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    Leslie Floren, PharmD

    TitleAdjunct Faculty
    SchoolUCSF School of Pharmacy
    Address513 Parnassus Avenue
    San Francisco CA 94117
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPost-Doc Fellow/Scholar School of Pharmacy1997
      University of California, San Francisco Residency School of Pharmacy
      University of California, San FranciscoPharm.D. School of Pharmacy1994
      Collapse Awards and Honors
      2012UCSF Teaching Scholars Program
      2010Long Award for Excellence in Teaching
      2005 - 2012UCSF School of Pharmacy Dean’s Recognition for Excellence in Teaching
      1995 - 1997Postdoctoral Research Fellowship, Department of Biopharmaceutical Sciences, UCSF

      Collapse Overview 
      Collapse Overview
      Leslie Carstensen Floren, PharmD, DABCP is an Associate Adjunct Professor of Bioengineering and Therapeutic Sciences (BTS) in the School of Pharmacy at UCSF, the Academic Coordinator and Director of Professional and Postdoctoral Educational Affairs in BTS as well as the co-Director of the NIH-funded, UCSF Clinical Pharmacology Fellowship Training Program. Her teaching responsibilities for the past several years have included, primarily, teaching pharmacokinetics/pharmacodynamics, clinical pharmacology and principles of drug development and regulatory sciences to a wide variety of students, including professional students in the PharmD program, Clinical Pharmacology Fellows, junior faculty members, and working professionals from industrial backgrounds. Teaching is one of her greatest pleasures and she has been honored to receive the School of Pharmacy Dean’s Recognition for Excellence in Teaching every year since 2005 and, in 2010, she received the highest honor in the School of Pharmacy for teaching, the Long Award for Excellence in Teaching. Dr. Floren has a keen interest in curriculum development, teaching methodology and assessment, educational technology and online education and will begin training in the School of Medicine 2012-2013 Teaching Scholars Program in order to develop innovative curricula, to implement novel teaching methods and to use technology in order to “bring to life” the principles of Pharmacokinetics, Pharmacodynamics and Clinical Pharmacology for a wide variety of students within and across disciplines and, ultimately, to have a positive impact on patient health. She also plans to conduct scholarly research that will demonstrate the utility of practice-based teaching methods in order to advance interdisciplinary pharmaceutical sciences education within UCSF, our local community and across the country.

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. PMID: 24030928; PMCID: PMC4018225.
      2. Daud AI, Xu C, Hwu WJ, Urbas P, Andrews S, Papadopoulos NE, Floren LC, Yver A, Deconti RC, Sondak VK. . . Cancer Chemother Pharmacol. Pharmacokinetic/pharmacodynamic analysis of adjuvant pegylated interferon alpha-2b in patients with resected high-risk melanoma. 2011; (67):657-66.
      3. DeConti RC, Algazi AP, Andrews S, Urbas P, Born O, Stoeckigt D, Floren L, Hwang J, Weber J, Sondak VK, Daud AI. . . Br J Cancer. Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma. 2010; (10):1548-53.
      4. GR Tonn, SG Wong, SC Wong, MG Johnson, J Ma, R Cho, LC Floren, K Kersey, K Berry, AP Marcus, X Wang, B Van Lengerich, JC Medina, PG Pearson, and BK Wong. . . Drug Metab Dispos. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing. 2009; (37):502-13.
      5. LA Frassetto, Thai T, Aggarwal A, Bucher P, Jacobsen W, U Christians, LZ Benet, LC Floren. . . Drug Metab Pharmacokinet. Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV+ Subjects. 2003; (18):114-20.
      6. LC Floren, A Wiznia , SA Hayashi, A Jaywardene, K Stanley, G Johnson, S Nachman, P Krosstad, F Aweeka. . . Pediatrics. Nelfinavir pharmacokinetics in stable HIV-positive children: AIDS Clinical Trials Group Protocol 377. 2003; 3(112):e220-27.
      7. L Mancinelli, L Frassetto, LC Floren, D Dressler, S Carrier, I Bekersky, LZ Benet, U Christians. . . Clin Pharmacol Ther. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. 2001; (69):24-31.
      8. C Cheng and LC Floren. . . CJHP. Pharmacogenetics: The clinical significance of cytochrome P450 polymorphisms. 1998; (10):11-4.
      9. LC Floren, MF Hebert, AP Venook, VC Jordan, A Cisneros, and KA Somberg. . . Ann Onc. Tamoxifen in liver disease: potential exacerbation of hepatic function. 1998; (9):1123-26.
      10. U Christians, W Jacobsen and LC Floren. . . Pharmacol Ther. Metabolism and drug interactions of the 3-hydroxy-3methylglutaryl Coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?. 1998; (80):1-34.
      11. U Christians, LC Floren, G Kirchner, and K-F Sewing. . . Transplantationsmedizen. The clinical pharmacokinetics of macrolide immunosuppressants and its impact on the clinical management of organ transplantation. 1997; (9):S2-S6.
      12. LC Floren, I Bekersky, LZ Benet, QA Mekki, DE Dressler, JW Lee, JP Roberts, and MF Hebert. . . Clin Pharmacol Ther. Tacrolimus oral bioavailability doubles with co-administration of ketoconazole. 1997; (62):41-9.
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