Daniel Southworth, PhD

Title(s)Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #310A
San Francisco CA 94158
Phone415-502-3775
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Awards and Honors
    American Heart Association2013  - 2016Top Scientist Development Award
    Alzheimer's Association2012  - 2014New Investigator Award
    University of Michigan2011Biological Sciences Scholar
    American Cancer Society2007  - 2010Postdoctoral Fellowship
    Johns Hopkins University2004Paul Ehrlich Research Award

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Protein Disaggregation and Turnover by AAA+ Chaperones
    NIH R01GM138690Jul 1, 2021 - Mar 31, 2025
    Role: Principal Investigator
    Probing the Role of Chaperone-TPR Complexes in Tau Proteostasis
    NIH RF1AG068125Sep 1, 2020 - Aug 31, 2024
    Role: Co-Principal Investigator
    The molecular mechanisms of nutrient- and stress-dependent mTORC1 regulation mediated by human Sestrin2.
    NIH R01DK111465Sep 19, 2016 - Aug 31, 2021
    Role: Co-Investigator
    Defining the conformational cycle of nitric oxide synthases
    NIH R01GM110001Sep 1, 2015 - Aug 31, 2021
    Role: Principal Investigator
    Exploration of Molecular Chaperone Complexes During Active Protein Triage
    NIH R01GM109896Jun 1, 2014 - Feb 28, 2019
    Role: Co-Investigator
    Mechanisms of motor neuron toxicity in Kennedy disease
    NIH R01NS055746Mar 5, 2007 - Apr 30, 2022
    Role: Co-Principal Investigator
    Mechanisms of Activation for Human Small Heat Shock Proteins: An Integrated Approach
    NIH R01EY017370Apr 1, 2006 - Jun 30, 2020
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils. PLoS Biol. 2024 Oct; 22(10):e3002650. Huettemann P, Mahadevan P, Lempart J, Tse E, Dehury B, Edwards BFP, Southworth DR, Sahoo BR, Jakob U. PMID: 39480879; PMCID: PMC11527176.
      View in: PubMed   Mentions:
    2. Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP. Nat Commun. 2024 Sep 12; 15(1):7972. Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. PMID: 39266525; PMCID: PMC11393453.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Nat Struct Mol Biol. 2024 Jul 01. Braxton JR, Shao H, Tse E, Gestwicki JE, Southworth DR. PMID: 38951622.
      View in: PubMed   Mentions: 1     Fields:    
    4. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta Neuropathol Commun. 2024 06 12; 12(1):94. Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C. PMID: 38867338; PMCID: PMC11167798.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv. 2024 May 28. Ghosh U, Tse E, Yang H, Shi M, Carlo CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C. PMID: 38617229; PMCID: PMC11014571.
      View in: PubMed   Mentions:
    6. Amyloid Accelerator Polyphosphate Implicated as the Mystery Density in α-Synuclein Fibrils. bioRxiv. 2024 May 02. Huettemann P, Mahadevan P, Lempart J, Tse E, Dehury B, Edwards BFP, Southworth DR, Sahoo BR, Jakob U. PMID: 38746133; PMCID: PMC11092616.
      View in: PubMed   Mentions:
    7. Design principles to tailor Hsp104 therapeutics. bioRxiv. 2024 Apr 28. Lin J, Carman PJ, Gambogi CW, Kendsersky NM, Chuang E, Gates SN, Yokom AL, Rizo AN, Southworth DR, Shorter J. PMID: 38712168; PMCID: PMC11071516.
      View in: PubMed   Mentions:
    8. Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry. J Biol Chem. 2024 Jan; 300(1):105464. Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. PMID: 37979917; PMCID: PMC10716779.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    9. The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat Struct Mol Biol. 2023 Dec; 30(12):2009-2019. Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. PMID: 37945741; PMCID: PMC10716044.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality. J Biol Chem. 2023 11; 299(11):105182. Braxton JR, Southworth DR. PMID: 37611827; PMCID: PMC10641518.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv. 2023 Aug 16. Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. PMID: 37645969; PMCID: PMC10462110.
      View in: PubMed   Mentions:
    12. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). J Mol Biol. 2023 06 01; 435(11):168026. Nadel CM, Thwin AC, Callahan M, Lee K, Connelly E, Craik CS, Southworth DR, Gestwicki JE. PMID: 37330289; PMCID: PMC10491737.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nat Commun. 2023 05 26; 14(1):3048. Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR. PMID: 37236970; PMCID: PMC10220082.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    14. Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. bioRxiv. 2023 May 15. Braxton JR, Shao H, Tse E, Gestwicki JE, Southworth DR. PMID: 37293102; PMCID: PMC10245740.
      View in: PubMed   Mentions:
    15. The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. bioRxiv. 2023 May 15. Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. PMID: 37292947; PMCID: PMC10245715.
      View in: PubMed   Mentions:
    16. Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. J Am Chem Soc. 2023 Feb 08. Montgomery KM, Carroll EC, Thwin AC, Quddus AY, Hodges P, Southworth DR, Gestwicki JE. PMID: 36753572; PMCID: PMC9951223.
      View in: PubMed   Mentions: 8     Fields:    
    17. Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Rep. 2022 09 27; 40(13):111408. Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Gupta K, Southworth DR, Shorter J. PMID: 36170828; PMCID: PMC9584538.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Cryo-EM structures reveal dramatic remodeling of the p97 hexamer by the multi-domain adapter UBXD1. Acta Crystallographica Section A: Foundations and advances. 2022 Jul 29; 78(a1):a202-a202. Braxton BJ, Altobelli AC, Arkin AM, Southworth SD. .
      View in: Publisher Site   Mentions:
    19. Structural and mechanistic studies of Skd3 (human CLPB) provide insight into disease-causing mutations and reveal unique AAA+ oligomerization. Biophysical Journal. 2022 Feb 1; 121(3):325a. Rizo RA, Cupo CR, Shorter SJ, Southworth SD. .
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    20. Structural basis for client engagement and chaperone cycling by human mitochondrial Hsp60. Biophysical Journal. 2022 Feb 1; 121(3):323a. Braxton BJ, Gestwicki GJ, Southworth SD. .
      View in: Publisher Site   Mentions:
    21. Structural basis for recognition of the Hsp90 closed, ATP state by the TPR-containing co-chaperone FKBP51. Alzheimer's & Dementia. 2021 Dec 1; 17(S3). Lee LK, Thwin TA, Tse TE, Gates GS, Southworth SD. .
      View in: Publisher Site   Mentions:
    22. Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes. Structure. 2022 01 06; 30(1):156-171.e12. Seraphim TV, Nano N, Cheung YWS, Aluksanasuwan S, Colleti C, Mao YQ, Bhandari V, Young G, Höll L, Phanse S, Gordiyenko Y, Southworth DR, Robinson CV, Thongboonkerd V, Gava LM, Borges JC, Babu M, Barbosa LRS, Ramos CHI, Kukura P, Houry WA. PMID: 34492227.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Mol Cell. 2021 09 02; 81(17):3496-3508.e5. Lee K, Thwin AC, Nadel CM, Tse E, Gates SN, Gestwicki JE, Southworth DR. PMID: 34380015; PMCID: PMC8418782.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34031651; PMCID: PMC8142659.
      View in: PubMed   Mentions: 1  
    25. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. J Struct Biol. 2021 09; 213(3):107745. Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA. PMID: 33984504.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    26. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions: 4  
    27. Conformational Plasticity of the Clpap Aaa+ Protease Couples Protein Unfolding and Proteolysis. Biophysical Journal. 2021 Feb 1; 120(3):99a. Rizo RA, Lopez LK, Shorter SJ, Southworth SD. .
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    28. Structural Basis for Recognition of the Hsp90 Closed, ATP State by the TPR-Containing Co-Chaperone FKBP51. Biophysical Journal. 2021 Feb 1; 120(3):197a. Lee LK, Thwin TA, Southworth SD. .
      View in: Publisher Site   Mentions:
    29. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 380     Fields:    Translation:HumansCells
    30. Practical Considerations of Using the K3 Camera in CDS Mode for High-resolution and High-throughput Single Particle Cryo-EM. Microscopy and Microanalysis. 2020 Jul 30; 1-1. Sun SM, Azumaya AC, Tse TE, Southworth SD, Verba VK, Frost FA, Cheng CY, Agard AD. .
      View in: Publisher Site   Mentions:
    31. Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat Struct Mol Biol. 2020 05; 27(5):406-416. Lopez KE, Rizo AN, Tse E, Lin J, Scull NW, Thwin AC, Lucius AL, Shorter J, Southworth DR. PMID: 32313240; PMCID: PMC7529148.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    32. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019 12 13; 294(50):18952-18966. Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. PMID: 31578281; PMCID: PMC6916486.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    33. Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity. Life Sci Alliance. 2019 10; 2(5). Lempart J, Tse E, Lauer JA, Ivanova MI, Sutter A, Yoo N, Huettemann P, Southworth D, Jakob U. PMID: 31533964; PMCID: PMC6751573.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Rep. 2019 08 20; 28(8):2080-2095.e6. Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J. PMID: 31433984; PMCID: PMC6750954.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    35. Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase. Cold Spring Harb Perspect Biol. 2019 08 01; 11(8). Shorter J, Southworth DR. PMID: 30745294; PMCID: PMC6671941.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    36. Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nat Commun. 2019 06 03; 10(1):2393. Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR. PMID: 31160557; PMCID: PMC6546751.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    37. Allosteric Regulation of Oligomerization by a B12 Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria. Cell Chem Biol. 2019 07 18; 26(7):960-969.e4. Ruetz M, Campanello GC, McDevitt L, Yokom AL, Yadav PK, Watkins D, Rosenblatt DS, Ohi MD, Southworth DR, Banerjee R. PMID: 31056463; PMCID: PMC6642015.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nat Commun. 2019 02 08; 10(1):659. Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U. PMID: 30737390; PMCID: PMC6368585.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Cryo-EM Structural Analysis of Neuronal Nitric Oxide Synthase. Biophysical Journal. 2019 Feb 1; 116(3):187a-188a. Pospiech PT, Morishima MY, Osawa OY, Southworth SD. .
      View in: Publisher Site   Mentions:
    40. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nat Commun. 2018 11 01; 9(1):4563. Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. PMID: 30385828; PMCID: PMC6212398.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    41. Polyphosphate Stabilizes Protein Unfolding Intermediates as Soluble Amyloid-like Oligomers. J Mol Biol. 2018 10 19; 430(21):4195-4208. Yoo NG, Dogra S, Meinen BA, Tse E, Haefliger J, Southworth DR, Gray MJ, Dahl JU, Jakob U. PMID: 30130556; PMCID: PMC6186493.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    42. Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery. Mol Pharmacol. 2018 09; 94(3):984-991. Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. PMID: 29941666; PMCID: PMC6064783.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    43. The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis. J Biol Chem. 2018 05 18; 293(20):7727-7736. Zhang H, Yokom AL, Cheng S, Su M, Hollenberg PF, Southworth DR, Osawa Y. PMID: 29618513; PMCID: PMC5961045.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    44. X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition. J Biol Chem. 2018 02 16; 293(7):2370-2380. Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. PMID: 29255093; PMCID: PMC5818200.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    45. Switch I-dependent allosteric signaling in a G-protein chaperone-B12 enzyme complex. J Biol Chem. 2017 10 27; 292(43):17617-17625. Campanello GC, Lofgren M, Yokom AL, Southworth DR, Banerjee R. PMID: 28882898; PMCID: PMC5663867.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    46. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 2017 07 21; 357(6348):273-279. Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. PMID: 28619716; PMCID: PMC5770238.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    47. Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing. FEBS Lett. 2017 06; 591(11):1601-1610. Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ. PMID: 28303570; PMCID: PMC5468478.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. THE STRUCTURAL BASIS FOR POLYPEPTIDE TRANSLOCATION BY THE HSP104 DISAGGREGASE. The FASEB Journal. 2017 Apr 1; 31(S1). Southworth SD, Yokom YA, Gates GS, Jackerel JM, Shorter SJ. .
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    49. BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. J Mol Biol. 2017 01 06; 429(1):128-141. Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. PMID: 27884606; PMCID: PMC5186407.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    50. Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Mol Cell. 2016 09 01; 63(5):768-80. Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. PMID: 27570072; PMCID: PMC5234082.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    51. Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nat Struct Mol Biol. 2016 09; 23(9):830-7. Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. PMID: 27478928; PMCID: PMC5509435.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    52. Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy. Structure. 2016 05 03; 24(5):657-666. Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR. PMID: 27112599.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    53. Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation. Biochemistry. 2015 Dec 08; 54(48):7120-31. Assimon VA, Southworth DR, Gestwicki JE. PMID: 26565746; PMCID: PMC4714923.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    54. Single-particle cryo-electron microscopy of macromolecular complexes. Microscopy (Oxf). 2016 Feb; 65(1):9-22. Skiniotis G, Southworth DR. PMID: 26611544; PMCID: PMC5895108.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    55. A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis. Elife. 2015 May 11; 4. Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE. PMID: 25962097; PMCID: PMC4456606.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    56. Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1. Biochim Biophys Acta. 2015 Jun; 1850(6):1310-8. Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP. PMID: 25783003; PMCID: PMC4398645.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    57. Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E616-24. Teixeira F, Castro H, Cruz T, Tse E, Koldewey P, Southworth DR, Tomás AM, Jakob U. PMID: 25646478; PMCID: PMC4343147.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    58. The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Mol Cell. 2014 Oct 02; 56(1):116-27. Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U. PMID: 25242142; PMCID: PMC4204210.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    59. Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles. Cell. 2014 Jun 19; 157(7):1685-97. Kirschke E, Goswami D, Southworth D, Griffin PR, Agard DA. PMID: 24949977; PMCID: PMC4087167.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansCells
    60. Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain. J Biol Chem. 2014 Jun 13; 289(24):16855-65. Yokom AL, Morishima Y, Lau M, Su M, Glukhova A, Osawa Y, Southworth DR. PMID: 24737326; PMCID: PMC4059128.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    61. KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation. Neoplasia. 2014 Feb; 16(2):115-28. Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D. PMID: 24709419; PMCID: PMC3978392.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    62. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. J Biol Chem. 2014 Jan 31; 289(5):2908-17. Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. PMID: 24327656; PMCID: PMC3908423.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    63. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 2013 Aug 13; 52(32):5354-64. Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. PMID: 23865999; PMCID: PMC3856692.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    64. The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis. Protein Sci. 2012 Aug; 21(8):1162-71. Cunningham CN, Southworth DR, Krukenberg KA, Agard DA. PMID: 22653663; PMCID: PMC3537237.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    65. Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex. Mol Cell. 2011 Jun 24; 42(6):771-81. Southworth DR, Agard DA. PMID: 21700222; PMCID: PMC3144320.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    66. High-Q nanomechanics via destructive interference of elastic waves. Phys Rev Lett. 2011 Jan 28; 106(4):047205. Wilson-Rae I, Barton RA, Verbridge SS, Southworth DR, Ilic B, Craighead HG, Parpia JM. PMID: 21405358.
      View in: PubMed   Mentions: 12     Fields:    
    67. Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide. Protein Sci. 2009 Sep; 18(9):1815-27. Krukenberg KA, Böttcher UM, Southworth DR, Agard DA. PMID: 19554567; PMCID: PMC2777357.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    68. pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation. J Mol Biol. 2009 Jul 10; 390(2):278-91. Krukenberg KA, Southworth DR, Street TO, Agard DA. PMID: 19427321; PMCID: PMC2735500.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    69. Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. Mol Cell. 2008 Dec 05; 32(5):631-40. Southworth DR, Agard DA. PMID: 19061638; PMCID: PMC2633443.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    70. Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol. 2007 Dec 07; 374(4):1065-76. Sharma D, Cukras AR, Rogers EJ, Southworth DR, Green R. PMID: 17967466; PMCID: PMC2200631.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    71. Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell. 2006 Oct 20; 127(2):329-40. Shiau AK, Harris SF, Southworth DR, Agard DA. PMID: 17055434.
      View in: PubMed   Mentions: 219     Fields:    Translation:Cells
    72. EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding. RNA. 2004 Jan; 10(1):102-13. Sharma D, Southworth DR, Green R. PMID: 14681589; PMCID: PMC1370522.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    73. Demonstration of the role of the DnaK chaperone system in assembly of 30S ribosomal subunits using a purified in vitro system. RNA. 2003 Dec; 9(12):1418-21. Maki JA, Southworth DR, Culver GM. PMID: 14623997; PMCID: PMC1370495.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    74. Ribosomal translocation: sparsomycin pushes the button. Curr Biol. 2003 Aug 19; 13(16):R652-4. Southworth DR, Green R. PMID: 12932345.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    75. Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex. Mol Cell. 2003 Aug; 12(2):321-8. Cukras AR, Southworth DR, Brunelle JL, Culver GM, Green R. PMID: 14536072.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    76. EFG-independent translocation of the mRNA:tRNA complex is promoted by modification of the ribosome with thiol-specific reagents. J Mol Biol. 2002 Dec 06; 324(4):611-23. Southworth DR, Brunelle JL, Green R. PMID: 12460565.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
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