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Ida Sim, PhD, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
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    Collapse Biography 
    Collapse education and training
    Stanford UniversityM.D.1990
    Stanford UniversityPhD1997Medical Informatics
    Collapse Awards and Honors
    American Society for Clinical Investigation2010Elected Member
    American College of Medial Informatics2007Elected Fellow
    American Medical Informatics Association2005Leadership Award
    White House Office of Science Technology and Policy2000United States Presidential Early Career Award for Scientists and Engineers

    Collapse Overview 
    Collapse overview
    Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine at the University of California, San Francisco, where she co-directs Biomedical Informatics at UCSF's Clinical and Translational Sciences Institute. Her current research focuses on the use of mobile apps and sensors to improve health and manage disease for populations and individuals, and to make clinical research faster and less expensive. She is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Dr. Sim is also a co-investigator and Consortium Core Lead with the Mobile Data to Knowledge NIH Center of Excellence.

    In 2005, Dr. Sim was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration and defined the common 20-item Trial Registration Data Set that all registers worldwide adhere to. She served on the Institute of Medicine's committee on Strategies of Responsible Sharing of Clinical Trial Data and is now the technical lead of the MRCT Framework for Data Sharing international effort to build a single global portal for sharing individual participant-level data from clinical trials.

    Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and Institute of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.


    Collapse Research 
    Collapse Research Activities and Funding
    Ontology-Based Integration of Human Studies Data
    NIH/NCRR R01RR026040Sep 9, 2009 - May 31, 2013
    Role: Principal Investigator
    The Trial Bank Project
    NIH/NLM R01LM006780Jul 1, 1999 - Mar 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Global Health
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bierer BE, Li R, Barnes M, Sim I. A Global, Neutral Platform for Sharing Trial Data. N Engl J Med. 2016 Jun 23; 374(25):2411-3. PMID: 27168194.
      View in: PubMed
    2. He Z, Ryan P, Hoxha J, Wang S, Carini S, Sim I, Weng C. Multivariate analysis of the population representativeness of related clinical studies. J Biomed Inform. 2016 Apr; 60:66-76. PMID: 26820188.
      View in: PubMed
    3. Elliott JH, Grimshaw J, Altman R, Bero L, Goodman SN, Henry D, Macleod M, Tovey D, Tugwell P, White H, Sim I. Informatics: Make sense of health data. Nature. 2015 Nov 5; 527(7576):31-2. PMID: 26536942.
      View in: PubMed
    4. Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Trials. 2015; 16:67. PMID: 25881274; PMCID: PMC4367894.
    5. He Z, Carini S, Sim I, Weng C. Visual aggregate analysis of eligibility features of clinical trials. J Biomed Inform. 2015 Apr; 54:241-55. PMID: 25615940; PMCID: PMC4408222 [Available on 04/01/16].
    6. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Stud Health Technol Inform. 2015; 216:736-40. PMID: 26262149.
      View in: PubMed
    7. He Z, Carini S, Hao T, Sim I, Weng C. A method for analyzing commonalities in clinical trial target populations. AMIA Annu Symp Proc. 2014; 2014:1777-86. PMID: 25954450; PMCID: PMC4419878.
    8. Flatley Brennan P, Valdez R, Alexander G, Arora S, Bernstam EV, Edmunds M, Kirienko N, Martin RD, Sim I, Skiba D, Rosenbloom T. Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting. J Am Med Inform Assoc. 2015 Apr; 22(e1):e2-6. PMID: 25359545.
      View in: PubMed
    9. DePasse JW, Chen CE, Sawyer A, Jethwani K, Sim I. Academic Medical Centers as digital health catalysts. Healthc (Amst). 2014 Sep; 2(3):173-6. PMID: 26250503.
      View in: PubMed
    10. Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research. J Biomed Inform. 2014 Dec; 52:78-91. PMID: 24239612; PMCID: PMC4019723 [Available on 12/01/15].
    11. Cohen AM, Demner-Fushman D, Iorio A, Sim I, Smalheiser NR. Tools for Identifying Reliable Evidence and Implementing it in Everyday Clinical Care. AMIA Jt Summits Transl Sci Proc. 2013; 2013:42-4. PMID: 24303233; PMCID: PMC3845785.
    12. Roumiantseva D, Carini S, Sim I, Wagner TH. Sponsorship and design characteristics of trials registered in ClinicalTrials.gov. Contemp Clin Trials. 2013 Mar; 34(2):348-55. PMID: 23380028.
      View in: PubMed
    13. Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V. Ontology-based federated data access to human studies information. AMIA Annu Symp Proc. 2012; 2012:856-65. PMID: 23304360; PMCID: PMC3540523.
    14. Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J. Deriving an abstraction network to support quality assurance in OCRe. AMIA Annu Symp Proc. 2012; 2012:681-9. PMID: 23304341; PMCID: PMC3540580.
    15. Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I. Making sense of mobile health data: an open architecture to improve individual- and population-level health. J Med Internet Res. 2012; 14(4):e112. PMID: 22875563; PMCID: PMC3510692.
    16. Boland MR, Tu SW, Carini S, Sim I, Weng C. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. AMIA Jt Summits Transl Sci Proc. 2012; 2012:71-80. PMID: 22779055; PMCID: PMC3392056.
    17. Bhavnani SK, Carini S, Ross J, Sim I. Network analysis of clinical trials on depression: implications for comparative effectiveness research. AMIA Annu Symp Proc. 2010; 2010:51-5. PMID: 21346939; PMCID: PMC3041357.
    18. Estrin D, Sim I. Health care delivery. Open mHealth architecture: an engine for health care innovation. Science. 2010 Nov 5; 330(6005):759-60. PMID: 21051617.
      View in: PubMed
    19. Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I. ExaCT: automatic extraction of clinical trial characteristics from journal publications. BMC Med Inform Decis Mak. 2010; 10:56. PMID: 20920176; PMCID: PMC2954855.
    20. Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I. A practical method for transforming free-text eligibility criteria into computable criteria. J Biomed Inform. 2011 Apr; 44(2):239-50. PMID: 20851207; PMCID: PMC3129371.
    21. Ross J, Tu S, Carini S, Sim I. Analysis of eligibility criteria complexity in clinical trials. AMIA Jt Summits Transl Sci Proc. 2010; 2010:46-50. PMID: 21347148; PMCID: PMC3041539.
    22. Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ. Ontology mapping and data discovery for the translational investigator. AMIA Jt Summits Transl Sci Proc. 2010; 2010:66-70. PMID: 21347152; PMCID: PMC3041530.
    23. Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S. The human studies database project: federating human studies design data using the ontology of clinical research. AMIA Jt Summits Transl Sci Proc. 2010; 2010:51-5. PMID: 21347149; PMCID: PMC3041546.
    24. Weng C, Tu SW, Sim I, Richesson R. Formal representation of eligibility criteria: a literature review. J Biomed Inform. 2010 Jun; 43(3):451-67. PMID: 20034594; PMCID: PMC2878905.
    25. Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I. Development and evaluation of a study design typology for human research. AMIA Annu Symp Proc. 2009; 2009:81-5. PMID: 20351827; PMCID: PMC2815479.
    26. Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey. Trials. 2009; 10:56. PMID: 19624821; PMCID: PMC2734552.
    27. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Acad Med. 2009 Jul; 84(7):964-70. PMID: 19550198; PMCID: PMC2884382.
    28. Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ. Unintended consequences of health information technology: a need for biomedical informatics. J Biomed Inform. 2010 Oct; 43(5):828-30. PMID: 19508898; PMCID: PMC2891863.
    29. Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH. Keeping raw data in context. Science. 2009 Feb 6; 323(5915):713. PMID: 19197039.
      View in: PubMed
    30. Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE. Changes to NIH grant system may backfire. Science. 2008 Nov 21; 322(5905):1187-8. PMID: 19023064.
      View in: PubMed
    31. de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I. Automated information extraction of key trial design elements from clinical trial publications. AMIA Annu Symp Proc. 2008; 141-5. PMID: 18999067; PMCID: PMC2655966.
    32. Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA. Characterizing primary care research: PCROM versus BRIDG. AMIA Annu Symp Proc. 2008; 1145. PMID: 18998919.
      View in: PubMed
    33. Hernandez ME, Carini S, Storey MA, Sim I. An interactive tool for visualizing design heterogeneity in clinical trials. AMIA Annu Symp Proc. 2008; 298-302. PMID: 18998925; PMCID: PMC2656051.
    34. Lee K, Bacchetti P, Sim I. Publication of clinical trials supporting successful new drug applications: a literature analysis. PLoS Med. 2008 Sep 23; 5(9):e191. PMID: 18816163; PMCID: PMC2553819.
    35. Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. J Am Med Inform Assoc. 2008 Sep-Oct; 15(5):661-70. PMID: 18579829; PMCID: PMC2528032.
    36. Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E. Reporting the findings of clinical trials: a discussion paper. Bull World Health Organ. 2008 Jun; 86(6):492-3. PMID: 18568282; PMCID: PMC2647457.
    37. Sim I. Trial registration for public trust: making the case for medical devices. J Gen Intern Med. 2008 Jan; 23 Suppl 1:64-8. PMID: 18095047; PMCID: PMC2150638.
    38. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]. Rev Panam Salud Publica. 2006 Jun; 19(6):413-6. PMID: 16968596.
      View in: PubMed
    39. Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Lancet. 2006 May 20; 367(9523):1631-3. PMID: 16714166.
      View in: PubMed
    40. Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T. Assessing clinical trial results. Science. 2006 Apr 21; 312(5772):365-6; author reply 365-6. PMID: 16634140.
      View in: PubMed
    41. Gülmezoglu AM, Sim I. International clinical trial registration: any progress? Wien Klin Wochenschr. 2006 Feb; 118(1-2):1-2. PMID: 16489516.
      View in: PubMed
    42. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. J Biomed Inform. 2006 Dec; 39(6):656-67. PMID: 16442854.
      View in: PubMed
    43. Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. OMICS. 2006; 10(2):185-98. PMID: 16901225.
      View in: PubMed
    44. Olasov B, Sim I. RuleEd, a web-based semantic network interface for constructing and revising computable eligibility rules. AMIA Annu Symp Proc. 2006; 1051. PMID: 17238670; PMCID: PMC1839587.
    45. Sim I, Detmer DE. Beyond trial registration: a global trial bank for clinical trial reporting. PLoS Med. 2005 Nov; 2(11):e365. PMID: 16220999; PMCID: PMC1255763.
    46. Miller RH, West C, Brown TM, Sim I, Ganchoff C. The value of electronic health records in solo or small group practices. Health Aff (Millwood). 2005 Sep-Oct; 24(5):1127-37. PMID: 16162555.
      View in: PubMed
    47. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ. 2005 Apr 23; 330(7497):956-8. PMID: 15845980; PMCID: PMC556346.
    48. Sim I, Cummings SR. Quantifying the gap between proof and practice. Evid Based Cardiovasc Med. 2004 Dec; 8(4):287-90. PMID: 16379955.
      View in: PubMed
    49. Sim I, Olasov B, Carini S. An ontology of randomized controlled trials for evidence-based practice: content specification and evaluation using the competency decomposition method. J Biomed Inform. 2004 Apr; 37(2):108-19. PMID: 15120657.
      View in: PubMed
    50. Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Health Aff (Millwood). 2004 Mar-Apr; 23(2):116-26. PMID: 15046136.
      View in: PubMed
    51. Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Stud Health Technol Inform. 2004; 107(Pt 1):578-81. PMID: 15360878.
      View in: PubMed
    52. Cuadros J, Sim I. EyePACS: an open source clinical communication system for eye care. Stud Health Technol Inform. 2004; 107(Pt 1):207-11. PMID: 15360804.
      View in: PubMed
    53. Sim I, Carini S, Olasov B, Jeng S. Trial bank publishing: phase I results. Stud Health Technol Inform. 2004; 107(Pt 2):1476-80. PMID: 15361060.
      View in: PubMed
    54. Miller RH, Sim I, Newman J. Electronic medical records in solo/small groups: a qualitative study of physician user types. Stud Health Technol Inform. 2004; 107(Pt 1):658-62. PMID: 15360895.
      View in: PubMed
    55. Sim I, Cummings SR. A new framework for describing and quantifying the gap between proof and practice. Med Care. 2003 Aug; 41(8):874-81. PMID: 12886168.
      View in: PubMed
    56. Carini S, Sim I. SysBank: a knowledge base for systematic reviews of randomized clinical trials. AMIA Annu Symp Proc. 2003; 804. PMID: 14728309; PMCID: PMC1479927.
    57. Sim I, Berlin A. A framework for classifying decision support systems. AMIA Annu Symp Proc. 2003; 599-603. PMID: 14728243; PMCID: PMC1480261.
    58. Sim I, Olasov B, Carini S. The Trial Bank system: capturing randomized trials for evidence-based medicine. AMIA Annu Symp Proc. 2003; 1076. PMID: 14728579; PMCID: PMC1479965.
    59. Sim I, Sanders GD, McDonald KM. Evidence-based practice for mere mortals: the role of informatics and health services research. J Gen Intern Med. 2002 Apr; 17(4):302-8. PMID: 11972727; PMCID: PMC1495037.
    60. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. J Gen Intern Med. 2002 Mar; 17(3):230-4. PMID: 11929510; PMCID: PMC1495016.
    61. Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC. Clinical decision support systems for the practice of evidence-based medicine. J Am Med Inform Assoc. 2001 Nov-Dec; 8(6):527-34. PMID: 11687560; PMCID: PMC130063.
    62. Sim I, Owens DK, Lavori PW, Rennels GD. Electronic trial banks: a complementary method for reporting randomized trials. Med Decis Making. 2000 Oct-Dec; 20(4):440-50. PMID: 11059477.
      View in: PubMed
    63. Sim I, Lavori P. Meta-analyses and large randomized, controlled trials. N Engl J Med. 1998 Jan 1; 338(1):61; author reply 61-2. PMID: 9424568.
      View in: PubMed
    64. Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Circulation. 1997 Nov 4; 96(9):2823-9. PMID: 9386144.
      View in: PubMed
    65. Sim I, Hlatky MA. Growing pains of meta-analysis. BMJ. 1996 Sep 21; 313(7059):702-3. PMID: 8819428; PMCID: PMC2352128.
    66. Sim I, Gupta M, McDonald K, Bourassa MG, Hlatky MA. A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease. Am J Cardiol. 1995 Nov 15; 76(14):1025-9. PMID: 7484855.
      View in: PubMed
    67. Sim I, Rennels G. A trial bank model for the publication of clinical trials. Proc Annu Symp Comput Appl Med Care. 1995; 863-7. PMID: 8563415; PMCID: PMC2579216.
    68. Pratt W, Sim I. Physician's information customizer (PIC): using a shareable user model to filter the medical literature. Medinfo. 1995; 8 Pt 2:1447-51. PMID: 8591472.
      View in: PubMed
    69. Burcham TS, Sim I, Bolin LM, Shooter EM. The NGF complex from the African rat Mastomys natalensis. Neurochem Res. 1991 Jun; 16(6):603-12. PMID: 1791910.
      View in: PubMed
    70. Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim I. Synthesis and antiviral activity of metabolites of rimantadine. J Med Chem. 1990 Jul; 33(7):1992-5. PMID: 2362279.
      View in: PubMed
    71. Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. Int J Hyperthermia. 1987 Mar-Apr; 3(2):123-32. PMID: 3036971.
      View in: PubMed
    72. Frankfurt M, Siegel RA, Sim I, Wuttke W. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain. Neuroendocrinology. 1986; 42(3):226-31. PMID: 2419781.
      View in: PubMed
    73. Frankfurt M, Siegel RA, Sim I, Wuttke W. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences. Brain Res. 1985 Dec 9; 358(1-2):53-8. PMID: 2416392.
      View in: PubMed
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