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Joanna Phillips, MD, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentNeurological Surgery
Address1450 Third St
San Francisco CA 94158
Phone415-514-4929
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    University of PennsylvaniaM.D.2002School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Heparan sulfate proteoglycans as critical regulators of brain cancer malignancy
    NIH/NINDS R01NS081117Sep 30, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    NIH/NCI U01CA168878Aug 16, 2012 - Jun 30, 2017
    Role: Co-Principal Investigator
    Biophysical and molecular dialogue of glioma cells and the brain microenvironment
    NIH/NCI U54CA163155Sep 26, 2011 - Jul 31, 2016
    Role: Co-Investigator
    The role of microglia and macrophages in the development of brain tumors
    NIH/NINDS K08NS063456Jul 1, 2008 - Jun 30, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips J, Aghi MK, Mehta S, Jain RK, Rowitch DH. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018 May 14; 33(5):874-889.e7. PMID: 29681511.
      View in: PubMed
    2. Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips J, Solomon DA, Costello JF. Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. Neuro Oncol. 2018 Apr 09; 20(5):632-641. PMID: 29077933.
      View in: PubMed
    3. Vasudevan HN, Braunstein SE, Phillips J, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR. Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation. Cell Rep. 2018 Mar 27; 22(13):3672-3683. PMID: 29590631.
      View in: PubMed
    4. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips J, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. PMID: 29476136.
      View in: PubMed
    5. Pekmezci M, Stevers M, Phillips J, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 Mar; 135(3):485-488. PMID: 29428973.
      View in: PubMed
    6. Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips J, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol Cancer Res. 2018 Feb 05. PMID: 29431617.
      View in: PubMed
    7. Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips J, Ronen SM. 2-hydroxyglutarate-mediated autophagy of the endoplasmic reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas. Cancer Res. 2018 Jan 22. PMID: 29358170.
      View in: PubMed
    8. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips J, Garg K, Rabban JT, Zaloudek C, Solomon DA. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 Apr; 31(4):660-673. PMID: 29148537.
      View in: PubMed
    9. Lopez GY, Oberheim Bush NA, Phillips J, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA. Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression. Acta Neuropathol. 2017 Dec; 134(6):961-963. PMID: 29063183.
      View in: PubMed
    10. Autry A, Phillips J, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903. PMID: 28942218.
      View in: PubMed
    11. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips J, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):10743-10748. PMID: 28916733.
      View in: PubMed
    12. Tran VM, Wade A, McKinney A, Chen K, Lindberg OR, Engler JR, Persson AI, Phillips J. Heparan Sulfate Glycosaminoglycans in Glioblastoma Promote Tumor Invasion. Mol Cancer Res. 2017 Nov; 15(11):1623-1633. PMID: 28778876.
      View in: PubMed
    13. Wahl M, Chang SM, Phillips J, Molinaro AM, Costello JF, Mazor T, Alexandrescu S, Lupo JM, Nelson SJ, Berger M, Prados M, Taylor JW, Butowski N, Clarke JL, Haas-Kogan D. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639. PMID: 28759109.
      View in: PubMed
    14. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips J, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. PMID: 28453743.
      View in: PubMed
    15. Jalbert LE, Elkhaled A, Phillips J, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792. PMID: 28327577.
      View in: PubMed
    16. Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips J, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017 03 13; 31(3):424-435. PMID: 28292440.
      View in: PubMed
    17. Wahl M, Phillips J, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251. PMID: 27571885.
      View in: PubMed
    18. Neill E, Luks T, Dayal M, Phillips J, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 03; 132(1):171-179. PMID: 28124178.
      View in: PubMed
    19. Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, David James C, Molinaro AM, Shieh JT, Phillips J. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016 Nov 29; 7(48):79101-79116. PMID: 27738329.
      View in: PubMed
    20. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips J, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345. PMID: 27820599.
      View in: PubMed
    21. Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips J, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW. Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia. Brain. 2016 12; 139(Pt 12):3202-3216. PMID: 27797809.
      View in: PubMed
    22. Ge X, Gong H, Dumas K, Litwin J, Phillips J, Waisfisz Q, Weiss MM, Hendriks Y, Stuurman KE, Nelson SF, Grody WW, Lee H, Kwok PY, Shieh JT. Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation. NPJ Genom Med. 2016; 1. PMID: 28868155.
      View in: PubMed
    23. Phillips J, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 11; 132(5):757-760. PMID: 27624885.
      View in: PubMed
    24. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips J, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 12; 130(3):543-552. PMID: 27624915.
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    25. Lal S, Peng KW, Steele MB, Jenks N, Ma H, Kohanbash G, Phillips J, Raffel C. Safety Study: Intraventricular Injection of a Modified Oncolytic Measles Virus into Measles-Immune, hCD46-Transgenic, IFNaRko Mice. Hum Gene Ther Clin Dev. 2016 12; 27(4):145-151. PMID: 27604429.
      View in: PubMed
    26. Wood MD, Reis GF, Reuss DE, Phillips J. Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence. J Neuropathol Exp Neurol. 2016 Oct; 75(10):925-935. PMID: 27539476.
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    27. Mukherjee J, Ohba S, See WL, Phillips J, Molinaro AM, Pieper RO. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016 Jul 01; 139(1):99-111. PMID: 26874904.
      View in: PubMed
    28. Jalbert LE, Neill E, Phillips J, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 08; 18(8):1169-79. PMID: 26911151; PMCID: PMC4933480.
      View in: PubMed, PubMed Central
    29. Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips J, Ronen SM. MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival. Mol Cancer Ther. 2016 05; 15(5):1113-22. PMID: 26883274; PMCID: PMC4873419 [Available on 05/01/17].
      View in: PubMed, PubMed Central
    30. Solomon DA, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips J, Perry A. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2016 09; 26(5):569-80. PMID: 26517431.
      View in: PubMed
    31. Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips J, Berger MS, Nicolaides T, James CD, Petritsch CK. Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res. 2015 Dec 15; 75(24):5355-66. PMID: 26573800; PMCID: PMC4698003 [Available on 12/15/16].
      View in: PubMed, PubMed Central
    32. Mazor T, Pankov A, Johnson BE, Hong C, Hamilton EG, Bell RJA, Smirnov IV, Reis GF, Phillips J, Barnes MJ, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers MLM, Bollen AW, Taylor BS, Molinaro AM, Olshen AB, Chang SM, Song JS, Costello JF. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell. 2015 Sep 14; 28(3):307-317. PMID: 26373278; PMCID: PMC4573399.
      View in: PubMed, PubMed Central
    33. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips J, Pieper RO, Ronen SM. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Res. 2015 Aug 01; 75(15):2999-3009. PMID: 26045167; PMCID: PMC4526330.
      View in: PubMed, PubMed Central
    34. Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro AM, Phillips J, Vogel H, Wiencke JK, Wrensch MR, Walsh KM, Perry A. CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas. J Neuropathol Exp Neurol. 2015 May; 74(5):442-52. PMID: 25853694; PMCID: PMC4397174.
      View in: PubMed, PubMed Central
    35. Prados MD, Byron SA, Tran NL, Phillips J, Molinaro AM, Ligon KL, Wen PY, Kuhn JG, Mellinghoff IK, de Groot JF, Colman H, Cloughesy TF, Chang SM, Ryken TC, Tembe WD, Kiefer JA, Berens ME, Craig DW, Carpten JD, Trent JM. Toward precision medicine in glioblastoma: the promise and the challenges. Neuro Oncol. 2015 Aug; 17(8):1051-63. PMID: 25934816; PMCID: PMC4490873.
      View in: PubMed, PubMed Central
    36. Safaee M, Fakurnejad S, Bloch O, Clark AJ, Ivan ME, Sun MZ, Oh T, Phillips J, Parsa AT. Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells. PLoS One. 2015; 10(2):e0111532. PMID: 25714433; PMCID: PMC4340952.
      View in: PubMed, PubMed Central
    37. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips J, Ronen SM. Metabolic reprogramming in mutant IDH1 glioma cells. PLoS One. 2015; 10(2):e0118781. PMID: 25706986; PMCID: PMC4338038.
      View in: PubMed, PubMed Central
    38. Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips J. Glycosylation alterations in lung and brain cancer. Adv Cancer Res. 2015; 126:305-44. PMID: 25727152.
      View in: PubMed
    39. Wade A, Engler JR, Tran VM, Phillips J. Measuring sulfatase expression and invasion in glioblastoma. Methods Mol Biol. 2015; 1229:507-16. PMID: 25325976.
      View in: PubMed
    40. Phillips J, Tihan T, Fuller G. Practical molecular pathology and histopathology of embryonal tumors. Surg Pathol Clin. 2015 Mar; 8(1):73-88. PMID: 25783823.
      View in: PubMed
    41. Singer MS, Phillips J, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 02; 440:72-8. PMID: 25444749; PMCID: PMC4305470.
      View in: PubMed, PubMed Central
    42. Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips J, Ronen SM. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. PLoS One. 2014; 9(9):e108289. PMID: 25243911; PMCID: PMC4171511.
      View in: PubMed, PubMed Central
    43. Ivan ME, Safaee M, Oh T, Clark AJ, Sun MZ, Kim J, Bloch O, Jahangiri A, Phillips J, Aghi MK, Parsa AT. Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas. J Neurooncol. 2015 Jan; 121(1):53-61. PMID: 25200831.
      View in: PubMed
    44. Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips J, Molinaro AM, Chang SM, Nelson SJ. Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy. NMR Biomed. 2014 May; 27(5):578-93. PMID: 24596146; PMCID: PMC3983568.
      View in: PubMed, PubMed Central
    45. Wade A, McKinney A, Phillips J. Matrix regulators in neural stem cell functions. Biochim Biophys Acta. 2014 Aug; 1840(8):2520-5. PMID: 24447567; PMCID: PMC4074566.
      View in: PubMed, PubMed Central
    46. Solomon DA, Kim JS, Bondaruk J, Shariat SF, Wang ZF, Elkahloun AG, Ozawa T, Gerard J, Zhuang D, Zhang S, Navai N, Siefker-Radtke A, Phillips J, Robinson BD, Rubin MA, Volkmer B, Hautmann R, Küfer R, Hogendoorn PC, Netto G, Theodorescu D, James CD, Czerniak B, Miettinen M, Waldman T. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013 Dec; 45(12):1428-30. PMID: 24121789; PMCID: PMC3875130.
      View in: PubMed, PubMed Central
    47. Sun MZ, Oh MC, Ivan ME, Kaur G, Safaee M, Kim JM, Phillips J, Auguste KI, Parsa AT. Current management of choroid plexus carcinomas. Neurosurg Rev. 2014 Apr; 37(2):179-92; discussion 192. PMID: 24068529.
      View in: PubMed
    48. Sun MZ, Kim JM, Oh MC, Safaee M, Kaur G, Clark AJ, Bloch O, Ivan ME, Kaur R, Oh T, Fouse SD, Phillips J, Berger MS, Parsa AT. Na?/K?-ATPase ß2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells. Neuro Oncol. 2013 Nov; 15(11):1518-31. PMID: 23887941; PMCID: PMC3813412.
      View in: PubMed, PubMed Central
    49. Abedalthagafi M, Phillips J, Kim GE, Mueller S, Haas-Kogen DA, Marshall RE, Croul SE, Santi MR, Cheng J, Zhou S, Sullivan LM, Martinez-Lage M, Judkins AR, Perry A. The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas. Mod Pathol. 2013 Nov; 26(11):1425-32. PMID: 23765250.
      View in: PubMed
    50. DeLance AR, Safaee M, Oh MC, Clark AJ, Kaur G, Sun MZ, Bollen AW, Phillips J, Parsa AT. Tuberculoma of the central nervous system. J Clin Neurosci. 2013 Oct; 20(10):1333-41. PMID: 23768968.
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    51. Reis GF, Bloomer MM, Perry A, Phillips J, Grenert JP, Karnezis AN, Tihan T. Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system. Mod Pathol. 2013 Oct; 26(10):1279-87. PMID: 23702730.
      View in: PubMed
    52. Phillips J, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 2013 Sep; 23(5):565-73. PMID: 23438035; PMCID: PMC3715570.
      View in: PubMed, PubMed Central
    53. Mukherjee J, Phillips J, Zheng S, Wiencke J, Ronen SM, Pieper RO. Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. PLoS One. 2013; 8(2):e57610. PMID: 23451252; PMCID: PMC3581484.
      View in: PubMed, PubMed Central
    54. Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips J, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429. PMID: 24019001; PMCID: PMC3908661.
      View in: PubMed, PubMed Central
    55. Wiencke JK, Accomando WP, Zheng S, Patoka J, Dou X, Phillips J, Hsuang G, Christensen BC, Houseman EA, Koestler DC, Bracci P, Wiemels JL, Wrensch M, Nelson HH, Kelsey KT. Epigenetic biomarkers of T-cells in human glioma. Epigenetics. 2012 Dec 01; 7(12):1391-402. PMID: 23108258; PMCID: PMC3528694.
      View in: PubMed, PubMed Central
    56. Hashizume R, Smirnov I, Liu S, Phillips J, Hyer J, McKnight TR, Wendland M, Prados M, Banerjee A, Nicolaides T, Mueller S, James CD, Gupta N. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec; 110(3):305-13. PMID: 22983601.
      View in: PubMed
    57. Engler JR, Robinson AE, Smirnov I, Hodgson JG, Berger MS, Gupta N, James CD, Molinaro A, Phillips J. Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One. 2012; 7(8):e43339. PMID: 22937035; PMCID: PMC3425586.
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    58. Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips J, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Jul; 70(1):33-9. PMID: 22851374; PMCID: PMC3630274.
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    59. Lu KV, Chang JP, Parachoniak CA, Pandika MM, Aghi MK, Meyronet D, Isachenko N, Fouse SD, Phillips J, Cheresh DA, Park M, Bergers G. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell. 2012 Jul 10; 22(1):21-35. PMID: 22789536; PMCID: PMC4068350.
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    60. Barajas RF, Phillips J, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang SM, Nelson SJ. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54. PMID: 22711606; PMCID: PMC3379808.
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    61. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips J, Taylor MD, Weiss WA. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell. 2012 May 15; 21(5):601-13. PMID: 22624711; PMCID: PMC3360885.
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    62. Huillard E, Hashizume R, Phillips J, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5. PMID: 22586120; PMCID: PMC3365162.
      View in: PubMed, PubMed Central
    63. Phillips J. Novel therapeutic targets in the brain tumor microenvironment. Oncotarget. 2012 May; 3(5):568-75. PMID: 22643827; PMCID: PMC3388186.
      View in: PubMed, PubMed Central
    64. Phillips J, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22. PMID: 22293178; PMCID: PMC3287216.
      View in: PubMed, PubMed Central
    65. Elkhaled A, Jalbert LE, Phillips J, Yoshihara HAI, Parvataneni R, Srinivasan R, Bourne G, Berger MS, Chang SM, Cha S, Nelson SJ. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. Sci Transl Med. 2012 Jan 11; 4(116):116ra5. PMID: 22238333; PMCID: PMC3772177.
      View in: PubMed, PubMed Central
    66. Goldhoff P, Clarke J, Smirnov I, Berger MS, Prados MD, James CD, Perry A, Phillips J. Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype. J Neuropathol Exp Neurol. 2012 Jan; 71(1):83-9. PMID: 22157621; PMCID: PMC3246124.
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    67. Park I, Bok R, Ozawa T, Phillips J, James CD, Vigneron DB, Ronen SM, Nelson SJ. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging. 2011 Jun; 33(6):1284-90. PMID: 21590996; PMCID: PMC4983457.
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    68. McKnight TR, Smith KJ, Chu PW, Chiu KS, Cloyd CP, Chang SM, Phillips J, Berger MS. Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma. J Magn Reson Imaging. 2011 Apr; 33(4):808-16. PMID: 21448944; PMCID: PMC3076678.
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    69. Kane AJ, Sughrue ME, Rutkowski MJ, Phillips J, Parsa AT. EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. Neuroreport. 2010 Nov 17; 21(16):1018-22. PMID: 20827226; PMCID: PMC3064464.
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    70. Srinivasan R, Phillips J, Vandenberg SR, Polley MY, Bourne G, Au A, Pirzkall A, Cha S, Chang SM, Nelson SJ. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM. Neuro Oncol. 2010 Nov; 12(11):1152-61. PMID: 20647244; PMCID: PMC3098023.
      View in: PubMed, PubMed Central
    71. Phillips J, Misra A, Feuerstein BG, Kunwar S, Tihan T. Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization. Arch Pathol Lab Med. 2010 Jul; 134(7):1063-9. PMID: 20586639; PMCID: PMC3161118.
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    72. Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips J, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L. Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 2010 May 15; 24(10):1059-72. PMID: 20478998; PMCID: PMC2867210.
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    73. Smith JS, Quiñones-Hinojosa A, Phillips J, Bollen AW, McDermott MW, Cha S. Limitations of diffusion-weighted imaging in distinguishing between a brain tumor and a central nervous system histoplasmoma. J Neurooncol. 2006 Sep; 79(2):217-8. PMID: 16850113.
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    74. Josephson SA, Pillai DR, Phillips J, Chou D. Neurolisteriosis presenting as cervical myelitis in an immunocompetent patient. Neurology. 2006 Apr 11; 66(7):1122-3. PMID: 16606936.
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    75. Phillips J, Mahony BS, Siebert JR, Lalani T, Fligner CL, Kapur RP. Dandy-Walker malformation complex: correlation between ultrasonographic diagnosis and postmortem neuropathology. Obstet Gynecol. 2006 Mar; 107(3):685-93. PMID: 16507942.
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    76. MacNamara KC, Chua MM, Phillips J, Weiss SR. Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence. J Virol. 2005 Jul; 79(14):9108-18. PMID: 15994805; PMCID: PMC1168726.
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    77. Tsai JC, de Groot L, Pinon JD, Iacono KT, Phillips J, Seo SH, Lavi E, Weiss SR. Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system. Virology. 2003 Aug 01; 312(2):369-80. PMID: 12919742.
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    78. Phillips J, Chua MM, Rall GF, Weiss SR. Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system. Virology. 2002 Sep 15; 301(1):109-20. PMID: 12359451.
      View in: PubMed
    79. Phillips J, Chua M, Seo SH, Weiss SR. Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence. J Neurovirol. 2001 Oct; 7(5):421-31. PMID: 11582514.
      View in: PubMed
    80. Chua MM, Phillips J, Seo SH, Lavi E, Weiss SR. Mutation of the immunodominant CD8+ epitope in the MHV-4 spike protein. Adv Exp Med Biol. 2001; 494:121-5. PMID: 11774455.
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    81. Phillips J, Weiss SR. MHV neuropathogenesis: the study of chimeric S genes and mutations in the hypervariable region. Adv Exp Med Biol. 2001; 494:115-9. PMID: 11774454.
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    82. Phillips J, Chua MM, Lavi E, Weiss SR. Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: the murine coronavirus spike protein is a major determinant of neurovirulence. J Virol. 1999 Sep; 73(9):7752-60. PMID: 10438865; PMCID: PMC104302.
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