Zhonghui Guan, MD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address1550 Fourth Street, #345
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San Francisco, CA08/2009Clinical Pain Fellow
    Massachusetts General Hospital, Boston, MA08/2008Anesthesia Resident
    Columbia University, New York, NY07/2004Associate Research Scientist
    National Institute of Health (NIH), Bethesda, MD04/1999Postdoctoral Research Scientist
    Peking Union Medical College (PUMC), Beijing, ChinaMD07/1994Medicine
    Collapse Awards and Honors
    U.S. News & World Report2012Top Doctor in Pain Management

    Collapse Overview 
    Collapse Overview
    Dr. Zhonghui Guan is an anesthesiologist and pain management specialist. He has particular expertise in treating chronic pain, including low back pain, neck pain, neuropathic pain, complex regional pain syndrome, failed back surgery syndrome and cancer pain.

    In his research, Guan focuses on better understanding the regulation of gene expression in chronic pain. Gene expression regulation is essentially cell processes that control synthesis of proteins or other products that play a role in body functions.

    Guan earned his medical degree at Peking Union Medical College in Beijing. He completed an anesthesia residency at Massachusetts General Hospital, followed by a pain management fellowship at UCSF.

    Guan is a member of numerous professional organizations, including the American Society of Anesthesiologists, California Society of Anesthesiologists and Society for Neuroscience.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms and consequences of Hedgehog signaling and immune infiltration in schwannoma
    DOD NFRP NF200021Jul 15, 2021 - Jul 14, 2023
    Role: Co-Investigator
    Mechanism of microglia proliferation
    NIH R01NS121144Jun 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Regulation of Nerve Injury-induced Gene Expression in Neuropathic Pain
    NIH R01NS100801Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Epigenetic regulation in neuropathic pain
    NIH K08NS078050Sep 30, 2012 - Aug 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Clin Transl Med. 2024 Apr; 14(4):e1650. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z. PMID: 38649772; PMCID: PMC11035380.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Mismatched Postsurgical Opioid Prescription to Liver Transplant Patients: A Retrospective Cohort Study From a Single High-volume Transplant Center. Transplantation. 2024 Feb 01; 108(2):483-490. Chen VJ, Guan LS, Bokoch MP, Langnas E, Kothari R, Croci R, Campbell LJ, Quan D, Freise C, Guan Z. PMID: 38259180.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Opioid Overprescription and Underprescription to Patients After Otolaryngology-Head and Neck Surgery. JAMA Otolaryngol Head Neck Surg. 2023 08 01; 149(8):756-758. Kuo J, Langnas E, Zhang L, Seth R, Guan Z. PMID: 37347473; PMCID: PMC10288375.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study. Pain. 2023 Nov 01; 164(11):2615-2621. Campbell LJ, Mummaneni PV, Letchuman V, Langnas E, Agarwal N, Guan LS, Croci R, Vargas E, Reisner L, Bickler P, Chou D, Chang E, Guan Z. PMID: 37326642.
      View in: PubMed   Mentions:    Fields:    
    5. A Procedure for Mouse Dorsal Root Ganglion Cryosectioning. J Vis Exp. 2023 06 09; (196). He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z. PMID: 37358286.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Discharge Opioid Over- and Underprescription to Patients after General Surgery: A Retrospective Cohort Study. J Am Coll Surg. 2023 08 01; 237(2):332-342. Guan LS, Langnas E, Bongiovanni T, Campbell LJ, Wick EC, Guan Z. PMID: 37096926.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients. Neurosurgery. 2023 03 01; 92(3):490-496. Letchuman V, He L, Mummaneni PV, Agarwal N, Campbell LJ, Shabani S, Chan AK, Abrecht CR, Miller C, Sankaran S, Rambachan A, Croci R, Berven SH, Chou D, Holly LT, Guan Z. PMID: 36700672.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice. J Pain Res. 2022; 15:2223-2248. Su PP, Zhang L, He L, Zhao N, Guan Z. PMID: 35957964; PMCID: PMC9359791.
      View in: PubMed   Mentions: 6  
    9. Opioid prescribing practices at hospital discharge for surgical patients before and after the Centers for Disease Control and Prevention's 2016 opioid prescribing guideline. BMC Anesthesiol. 2022 05 11; 22(1):141. Langnas E, Bishara A, Croci R, Rodriguez-Monguio R, Wick EC, Chen CL, Guan Z. PMID: 35546657; PMCID: PMC9097447.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control. Front Cell Neurosci. 2022; 16:891631. Xiang X, Chen Y, Li KX, Fang J, Bickler PE, Guan Z, Zhou W. PMID: 35558876; PMCID: PMC9090436.
      View in: PubMed   Mentions: 2  
    11. Identification of Foramen Ovale With H-Figure Fluoroscopic Landmark Improves Treatment Outcomes in Idiopathic Trigeminal Neuralgia. Anesth Analg. 2022 10 01; 135(4):837-844. He LL, Zhao WX, Paul Su PY, Sun QR, Guo GL, Yue JN, Ni JX, Yang LQ, Guan Z. PMID: 35426836; PMCID: PMC9495645.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase. Cell Discov. 2022 Apr 12; 8(1):34. Tan W, Su PP, Leff J, Gao X, Chen J, Guan AK, Kalyanasundaram G, Ma A, Guan Z. PMID: 35411038; PMCID: PMC9001707.
      View in: PubMed   Mentions: 4  
    13. Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice. J Vis Exp. 2022 01 25; (179). He L, Zhao W, Zhang L, Ilango M, Zhao N, Yang L, Guan Z. PMID: 35156658.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. Function of Oncogene Mycn in Adult Neurogenesis and Oligodendrogenesis. Mol Neurobiol. 2022 Jan; 59(1):77-92. Chen J, Guan Z. PMID: 34625907; PMCID: PMC8786763.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. Novel method of locating the foramen ovale: a stable chair with solid legs. Reg Anesth Pain Med. 2022 01; 47(1):70. He L, Guan Z. PMID: 33952682.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Perioperative Use of Gabapentinoids: Comment. Anesthesiology. 2021 04 01; 134(4):665-666. Su PP, Guan Z. PMID: 33404633; PMCID: PMC7978162.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain Rep. 2021; 6(1):e883. Yu X, Basbaum A, Guan Z. PMID: 33981926; PMCID: PMC8108585.
      View in: PubMed   Mentions: 20  
    18. Ion Channels in Anesthesia. Adv Exp Med Biol. 2021; 1349:401-413. Zhou W, Guan Z. PMID: 35138625.
      View in: PubMed   Mentions: 2     Fields:    
    19. Novel fluoroscopic landmark to significantly facilitate the visualization of foramen ovale in treating idiopathic trigeminal neuralgia. Reg Anesth Pain Med. 2021 04; 46(4):350-353. He L, Zhao W, Su PP, Guo G, Yue J, Ni J, Yang L, Guan Z. PMID: 33328267.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun. 2020 01 14; 11(1):264. Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI. PMID: 31937758; PMCID: PMC6959328.
      View in: PubMed   Mentions: 168     Fields:    Translation:AnimalsCells
    21. Rapid Isolation of Dorsal Root Ganglion Macrophages. J Vis Exp. 2019 09 07; (151). Yu X, Leff J, Guan Z. PMID: 31545312; PMCID: PMC6778691.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Case Report and Literature Review: Interventional Management of Erythromelalgia. Transl Perioper Pain Med. 2019; 6(4):91-97. Chinn G, Guan Z. PMID: 31592193; PMCID: PMC6779334.
      View in: PubMed   Mentions: 1  
    23. Spinal Cord Stimulation for Failed Back Surgery Syndrome -- Patient Selection Considerations. Transl Perioper Pain Med. 2019; 6(3):81-90. Palmer N, Guan Z, Chai NC. PMID: 31687422; PMCID: PMC6828157.
      View in: PubMed   Mentions: 11  
    24. Anesthetic management of radical nephrectomy in patients with renal cell carcinoma involving renal vein or inferior vena cava. Tumori. 2019 Oct; 105(5):411-416. Chen K, Wang J, Dai J, Luo A, Tian Y, Guan Z, Wang X. PMID: 30940005.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Transcription factor Sp4 is required for hyperalgesic state persistence. PLoS One. 2019; 14(2):e0211349. Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M. PMID: 30811405; PMCID: PMC6392229.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Activation of orexin system facilitates anesthesia emergence and pain control. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10740-E10747. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY. PMID: 30348769; PMCID: PMC6233126.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    27. Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 2016; 5. Guan Z, Hellman J, Schumacher M. PMID: 27781082; PMCID: PMC5054801.
      View in: PubMed   Mentions: 11     Fields:    
    28. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. PMID: 26642091; PMCID: PMC4703328.
      View in: PubMed   Mentions: 223     Fields:    Translation:AnimalsCells
    29. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun; 156(6):1084-1091. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI. PMID: 25760475; PMCID: PMC4431911.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    30. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci. 2015 Jan 14; 35(2):648-57. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI. PMID: 25589759; PMCID: PMC4293415.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    31. Misalignment of disposable pulse oximeter probes results in false saturation readings that influence anesthetic management. Anesth Analg. 2009 Nov; 109(5):1530-3. Guan Z, Baker K, Sandberg WS. PMID: 19843792.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes. Genetics. 2006 May; 173(1):243-53. Yu JX, Guan Z, Nash HA. PMID: 16510791; PMCID: PMC1461445.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19186-91. Levine AA, Guan Z, Barco A, Xu S, Kandel ER, Schwartz JH. PMID: 16380431; PMCID: PMC1323217.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    34. p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia. J Neurosci. 2003 Aug 13; 23(19):7317-25. Guan Z, Kim JH, Lomvardas S, Holick K, Xu S, Kandel ER, Schwartz JH. PMID: 12917365; PMCID: PMC6740437.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    35. Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell. 2002 Nov 15; 111(4):483-93. Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER. PMID: 12437922.
      View in: PubMed   Mentions: 193     Fields:    Translation:AnimalsCells
    36. Mushroom body defect, a gene involved in the control of neuroblast proliferation in Drosophila, encodes a coiled-coil protein. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8122-7. Guan Z, Prado A, Melzig J, Heisenberg M, Nash HA, Raabe T. PMID: 10884435; PMCID: PMC16680.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    37. A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the X-chromosomal 12E region. J Neurogenet. 2000 Apr; 14(1):25-42. Guan Z, Scott RL, Nash HA. PMID: 10938546.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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