Paolo Rinaudo, MD, PhD

Title(s)Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
ORCID ORCID Icon0000-0002-6528-6009 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of TorinoM.D.1992School of Medicine
    University of TorinoPh.D.1997School of Medicine
    Yale UniversityResidency2001Obstetrics and Gyencology
    University of PennsylvaniaFellowship2004Reproductive Endocrinology and Infertility

    Collapse Overview 
    Collapse Overview
    Dr. Paolo Rinaudo is a specialist in reproductive endocrinology and fertility at the UCSF Center for Reproductive Health. In addition to caring for patients with fertility and endocrinological problems, Rinaudo conducts research on pre-implantation embryo development and the long-term consequences of in vitro culture. He is the recipient of numerous prestigious honors and awards, including the ASRM/Serono grant in reproductive biology and the President Presenter Award at the 50th annual meeting of the Society for Gynecological Investigation, Washington, DC. He is a member of professional societies, such as the American Society for Reproductive Medicine, American College of Obstetrics and Gynecology and Society for Reproductive Endocrinology and Infertility.

    Rinaudo earned a medical degree at Torino Medical School and a doctorate at Torino University in Torino, Italy. He completed a residency in obstetrics and gynecology at Yale University, followed by a fellowship in reproductive endocrinology and infertility at the Hospital of the University of Pennsylvania. He is an Associate Professor in residence in the department of Obstetrics, Gynecology and Reproductive Sciences at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Long-Term Health Effect of Fertility Treatments Using an Animal Model
    NIH R01HD092267Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Epigenetic Programming of Health and Disease in the Preimplantation Embyro
    NIH R01HD082039Dec 1, 2015 - Nov 30, 2018
    Role: Principal Investigator
    Effect of preimplantation embryo culture on adult glucose homeostasis
    NIH R01HD062803Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Noninvasive assessment of embryo implantation potential using 1H NMR metabonomics
    NIH R21HD054956Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. DNA methylation profile of liver of mice conceived by in vitro fertilization. J Dev Orig Health Dis. 2021 Jun 14; 1-9. Lira-Albarrán S, Liu X, Lee SH, Rinaudo P. PMID: 34121654.
      View in: PubMed   Mentions:    Fields:    
    2. Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies. J Pediatr. 2021 May 20. Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA. PMID: 34023343.
      View in: PubMed   Mentions:    Fields:    
    3. Will PRP therapy find a niche in reproductive medicine? Not ready for prime time. J Assist Reprod Genet. 2021 Apr 23. Rinaudo P, Albertini D. PMID: 33893608.
      View in: PubMed   Mentions:    Fields:    
    4. Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF. Mol Hum Reprod. 2020 11 01; 26(11):866-878. Ruggeri E, Lira-Albarrán S, Grow EJ, Liu X, Harner R, Maltepe E, Ramalho-Santos M, Donjacour A, Rinaudo P. PMID: 33010164.
      View in: PubMed   Mentions:    Fields:    
    5. The Effect of Prenatal Treatments on Offspring Events in the Presence of Competing Events: An Application to a Randomized Trial of Fertility Therapies. Epidemiology. 2020 09; 31(5):636-643. Chiu YH, Stensrud MJ, Dahabreh IJ, Rinaudo P, Diamond MP, Hsu J, Hernández-Díaz S, Hernán MA. PMID: 32501812.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos. Hum Reprod. 2020 06 01; 35(6):1476. Belli M, Zhang L, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA, Macchiarelli G, Rinaudo P. PMID: 32436960.
      View in: PubMed   Mentions: 1     Fields:    
    7. Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures. Int J Environ Res Public Health. 2020 05 13; 17(10). Belli M, Rinaudo P, Palmerini MG, Ruggeri E, Antonouli S, Nottola SA, Macchiarelli G. PMID: 32413976.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age. Pediatr Pulmonol. 2019 11; 54(11):1844-1852. Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA. PMID: 31328432.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos. Hum Reprod. 2019 04 01; 34(4):601-611. Belli M, Zhang L, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA, Macchiarelli G, Rinaudo P. PMID: 30865267.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    10. Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting? Semin Reprod Med. 2018 05; 36(3-04):204-210. Rinaudo P, Adeleye A. PMID: 30866007.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Promising noninvasive microscopy imaging technique evaluates metabolic markers in mouse oocytes. Fertil Steril. 2018 12; 110(7):1271. Rinaudo P, Albertini D. PMID: 30503123.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placental Pgr and Igf2 in a mouse model. Biol Reprod. 2018 10 01; 99(4):864-876. Ding T, Mokshagundam S, Rinaudo PF, Osteen KG, Bruner-Tran KL. PMID: 29741588.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    13. Advanced Paternal Age Affects Sperm Count and Anogenital Distance in Mouse Offspring. Reprod Sci. 2018 04; 25(4):515-522. Caballero-Campo P, Lin W, Simbulan R, Liu X, Feuer S, Donjacour A, Rinaudo PF. PMID: 29554862.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Report from the 2016 University of California, San Francisco, Center for Reproductive Sciences retreat. Mol Reprod Dev. 2017 10; 84(10):1024-1026. Rinaudo PF, Conti M. PMID: 28736970.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    15. An initial step in examining long-term outcomes for children born after IVF. Reprod Biomed Online. 2017 08; 35(2):130-131. Hsu J, Velasco JAG, Rinaudo P. PMID: 28652097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. To freeze or not to freeze: heating the debate but cooling the practice? J Assist Reprod Genet. 2017 Feb; 34(2):187-189. Rinaudo PF, Hsu J. PMID: 28091759.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures. Reproduction. 2016 Oct 31. Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P. PMID: 27799627.
      View in: PubMed   Mentions: 3     Fields:    
    18. From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel). 2016 Aug 09; 4(3). Feuer S, Rinaudo P. PMID: 27517965.
      View in: PubMed   Mentions:
    19. Unwind and transcribe: chromatin reprogramming in the early mammalian embryo. Curr Opin Genet Dev. 2015 Oct; 34:17-23. Biechele S, Lin CJ, Rinaudo PF, Ramalho-Santos M. PMID: 26183187.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential. PLoS One. 2015; 10(2):e0117422. Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P. PMID: 25723476.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 17; 10(6):891-899. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. PMID: 25683712.
      View in: PubMed   Mentions: 28     Fields:    
    22. 150 years of congenital adrenal hyperplasia: translation and commentary of De Crecchio's classic paper from 1865. Endocrinology. 2015 Apr; 156(4):1210-7. Delle Piane L, Rinaudo PF, Miller WL. PMID: 25635623.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. A critical review of bi-dimensional and three-dimensional ultrasound techniques to monitor follicle growth: do they help improving IVF outcome? Reprod Biol Endocrinol. 2014 Nov 24; 12:107. Revelli A, Martiny G, Delle Piane L, Benedetto C, Rinaudo P, Tur-Kaspa I. PMID: 25420733.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. Behavior and brain gene expression changes in mice exposed to preimplantation and prenatal stress. Reprod Sci. 2015 Jan; 22(1):23-30. Strata F, Giritharan G, Sebastiano FD, Piane LD, Kao CN, Donjacour A, Rinaudo P. PMID: 25398605.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    25. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am J Pathol. 2014 Dec; 184(12):3321-31. Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E. PMID: 25307528.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    26. Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. Endocrinology. 2014 Nov; 155(11):4554-67. Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF. PMID: 25211591.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding. Hum Reprod Update. 2014 Nov-Dec; 20(6):822-39. Bloise E, Feuer SK, Rinaudo PF. PMID: 24947475.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    28. In vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model. Biol Reprod. 2014 Apr; 90(4):80. Donjacour A, Liu X, Lin W, Simbulan R, Rinaudo PF. PMID: 24621920.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    29. Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. Endocrinology. 2014 May; 155(5):1956-69. Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF. PMID: 24684304.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    30. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. J Cell Physiol. 2014 Jan; 229(1):68-78. Caballero-Campo P, Buffone MG, Benencia F, Conejo-García JR, Rinaudo PF, Gerton GL. PMID: 23765988.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    31. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One. 2013; 8(4):e62758. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E. PMID: 23646141.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS One. 2013; 8(2):e56949. Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E. PMID: 23437279.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    33. Bovine preimplantation embryo development is affected by the stiffness of the culture substrate. Mol Reprod Dev. 2013 Mar; 80(3):184. Rivera RM, Rinaudo P. PMID: 23325633.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Preimplantation stress and development. Birth Defects Res C Embryo Today. 2012 Dec; 96(4):299-314. Feuer S, Rinaudo P. PMID: 24203919.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    35. (1)H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos. J Assist Reprod Genet. 2012 Dec; 29(12):1435-42. Rinaudo P, Shen S, Hua J, Qian S, Prabhu U, Garcia E, Cedars M, Sukumaran D, Szyperski T, Andrews C. PMID: 23090745.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet. 2012 Nov; 29(11):1203-5. Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF. PMID: 22941385.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    37. Effect of substrate stiffness on early mouse embryo development. PLoS One. 2012; 7(7):e41717. Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P. PMID: 22860009.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    38. Impaired placental nutrient transport in mice generated by in vitro fertilization. Endocrinology. 2012 Jul; 153(7):3457-67. Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P. PMID: 22562173.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    39. Fetal programming and metabolic syndrome. Annu Rev Physiol. 2012; 74:107-30. Rinaudo P, Wang E. PMID: 21910625.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    40. Preimplantation mouse embryo selection guided by light-induced dielectrophoresis. PLoS One. 2010 Apr 13; 5(4):e10160. Valley JK, Swinton P, Boscardin WJ, Lue TF, Rinaudo PF, Wu MC, Garcia MM. PMID: 20405021.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Fertilization rate is an independent predictor of implantation rate. Fertil Steril. 2010 Sep; 94(4):1328-1333. Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI. PMID: 19560757.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol. 2009 May 04; 7:40. Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P. PMID: 19413899.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    43. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol. 2009 Apr 23; 7:35. Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD, Cedars MI. PMID: 19389255.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    44. Fetal origins of perinatal morbidity and/or adult disease. Semin Reprod Med. 2008 Sep; 26(5):436-45. Rinaudo PF, Lamb J. PMID: 18825611.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    45. A quantitative assessment of follicle size on oocyte developmental competence. Fertil Steril. 2008 Sep; 90(3):684-90. Rosen MP, Shen S, Dobson AT, Rinaudo PF, McCulloch CE, Cedars MI. PMID: 18249377.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    46. Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos. Reproduction. 2007 Jul; 134(1):63-72. Giritharan G, Talbi S, Donjacour A, Di Sebastiano F, Dobson AT, Rinaudo PF. PMID: 17641089.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    47. Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity. Fertil Steril. 2007 Sep; 88(3):632-8. Rosen MP, Shen S, McCulloch CE, Rinaudo PF, Cedars MI, Dobson AT. PMID: 17572411.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    48. A computational parameter study of embryo transfer. Ann Biomed Eng. 2007 Apr; 35(4):659-71. Lauko IG, Rinaudo P, Dashev S. PMID: 17286205.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Effects of oxygen tension on gene expression in preimplantation mouse embryos. Fertil Steril. 2006 Oct; 86(4 Suppl):1252-65, 1265.e1-36. Rinaudo PF, Giritharan G, Talbi S, Dobson AT, Schultz RM. PMID: 17008149.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    50. Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos. Reproduction. 2004 Sep; 128(3):301-11. Rinaudo P, Schultz RM. PMID: 15333781.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    51. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004 Jul; 104(1):50-5. Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W. PMID: 15229000.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    52. Acute and chronic presentation of ectopic pregnancy may be two clinical entities. Fertil Steril. 2003 Dec; 80(6):1345-51. Barnhart KT, Rinaudo P, Hummel A, Pena J, Sammel MD, Chittams J. PMID: 14667867.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Do assisted reproductive technologies cause adverse fetal outcomes? Fertil Steril. 2003 Jun; 79(6):1270-2. Kovalevsky G, Rinaudo P, Coutifaris C. PMID: 12798870.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    54. Primary psoas abscess complicating a normal vaginal delivery. Obstet Gynecol. 2002 May; 99(5 Pt 2):906-9. Shahabi S, Klein JP, Rinaudo PF. PMID: 11975954.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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