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David Rowitch, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-476-7242
ORCID ORCID Icon0000-0002-0079-0060 Additional info
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1989School of Medicine
    University of Cambridge , Cambridge UKPhD1988Biochemistry
    University of California San DiegoBA1982Biochemistry, Cell Biology
    Collapse Awards and Honors
    Academy of Medical Sciences2018Fellow

    Collapse Overview 
    Collapse Overview
    I attended UCLA and University of Cambridge for my MD and PhD degrees and then trained as a pediatrician and neonatologist at Boston Children’s Hospital. I was a postdoctoral fellow in Andy McMahon’s lab at Harvard University. As a physician-scientist, I have investigated extensions of neuroscience that can impact our understanding of human neurological diseases, particularly cerebral palsy, multiple sclerosis and brain cancers. For over 15 years we have investigated the developmental genetics of the glial lineages of the brain and novel functions for astrocytes and oligodendrocytes. I helped establish the first “Neuro-NICU” in the USA at UCSF. This inter-disciplinary unit, focused on newborn neurological injuries, has improved standards of care and has facilitated basic and clinical research. I directed a first-in-man Phase I study of neural stem cell transplant into the human brain for leukodystrophy as an approach for demyelinating disorders. As a HHMI Investigator, I established a basic program of research in human neonatal brain development that has attracted support of an NINDS PO1. In 2016 I joined University of Cambridge as Head of Department of Paediatrics, where we investigate application of whole genome sequencing in care of intensively ill children. I am a Wellcome Trust Senior Investigator with a laboratory in the Wellcome-MRC Cambridge Stem Cell Institute. I am an Adjunct Professor of Pediatrics and Neurosurgery and have a lab at UCSF in the Eli and Edyth Broad Institute for Stem Cell Research and Regenerative Medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    Myel-IN-Crisis
    European Research Council Advanced Grant Oct 1, 2018 - Sep 30, 2023
    Role: Principal Investigator
    Functional Diversity of Astrocytes
    Wellcome Trust Senior Investigator Award Oct 1, 2016 - Sep 1, 2022
    Role: Principal Investigator
    Regulation of Cellular Pathwaysin Human Brain Development
    NIH/NINDS P01NS083513Jul 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Graduate Training Program in Neonatal-Perinatal Translational Research
    NIH/NICHD T32HD071860May 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Cellular and Genetic Origins of Astrocytes
    NIH/NINDS R01NS059893Feb 1, 2008 - Jan 31, 2014
    Role: Principal Investigator
    Mechanisms of hedge-hog induced neuroproliferation
    NIH/NINDS R01NS047527Jul 1, 2004 - Feb 28, 2009
    Role: Principal Investigator
    FUNCTIONAL GENOMIC ANALYSIS OF THE DEVELOPING CEREBELLUM
    NIH/NINDS R21NS041764Sep 27, 2000 - Aug 31, 2003
    Role: Principal Investigator
    Oligodendrocyte Lineage Gene Function in the CNS
    NIH/NINDS R01NS040511Aug 1, 2000 - Mar 31, 2010
    Role: Principal Investigator
    WNT-1 REGULATION IN MOUSE DEVELOPMENT
    NIH/NICHD K08HD001182Sep 30, 1997 - Jul 31, 2000
    Role: Principal Investigator
    Graduate Research Training in Perinatal Biology
    NIH/NICHD T32HD007162Jul 1, 1979 - Jun 30, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. Cell. 2020 Jul 09. Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR. PMID: 32679030.
      View in: PubMed   Mentions:    Fields:    
    2. Applying support-vector machine learning algorithms toward predicting host-guest interactions with cucurbit[7]uril. Phys Chem Chem Phys. 2020 Jun 26. Tabet A, Gebhart T, Wu G, Readman C, Pierson Smela M, Rana VK, Baker C, Bulstrode H, Anikeeva P, Rowitch DH, Scherman OA. PMID: 32588846.
      View in: PubMed   Mentions:    Fields:    
    3. Oxygen Tension and the VHL-Hif1a Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit. Neuron. 2020 May 20; 106(4):607-623.e5. Kullmann JA, Trivedi N, Howell D, Laumonnerie C, Nguyen V, Banerjee SS, Stabley DR, Shirinifard A, Rowitch DH, Solecki DJ. PMID: 32183943.
      View in: PubMed   Mentions:    Fields:    
    4. Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map. Nat Neurosci. 2020 Apr; 23(4):500-509. Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH. PMID: 32203496.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. An update on human astrocytes and their role in development and disease. Glia. 2020 04; 68(4):685-704. de Majo M, Koontz M, Rowitch D, Ullian EM. PMID: 31926040.
      View in: PubMed   Mentions:    Fields:    
    6. Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Neuron. 2020 03 04; 105(5):855-866.e5. Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. PMID: 31924446.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Decreased microglial Wnt/ß-catenin signalling drives microglial pro-inflammatory activation in the developing brain. Brain. 2019 12 01; 142(12):3806-3833. Van Steenwinckel J, Schang AL, Krishnan ML, Degos V, Delahaye-Duriez A, Bokobza C, Csaba Z, Verdonk F, Montané A, Sigaut S, Hennebert O, Lebon S, Schwendimann L, Le Charpentier T, Hassan-Abdi R, Ball G, Aljabar P, Saxena A, Holloway RK, Birchmeier W, Baud O, Rowitch D, Miron V, Chretien F, Leconte C, Besson VC, Petretto EG, Edwards AD, Hagberg H, Soussi-Yanicostas N, Fleiss B, Gressens P. PMID: 31665242.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation. Cell Stem Cell. 2019 Oct 03; 25(4):531-541.e6. Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M. PMID: 31585094.
      View in: PubMed   Mentions: 1     Fields:    
    9. Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature. 2019 Sep; 573(7773):E3. Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez GA, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KJ. PMID: 31462780.
      View in: PubMed   Mentions:    Fields:    
    10. Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature. 2019 09; 573(7772):130-134. Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez GA, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KJ. PMID: 31413369.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2019 08 13; 13(2):254-261. Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH. PMID: 31378671.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Challenges to curing primary brain tumours. Nat Rev Clin Oncol. 2019 08; 16(8):509-520. Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. PMID: 30733593.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    13. Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'. Nat Rev Clin Oncol. 2019 08; 16(8):522-523. Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. PMID: 31150022.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature. 2019 09; 573(7772):75-82. Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH. PMID: 31316211.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Single-cell genomics identifies cell type-specific molecular changes in autism. Science. 2019 05 17; 364(6441):685-689. Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR. PMID: 31097668.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams. J Comp Neurol. 2019 12 01; 527(17):2843-2859. Ellis JK, Sorrells SF, Mikhailova S, Chavali M, Chang S, Sabeur K, Mcquillen P, Rowitch DH. PMID: 31050805.
      View in: PubMed   Mentions:    Fields:    
    17. The neurointensive nursery: concept, development, and insights gained. Curr Opin Pediatr. 2019 04; 31(2):202-209. Glass HC, Ferriero DM, Rowitch DH, Shimotake TK. PMID: 30720542.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children. Intensive Care Med. 2019 05; 45(5):627-636. French CE, Delon I, Dolling H, Sanchis-Juan A, Shamardina O, Mégy K, Abbs S, Austin T, Bowdin S, Branco RG, Firth H, Rowitch DH, Raymond FL. PMID: 30847515.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018 11; 563(7731):347-353. Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, Park JE, Stephenson E, Polanski K, Goncalves A, Gardner L, Holmqvist S, Henriksson J, Zou A, Sharkey AM, Millar B, Innes B, Wood L, Wilbrey-Clark A, Payne RP, Ivarsson MA, Lisgo S, Filby A, Rowitch DH, Bulmer JN, Wright GJ, Stubbington MJT, Haniffa M, Moffett A, Teichmann SA. PMID: 30429548.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    20. Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis. Cereb Cortex. 2018 11 01; 28(11):3797-3815. Pla R, Stanco A, Howard MA, Rubin AN, Vogt D, Mortimer N, Cobos I, Potter GB, Lindtner S, Price JD, Nord AS, Visel A, Schreiner CE, Baraban SC, Rowitch DH, Rubenstein JLR. PMID: 29028947.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. New Recipes for Myelinating Oligodendrocytes. Cell Stem Cell. 2018 10 04; 23(4):464-465. Nobuta H, Stockley JH, Rowitch DH. PMID: 30290175.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. Elife. 2018 09 11; 7. Schirmer L, Möbius W, Zhao C, Cruz-Herranz A, Ben Haim L, Cordano C, Shiow LR, Kelley KW, Sadowski B, Timmons G, Pröbstel AK, Wright JN, Sin JH, Devereux M, Morrison DE, Chang SM, Sabeur K, Green AJ, Nave KA, Franklin RJ, Rowitch DH. PMID: 30204081.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    23. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018 05 14; 33(5):874-889.e7. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH. PMID: 29681511.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    24. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018 04 18; 98(2):306-319.e7. Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. PMID: 29606582.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury. Cerebellum. 2018 Apr; 17(2):213-227. Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH. PMID: 29134361.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem Cell Reports. 2017 12 12; 9(6):1745-1753. Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM. PMID: 29198827.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury. Glia. 2018 02; 66(2):221-238. van Tilborg E, de Theije CGM, van Hal M, Wagenaar N, de Vries LS, Benders MJ, Rowitch DH, Nijboer CH. PMID: 29134703.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    28. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    29. Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury. Glia. 2017 12; 65(12):2024-2037. Shiow LR, Favrais G, Schirmer L, Schang AL, Cipriani S, Andres C, Wright JN, Nobuta H, Fleiss B, Gressens P, Rowitch DH. PMID: 28856805.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. The role of prenatal steroids at 34-36 weeks of gestation. Arch Dis Child Fetal Neonatal Ed. 2017 Jul; 102(4):F284-F285. Smith GC, Rowitch D, Mol BW. PMID: 28377385.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Olig1 is required for noggin-induced neonatal myelin repair. Ann Neurol. 2017 Apr; 81(4):560-571. Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH. PMID: 28253550.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177. Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD. PMID: 28355568.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone. Dev Neurosci. 2016; 38(6):430-444. Dawes WJ, Zhang X, Fancy SPJ, Rowitch D, Marino S. PMID: 28343214.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 01 26; 541(7638):481-487. Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA. PMID: 28099414.
      View in: PubMed   Mentions: 436     Fields:    Translation:HumansAnimalsCells
    35. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016 12 19; 7:13866. Jablonska B, Gierdalski M, Chew LJ, Hawley T, Catron M, Lichauco A, Cabrera-Luque J, Yuen T, Rowitch D, Gallo V. PMID: 27991597.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    36. Functional diversity of astrocytes in neural circuit regulation. Nat Rev Neurosci. 2017 01; 18(1):31-41. Ben Haim L, Rowitch DH. PMID: 27904142.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    37. Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease. Stem Cells. 2017 02; 35(2):311-315. Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA. PMID: 27882623.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    38. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308). Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. PMID: 27846470.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    39. Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells. Cell Rep. 2016 09 13; 16(11):2838-2845. Kupp R, Shtayer L, Tien AC, Szeto E, Sanai N, Rowitch DH, Mehta S. PMID: 27626655.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    40. The Role of the Neurointensive Care Nursery for Neonatal Encephalopathy. Clin Perinatol. 2016 Sep; 43(3):547-57. Glass HC, Rowitch DH. PMID: 27524453.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    42. Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. Pediatr Res. 2016 11; 80(5):635-640. Christou H, Dizon ML, Farrow KN, Jadcherla SR, Leeman KT, Maheshwari A, Rubin LP, Stansfield BK, Rowitch DH. PMID: 27434118.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Identification of proliferative progenitors associated with prominent postnatal growth of the pons. Nat Commun. 2016 05 18; 7:11628. Lindquist RA, Guinto CD, Rodas-Rodriguez JL, Fuentealba LC, Tate MC, Rowitch DH, Alvarez-Buylla A. PMID: 27188978.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    44. Astrocytes: The Final Frontier…. Neuron. 2016 Jan 06; 89(1):1-2. Kelley KW, Rowitch DH. PMID: 26748083.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome. Acta Neuropathol. 2015 Aug; 130(2):171-83. Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ. PMID: 25975378.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    46. Dysregulation of astrocyte extracellular signaling in Costello syndrome. Sci Transl Med. 2015 May 06; 7(286):286ra66. Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM. PMID: 25947161.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    47. Disease specific therapies in leukodystrophies and leukoencephalopathies. Mol Genet Metab. 2015 Apr; 114(4):527-36. Helman G, Van Haren K, Bonkowsky JL, Bernard G, Pizzino A, Braverman N, Suhr D, Patterson MC, Ali Fatemi S, Leonard J, van der Knaap MS, Back SA, Damiani S, Goldman SA, Takanohashi A, Petryniak M, Rowitch D, Messing A, Wrabetz L, Schiffmann R, Eichler F, Escolar ML, Vanderver A. PMID: 25684057.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    48. Postnatal growth of the human pons: a morphometric and immunohistochemical analysis. J Comp Neurol. 2015 Feb 15; 523(3):449-62. Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A. PMID: 25307966.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    49. Astrocyte development and heterogeneity. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(1):a020362. Bayraktar OA, Fuentealba LC, Alvarez-Buylla A, Rowitch DH. PMID: 25414368.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    50. Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell. 2014 Jul 17; 158(2):383-396. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH. PMID: 25018103.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    51. Hypomyelinating leukodystrophies: translational research progress and prospects. Ann Neurol. 2014 Jul; 76(1):5-19. Pouwels PJ, Vanderver A, Bernard G, Wolf NI, Dreha-Kulczewksi SF, Deoni SC, Bertini E, Kohlschütter A, Richardson W, Ffrench-Constant C, Köhler W, Rowitch D, Barkovich AJ. PMID: 24916848.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    52. An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci. 2014 Jun 18; 34(25):8507-18. Meijer DH, Sun Y, Liu T, Kane MF, Alberta JA, Adelmant G, Kupp R, Marto JA, Rowitch DH, Nakatani Y, Stiles CD, Mehta S. PMID: 24948806.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. PMID: 24776795.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
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    79. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304. Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR. PMID: 22160722.
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    100. Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma. Cancer Res. 2010 Jul 01; 70(13):5220-5. Heine VM, Priller M, Ling J, Rowitch DH, Schüller U. PMID: 20530674.
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    122. Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination. Glia. 2007 Mar; 55(4):400-11. Zeger M, Popken G, Zhang J, Xuan S, Lu QR, Schwab MH, Nave KA, Rowitch D, D'Ercole AJ, Ye P. PMID: 17186502.
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    123. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007 Feb 15; 53(4):503-17. Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. PMID: 17296553.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    124. Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol. 2006 Dec; 65(12):1149-56. Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN. PMID: 17146289.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    125. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 2006 Oct 15; 66(20):10171-8. Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. PMID: 17047082.
      View in: PubMed   Mentions: 129     Fields:    Translation:Animals
    126. Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis. Mol Cell Neurosci. 2006 Nov; 33(3):247-59. Schüller U, Kho AT, Zhao Q, Ma Q, Rowitch DH. PMID: 16962790.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    127. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res. 2006 Sep 01; 66(17):8655-61. Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, de Alborán IM, Olson JM, Eisenman RN. PMID: 16951180.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    128. Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res. 2006 Aug 15; 66(16):8139-46. Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, Matthay KK, Rowitch D, Weiss WA. PMID: 16912192.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    129. Origin of oligodendrocytes in the subventricular zone of the adult brain. J Neurosci. 2006 Jul 26; 26(30):7907-18. Menn B, Garcia-Verdugo JM, Yaschine C, Gonzalez-Perez O, Rowitch D, Alvarez-Buylla A. PMID: 16870736.
      View in: PubMed   Mentions: 325     Fields:    Translation:AnimalsCells
    130. Beta-catenin function is required for cerebellar morphogenesis. Brain Res. 2007 Apr 06; 1140:161-9. Schüller U, Rowitch DH. PMID: 16824494.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    131. Olig gene function in CNS development and disease. Glia. 2006 Jul; 54(1):1-10. Ligon KL, Fancy SP, Franklin RJ, Rowitch DH. PMID: 16652341.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    132. Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord. Glia. 2006 Jul; 54(1):35-46. Kitada M, Rowitch DH. PMID: 16673374.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    133. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7853-8. Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH. PMID: 16682644.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    134. Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol. 2006 Apr 01; 292(1):152-64. Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH. PMID: 16469306.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    135. Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18183-8. Buffo A, Vosko MR, Ertürk D, Hamann GF, Jucker M, Rowitch D, Götz M. PMID: 16330768.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    136. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature. 2005 Nov 17; 438(7066):360-3. Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH. PMID: 16292311.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    137. Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol. 2005 Nov; 64(11):948-55. Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN. PMID: 16254489.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    138. Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn. 2005 Nov; 234(3):633-50. Matei V, Pauley S, Kaing S, Rowitch D, Beisel KW, Morris K, Feng F, Jones K, Lee J, Fritzsch B. PMID: 16145671.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    139. The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell. 2005 Sep; 9(3):327-38. Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM. PMID: 16139224.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    140. Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification. Neuropathol Appl Neurobiol. 2005 Feb; 31(1):62-9. Mokhtari K, Paris S, Aguirre-Cruz L, Privat N, Crinière E, Marie Y, Hauw JJ, Kujas M, Rowitch D, Hoang-Xuan K, Delattre JY, Sanson M. PMID: 15634232.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    141. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q. PMID: 15618518.
      View in: PubMed   Mentions: 189     Fields:    Translation:Animals
    142. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004 Dec 17; 306(5704):2111-5. Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD. PMID: 15604411.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    143. Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A. 2004 Jun 01; 101(22):8384-9. Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA. PMID: 15155908.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    144. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004 May; 63(5):499-509. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. PMID: 15198128.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    145. Glial specification in the vertebrate neural tube. Nat Rev Neurosci. 2004 May; 5(5):409-19. Rowitch DH. PMID: 15100723.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    146. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6502-7. Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, de Crombrugghe B. PMID: 15096597.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    147. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev. 2004 Mar 15; 18(6):629-40. Kho AT, Zhao Q, Cai Z, Butte AJ, Kim JY, Pomeroy SL, Rowitch DH, Kohane IS. PMID: 15075291.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    148. Synchronization of goat fibroblast cells at quiescent stage and determination of their transition from G0 to G1 by detection of cyclin D1 mRNA. Cloning Stem Cells. 2004; 6(2):58-66. Memili E, Behboodi E, Overton SA, Kenney AM, O'Coin M, Zahedi A, Rowitch DH, Echelard Y. PMID: 15268778.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    149. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development. 2004 Jan; 131(1):217-28. Kenney AM, Widlund HR, Rowitch DH. PMID: 14660435.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    150. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol. 2003 Nov 01; 263(1):50-66. Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL. PMID: 14568546.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    151. Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci. 2003 Oct 22; 23(29):9547-56. Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD. PMID: 14573534.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    152. Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9360-5. Mori-Akiyama Y, Akiyama H, Rowitch DH, de Crombrugghe B. PMID: 12878728.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    153. Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development. 2003 May; 130(10):2275-87. Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH. PMID: 12668639.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    154. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development. 2003 Jan; 130(1):15-28. Kenney AM, Cole MD, Rowitch DH. PMID: 12441288.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    155. Development of mice expressing a single D-type cyclin. Genes Dev. 2002 Dec 15; 16(24):3277-89. Ciemerych MA, Kenney AM, Sicinska E, Kalaszczynska I, Bronson RT, Rowitch DH, Gardner H, Sicinski P. PMID: 12502747.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    156. An 'oligarchy' rules neural development. Trends Neurosci. 2002 Aug; 25(8):417-22. Rowitch DH, Lu QR, Kessaris N, Richardson WD. PMID: 12127759.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    157. Medulloblastoma: a problem of developmental biology. Cancer Cell. 2002 Jul; 2(1):7-8. Rubin JB, Rowitch DH. PMID: 12150819.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    158. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5704-9. Zhao Q, Kho A, Kenney AM, Yuk Di DI, Kohane I, Rowitch DH. PMID: 11960025.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    159. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 05; 109(1):75-86. Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH. PMID: 11955448.
      View in: PubMed   Mentions: 334     Fields:    Translation:AnimalsCells
    160. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002 Apr; 1(3):269-77. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. PMID: 12086863.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    161. Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev. 2002 Feb; 111(1-2):75-87. Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ. PMID: 11804780.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    162. Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci. 2001 Oct; 18(4):434-41. Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH. PMID: 11640898.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    163. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci. 2001 Oct; 4(10):973-4. Lu QR, Cai L, Rowitch D, Cepko CL, Stiles CD. PMID: 11574831.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    164. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol. 2001 Sep 18; 11(18):1413-20. Sun T, Echelard Y, Lu R, Yuk DI, Kaing S, Stiles CD, Rowitch DH. PMID: 11566099.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    165. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10851-6. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM. PMID: 11526205.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    166. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development. 2001 Jul; 128(13):2545-54. Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH, Richardson WD. PMID: 11493571.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    167. Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives. Int J Dev Neurosci. 2001 Jul; 19(4):379-85. Woodruff RH, Tekki-Kessaris N, Stiles CD, Rowitch DH, Richardson WD. PMID: 11378298.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    168. Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Dev Dyn. 2001 Jul; 221(3):342-9. Lagutin O, Zhu CC, Furuta Y, Rowitch DH, McMahon AP, Oliver G. PMID: 11458394.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    169. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 2001 Jun 01; 15(11):1311-33. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. PMID: 11390353.
      View in: PubMed   Mentions: 380     Fields:    Translation:HumansAnimals
    170. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 2001 Apr; 128(8):1253-64. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R. PMID: 11262227.
      View in: PubMed   Mentions: 478     Fields:    Translation:AnimalsCells
    171. Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase. J Biol Chem. 2001 Jun 15; 276(24):21737-44. Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S. PMID: 11278382.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    172. Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives. Dev Biol. 2001 Jan 01; 229(1):128-40. Kuschert S, Rowitch DH, Haenig B, McMahon AP, Kispert A. PMID: 11133159.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    173. Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol. 2000 Dec; 20(23):9055-67. Kenney AM, Rowitch DH. PMID: 11074003.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    174. Fate of the mammalian cardiac neural crest. Development. 2000 Apr; 127(8):1607-16. Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. PMID: 10725237.
      View in: PubMed   Mentions: 374     Fields:    Translation:Animals
    175. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 2000 Apr; 127(8):1671-9. Chai Y, Jiang X, Ito Y, Bringas P, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM. PMID: 10725243.
      View in: PubMed   Mentions: 411     Fields:    Translation:Animals
    176. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000 Feb; 25(2):317-29. Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH. PMID: 10719888.
      View in: PubMed   Mentions: 225     Fields:    Translation:AnimalsCells
    177. Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum. Brain Res Dev Brain Res. 1999 Oct 20; 117(1):99-108. Rowitch DH, Kispert A, McMahon AP. PMID: 10536237.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    178. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci. 1999 Oct 15; 19(20):8954-65. Rowitch DH, S-Jacques B, Lee SM, Flax JD, Snyder EY, McMahon AP. PMID: 10516314.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    179. Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor. Teratology. 1999 Jul; 60(1):22-8. Rowitch DH, Danielian PS, McMahon AP, Zec N. PMID: 10413335.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    180. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol. 1998 Dec 03; 8(24):1323-6. Danielian PS, Muccino D, Rowitch DH, Michael SK, McMahon AP. PMID: 9843687.
      View in: PubMed   Mentions: 555     Fields:    Translation:AnimalsCells
    181. Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate. Development. 1998 Jul; 125(14):2735-46. Rowitch DH, Echelard Y, Danielian PS, Gellner K, Brenner S, McMahon AP. PMID: 9636087.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    182. GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev Biol. 1997 Dec 01; 192(1):193-8. Pepicelli CV, Kispert A, Rowitch DH, McMahon AP. PMID: 9405108.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    183. Expression of the homeobox-containing genes EN1 and EN2 in human fetal midgestational medulla and cerebellum. J Neuropathol Exp Neurol. 1997 Mar; 56(3):236-42. Zec N, Rowitch DH, Bitgood MJ, Kinney HC. PMID: 9056537.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    184. Cell interactions in patterning the mammalian midbrain. Cold Spring Harb Symp Quant Biol. 1997; 62:535-44. Rowitch DH, Danielian PS, Lee SM, Echelard Y, McMahon AP. PMID: 9598387.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    185. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development. 1996 Nov; 122(11):3627-37. Kispert A, Vainio S, Shen L, Rowitch DH, McMahon AP. PMID: 8951078.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    186. Topical iodine and neonatal hypothyroidism. Arch Pediatr Adolesc Med. 1995 Dec; 149(12):1336-9. Gordon CM, Rowitch DH, Mitchell ML, Kohane IS. PMID: 7489070.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    187. A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain. Mech Dev. 1995 Sep; 53(1):87-96. Iler N, Rowitch DH, Echelard Y, McMahon AP, Abate-Shen C. PMID: 8555114.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    188. Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech Dev. 1995 Jul; 52(1):3-8. Rowitch DH, McMahon AP. PMID: 7577673.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    189. Neonatal herpes simplex virus infection presenting as fulminant liver failure. Pediatr Infect Dis J. 1995 Mar; 14(3):242-4. Greenes DS, Rowitch D, Thorne GM, Perez-Atayde A, Lee FS, Goldmann D. PMID: 7761194.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    190. Effect of coat protein mutations in bacteriophage fd studied by sedimentation analysis. Biophys J. 1992 Nov; 63(5):1293-8. Molina-Garcia AD, Harding SE, Diaz FG, de la Torre JG, Rowitch D, Perham RN. PMID: 19431854.
      View in: PubMed   Mentions:    Fields:    
    191. Variable electrostatic interaction between DNA and coat protein in filamentous bacteriophage assembly. J Mol Biol. 1988 Dec 05; 204(3):663-74. Rowitch DH, Hunter GJ, Perham RN. PMID: 3066910.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    192. Cloning and expression of the filamentous bacteriophage Pf1 major coat protein gene in Escherichia coli. Membrane protein processing and virus assembly. J Mol Biol. 1987 Jun 20; 195(4):873-84. Rowitch DH, Perham RN. PMID: 3309343.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    193. Interactions between DNA and coat protein in the structure and assembly of filamentous bacteriophage fd. Nature. 1987 May 21-27; 327(6119):252-4. Hunter GJ, Rowitch DH, Perham RN. PMID: 3106834.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    194. The metabolic defect of methionine dependence occurs frequently in human tumor cell lines. Biochem Biophys Res Commun. 1983 Dec 16; 117(2):429-34. Mecham JO, Rowitch D, Wallace CD, Stern PH, Hoffman RM. PMID: 6661235.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    195. Extent of DNA methylation in human tumor cells. J Natl Cancer Inst. 1983 Oct; 71(4):755-64. Diala ES, Cheah MS, Rowitch D, Hoffman RM. PMID: 6578371.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
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