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Lynda Frassetto, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-476-6143
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoFellowship1992School of Medicine
    SUNY DownstateInternal Medicine1987Medicine

    Collapse Overview 
    Collapse Overview
    Lynda Frassetto, MD, is a Professor Emeritus of Medicine in the Division of Nephrology at the University of California, San Francisco (USCF). She grew up in the greater New York metropolitan area and attended college and medical school in Connecticut.

    She trained as a nephrologist at UCSF and was in private practice in San Francisco before returning to UCSF to start her research career with Drs. Anthony Sebastian and R. Curtis Morris Jr. Over approximately 20 years, the group published papers on regulation of acid base balance in healthy and aging people and dietary influences on acid-base balance in healthy people and those with diabetes.

    Dr. Frassetto also collaborates with Dr. Leslie Z Benet, past chair of the Department of Biopharmaceutical Sciences at UCSF. Dr. Benet has pioneered a novel model predicting drug interactions in vivo, depending on the degree of in vitro membrane transporter and intracellular metabolizing enzyme interactions with a specific drug, xenobiotic or toxin. These predictions are then tested in clinical trials in healthy people and those with kidney disease, diabetes or HIV before and after transplantation.

    In addition to research, Dr. Frassetto was the director of the adult Clinical Research Center at the Parnassus Campus in UCSF’s Clinical and Translational Science Institute, and still supervises inpatient and outpatient care at three of the University’s hospital campuses. For the last several years, she has also been participating in and teaching programs that teach UC students and faculty better communication and behavioral stress modification techniques.

    Collapse Research 
    Collapse Research Activities and Funding
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

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    Collapse Clinical Trials
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Frassetto LA, Sebastian A. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. Med Hypotheses. 2019 Mar; 124:95-97. PMID: 30798927.
      View in: PubMed
    2. Frassetto LA, Sebastian A. . .Med Hypotheses. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. 2019; 124:95-97.
    3. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 Jan 16. PMID: 30652304.
      View in: PubMed
    4. Sebastian A, Cordain L, Frassetto L, Banerjee T, Morris RC. Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in daily selection of foods in respect of their potassium and sodium content resulting in oxidative stress-induced dysfunction of the vascular endothelium, vascular smooth muscle, and perivascular tissues. Med Hypotheses. 2018 Oct; 119:110-119. PMID: 30122481.
      View in: PubMed
    5. Frassetto L. Another strategy to help counter the effects of low gravity? Am J Clin Nutr. 2018 May 01; 107(5):681-682. PMID: 29722853.
      View in: PubMed
    6. Frassetto L, Banerjee T, Powe N, Sebastian A. Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject. Nutrients. 2018 Apr 21; 10(4). PMID: 29690515.
      View in: PubMed
    7. Hietavala EM, Ihalainen JK, Frassetto LA, Schumann M, Eklund D, Pitkänen H, Häkkinen K, Mero AA. Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling. Nutrients. 2018 Mar 08; 10(3). PMID: 29517990.
      View in: PubMed
    8. Hietavala EM, Stout JR, Frassetto LA, Puurtinen R, Pitkänen H, Selänne H, Suominen H, Mero AA. Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex. Appl Physiol Nutr Metab. 2017 Dec; 42(12):1330-1340. PMID: 28825967.
      View in: PubMed
    9. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757. PMID: 28385543.
      View in: PubMed
    10. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy. Ann Nucl Med. 2017 May; 31(4):295-303. PMID: 28260185.
      View in: PubMed
    11. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628. PMID: 28028768.
      View in: PubMed
    12. Parmenter BH, Slater GJ, Frassetto LA. Spot-testing urine pH, a novel dietary biomarker? A randomised cross-over trial. Nutr Diet. 2017 Jul; 74(3):313-319. PMID: 28731600.
      View in: PubMed
    13. Parmenter BH, Slater GJ, Frassetto LA. Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database. Nutr Diet. 2017 Jul; 74(3):308-312. PMID: 28731602.
      View in: PubMed
    14. Frassetto LA, Gibson S. Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient. Case Rep Nephrol. 2016; 2016:9106935. PMID: 27200198; PMCID: PMC4856909.
    15. Sebastian A, Frassetto LA. A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton's base reservoir with net base-producing diets. Med Hypotheses. 2016 Jun; 91:103-108. PMID: 27142156.
      View in: PubMed
    16. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J. 2015 Feb; 29(2):589-96. PMID: 25342129; PMCID: PMC4314222.
    17. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. PMID: 25274610; PMCID: PMC4389759.
    18. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan; 31(1):1-13. PMID: 25287761.
      View in: PubMed
    19. Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR. Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens. J Bone Miner Res. 2014 Jun; 29(6):1337-45. PMID: 24293094; PMCID: PMC4029859.
    20. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. PMID: 24389906; PMCID: PMC4018220.
    21. Fontes-Villalba M, Jönsson T, Granfeldt Y, Frassetto LA, Sundquist J, Sundquist K, Carrera-Bastos P, Fika-Hernándo M, Picazo Ó, Lindeberg S. A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study--Alimentation and Diabetes in Lanzarote--ADILAN. Trials. 2014 Jan 02; 15:2. PMID: 24383431; PMCID: PMC3884016.
    22. Delgado C, Frassetto L. Hip fractures in hemodialysis patients. Am J Kidney Dis. 2013 Oct; 62(4):653-5. PMID: 24054940.
      View in: PubMed
    23. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. PMID: 24030928; PMCID: PMC4018225.
    24. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 04; 10(11):4032-7. PMID: 23980906; PMCID: PMC3946491.
    25. Frassetto LA, Sebastian A. Commentary to accompany the paper entitled 'nutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney', by Jean-Philippe Bonjour. Br J Nutr. 2013 Dec 14; 110(11):1935-7. PMID: 23769203.
      View in: PubMed
    26. Lanham-New SA, Lambert H, Frassetto L. Potassium. Adv Nutr. 2012 Nov 01; 3(6):820-1. PMID: 23153736; PMCID: PMC3648706.
    27. Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen K. Effects of modality change on health-related quality of life. Hemodial Int. 2012 Jul; 16(3):377-86. PMID: 22413899; PMCID: PMC3376656.
    28. Shi L, Libuda L, Schönau E, Frassetto L, Remer T. Long term higher urinary calcium excretion within the normal physiologic range predicts impaired bone status of the proximal radius in healthy children with higher potential renal acid load. Bone. 2012 May; 50(5):1026-31. PMID: 22342797.
      View in: PubMed
    29. Frassetto L, Kohlstadt I. Treatment and prevention of kidney stones: an update. Am Fam Physician. 2011 Dec 01; 84(11):1234-42. PMID: 22150656.
      View in: PubMed
    30. Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metab Dispos. 2011 Nov; 39(11):2017-9. PMID: 21849516; PMCID: PMC3198899.
    31. Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation. 2010 Dec 27; 90(12):1595-601. PMID: 20978464; PMCID: PMC4296579.
    32. Pushkin R, Frassetto L, Tsourounis C, Segal ES, Kim S. Improving the reporting of adverse drug reactions in the hospital setting. Postgrad Med. 2010 Nov; 122(6):154-64. PMID: 21084792.
      View in: PubMed
    33. Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen KL. Effects of modality change and transplant on peak oxygen uptake in patients with kidney failure. Am J Kidney Dis. 2011 Jan; 57(1):113-22. PMID: 20870330; PMCID: PMC3010466.
    34. Gordon PL, Frassetto LA. Management of osteoporosis in CKD Stages 3 to 5. Am J Kidney Dis. 2010 May; 55(5):941-56. PMID: 20438987.
      View in: PubMed
    35. Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG. Clinical islet transplantation at the University of California, San Francisco. Clin Transpl. 2010; 235-43. PMID: 21698834.
      View in: PubMed
    36. Pizzorno J, Frassetto LA, Katzinger J. Diet-induced acidosis: is it real and clinically relevant? Br J Nutr. 2010 Apr; 103(8):1185-94. PMID: 20003625.
      View in: PubMed
    37. Tuot D, Gibson S, Caughey AB, Frassetto LA. Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: case report and review of the literature. Int Urol Nephrol. 2010 Mar; 42(1):233-7. PMID: 19911296; PMCID: PMC2844957.
    38. Tan-Tam CC, Frassetto LA, Stock PG. Liver and kidney transplantation in HIV-infected patients. AIDS Rev. 2009 Oct-Dec; 11(4):190-204. PMID: 19940946.
      View in: PubMed
    39. Frassetto LA, Tan-Tam C, Stock PG. Renal transplantation in patients with HIV. Nat Rev Nephrol. 2009 Oct; 5(10):582-9. PMID: 19776780; PMCID: PMC2925992.
    40. Frassetto LA, Hsu CY. Metabolic acidosis and progression of chronic kidney disease. J Am Soc Nephrol. 2009 Sep; 20(9):1869-70. PMID: 19696222.
      View in: PubMed
    41. Berkemeyer S, Vormann J, Günther AL, Rylander R, Frassetto LA, Remer T. Renal net acid excretion capacity is comparable in prepubescence, adolescence, and young adulthood but falls with aging. J Am Geriatr Soc. 2008 Aug; 56(8):1442-8. PMID: 18808599.
      View in: PubMed
    42. Gannon RH, Millward DJ, Brown JE, Macdonald HM, Lovell DP, Frassetto LA, Remer T, Lanham-New SA. Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over. Br J Nutr. 2008 Sep; 100(3):615-23. PMID: 18394215.
      View in: PubMed
    43. Frassetto LA, Morris RC, Sellmeyer DE, Sebastian A. Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets. J Nutr. 2008 Feb; 138(2):419S-422S. PMID: 18203914.
      View in: PubMed
    44. Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, Tylavsky FA. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. J Nutr. 2007 Jun; 137(6):1491-2. PMID: 17513412.
      View in: PubMed
    45. Frassetto LA, Morris RC, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F521-5. PMID: 17522265.
      View in: PubMed
    46. Nicandro JP, Tsourounis C, Frassetto L, Guglielmo BJ. In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4. J Herb Pharmacother. 2007; 7(1):39-56. PMID: 17594986.
      View in: PubMed
    47. Roland ME, Carlson LL, Frassetto LA, Stock PG. Solid organ transplantation: referral, management, and outcomes in HIV-infected patients. AIDS Read. 2006 Dec; 16(12):664-8, 675-8. PMID: 17195325.
      View in: PubMed
    48. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC. The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes. Semin Nephrol. 2006 Nov; 26(6):447-53. PMID: 17275582.
      View in: PubMed
    49. Morris RC, Schmidlin O, Frassetto LA, Sebastian A. Relationship and interaction between sodium and potassium. J Am Coll Nutr. 2006 Jun; 25(3 Suppl):262S-270S. PMID: 16772638.
      View in: PubMed
    50. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. PMID: 16628600.
      View in: PubMed
    51. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006 Jan; 109(1-2):1-11. PMID: 16085315.
      View in: PubMed
    52. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Nephrology (Carlton). 2005 Aug; 10(4):393-9. PMID: 16109088.
      View in: PubMed
    53. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. PMID: 16003227.
      View in: PubMed
    54. Frassetto L, Morris RC, Sebastian A. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab. 2005 Feb; 90(2):831-4. PMID: 15572425.
      View in: PubMed
    55. Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov; 32(11):1239-46. PMID: 15286055.
      View in: PubMed
    56. Frassetto LA, Benet LZ. Pharmacogenomics and transplantation: where are we? Am J Transplant. 2004 Jun; 4(6):843. PMID: 15147415.
      View in: PubMed
    57. Stock PG, Roland ME, Carlson L, Freise CE, Roberts JP, Hirose R, Terrault NA, Frassetto LA, Palefsky JM, Tomlanovich SJ, Ascher NL. Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation. 2003 Jul 27; 76(2):370-5. PMID: 12883195.
      View in: PubMed
    58. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. PMID: 15618725.
      View in: PubMed
    59. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr. 2002 Dec; 76(6):1308-16. PMID: 12450898.
      View in: PubMed
    60. Sherman ME, Shepherd J, Frassetto L, Genant HK. Discrepancy in results between spine and hip scans of a woman with end stage renal disease. J Clin Densitom. 2002; 5(1):95-8. PMID: 11940734.
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