Paolo Rinaudo, MD, PhD

Title(s)Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of TorinoM.D.1992School of Medicine
    University of TorinoPh.D.1997School of Medicine
    Yale UniversityResidency2001Obstetrics and Gyencology
    University of PennsylvaniaFellowship2004Reproductive Endocrinology and Infertility

    Collapse Overview 
    Collapse Overview
    Dr. Paolo Rinaudo is a specialist in reproductive endocrinology and fertility at the UCSF Center for Reproductive Health. In addition to caring for patients with fertility and endocrinological problems, Rinaudo conducts research on pre-implantation embryo development and the long-term consequences of in vitro culture. He is the recipient of numerous prestigious honors and awards, including the ASRM/Serono grant in reproductive biology and the President Presenter Award at the 50th annual meeting of the Society for Gynecological Investigation, Washington, DC. He is a member of professional societies, such as the American Society for Reproductive Medicine, American College of Obstetrics and Gynecology and Society for Reproductive Endocrinology and Infertility.

    Rinaudo earned a medical degree at Torino Medical School and a doctorate at Torino University in Torino, Italy. He completed a residency in obstetrics and gynecology at Yale University, followed by a fellowship in reproductive endocrinology and infertility at the Hospital of the University of Pennsylvania. He is an Associate Professor in residence in the department of Obstetrics, Gynecology and Reproductive Sciences at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Long-Term Health Effect of Fertility Treatments Using an Animal Model
    NIH/NICHD R01HD092267Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Epigenetic Programming of Health and Disease in the Preimplantation Embyro
    NIH/NICHD R01HD082039Dec 1, 2015 - Nov 30, 2017
    Role: Principal Investigator
    Effect of preimplantation embryo culture on adult glucose homeostasis
    NIH/NICHD R01HD062803Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Noninvasive assessment of embryo implantation potential using 1H NMR metabonomics
    NIH/NICHD R21HD054956Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rinaudo P, Adeleye A. Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting? Semin Reprod Med. 2018 May; 36(3-04):204-210. PMID: 30866007.
      View in: PubMed
    2. Ding T, Mokshagundam S, Rinaudo PF, Osteen KG, Bruner-Tran KL. Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placental Pgr and Igf2 in a mouse model. Biol Reprod. 2018 Oct 01; 99(4):864-876. PMID: 29741588.
      View in: PubMed
    3. Caballero-Campo P, Lin W, Simbulan R, Liu X, Feuer S, Donjacour A, Rinaudo PF. Advanced Paternal Age Affects Sperm Count and Anogenital Distance in Mouse Offspring. Reprod Sci. 2018 04; 25(4):515-522. PMID: 29554862.
      View in: PubMed
    4. Rinaudo PF, Conti M. Report from the 2016 University of California, San Francisco, Center for Reproductive Sciences retreat. Mol Reprod Dev. 2017 10; 84(10):1024-1026. PMID: 28736970.
      View in: PubMed
    5. Hsu J, Velasco JAG, Rinaudo P. An initial step in examining long-term outcomes for children born after IVF. Reprod Biomed Online. 2017 08; 35(2):130-131. PMID: 28652097.
      View in: PubMed
    6. Rinaudo PF, Hsu J. To freeze or not to freeze: heating the debate but cooling the practice? J Assist Reprod Genet. 2017 Feb; 34(2):187-189. PMID: 28091759.
      View in: PubMed
    7. Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P. Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures. Reproduction. 2016 Oct 31. PMID: 27799627.
      View in: PubMed
    8. Feuer S, Rinaudo P. From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel). 2016 Aug 09; 4(3). PMID: 27517965.
      View in: PubMed
    9. Biechele S, Lin CJ, Rinaudo PF, Ramalho-Santos M. Unwind and transcribe: chromatin reprogramming in the early mammalian embryo. Curr Opin Genet Dev. 2015 Oct; 34:17-23. PMID: 26183187; PMCID: PMC4674342 [Available on 10/01/16].
    10. Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P. Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential. PLoS One. 2015; 10(2):e0117422. PMID: 25723476; PMCID: PMC4344309.
    11. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 12. PMID: 25683712.
      View in: PubMed
    12. Delle Piane L, Rinaudo PF, Miller WL. 150 years of congenital adrenal hyperplasia: translation and commentary of De Crecchio's classic paper from 1865. Endocrinology. 2015 Apr; 156(4):1210-7. PMID: 25635623.
      View in: PubMed
    13. Revelli A, Martiny G, Delle Piane L, Benedetto C, Rinaudo P, Tur-Kaspa I. A critical review of bi-dimensional and three-dimensional ultrasound techniques to monitor follicle growth: do they help improving IVF outcome? Reprod Biol Endocrinol. 2014 Nov 24; 12:107. PMID: 25420733; PMCID: PMC4255967.
    14. Strata F, Giritharan G, Sebastiano FD, Piane LD, Kao CN, Donjacour A, Rinaudo P. Behavior and brain gene expression changes in mice exposed to preimplantation and prenatal stress. Reprod Sci. 2015 Jan; 22(1):23-30. PMID: 25398605; PMCID: PMC4275453.
    15. Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am J Pathol. 2014 Dec; 184(12):3321-31. PMID: 25307528; PMCID: PMC4258498.
    16. Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF. Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. Endocrinology. 2014 Nov; 155(11):4554-67. PMID: 25211591.
      View in: PubMed
    17. Bloise E, Feuer SK, Rinaudo PF. Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding. Hum Reprod Update. 2014 Nov-Dec; 20(6):822-39. PMID: 24947475; PMCID: PMC4196686.
    18. Donjacour A, Liu X, Lin W, Simbulan R, Rinaudo PF. In vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model. Biol Reprod. 2014 Apr; 90(4):80. PMID: 24621920; PMCID: PMC4076384.
    19. Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF. Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. Endocrinology. 2014 May; 155(5):1956-69. PMID: 24684304.
      View in: PubMed
    20. Caballero-Campo P, Buffone MG, Benencia F, Conejo-GarcĂ­a JR, Rinaudo PF, Gerton GL. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. J Cell Physiol. 2014 Jan; 229(1):68-78. PMID: 23765988; PMCID: PMC3807638.
    21. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One. 2013; 8(4):e62758. PMID: 23646141; PMCID: PMC3639984.
    22. Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS One. 2013; 8(2):e56949. PMID: 23437279; PMCID: PMC3578927.
    23. Rivera RM, Rinaudo P. Bovine preimplantation embryo development is affected by the stiffness of the culture substrate. Mol Reprod Dev. 2013 Mar; 80(3):184. PMID: 23325633; PMCID: PMC4121333.
    24. Feuer S, Rinaudo P. Preimplantation stress and development. Birth Defects Res C Embryo Today. 2012 Dec; 96(4):299-314. PMID: 24203919; PMCID: PMC3824155.
    25. Rinaudo P, Shen S, Hua J, Qian S, Prabhu U, Garcia E, Cedars M, Sukumaran D, Szyperski T, Andrews C. (1)H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos. J Assist Reprod Genet. 2012 Dec; 29(12):1435-42. PMID: 23090745; PMCID: PMC3528870.
    26. Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF. Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet. 2012 Nov; 29(11):1203-5. PMID: 22941385; PMCID: PMC3510378.
    27. Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P. Effect of substrate stiffness on early mouse embryo development. PLoS One. 2012; 7(7):e41717. PMID: 22860009.
      View in: PubMed
    28. Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P. Impaired placental nutrient transport in mice generated by in vitro fertilization. Endocrinology. 2012 Jul; 153(7):3457-67. PMID: 22562173.
      View in: PubMed
    29. Rinaudo P, Wang E. Fetal programming and metabolic syndrome. Annu Rev Physiol. 2012; 74:107-30. PMID: 21910625; PMCID: PMC4132057.
    30. Valley JK, Swinton P, Boscardin WJ, Lue TF, Rinaudo PF, Wu MC, Garcia MM. Preimplantation mouse embryo selection guided by light-induced dielectrophoresis. PLoS One. 2010 Apr 13; 5(4):e10160. PMID: 20405021; PMCID: PMC2854157.
    31. Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI. Fertilization rate is an independent predictor of implantation rate. Fertil Steril. 2010 Sep; 94(4):1328-33. PMID: 19560757.
      View in: PubMed
    32. Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol. 2009 May 04; 7:40. PMID: 19413899; PMCID: PMC2685803.
    33. Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD, Cedars MI. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol. 2009 Apr 23; 7:35. PMID: 19389255; PMCID: PMC2679036.
    34. Rinaudo PF, Lamb J. Fetal origins of perinatal morbidity and/or adult disease. Semin Reprod Med. 2008 Sep; 26(5):436-45. PMID: 18825611.
      View in: PubMed
    35. Rosen MP, Shen S, Dobson AT, Rinaudo PF, McCulloch CE, Cedars MI. A quantitative assessment of follicle size on oocyte developmental competence. Fertil Steril. 2008 Sep; 90(3):684-90. PMID: 18249377; PMCID: PMC4624406.
    36. Giritharan G, Talbi S, Donjacour A, Di Sebastiano F, Dobson AT, Rinaudo PF. Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos. Reproduction. 2007 Jul; 134(1):63-72. PMID: 17641089.
      View in: PubMed
    37. Rosen MP, Shen S, McCulloch CE, Rinaudo PF, Cedars MI, Dobson AT. Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity. Fertil Steril. 2007 Sep; 88(3):632-8. PMID: 17572411.
      View in: PubMed
    38. Lauko IG, Rinaudo P, Dashev S. A computational parameter study of embryo transfer. Ann Biomed Eng. 2007 Apr; 35(4):659-71. PMID: 17286205.
      View in: PubMed
    39. Rinaudo PF, Giritharan G, Talbi S, Dobson AT, Schultz RM. Effects of oxygen tension on gene expression in preimplantation mouse embryos. Fertil Steril. 2006 Oct; 86(4 Suppl):1252-65, 1265.e1-36. PMID: 17008149.
      View in: PubMed
    40. Rinaudo P, Schultz RM. Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos. Reproduction. 2004 Sep; 128(3):301-11. PMID: 15333781.
      View in: PubMed
    41. Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004 Jul; 104(1):50-5. PMID: 15229000.
      View in: PubMed
    42. Barnhart KT, Rinaudo P, Hummel A, Pena J, Sammel MD, Chittams J. Acute and chronic presentation of ectopic pregnancy may be two clinical entities. Fertil Steril. 2003 Dec; 80(6):1345-51. PMID: 14667867.
      View in: PubMed
    43. Kovalevsky G, Rinaudo P, Coutifaris C. Do assisted reproductive technologies cause adverse fetal outcomes? Fertil Steril. 2003 Jun; 79(6):1270-2. PMID: 12798870.
      View in: PubMed
    44. Shahabi S, Klein JP, Rinaudo PF. Primary psoas abscess complicating a normal vaginal delivery. Obstet Gynecol. 2002 May; 99(5 Pt 2):906-9. PMID: 11975954.
      View in: PubMed