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    Adam Gazzaley, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94143
    Phone415-476-2162

       Overview 
       Overview
      The Gazzaley lab is a cognitive neuroscience research lab at the University of California, San Francisco focused on studying the neural mechanisms of memory and attention, how these processes change with normal aging and dementia, and how we might intervene therapeutically to alleviate memory and attention deficits.

      The lab utilizes state of the art techniques and analytical approaches to address its scientific and clinical goals by coupling behavioral assessments, functional magnetic resonance imaging (fMRI), electroencephalography (EEG) and transcranial magnetic stimulation (TMS).

      Under the direction of Dr. Adam Gazzaley the lab supports research associates, undergraduates, medical students and residents, PhD students, and post-doctoral fellows in their research and educational development.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Pa J, Gazzaley A. Flavanol-rich food for thought. Nat Neurosci. 2014 Nov 21; 17(12):1624-5.
        View in: PubMed
      2. Wais PE, Gazzaley A. External distraction impairs categorization performance in older adults. Psychol Aging. 2014 Sep; 29(3):666-71.
        View in: PubMed
      3. Guerreiro MJ, Anguera JA, Mishra J, Van Gerven PW, Gazzaley A. Age-equivalent Top-Down Modulation during Cross-modal Selective Attention. J Cogn Neurosci. 2014 Dec; 26(12):2827-39.
        View in: PubMed
      4. Chadick JZ, Zanto TP, Gazzaley A. Structural and functional differences in medial prefrontal cortex underlie distractibility and suppression deficits in ageing. Nat Commun. 2014; 5:4223.
        View in: PubMed
      5. Mishra J, Gazzaley A. Harnessing the neuroplastic potential of the human brain & the future of cognitive rehabilitation. Front Hum Neurosci. 2014; 8:218.
        View in: PubMed
      6. Wais PE, Gazzaley A. Distractibility during retrieval of long-term memory: domain-general interference, neural networks and increased susceptibility in normal aging. Front Psychol. 2014; 5:280.
        View in: PubMed
      7. Pa J, Dutt S, Mirsky JB, Heuer HW, Keselman P, Kong E, Trujillo A, Gazzaley A, Kramer JH, Seeley WW, Miller BL, Boxer AL. The functional oculomotor network and saccadic cognitive control in healthy elders. Neuroimage. 2014 Jul 15; 95:61-8.
        View in: PubMed
      8. Jantz TK, Tomory JJ, Merrick C, Cooper S, Gazzaley A, Morsella E. Subjective aspects of working memory performance: Memoranda-related imagery. Conscious Cogn. 2014 Apr; 25:88-100.
        View in: PubMed
      9. Mishra J, Gazzaley A. Preserved Discrimination Performance and Neural Processing during Crossmodal Attention in Aging. PLoS One. 2013; 8(11):e81894.
        View in: PubMed
      10. Zanto TP, Gazzaley A. Fronto-parietal network: flexible hub of cognitive control. Trends Cogn Sci. 2013 Dec; 17(12):602-3.
        View in: PubMed
      11. Zanto TP, Chadick JZ, Satris G, Gazzaley A. Rapid functional reorganization in human cortex following neural perturbation. J Neurosci. 2013 Oct 9; 33(41):16268-74.
        View in: PubMed
      12. Anguera JA, Lyman K, Zanto TP, Bollinger J, Gazzaley A. Reconciling the influence of task-set switching and motor inhibition processes on stop signal after-effects. Front Psychol. 2013; 4:649.
        View in: PubMed
      13. Allen AK, Wilkins K, Gazzaley A, Morsella E. Conscious thoughts from reflex-like processes: A new experimental paradigm for consciousness research. Conscious Cogn. 2013 Dec; 22(4):1318-31.
        View in: PubMed
      14. Zanto TP, Pa J, Gazzaley A. Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment. Neuroimage. 2014 Jan; 84:443-52.
        View in: PubMed
      15. Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, Gazzaley A. Video game training enhances cognitive control in older adults. Nature. 2013 Sep 5; 501(7465):97-101.
        View in: PubMed
      16. Zanto TP, Sekuler R, Dube C, Gazzaley A. Age-related changes in expectation-based modulation of motion detectability. PLoS One. 2013; 8(8):e69766.
        View in: PubMed
      17. Zanto TP, Chadick JZ, Gazzaley A. Anticipatory alpha phase influences visual working memory performance. Neuroimage. 2014 Jan 15; 85 Pt 2:794-802.
        View in: PubMed
      18. Mishra J, Zanto T, Nilakantan A, Gazzaley A. Comparable mechanisms of working memory interference by auditory and visual motion in youth and aging. Neuropsychologia. 2013 Aug; 51(10):1896-906.
        View in: PubMed
      19. Pa J, Berry AS, Compagnone M, Boccanfuso J, Greenhouse I, Rubens MT, Johnson JK, Gazzaley A. Cholinergic enhancement of functional networks in older adults with mild cognitive impairment. Ann Neurol. 2013 Jun; 73(6):762-73.
        View in: PubMed
      20. Voytek B, Gazzaley A. Stimulating the aging brain. Ann Neurol. 2013 Jan; 73(1):1-3.
        View in: PubMed
      21. Mishra J, Anguera JA, Ziegler DA, Gazzaley A. A cognitive framework for understanding and improving interference resolution in the brain. Prog Brain Res. 2013; 207:351-77.
        View in: PubMed
      22. Hubbard J, Rigby T, Godwin CA, Gazzaley A, Morsella E. Representations in working memory yield interference effects found with externally-triggered representations. Acta Psychol (Amst). 2013 Jan; 142(1):127-35.
        View in: PubMed
      23. Cashdollar N, Fukuda K, Bocklage A, Aurtenetxe S, Vogel EK, Gazzaley A. Prolonged disengagement from attentional capture in normal aging. Psychol Aging. 2013 Mar; 28(1):77-86.
        View in: PubMed
      24. Mishra J, Gazzaley A. Attention distributed across sensory modalities enhances perceptual performance. J Neurosci. 2012 Aug 29; 32(35):12294-302.
        View in: PubMed
      25. Gazzaley A, Nobre AC. Top-down modulation: bridging selective attention and working memory. Trends Cogn Sci. 2012 Feb; 16(2):129-35.
        View in: PubMed
      26. Wais PE, Gazzaley A. The impact of auditory distraction on retrieval of visual memories. Psychon Bull Rev. 2011 Dec; 18(6):1090-7.
        View in: PubMed
      27. Wais PE, Martin GM, Gazzaley A. The impact of visual distraction on episodic retrieval in older adults. Brain Res. 2012 Jan 9; 1430:78-85.
        View in: PubMed
      28. Kalkstein J, Checksfield K, Bollinger J, Gazzaley A. Diminished top-down control underlies a visual imagery deficit in normal aging. J Neurosci. 2011 Nov 2; 31(44):15768-74.
        View in: PubMed
      29. D'Esposito M, Gazzaley A. Can age-associated memory decline be treated? N Engl J Med. 2011 Oct 6; 365(14):1346-7.
        View in: PubMed
      30. Anguera JA, Gazzaley A. Dissociation of motor and sensory inhibition processes in normal aging. Clin Neurophysiol. 2012 Apr; 123(4):730-40.
        View in: PubMed
      31. Zanto TP, Pan P, Liu H, Bollinger J, Nobre AC, Gazzaley A. Age-related changes in orienting attention in time. J Neurosci. 2011 Aug 31; 31(35):12461-70.
        View in: PubMed
      32. Wais PE, Kim OY, Gazzaley A. Distractibility during episodic retrieval is exacerbated by perturbation of left ventrolateral prefrontal cortex. Cereb Cortex. 2012 Mar; 22(3):717-24.
        View in: PubMed
      33. Hubbard J, Gazzaley A, Morsella E. Traditional response interference effects from anticipated action outcomes: a response-effect compatibility paradigm. Acta Psychol (Amst). 2011 Sep; 138(1):106-10.
        View in: PubMed
      34. Chadick JZ, Gazzaley A. Differential coupling of visual cortex with default or frontal-parietal network based on goals. Nat Neurosci. 2011 Jul; 14(7):830-2.
        View in: PubMed
      35. Clapp WC, Rubens MT, Sabharwal J, Gazzaley A. Deficit in switching between functional brain networks underlies the impact of multitasking on working memory in older adults. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7212-7.
        View in: PubMed
      36. Wendelken C, Baym CL, Gazzaley A, Bunge SA. Neural indices of improved attentional modulation over middle childhood. Dev Cogn Neurosci. 2011 Apr; 1(2):175-86.
        View in: PubMed
      37. Zanto TP, Rubens MT, Thangavel A, Gazzaley A. Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory. Nat Neurosci. 2011 May; 14(5):656-61.
        View in: PubMed
      38. Bollinger J, Rubens MT, Masangkay E, Kalkstein J, Gazzaley A. An expectation-based memory deficit in aging. Neuropsychologia. 2011 May; 49(6):1466-75.
        View in: PubMed
      39. Gazzaley A, Small SA. Alzheimer's disease. Network. 2011; 22(1-4):173-85.
        View in: PubMed
      40. Gazzaley A. Influence of early attentional modulation on working memory. Neuropsychologia. 2011 May; 49(6):1410-24.
        View in: PubMed
      41. Bollinger J, Rubens MT, Zanto TP, Gazzaley A. Expectation-driven changes in cortical functional connectivity influence working memory and long-term memory performance. J Neurosci. 2010 Oct 27; 30(43):14399-410.
        View in: PubMed
      42. Berry AS, Zanto TP, Clapp WC, Hardy JL, Delahunt PB, Mahncke HW, Gazzaley A. The influence of perceptual training on working memory in older adults. PLoS One. 2010; 5(7):e11537.
        View in: PubMed
      43. Wais PE, Rubens MT, Boccanfuso J, Gazzaley A. Neural mechanisms underlying the impact of visual distraction on retrieval of long-term memory. J Neurosci. 2010 Jun 23; 30(25):8541-50.
        View in: PubMed
      44. Zanto TP, Rubens MT, Bollinger J, Gazzaley A. Top-down modulation of visual feature processing: the role of the inferior frontal junction. Neuroimage. 2010 Nov 1; 53(2):736-45.
        View in: PubMed
      45. Rutman AM, Clapp WC, Chadick JZ, Gazzaley A. Early top-down control of visual processing predicts working memory performance. J Cogn Neurosci. 2010 Jun; 22(6):1224-34.
        View in: PubMed
      46. Clapp WC, Gazzaley A. Distinct mechanisms for the impact of distraction and interruption on working memory in aging. Neurobiol Aging. 2012 Jan; 33(1):134-48.
        View in: PubMed
      47. Zanto TP, Toy B, Gazzaley A. Delays in neural processing during working memory encoding in normal aging. Neuropsychologia. 2010 Jan; 48(1):13-25.
        View in: PubMed
      48. Morsella E, Wilson LE, Berger CC, Honhongva M, Gazzaley A, Bargh JA. Subjective aspects of cognitive control at different stages of processing. Atten Percept Psychophys. 2009 Nov; 71(8):1807-24.
        View in: PubMed
      49. Zanto TP, Hennigan K, Ostberg M, Clapp WC, Gazzaley A. Predictive knowledge of stimulus relevance does not influence top-down suppression of irrelevant information in older adults. Cortex. 2010 Apr; 46(4):564-74.
        View in: PubMed
      50. Clapp WC, Rubens MT, Gazzaley A. Mechanisms of working memory disruption by external interference. Cereb Cortex. 2010 Apr; 20(4):859-72.
        View in: PubMed
      51. Berry AS, Zanto TP, Rutman AM, Clapp WC, Gazzaley A. Practice-related improvement in working memory is modulated by changes in processing external interference. J Neurophysiol. 2009 Sep; 102(3):1779-89.
        View in: PubMed
      52. Pa J, Boxer A, Chao LL, Gazzaley A, Freeman K, Kramer J, Miller BL, Weiner MW, Neuhaus J, Johnson JK. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Ann Neurol. 2009 Apr; 65(4):414-23.
        View in: PubMed
      53. Zanto TP, Gazzaley A. Neural suppression of irrelevant information underlies optimal working memory performance. J Neurosci. 2009 Mar 11; 29(10):3059-66.
        View in: PubMed
      54. Rissman J, Gazzaley A, D'Esposito M. The effect of non-visual working memory load on top-down modulation of visual processing. Neuropsychologia. 2009 Jun; 47(7):1637-46.
        View in: PubMed
      55. Gazzaley A, Clapp W, Kelley J, McEvoy K, Knight RT, D'Esposito M. Age-related top-down suppression deficit in the early stages of cortical visual memory processing. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):13122-6.
        View in: PubMed
      56. Rissman J, Gazzaley A, D'Esposito M. Dynamic adjustments in prefrontal, hippocampal, and inferior temporal interactions with increasing visual working memory load. Cereb Cortex. 2008 Jul; 18(7):1618-29.
        View in: PubMed
      57. Handwerker DA, Gazzaley A, Inglis BA, D'Esposito M. Reducing vascular variability of fMRI data across aging populations using a breathholding task. Hum Brain Mapp. 2007 Sep; 28(9):846-59.
        View in: PubMed
      58. Gazzaley A, Rissman J, Cooney J, Rutman A, Seibert T, Clapp W, D'Esposito M. Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing. Cereb Cortex. 2007 Sep; 17 Suppl 1:i125-35.
        View in: PubMed
      59. Gazzaley A, Sheridan MA, Cooney JW, D'Esposito M. Age-related deficits in component processes of working memory. Neuropsychology. 2007 Sep; 21(5):532-9.
        View in: PubMed
      60. Gazzaley A, D'Esposito M. Top-down modulation and normal aging. Ann N Y Acad Sci. 2007 Feb; 1097:67-83.
        View in: PubMed
      61. Krawczyk DC, Gazzaley A, D'Esposito M. Reward modulation of prefrontal and visual association cortex during an incentive working memory task. Brain Res. 2007 Apr 13; 1141:168-77.
        View in: PubMed
      62. D'Esposito M, Cooney JW, Gazzaley A, Gibbs SE, Postle BR. Is the prefrontal cortex necessary for delay task performance? Evidence from lesion and FMRI data. J Int Neuropsychol Soc. 2006 Mar; 12(2):248-60.
        View in: PubMed
      63. Huh TJ, Kramer JH, Gazzaley A, Delis DC. Response bias and aging on a recognition memory task. J Int Neuropsychol Soc. 2006 Jan; 12(1):1-7.
        View in: PubMed
      64. Gazzaley A, Cooney JW, Rissman J, D'Esposito M. Top-down suppression deficit underlies working memory impairment in normal aging. Nat Neurosci. 2005 Oct; 8(10):1298-300.
        View in: PubMed
      65. Gazzaley A, Cooney JW, McEvoy K, Knight RT, D'Esposito M. Top-down enhancement and suppression of the magnitude and speed of neural activity. J Cogn Neurosci. 2005 Mar; 17(3):507-17.
        View in: PubMed
      66. Gazzaley A, Rissman J, D'Esposito M. Functional connectivity during working memory maintenance. Cogn Affect Behav Neurosci. 2004 Dec; 4(4):580-99.
        View in: PubMed
      67. Rissman J, Gazzaley A, D'Esposito M. Measuring functional connectivity during distinct stages of a cognitive task. Neuroimage. 2004 Oct; 23(2):752-63.
        View in: PubMed
      68. D'Esposito M, Deouell LY, Gazzaley A. Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging. Nat Rev Neurosci. 2003 Nov; 4(11):863-72.
        View in: PubMed
      69. Gazzaley A, D'Esposito M. The contribution of functional brain imaging to our understanding of cognitive aging. Sci Aging Knowledge Environ. 2003 Jan 29; 2003(4):PE2.
        View in: PubMed
      70. Gazzaley A, Kay S, Benson DL. Dendritic spine plasticity in hippocampus. Neuroscience. 2002; 111(4):853-62.
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      71. Adams MM, Gazzaley AH, Morrison JH. Attenuated lesion-induced N-methyl-D-aspartate receptor (NMDAR) plasticity in the dentate gyrus of aged rats following perforant path lesions. Exp Neurol. 2001 Nov; 172(1):244-9.
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      72. Gazzaley AH, Thakker MM, Hof PR, Morrison JH. Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. Neurobiol Aging. 1997 Sep-Oct; 18(5):549-53.
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      73. Gazzaley AH, Benson DL, Huntley GW, Morrison JH. Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentate gyrus granule cells after perforant path transection. J Neurosci. 1997 Mar 15; 17(6):2006-17.
        View in: PubMed
      74. Vissavajjhala P, Janssen WG, Hu Y, Gazzaley AH, Moran T, Hof PR, Morrison JH. Synaptic distribution of the AMPA-GluR2 subunit and its colocalization with calcium-binding proteins in rat cerebral cortex: an immunohistochemical study using a GluR2-specific monoclonal antibody. Exp Neurol. 1996 Dec; 142(2):296-312.
        View in: PubMed
      75. Gazzaley AH, Weiland NG, McEwen BS, Morrison JH. Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus. J Neurosci. 1996 Nov 1; 16(21):6830-8.
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      76. Morrison JH, Gazzaley AH. Age-related alterations of the N-methyl-D-aspartate receptor in the dentate gyrus. Mol Psychiatry. 1996 Nov; 1(5):356-8.
        View in: PubMed
      77. Gazzaley AH, Siegel SJ, Kordower JH, Mufson EJ, Morrison JH. Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc Natl Acad Sci U S A. 1996 Apr 2; 93(7):3121-5.
        View in: PubMed
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