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Mark Petersen, MD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-476-1888
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, San Francisco, CAFellowship2013Neonatology
    Stanford University / Lucile Packard Children's Hospital, Palo Alto, CAResidency2009Pediatrics
    University of Iowa Carver College of Medicine, Iowa City, IAM.D.2005Medicine
    University of Iowa, Iowa City, IAB.S.2001Biology
    Collapse Awards and Honors
    Gladstone Institutes2018Mentored Scientist Award for Scientific Excellence in Neuroscience
    University of California San Francisco Residency Program2011Nomination for Fellow Teaching Award
    Stanford University School of Medicine2007  - 2009Honor Roll for Teaching
    Stanford University School of Medicine2007  - 2008Letter of Distinction for Teaching
    University of Iowa Carver College of Medicine2005Alpha Omega Alpha (AOA) Honor Medical Society
    University of Iowa Carver College of Medicine2005Pediatric Faculty Award for Outstanding Performance in Pediatrics
    Univerisity of Iowa Carver College of Medicine2003W.R. Ingram Award for Superior Achievement in Medical Neuroscience
    University of Iowa2001Highest Distinction and Honors in Biology
    University of Iowa2001Robbie Prize for Excellence in Biological Research

    Collapse Overview 
    Collapse Overview
    My research centers on vascular mechanisms of neurological disease with a particular focus on neonatal brain injury. Blood vessels become damaged in the injured or diseased brain which allows proteins from the blood to leak into the nervous system. My work seeks to identify new therapies for neurological diseases by targeting toxic blood proteins and inflammatory signals at the blood-brain interface that block normal brain development and repair. To achieve this goal, our group has developed a multifaceted research program incorporating basic science studies of stem cells and animal models with translational studies of human tissue and blood biomarkers.

    We have discovered critical links between blood coagulation, inflammation, and stem cell dysfunction in neurological disease. The nervous system has long been defined by its limited capacity for regeneration which results in persistent neurological deficits after nervous system damage. Stem cells are abundant in the brain, but why these stem cells are unable to fully restore neural tissue after injury has remained a mystery. We found that the blood clotting protein fibrinogen causes inflammation in the brain and blocks stem cells from becoming mature, myelin-repairing cells. We are now designing therapies to overcome the inhibitory environment in the damaged nervous system to promote regeneration and normal brain development.

    Through collaborations with the UCSF Preterm Birth Initiative and UCSF Newborn Brain Research Institute, we are also extending our studies to explore how maternal inflammation and coagulation contribute to preterm birth and poor neonatal outcomes. By combining large population datasets with state-of-the-art multiplex and proteomic approaches to measure blood biomarkers, we hope to identify druggable pathways at the maternal-fetal interface that can be targeted to prevent or lessen the impact of preterm birth and neonatal brain injury.

    Collapse Research 
    Collapse Research Activities and Funding
    Fibrinogen-mediated mechanisms of preterm infant brain injury
    NIH/NINDS K02NS110973Jul 1, 2019 - Jun 30, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    3. Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain. 2018 06 01; 141(6):1637-1649. Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS. PMID: 29688408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    4. Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics. Nat Rev Neurosci. 2018 05; 19(5):283-301. Petersen MA, Ryu JK, Akassoglou K. PMID: 29618808.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    5. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    6. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015 Sep 10; 6:8164. Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. PMID: 26353940.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    7. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8. Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. PMID: 24740641.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    8. 220 Fibrinogen/CR3 signaling induces demyelination by promoting Th1 cell differentiation and peripheral macrophage recruitment into the CNS. Cytokine. 2013 Sep 1; 63(3):295. Jae Kyu Ryu, Kim M. Baeten, Mark A. Petersen, Sara G. Murray, Anke Meyer-Franke, Dimitrios Davalos, Catherine Bedard, Thomas Prod’homme, Israel F. Charo, Hans Lassmann, Jay L. Degen, Scott S. Zamvil, Katerina Akassoglou. .
      View in: Publisher Site   Mentions:
    9. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012; 3:1227. Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. PMID: 23187627.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    10. Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices. Glia. 2004 Apr 15; 46(2):195-206. Petersen MA, Dailey ME. PMID: 15042586.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells