Mark Petersen, MD
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Title(s) | Assistant Professor, Pediatrics |
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School | School of Medicine |
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Address | 550 16th. Street San Francisco CA 94158
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Phone | 415-476-1888 |
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vCard | Download vCard |
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Biography University of California San Francisco, San Francisco, CA | Fellowship | 2013 | Neonatology | Stanford University / Lucile Packard Children's Hospital, Palo Alto, CA | Residency | 2009 | Pediatrics | University of Iowa Carver College of Medicine, Iowa City, IA | M.D. | 2005 | Medicine | University of Iowa, Iowa City, IA | B.S. | 2001 | Biology |
Gladstone Institutes | 2018 | | Mentored Scientist Award for Scientific Excellence in Neuroscience | University of California San Francisco Residency Program | 2011 | | Nomination for Fellow Teaching Award | Stanford University School of Medicine | 2007
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| 2009 | Honor Roll for Teaching | Stanford University School of Medicine | 2007
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| 2008 | Letter of Distinction for Teaching | University of Iowa Carver College of Medicine | 2005 | | Alpha Omega Alpha (AOA) Honor Medical Society | University of Iowa Carver College of Medicine | 2005 | | Pediatric Faculty Award for Outstanding Performance in Pediatrics | Univerisity of Iowa Carver College of Medicine | 2003 | | W.R. Ingram Award for Superior Achievement in Medical Neuroscience | University of Iowa | 2001 | | Highest Distinction and Honors in Biology | University of Iowa | 2001 | | Robbie Prize for Excellence in Biological Research |
Overview My research centers on vascular mechanisms of neurological disease with a particular focus on neonatal brain injury. Blood vessels become damaged in the injured or diseased brain which allows proteins from the blood to leak into the nervous system. My work seeks to identify new therapies for neurological diseases by targeting toxic blood proteins and inflammatory signals at the blood-brain interface that block normal brain development and repair. To achieve this goal, our group has developed a multifaceted research program incorporating basic science studies of stem cells and animal models with translational studies of human tissue and blood biomarkers. We have discovered critical links between blood coagulation, inflammation, and stem cell dysfunction in neurological disease. The nervous system has long been defined by its limited capacity for regeneration which results in persistent neurological deficits after nervous system damage. Stem cells are abundant in the brain, but why these stem cells are unable to fully restore neural tissue after injury has remained a mystery. We found that the blood clotting protein fibrinogen causes inflammation in the brain and blocks stem cells from becoming mature, myelin-repairing cells. We are now designing therapies to overcome the inhibitory environment in the damaged nervous system to promote regeneration and normal brain development.
Through collaborations with the UCSF Preterm Birth Initiative and UCSF Newborn Brain Research Institute, we are also extending our studies to explore how maternal inflammation and coagulation contribute to preterm birth and poor neonatal outcomes. By combining large population datasets with state-of-the-art multiplex and proteomic approaches to measure blood biomarkers, we hope to identify druggable pathways at the maternal-fetal interface that can be targeted to prevent or lessen the impact of preterm birth and neonatal brain injury.
Research Bibliographic
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Racial and ethnic disparities in outcomes through 1 year of life in infants born prematurely: a population based study in California. J Perinatol. 2021 Jan 30.
Karvonen KL, Baer RJ, Rogers EE, Steurer MA, Ryckman KK, Feuer SK, Anderson JG, Franck LS, Gano D, Peterson MA, Oltman SP, Chambers BD, Neuhaus J, Rand L, Jelliffe-Pawlowski LL, Pantell MS. PMID: 33514879.
View in: PubMed Mentions: Fields:
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Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity. Pediatr Res. 2020 Oct 01.
PMID: 33003189.
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Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524.
Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Neurovascular interactions: Mechanisms, imaging, and therapeutics. IBRO Reports. 2019 Sep 1; 6:s33.
Katerina Akassoglou, Reshmi Tognatta, Mark Petersen. .
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Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223.
Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimals
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Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain. 2018 06 01; 141(6):1637-1649.
Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS. PMID: 29688408.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics. Nat Rev Neurosci. 2018 05; 19(5):283-301.
Petersen MA, Ryu JK, Akassoglou K. PMID: 29618808.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimals
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Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7.
Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015 Sep 10; 6:8164.
Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. PMID: 26353940.
View in: PubMed Mentions: 71 Fields: Translation: AnimalsCells
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Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8.
PMID: 24740641.
View in: PubMed Mentions: 29 Fields: Translation: AnimalsCells
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220 Fibrinogen/CR3 signaling induces demyelination by promoting Th1 cell differentiation and peripheral macrophage recruitment into the CNS. Cytokine. 2013 Sep 1; 63(3):295.
Jae Kyu Ryu, Kim M. Baeten, Mark A. Petersen, Sara G. Murray, Anke Meyer-Franke, Dimitrios Davalos, Catherine Bedard, Thomas Prod’homme, Israel F. Charo, Hans Lassmann, Jay L. Degen, Scott S. Zamvil, Katerina Akassoglou. .
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Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012; 3:1227.
PMID: 23187627.
View in: PubMed Mentions: 162 Fields: Translation: AnimalsCells
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Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices. Glia. 2004 Apr 15; 46(2):195-206.
Petersen MA, Dailey ME. PMID: 15042586.
View in: PubMed Mentions: 47 Fields: Translation: AnimalsCells
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Year | Publications |
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2004 | 1 | 2012 | 1 | 2013 | 1 | 2014 | 1 | 2015 | 1 | 2017 | 1 | 2018 | 3 | 2019 | 1 | 2020 | 2 | 2021 | 1 |
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