Paolo Rinaudo, MD, PhD

Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of TorinoM.D.1992School of Medicine
    University of TorinoPh.D.1997School of Medicine
    Yale UniversityResidency2001Obstetrics and Gyencology
    University of PennsylvaniaFellowship2004Reproductive Endocrinology and Infertility

    Collapse Overview 
    Collapse Overview
    Dr. Paolo Rinaudo is a specialist in reproductive endocrinology and fertility at the UCSF Center for Reproductive Health. In addition to caring for patients with fertility and endocrinological problems, Rinaudo conducts research on pre-implantation embryo development and the long-term consequences of in vitro culture. He is the recipient of numerous prestigious honors and awards, including the ASRM/Serono grant in reproductive biology and the President Presenter Award at the 50th annual meeting of the Society for Gynecological Investigation, Washington, DC. He is a member of professional societies, such as the American Society for Reproductive Medicine, American College of Obstetrics and Gynecology and Society for Reproductive Endocrinology and Infertility.

    Rinaudo earned a medical degree at Torino Medical School and a doctorate at Torino University in Torino, Italy. He completed a residency in obstetrics and gynecology at Yale University, followed by a fellowship in reproductive endocrinology and infertility at the Hospital of the University of Pennsylvania. He is an Associate Professor in residence in the department of Obstetrics, Gynecology and Reproductive Sciences at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Long-Term Health Effect of Fertility Treatments Using an Animal Model
    NIH/NICHD R01HD092267Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Epigenetic Programming of Health and Disease in the Preimplantation Embyro
    NIH/NICHD R01HD082039Dec 1, 2015 - Nov 30, 2017
    Role: Principal Investigator
    Effect of preimplantation embryo culture on adult glucose homeostasis
    NIH/NICHD R01HD062803Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Noninvasive assessment of embryo implantation potential using 1H NMR metabonomics
    NIH/NICHD R21HD054956Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Global Health
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hsu J, Velasco JAG, Rinaudo P. An initial step in examining long-term outcomes for children born after IVF. Reprod Biomed Online. 2017 08; 35(2):130-131. PMID: 28652097.
      View in: PubMed
    2. Feuer SK, Rinaudo P. Physiological, metabolic and transcriptional postnatal phenotypes of in vitro fertilization (IVF) in the mouse. J Dev Orig Health Dis. 2017 Apr 18; 1-8. PMID: 28416032.
      View in: PubMed
    3. Rinaudo P, Hsu J. To freeze or not to freeze: heating the debate but cooling the practice? J Assist Reprod Genet. 2017 Feb; 34(2):187-189. PMID: 28091759.
      View in: PubMed
    4. Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P. Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures. Reproduction. 2016 Oct 31. PMID: 27799627.
      View in: PubMed
    5. Feuer S, Rinaudo P. From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel). 2016 Aug 09; 4(3). PMID: 27517965.
      View in: PubMed
    6. Simbulan RK, Liu X, Feuer SK, Maltepe E, Donjacour A, Rinaudo P. Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue. J Dev Orig Health Dis. 2016 Feb; 7(1):73-82. PMID: 26511158.
      View in: PubMed
    7. Biechele S, Lin CJ, Rinaudo P, Ramalho-Santos M. Unwind and transcribe: chromatin reprogramming in the early mammalian embryo. Curr Opin Genet Dev. 2015 Oct; 34:17-23. PMID: 26183187; PMCID: PMC4674342 [Available on 10/01/16].
    8. Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P. Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential. PLoS One. 2015; 10(2):e0117422. PMID: 25723476; PMCID: PMC4344309.
    9. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo P, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 12. PMID: 25683712.
      View in: PubMed
    10. Delle Piane L, Rinaudo P, Miller WL. 150 years of congenital adrenal hyperplasia: translation and commentary of De Crecchio's classic paper from 1865. Endocrinology. 2015 Apr; 156(4):1210-7. PMID: 25635623.
      View in: PubMed
    11. Revelli A, Martiny G, Delle Piane L, Benedetto C, Rinaudo P, Tur-Kaspa I. A critical review of bi-dimensional and three-dimensional ultrasound techniques to monitor follicle growth: do they help improving IVF outcome? Reprod Biol Endocrinol. 2014 Nov 24; 12:107. PMID: 25420733; PMCID: PMC4255967.
    12. Strata F, Giritharan G, Sebastiano FD, Piane LD, Kao CN, Donjacour A, Rinaudo P. Behavior and brain gene expression changes in mice exposed to preimplantation and prenatal stress. Reprod Sci. 2015 Jan; 22(1):23-30. PMID: 25398605; PMCID: PMC4275453.
    13. Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo P, Maltepe E. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am J Pathol. 2014 Dec; 184(12):3321-31. PMID: 25307528; PMCID: PMC4258498.
    14. Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo P. Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. Endocrinology. 2014 Nov; 155(11):4554-67. PMID: 25211591; PMCID: PMC4197990.
    15. Bloise E, Feuer SK, Rinaudo P. Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding. Hum Reprod Update. 2014 Nov-Dec; 20(6):822-39. PMID: 24947475; PMCID: PMC4196686.
    16. Donjacour A, Liu X, Lin W, Simbulan R, Rinaudo P. In vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model. Biol Reprod. 2014 Apr; 90(4):80. PMID: 24621920; PMCID: PMC4076384.
    17. Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo P. Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. Endocrinology. 2014 May; 155(5):1956-69. PMID: 24684304; PMCID: PMC3990843.
    18. Caballero-Campo P, Buffone MG, Benencia F, Conejo-García JR, Rinaudo P, Gerton GL. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. J Cell Physiol. 2014 Jan; 229(1):68-78. PMID: 23765988; PMCID: PMC3807638.
    19. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo P, Rowitch DH, Aghi M, Maltepe E. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One. 2013; 8(4):e62758. PMID: 23646141; PMCID: PMC3639984.
    20. Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo P, Maltepe E. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS One. 2013; 8(2):e56949. PMID: 23437279; PMCID: PMC3578927.
    21. Rivera RM, Rinaudo P. Bovine preimplantation embryo development is affected by the stiffness of the culture substrate. Mol Reprod Dev. 2013 Mar; 80(3):184. PMID: 23325633; PMCID: PMC4121333.
    22. Feuer SK, Camarano L, Rinaudo P. ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies. Mol Hum Reprod. 2013 Apr; 19(4):189-204. PMID: 23264495; PMCID: PMC3598410.
    23. Feuer S, Rinaudo P. Preimplantation stress and development. Birth Defects Res C Embryo Today. 2012 Dec; 96(4):299-314. PMID: 24203919; PMCID: PMC3824155.
    24. Rinaudo P, Shen S, Hua J, Qian S, Prabhu U, Garcia E, Cedars M, Sukumaran D, Szyperski T, Andrews C. (1)H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos. J Assist Reprod Genet. 2012 Dec; 29(12):1435-42. PMID: 23090745; PMCID: PMC3528870.
    25. Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo P. Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet. 2012 Nov; 29(11):1203-5. PMID: 22941385; PMCID: PMC3510378.
    26. Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P. Effect of substrate stiffness on early mouse embryo development. PLoS One. 2012; 7(7):e41717. PMID: 22860009; PMCID: PMC3409240.
    27. Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P. Impaired placental nutrient transport in mice generated by in vitro fertilization. Endocrinology. 2012 Jul; 153(7):3457-67. PMID: 22562173; PMCID: PMC3380310.
    28. Giritharan G, Delle Piane L, Donjacour A, Esteban FJ, Horcajadas JA, Maltepe E, Rinaudo P. In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm. Reprod Sci. 2012 Mar; 19(3):243-52. PMID: 22383776; PMCID: PMC3343151.
    29. Rinaudo P, Wang E. Fetal programming and metabolic syndrome. Annu Rev Physiol. 2012; 74:107-30. PMID: 21910625; PMCID: PMC4132057.
    30. Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo P. Effect of ICSI on gene expression and development of mouse preimplantation embryos. Hum Reprod. 2010 Dec; 25(12):3012-24. PMID: 20889529; PMCID: PMC2989873.
    31. Delle Piane L, Lin W, Liu X, Donjacour A, Minasi P, Revelli A, Maltepe E, Rinaudo P. Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model. Hum Reprod. 2010 Aug; 25(8):2039-46. PMID: 20576634; PMCID: PMC2907231.
    32. Valley JK, Swinton P, Boscardin WJ, Lue TF, Rinaudo P, Wu MC, Garcia MM. Preimplantation mouse embryo selection guided by light-induced dielectrophoresis. PLoS One. 2010 Apr 13; 5(4):e10160. PMID: 20405021; PMCID: PMC2854157.
    33. Rosen MP, Shen S, Rinaudo P, Huddleston HG, McCulloch CE, Cedars MI. Fertilization rate is an independent predictor of implantation rate. Fertil Steril. 2010 Sep; 94(4):1328-33. PMID: 19560757.
      View in: PubMed
    34. Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol. 2009 May 04; 7:40. PMID: 19413899; PMCID: PMC2685803.
    35. Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo P, Lamb JD, Cedars MI. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol. 2009 Apr 23; 7:35. PMID: 19389255; PMCID: PMC2679036.
    36. Rinaudo P, Lamb J. Fetal origins of perinatal morbidity and/or adult disease. Semin Reprod Med. 2008 Sep; 26(5):436-45. PMID: 18825611.
      View in: PubMed
    37. Rosen MP, Shen S, Dobson AT, Rinaudo P, McCulloch CE, Cedars MI. A quantitative assessment of follicle size on oocyte developmental competence. Fertil Steril. 2008 Sep; 90(3):684-90. PMID: 18249377; PMCID: PMC4624406.
    38. Giritharan G, Talbi S, Donjacour A, Di Sebastiano F, Dobson AT, Rinaudo P. Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos. Reproduction. 2007 Jul; 134(1):63-72. PMID: 17641089.
      View in: PubMed
    39. Rosen MP, Shen S, McCulloch CE, Rinaudo P, Cedars MI, Dobson AT. Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity. Fertil Steril. 2007 Sep; 88(3):632-8. PMID: 17572411.
      View in: PubMed
    40. Lauko IG, Rinaudo P, Dashev S. A computational parameter study of embryo transfer. Ann Biomed Eng. 2007 Apr; 35(4):659-71. PMID: 17286205.
      View in: PubMed
    41. Dobson AT, Davis RM, Rosen MP, Shen S, Rinaudo P, Chan J, Cedars MI. Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF. Hum Reprod. 2007 Feb; 22(2):450-6. PMID: 17053001.
      View in: PubMed
    42. Rinaudo P, Giritharan G, Talbi S, Dobson AT, Schultz RM. Effects of oxygen tension on gene expression in preimplantation mouse embryos. Fertil Steril. 2006 Oct; 86(4 Suppl):1252-65, 1265.e1-36. PMID: 17008149.
      View in: PubMed
    43. Rinaudo P, Schultz RM. Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos. Reproduction. 2004 Sep; 128(3):301-11. PMID: 15333781.
      View in: PubMed
    44. Barnhart KT, Sammel MD, Rinaudo P, Zhou L, Hummel AC, Guo W. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004 Jul; 104(1):50-5. PMID: 15229000.
      View in: PubMed
    45. Barnhart KT, Rinaudo P, Hummel A, Pena J, Sammel MD, Chittams J. Acute and chronic presentation of ectopic pregnancy may be two clinical entities. Fertil Steril. 2003 Dec; 80(6):1345-51. PMID: 14667867.
      View in: PubMed
    46. Kovalevsky G, Rinaudo P, Coutifaris C. Do assisted reproductive technologies cause adverse fetal outcomes? Fertil Steril. 2003 Jun; 79(6):1270-2. PMID: 12798870.
      View in: PubMed
    47. Neuber E, Rinaudo P, Trimarchi JR, Sakkas D. Sequential assessment of individually cultured human embryos as an indicator of subsequent good quality blastocyst development. Hum Reprod. 2003 Jun; 18(6):1307-12. PMID: 12773464.
      View in: PubMed
    48. Shahabi S, Klein JP, Rinaudo P. Primary psoas abscess complicating a normal vaginal delivery. Obstet Gynecol. 2002 May; 99(5 Pt 2):906-9. PMID: 11975954.
      View in: PubMed
    49. Rinaudo P, Niven-Fairchild T, Buradagunta S, Massobrio M, Revelli A, Keefe DL. Microinjection of mitochondria into zygotes creates a model for studying the inheritance of mitochondrial DNA during preimplantation development. Fertil Steril. 1999 May; 71(5):912-8. PMID: 10231056.
      View in: PubMed
    50. Actis Dato GM, Rinaudo P, Revelli A, Actis Dato A, Punta G, Centofanti P, Cavaglià M, Barbato L, Massobrio M. Atrial septal defect and pregnancy: a retrospective analysis of obstetrical outcome before and after surgical correction. Minerva Cardioangiol. 1998 Mar; 46(3):63-8. PMID: 9677799.
      View in: PubMed
    51. Rinaudo P, Pepperell JR, Buradgunta S, Massobrio M, Keefe DL. Dissociation between intracellular calcium elevation and development of human oocytes treated with calcium ionophore. Fertil Steril. 1997 Dec; 68(6):1086-92. PMID: 9418702.
      View in: PubMed
    52. Behrman HR, Preston SL, Aten RF, Rinaudo P, Zreik TG. Hormone induction of ascorbic acid transport in immature granulosa cells. Endocrinology. 1996 Oct; 137(10):4316-21. PMID: 8828491.
      View in: PubMed
    53. Keefe D, Pepperell J, Rinaudo P, Kunkel J, Smith P. Identification of calcium flux in single preimplantation mouse embryos with the calcium-sensitive vibrating probe. Biol Bull. 1995 Oct-Nov; 189(2):200. PMID: 8541398.
      View in: PubMed
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