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Lynda Frassetto, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-6143
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    Collapse Biography 
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    University of California, San FranciscoFellowship1992School of Medicine
    SUNY DownstateInternal Medicine1987Medicine

    Collapse Overview 
    Collapse Overview
    Lynda Frassetto, MD, is a Professor Emeritus of Medicine in the Division of Nephrology at the University of California, San Francisco (USCF). She grew up in the greater New York metropolitan area and attended college and medical school in Connecticut.

    She trained as a nephrologist at UCSF and was in private practice in San Francisco before returning to UCSF to start her research career with Drs. Anthony Sebastian and R. Curtis Morris Jr. Over approximately 20 years, the group published papers on regulation of acid base balance in healthy and aging people and dietary influences on acid-base balance in healthy people and those with diabetes.

    Dr. Frassetto also collaborates with Dr. Leslie Z Benet, past chair of the Department of Biopharmaceutical Sciences at UCSF. Dr. Benet has pioneered a novel model predicting drug interactions in vivo, depending on the degree of in vitro membrane transporter and intracellular metabolizing enzyme interactions with a specific drug, xenobiotic or toxin. These predictions are then tested in clinical trials in healthy people and those with kidney disease, diabetes or HIV before and after transplantation.

    In addition to research, Dr. Frassetto was the director of the adult Clinical Research Center at the Parnassus Campus in UCSF’s Clinical and Translational Science Institute, and still supervises inpatient and outpatient care at three of the University’s hospital campuses. For the last several years, she has also been participating in and teaching programs that teach UC students and faculty better communication and behavioral stress modification techniques.

    Collapse Research 
    Collapse Research Activities and Funding
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Sep 29, 2006
    Role: Co-Investigator

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    Collapse Clinical Trials
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. How metabolic acidosis and kidney disease may accelerate the aging process. Eur J Clin Nutr. 2020 Aug; 74(Suppl 1):27-32. Frassetto LA, Sebastian A, DuBose TD. PMID: 32873954.
      View in: PubMed   Mentions:    Fields:    
    2. Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients. Eur J Clin Nutr. 2020 Aug; 74(Suppl 1):69-75. Angeloco LRN, Arces de Souza GC, Romão EA, Frassetto L, Chiarello PG. PMID: 32873960.
      View in: PubMed   Mentions:    Fields:    
    3. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharm Res. 2019 Sep 04; 36(11):155. Surofchy DD, Frassetto LA, Benet LZ. PMID: 31485804.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Corrigendum to "Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base" [Nutrition 31 (2015) 1-13]. Nutrition. 2019 Jun; 62:213. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. PMID: 30935711.
      View in: PubMed   Mentions:    Fields:    
    5. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. Med Hypotheses. 2019 Mar; 124:95-97. Frassetto LA, Sebastian A. PMID: 30798927.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Med Hypotheses. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. 2019; 124:95-97. Frassetto LA, Sebastian A. .
    7. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 02; 105(2):411-416. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. PMID: 30652304.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    8. Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in daily selection of foods in respect of their potassium and sodium content resulting in oxidative stress-induced dysfunction of the vascular endothelium, vascular smooth muscle, and perivascular tissues. Med Hypotheses. 2018 Oct; 119:110-119. Sebastian A, Cordain L, Frassetto L, Banerjee T, Morris RC. PMID: 30122481.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    9. Another strategy to help counter the effects of low gravity? Am J Clin Nutr. 2018 05 01; 107(5):681-682. Frassetto L. PMID: 29722853.
      View in: PubMed   Mentions:    Fields:    
    10. Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject. Nutrients. 2018 Apr 21; 10(4). Frassetto L, Banerjee T, Powe N, Sebastian A. PMID: 29690515.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    11. Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling. Nutrients. 2018 Mar 08; 10(3). Hietavala EM, Ihalainen JK, Frassetto LA, Schumann M, Eklund D, Pitkänen H, Häkkinen K, Mero AA. PMID: 29517990.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex. Appl Physiol Nutr Metab. 2017 Dec; 42(12):1330-1340. Hietavala EM, Stout JR, Frassetto LA, Puurtinen R, Pitkänen H, Selänne H, Suominen H, Mero AA. PMID: 28825967.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. PMID: 28385543.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    14. 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy. Ann Nucl Med. 2017 May; 31(4):295-303. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. PMID: 28260185.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. PMID: 28028768.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Spot-testing urine pH, a novel dietary biomarker? A randomised cross-over trial. Nutr Diet. 2017 Jul; 74(3):313-319. Parmenter BH, Slater GJ, Frassetto LA. PMID: 28731600.
      View in: PubMed   Mentions: 2     Fields:    
    17. Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database. Nutr Diet. 2017 Jul; 74(3):308-312. Parmenter BH, Slater GJ, Frassetto LA. PMID: 28731602.
      View in: PubMed   Mentions:    Fields:    
    18. Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient. Case Rep Nephrol. 2016; 2016:9106935. Frassetto LA, Gibson S. PMID: 27200198.
      View in: PubMed   Mentions:
    19. A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton's base reservoir with net base-producing diets. Med Hypotheses. 2016 Jun; 91:103-108. Sebastian A, Frassetto LA. PMID: 27142156.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2015 Dec; 69(12):1376. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A. PMID: 26626156.
      View in: PubMed   Mentions:    Fields:    
    21. A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes. Am J Transplant. 2016 Feb; 16(2):518-26. Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM. PMID: 26595767.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    22. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015 Aug; 69(8):944-8. Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L. PMID: 25828624.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    23. The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. Osteoporos Int. 2015 Apr; 26(4):1311-8. Lambert H, Frassetto L, Moore JB, Torgerson D, Gannon R, Burckhardt P, Lanham-New S. PMID: 25572045.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J. 2015 Feb; 29(2):589-96. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. PMID: 25342129.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    25. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. PMID: 25274610.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    26. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan; 31(1):1-13. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. PMID: 25287761.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    27. Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens. J Bone Miner Res. 2014 Jun; 29(6):1337-45. Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR. PMID: 24293094.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. PMID: 24389906.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study--Alimentation and Diabetes in Lanzarote--ADILAN. Trials. 2014 Jan 02; 15:2. Fontes-Villalba M, Jönsson T, Granfeldt Y, Frassetto LA, Sundquist J, Sundquist K, Carrera-Bastos P, Fika-Hernándo M, Picazo Ó, Lindeberg S. PMID: 24383431.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    30. Hip fractures in hemodialysis patients. Am J Kidney Dis. 2013 Oct; 62(4):653-5. Delgado C, Frassetto L. PMID: 24054940.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. PMID: 24030928.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    32. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 04; 10(11):4032-7. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. PMID: 23980906.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    33. Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets. Eur J Clin Nutr. 2013 Sep; 67(9):899-903. Frassetto LA, Shi L, Schloetter M, Sebastian A, Remer T. PMID: 23859996.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Commentary to accompany the paper entitled 'nutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney', by Jean-Philippe Bonjour. Br J Nutr. 2013 Dec 14; 110(11):1935-7. Frassetto LA, Sebastian A. PMID: 23769203.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation. Transplant Proc. 2013 Jan-Feb; 45(1):137-41. Chakkera HA, Chang YH, Bodner JK, Behmen S, Heilman RL, Reddy KS, Mulligan DC, Moss AA, Khamash H, Katariya N, Hewitt WR, Pitta TL, Frassetto LA. PMID: 23375287.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Potassium. Adv Nutr. 2012 Nov 01; 3(6):820-1. Lanham-New SA, Lambert H, Frassetto L. PMID: 23153736.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake. Eur J Clin Nutr. 2012 Dec; 66(12):1315-22. Frassetto LA, Hardcastle AC, Sebastian A, Aucott L, Fraser WD, Reid DM, Macdonald HM. PMID: 23093337.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects. Med Hypotheses. 2012 Aug; 79(2):189-92. Frassetto LA, Sebastian A. PMID: 22583559.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Effects of modality change on health-related quality of life. Hemodial Int. 2012 Jul; 16(3):377-86. Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen K. PMID: 22413899.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Long term higher urinary calcium excretion within the normal physiologic range predicts impaired bone status of the proximal radius in healthy children with higher potential renal acid load. Bone. 2012 May; 50(5):1026-31. Shi L, Libuda L, Schönau E, Frassetto L, Remer T. PMID: 22342797.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    41. Treatment and prevention of kidney stones: an update. Am Fam Physician. 2011 Dec 01; 84(11):1234-42. Frassetto L, Kohlstadt I. PMID: 22150656.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    42. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metab Dispos. 2011 Nov; 39(11):2017-9. Grover A, Frassetto LA, Benet LZ, Chakkera HA. PMID: 21849516.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    43. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation. 2010 Dec 27; 90(12):1595-601. Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. PMID: 20978464.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    44. Improving the reporting of adverse drug reactions in the hospital setting. Postgrad Med. 2010 Nov; 122(6):154-64. Pushkin R, Frassetto L, Tsourounis C, Segal ES, Kim S. PMID: 21084792.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    45. Effects of modality change and transplant on peak oxygen uptake in patients with kidney failure. Am J Kidney Dis. 2011 Jan; 57(1):113-22. Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen KL. PMID: 20870330.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Clin Pharmacol Ther. 2010 Oct; 88(4):540-7. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. PMID: 20703222.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    47. Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. Am J Transplant. 2010 Aug; 10(8):1870-80. Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. PMID: 20659093.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    48. Management of osteoporosis in CKD Stages 3 to 5. Am J Kidney Dis. 2010 May; 55(5):941-56. Gordon PL, Frassetto LA. PMID: 20438987.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    49. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Clin Pharmacol Ther. 2010 Apr; 87(4):465-72. Sun H, Frassetto LA, Huang Y, Benet LZ. PMID: 20090676.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    50. Clinical islet transplantation at the University of California, San Francisco. Clin Transpl. 2010; 235-43. Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG. PMID: 21698834.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. Diet-induced acidosis: is it real and clinically relevant? Br J Nutr. 2010 Apr; 103(8):1185-94. Pizzorno J, Frassetto LA, Katzinger J. PMID: 20003625.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    52. Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: case report and review of the literature. Int Urol Nephrol. 2010 Mar; 42(1):233-7. Tuot D, Gibson S, Caughey AB, Frassetto LA. PMID: 19911296.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. Renal transplantation in patients with HIV. Nat Rev Nephrol. 2009 Oct; 5(10):582-9. Frassetto LA, Tan-Tam C, Stock PG. PMID: 19776780.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    54. Liver and kidney transplantation in HIV-infected patients. AIDS Rev. 2009 Oct-Dec; 11(4):190-204. Tan-Tam CC, Frassetto LA, Stock PG. PMID: 19940946.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. Metabolic acidosis and progression of chronic kidney disease. J Am Soc Nephrol. 2009 Sep; 20(9):1869-70. Frassetto LA, Hsu CY. PMID: 19696222.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    56. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2009 Aug; 63(8):947-55. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A. PMID: 19209185.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    57. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther. 2009 Jan; 85(1):78-85. Zheng HX, Huang Y, Frassetto LA, Benet LZ. PMID: 18843263.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    58. Renal net acid excretion capacity is comparable in prepubescence, adolescence, and young adulthood but falls with aging. J Am Geriatr Soc. 2008 Aug; 56(8):1442-8. Berkemeyer S, Vormann J, Günther AL, Rylander R, Frassetto LA, Remer T. PMID: 18808599.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    59. Physical functioning in patients with chronic kidney disease. J Nephrol. 2008 Jul-Aug; 21(4):550-9. Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL, Painter P. PMID: 18651545.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    60. Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over. Br J Nutr. 2008 Sep; 100(3):615-23. Gannon RH, Millward DJ, Brown JE, Macdonald HM, Lovell DP, Frassetto LA, Remer T, Lanham-New SA. PMID: 18394215.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    61. Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets. J Nutr. 2008 Feb; 138(2):419S-422S. Frassetto LA, Morris RC, Sellmeyer DE, Sebastian A. PMID: 18203914.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    62. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant. 2008 Feb; 8(2):355-65. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. PMID: 18093266.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    63. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 17949460.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCellsCTClinical Trials
    64. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. J Nutr. 2007 Jun; 137(6):1491-2. Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, Tylavsky FA. PMID: 17513412.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    65. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F521-5. Frassetto LA, Morris RC, Sebastian A. PMID: 17522265.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    66. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Clin Pharmacol Ther. 2007 Jun; 81(6):828-32. Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. PMID: 17361125.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    67. In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4. J Herb Pharmacother. 2007; 7(1):39-56. Nicandro JP, Tsourounis C, Frassetto L, Guglielmo BJ. PMID: 17594986.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    68. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther. 2007 Feb; 81(2):194-204. Lau YY, Huang Y, Frassetto L, Benet LZ. PMID: 17192770.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    69. Solid organ transplantation: referral, management, and outcomes in HIV-infected patients. AIDS Read. 2006 Dec; 16(12):664-8, 675-8. Roland ME, Carlson LL, Frassetto LA, Stock PG. PMID: 17195325.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    70. The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes. Semin Nephrol. 2006 Nov; 26(6):447-53. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC. PMID: 17275582.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    71. Relationship and interaction between sodium and potassium. J Am Coll Nutr. 2006 Jun; 25(3 Suppl):262S-270S. Morris RC, Schmidlin O, Frassetto LA, Sebastian A. PMID: 16772638.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    72. A practical approach to the balance between acid production and renal acid excretion in humans. J Nephrol. 2006 Mar-Apr; 19 Suppl 9:S33-40. Frassetto LA, Morris RC, Sebastian A. PMID: 16736439.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    73. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. PMID: 16628600.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    74. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006 Jan; 109(1-2):1-11. Sun H, Frassetto L, Benet LZ. PMID: 16085315.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    75. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Nephrology (Carlton). 2005 Aug; 10(4):393-9. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. PMID: 16109088.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    76. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 16003227.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    77. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab. 2005 Feb; 90(2):831-4. Frassetto L, Morris RC, Sebastian A. PMID: 15572425.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    78. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov; 32(11):1239-46. Sun H, Huang Y, Frassetto L, Benet LZ. PMID: 15286055.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    79. Pharmacogenomics and transplantation: where are we? Am J Transplant. 2004 Jun; 4(6):843. Frassetto LA, Benet LZ. PMID: 15147415.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    80. Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation. 2003 Jul 27; 76(2):370-5. Stock PG, Roland ME, Carlson L, Freise CE, Roberts JP, Hirose R, Terrault NA, Frassetto LA, Palefsky JM, Tomlanovich SJ, Ascher NL. PMID: 12883195.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCTClinical Trials
    81. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. PMID: 15618725.
      View in: PubMed   Mentions: 6     Fields:    
    82. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr. 2002 Dec; 76(6):1308-16. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC. PMID: 12450898.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    83. Discrepancy in results between spine and hip scans of a woman with end stage renal disease. J Clin Densitom. 2002; 5(1):95-8. Sherman ME, Shepherd J, Frassetto L, Genant HK. PMID: 11940734.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    84. Solid organ transplantation in HIV-positive patients. Transplant Proc. 2001 Nov-Dec; 33(7-8):3646-8. Stock P, Roland M, Carlson L, Freise C, Hirose R, Terrault N, Frassetto L, Coates T, Roberts J, Ascher N. PMID: 11750549.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    85. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr. 2001 Oct; 40(5):200-13. Frassetto L, Morris RC, Sellmeyer DE, Todd K, Sebastian A. PMID: 11842945.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    86. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clin Pharmacol Ther. 2001 Jan; 69(1):24-31. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. PMID: 11180035.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    87. Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. J Gerontol A Biol Sci Med Sci. 2000 Oct; 55(10):M585-92. Frassetto LA, Todd KM, Morris RC, Sebastian A. PMID: 11034231.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    88. Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion. Kidney Int. 2000 Aug; 58(2):748-52. Frassetto LA, Nash E, Morris RC, Sebastian A. PMID: 10916098.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    89. Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications. Semin Nephrol. 1999 Sep; 19(5):487-93. Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. PMID: 10511388.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    90. Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Am J Clin Nutr. 1998 Sep; 68(3):576-83. Frassetto LA, Todd KM, Morris RC, Sebastian A. PMID: 9734733.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    91. Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. J Clin Endocrinol Metab. 1997 Jan; 82(1):254-9. Frassetto L, Morris RC, Sebastian A. PMID: 8989270.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    92. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am J Physiol. 1996 Dec; 271(6 Pt 2):F1114-22. Frassetto LA, Morris RC, Sebastian A. PMID: 8997384.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    93. Age and systemic acid-base equilibrium: analysis of published data. J Gerontol A Biol Sci Med Sci. 1996 Jan; 51(1):B91-9. Frassetto L, Sebastian A. PMID: 8548506.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    94. Erythropoietin in pregnancies complicated by severe anemia of renal failure. Obstet Gynecol. 1992 Sep; 80(3 Pt 2):485-8. Yankowitz J, Piraino B, Laifer SA, Frassetto L, Gavin L, Kitzmiller JL, Crombleholme W. PMID: 1495715.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    95. Increasing incidence of human immunodeficiency virus-associated nephropathy at San Francisco General Hospital. Am J Kidney Dis. 1991 Dec; 18(6):655-9. Frassetto L, Schoenfeld PY, Humphreys MH. PMID: 1962649.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
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