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    Ida Sim, PhD, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Phone415-514-8657

       Biography 
       Education and Training
      Stanford UniversityM.D.1990
       Awards and Honors
      American Society for Clinical Investigation2010Elected Member
      American College of Medial Informatics2007Elected Fellow
      American Medical Informatics Association2005Leadership Award
      White House Office of Science Technology and Policy2000United States Presidential Early Career Award for Scientists and Engineers

       Overview 
       Overview
      Ida Sim is Professor of Medicine and Co-Director of Biomedical Informatics of the Clinical and Translational Science Institute at UCSF, and Co-Founder of Open mHealth. She received her MD and her PhD in Medical Informatics from Stanford University, and her Primary Care Internal Medicine training from the Massachussetts General Hospital. She is also fellowship-trained in General Internal Medicine at Stanford University. Dr. Sim’s expertise is on knowledge-based technologies for clinical research and evidence-based practice, with a special focus on using mobile technologies for chronic care. In 2000, she received the United States Presidential Early Career Award for Scientists and Engineers (PECASE) for her Trial Bank Project R01, which developed fundamental informatics technologies for a computable knowledge base of randomized trials. This line of work now centers on the Ontology of Clinical Research and its application to clinical trials data sharing (e.g., http://hsdbwiki.org/) and infrastructure for mobile-based research studies.

      In 2011, Dr. Sim co-founded Open mHealth (http://openmhealth.org/), a non-profit to build an open source way for the mobile health (mHealth) ecosystem to share data, methods, and software to maximize the potential of mHealth to improve individual and population health. Our approach centers around an open software architecture with open APIs and reusable modules for data collection, analysis, and visualization to support systematic and shared learning. Open mHealth leverages existing tools, techniques, and standards and involves a growing community of commercial, academic, government, and non-profit organizations.

      In other work, Dr. Sim has published on clinical trial reporting bias, new models of scientific e-publication of clinical research, and the adoption of electronic health records in primary care practices for quality improvement. In policy work, Dr. Sim was the founding Project Coordinator of the World Health Organization’s International Clinical Trials Registry Platform, which sets global standards on clinical trial registration and reporting. She led the development of the Trial Registration Data Set, the common 20-item data set that all registers worldwide including ClinicalTrials.gov adheres to. She currently serves on the Institute of Medicine's committee on Strategies of Responsible Sharing of Clinical Trial Data (http://www.iom.edu/Activities/Research/SharingClinicalTrialData.aspx).

      At UCSF, Dr. Sim co-directs Biomedical Informatics for CTSI. She is an active primary care physician who teaches primary care medicine and also teaches in the K30 clinical research training program.

      Dr. Sim was a member of the National Research Council report on Computational Technology for Effective Health Care. She served on the editorial board of the Journal of Biomedical Informatics, is on the Advisory Board for PLoS One, is a Fellow of the American College of Medical Informatics, and an elected member of the American Society for Clinical Investigation.

      Keywords: mHealth, mobile health, data sharing, ontology, informatics, clinical trial reporting, clinical trial registration, primary care

       Interests
      Implementation Science, International (public health), Policy-making institute or agency, mHealth, Policy advocacy, Social media, Web site, use of information technology in primary care, clinical trial registration policy, changes in clinical research methods (IT and methodological), Mentoring junior faculty or trainees, Interdisciplinary research collaboration, Brief implementation science training courses

       ORNG Applications 
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Trials. 2015; 16(1):67.
        View in: PubMed
      2. Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM. The Ontology of Clinical Research (OCRe): An informatics foundation for the science of clinical research. J Biomed Inform. 2014 Dec; 52:78-91.
        View in: PubMed PMC4019723
      3. Cohen AM, Demner-Fushman D, Iorio A, Sim I, Smalheiser NR. Tools for Identifying Reliable Evidence and Implementing it in Everyday Clinical Care. AMIA Jt Summits Transl Sci Proc. 2013; 2013:42-4.
        View in: PubMed PMC3845785
      4. Roumiantseva D, Carini S, Sim I, Wagner TH. Sponsorship and design characteristics of trials registered in ClinicalTrials.gov. Contemp Clin Trials. 2013 Mar; 34(2):348-55.
        View in: PubMed
      5. Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J. Deriving an abstraction network to support quality assurance in OCRe. AMIA Annu Symp Proc. 2012; 2012:681-9.
        View in: PubMed PMC3540580
      6. Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V. Ontology-based federated data access to human studies information. AMIA Annu Symp Proc. 2012; 2012:856-65.
        View in: PubMed PMC3540523
      7. Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I. Making sense of mobile health data: an open architecture to improve individual- and population-level health. J Med Internet Res. 2012; 14(4):e112.
        View in: PubMed PMC3510692
      8. Boland MR, Tu SW, Carini S, Sim I, Weng C. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. AMIA Jt Summits Transl Sci Proc. 2012; 2012:71-80.
        View in: PubMed PMC3392056
      9. Bhavnani SK, Carini S, Ross J, Sim I. Network analysis of clinical trials on depression: implications for comparative effectiveness research. AMIA Annu Symp Proc. 2010; 2010:51-5.
        View in: PubMed PMC3041357
      10. Estrin D, Sim I. Health care delivery. Open mHealth architecture: an engine for health care innovation. Science. 2010 Nov 5; 330(6005):759-60.
        View in: PubMed
      11. Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I. ExaCT: automatic extraction of clinical trial characteristics from journal publications. BMC Med Inform Decis Mak. 2010; 10:56.
        View in: PubMed PMC2954855
      12. Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I. A practical method for transforming free-text eligibility criteria into computable criteria. J Biomed Inform. 2011 Apr; 44(2):239-50.
        View in: PubMed PMC3129371
      13. Ross J, Tu S, Carini S, Sim I. Analysis of eligibility criteria complexity in clinical trials. AMIA Jt Summits Transl Sci Proc. 2010; 2010:46-50.
        View in: PubMed PMC3041539
      14. Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S. The human studies database project: federating human studies design data using the ontology of clinical research. AMIA Jt Summits Transl Sci Proc. 2010; 2010:51-5.
        View in: PubMed PMC3041546
      15. Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ. Ontology mapping and data discovery for the translational investigator. AMIA Jt Summits Transl Sci Proc. 2010; 2010:66-70.
        View in: PubMed PMC3041530
      16. Weng C, Tu SW, Sim I, Richesson R. Formal representation of eligibility criteria: a literature review. J Biomed Inform. 2010 Jun; 43(3):451-67.
        View in: PubMed PMC2878905
      17. Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I. Development and evaluation of a study design typology for human research. AMIA Annu Symp Proc. 2009; 2009:81-5.
        View in: PubMed PMC2815479
      18. Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey. Trials. 2009; 10:56.
        View in: PubMed PMC2734552
      19. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Acad Med. 2009 Jul; 84(7):964-70.
        View in: PubMed PMC2884382
      20. Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ. Unintended consequences of health information technology: a need for biomedical informatics. J Biomed Inform. 2010 Oct; 43(5):828-30.
        View in: PubMed PMC2891863
      21. Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH. Keeping raw data in context. Science. 2009 Feb 6; 323(5915):713.
        View in: PubMed
      22. Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE. Changes to NIH grant system may backfire. Science. 2008 Nov 21; 322(5905):1187-8.
        View in: PubMed
      23. de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I. Automated information extraction of key trial design elements from clinical trial publications. AMIA Annu Symp Proc. 2008; 141-5.
        View in: PubMed PMC2655966
      24. Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA. Characterizing primary care research: PCROM versus BRIDG. AMIA Annu Symp Proc. 2008; 1145.
        View in: PubMed
      25. Hernandez ME, Carini S, Storey MA, Sim I. An interactive tool for visualizing design heterogeneity in clinical trials. AMIA Annu Symp Proc. 2008; 298-302.
        View in: PubMed PMC2656051
      26. Lee K, Bacchetti P, Sim I. Publication of clinical trials supporting successful new drug applications: a literature analysis. PLoS Med. 2008 Sep 23; 5(9):e191.
        View in: PubMed PMC2553819
      27. Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. J Am Med Inform Assoc. 2008 Sep-Oct; 15(5):661-70.
        View in: PubMed PMC2528032
      28. Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E. Reporting the findings of clinical trials: a discussion paper. Bull World Health Organ. 2008 Jun; 86(6):492-3.
        View in: PubMed PMC2647457
      29. Sim I. Trial registration for public trust: making the case for medical devices. J Gen Intern Med. 2008 Jan; 23 Suppl 1:64-8.
        View in: PubMed PMC2150638
      30. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]. Rev Panam Salud Publica. 2006 Jun; 19(6):413-6.
        View in: PubMed
      31. Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Lancet. 2006 May 20; 367(9523):1631-3.
        View in: PubMed
      32. Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T. Assessing clinical trial results. Science. 2006 Apr 21; 312(5772):365-6; author reply 365-6.
        View in: PubMed
      33. Gülmezoglu AM, Sim I. International clinical trial registration: any progress? Wien Klin Wochenschr. 2006 Feb; 118(1-2):1-2.
        View in: PubMed
      34. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. J Biomed Inform. 2006 Dec; 39(6):656-67.
        View in: PubMed
      35. Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. OMICS. 2006; 10(2):185-98.
        View in: PubMed
      36. Olasov B, Sim I. RuleEd, a web-based semantic network interface for constructing and revising computable eligibility rules. AMIA Annu Symp Proc. 2006; 1051.
        View in: PubMed PMC1839587
      37. Sim I, Detmer DE. Beyond trial registration: a global trial bank for clinical trial reporting. PLoS Med. 2005 Nov; 2(11):e365.
        View in: PubMed PMC1255763
      38. Miller RH, West C, Brown TM, Sim I, Ganchoff C. The value of electronic health records in solo or small group practices. Health Aff (Millwood). 2005 Sep-Oct; 24(5):1127-37.
        View in: PubMed
      39. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ. 2005 Apr 23; 330(7497):956-8.
        View in: PubMed PMC556346
      40. Sim I, Cummings SR. Quantifying the gap between proof and practice. Evid Based Cardiovasc Med. 2004 Dec; 8(4):287-90.
        View in: PubMed
      41. Sim I, Olasov B, Carini S. An ontology of randomized controlled trials for evidence-based practice: content specification and evaluation using the competency decomposition method. J Biomed Inform. 2004 Apr; 37(2):108-19.
        View in: PubMed
      42. Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Health Aff (Millwood). 2004 Mar-Apr; 23(2):116-26.
        View in: PubMed
      43. Cuadros J, Sim I. EyePACS: an open source clinical communication system for eye care. Stud Health Technol Inform. 2004; 107(Pt 1):207-11.
        View in: PubMed
      44. Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Stud Health Technol Inform. 2004; 107(Pt 1):578-81.
        View in: PubMed
      45. Miller RH, Sim I, Newman J. Electronic medical records in solo/small groups: a qualitative study of physician user types. Stud Health Technol Inform. 2004; 107(Pt 1):658-62.
        View in: PubMed
      46. Sim I, Carini S, Olasov B, Jeng S. Trial bank publishing: phase I results. Stud Health Technol Inform. 2004; 107(Pt 2):1476-80.
        View in: PubMed
      47. Sim I, Cummings SR. A new framework for describing and quantifying the gap between proof and practice. Med Care. 2003 Aug; 41(8):874-81.
        View in: PubMed
      48. Sim I, Berlin A. A framework for classifying decision support systems. AMIA Annu Symp Proc. 2003; 599-603.
        View in: PubMed PMC1480261
      49. Carini S, Sim I. SysBank: a knowledge base for systematic reviews of randomized clinical trials. AMIA Annu Symp Proc. 2003; 804.
        View in: PubMed PMC1479927
      50. Sim I, Olasov B, Carini S. The Trial Bank system: capturing randomized trials for evidence-based medicine. AMIA Annu Symp Proc. 2003; 1076.
        View in: PubMed PMC1479965
      51. Sim I, Sanders GD, McDonald KM. Evidence-based practice for mere mortals: the role of informatics and health services research. J Gen Intern Med. 2002 Apr; 17(4):302-8.
        View in: PubMed PMC1495037
      52. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. J Gen Intern Med. 2002 Mar; 17(3):230-4.
        View in: PubMed PMC1495016
      53. Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC. Clinical decision support systems for the practice of evidence-based medicine. J Am Med Inform Assoc. 2001 Nov-Dec; 8(6):527-34.
        View in: PubMed PMC130063
      54. Sim I, Owens DK, Lavori PW, Rennels GD. Electronic trial banks: a complementary method for reporting randomized trials. Med Decis Making. 2000 Oct-Dec; 20(4):440-50.
        View in: PubMed
      55. Sim I, Lavori P. Meta-analyses and large randomized, controlled trials. N Engl J Med. 1998 Jan 1; 338(1):61; author reply 61-2.
        View in: PubMed
      56. Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Circulation. 1997 Nov 4; 96(9):2823-9.
        View in: PubMed
      57. Sim I, Hlatky MA. Growing pains of meta-analysis. BMJ. 1996 Sep 21; 313(7059):702-3.
        View in: PubMed PMC2352128
      58. Sim I, Gupta M, McDonald K, Bourassa MG, Hlatky MA. A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease. Am J Cardiol. 1995 Nov 15; 76(14):1025-9.
        View in: PubMed
      59. Sim I, Rennels G. A trial bank model for the publication of clinical trials. Proc Annu Symp Comput Appl Med Care. 1995; 863-7.
        View in: PubMed PMC2579216
      60. Pratt W, Sim I. Physician's information customizer (PIC): using a shareable user model to filter the medical literature. Medinfo. 1995; 8 Pt 2:1447-51.
        View in: PubMed
      61. Burcham TS, Sim I, Bolin LM, Shooter EM. The NGF complex from the African rat Mastomys natalensis. Neurochem Res. 1991 Jun; 16(6):603-12.
        View in: PubMed
      62. Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Synthesis and antiviral activity of metabolites of rimantadine. J Med Chem. 1990 Jul; 33(7):1992-5.
        View in: PubMed
      63. Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. Int J Hyperthermia. 1987 Mar-Apr; 3(2):123-32.
        View in: PubMed
      64. Frankfurt M, Siegel RA, Sim I, Wuttke W. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain. Neuroendocrinology. 1986; 42(3):226-31.
        View in: PubMed
      65. Frankfurt M, Siegel RA, Sim I, Wuttke W. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences. Brain Res. 1985 Dec 9; 358(1-2):53-8.
        View in: PubMed
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