, Prados MD. A study of a different dose-intense infusion schedule of phenylacetate in patients with recurrent primary brain tumors consortium report. Invest New Drugs. 2003 Nov; 21(4):429-33. PMID: 14586210.
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    178. Lee J, Chang S, McDermott MW, Parsa AT. Intraventricular neurocytomas. Neurosurg Clin N Am. 2003 Oct; 14(4):483-508. PMID: 15024797.
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    179. Chang S, Nagueh SF, Spencer WH, Lakkis NM. Complete heart block: determinants and clinical impact in patients with hypertrophic obstructive cardiomyopathy undergoing nonsurgical septal reduction therapy. J Am Coll Cardiol. 2003 Jul 16; 42(2):296-300. PMID: 12875767.
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    180. Chang S, Parney IF, McDermott M, Barker FG, Schmidt MH, Huang W, Laws ER, Lillehei KO, Bernstein M, Brem H, Sloan AE, Berger M. Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project. J Neurosurg. 2003 Jun; 98(6):1175-81. PMID: 12816260.
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    181. Schmidt MH, Berger MS, Lamborn KR, Aldape K, McDermott MW, Prados MD, Chang S. Repeated operations for infiltrative low-grade gliomas without intervening therapy. J Neurosurg. 2003 Jun; 98(6):1165-9. PMID: 12816258.
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    182. Parney IF, Chang S. Current chemotherapy for glioblastoma. Cancer J. 2003 May-Jun; 9(3):149-56. PMID: 12952300.
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    183. Keng FY, Chang S, Cwajg E, He ZX, Lakkis NM, Nagueh SF, Spencer WH, Verani MS. Gated SPECT in patients with hypertrophic obstructive cardiomyopathy undergoing transcoronary ethanol septal ablation. J Nucl Cardiol. 2002 Nov-Dec; 9(6):594-600. PMID: 12466783.
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    184. Lutterbach J, Fauchon F, Schild SE, Chang S, Pagenstecher A, Volk B, Ostertag C, Momm F, Jouvet A. Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery. 2002 Jul; 51(1):44-55; discussion 55-6. PMID: 12182434.
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    185. Chang S, Barker FG, Schmidt MH, Sloan AE, Kasper R, Phillips L, Shih K, Hariharan S, Berger MS. Clinical trial participation among patients enrolled in the Glioma Outcomes Project. Cancer. 2002 May 15; 94(10):2681-7. PMID: 12173337.
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    186. Robins HI, Chang S, Prados MD, Yung WK, Hess K, Schiff D, Greenberg H, Fink K, Nicolas K, Kuhn JG, Cloughesy T, Junck L, Mehta M. A phase II trial of thymidine and carboplatin for recurrent malignant glioma: a North American Brain Tumor Consortium Study. Neuro Oncol. 2002 Apr; 4(2):109-14. PMID: 11916502; PMCID: PMC1920656.
    187. Chang S, Theodosopoulos P, Sneed P. Multidisciplinary management of adult anaplastic astrocytomas. Semin Radiat Oncol. 2001 Apr; 11(2):163-9. PMID: 11285554.
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