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Linda Chao, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentRadiology
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-221-4810
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    Collapse Biography 
    Collapse Awards and Honors
    National Institute of Mental Health1999Fellows Award for Research Excellence
    National Institute of Mental Health1994Pre-Doctoral Fellowship
    University of California, Davis1994Graduate Research Award

    Collapse Overview 
    Collapse overview
    Linda Chao, PhD, is an Associate Adjunct Professor in the Department of Radiology and Biomedical Imaging and in the Department of Psychiatry at the University of California, San Francisco. Dr. Chao obtained her BS in Biological Science from the University of California, Davis in 1991, and she completed her PhD studies in Neuroscience from UCD in 1996. For the past 11-years, she has served as leader for the Psychiatry Block of the Interdepartmental Studies course 104, Brain, Mind and Behavior for first-year medical students.

    Dr. Chao’s professional activities primarily consist of conducting basic research using neuropsychological and imaging techniques to characterize how normal aging, neurodegenerative processes, stress, and exposure to neurotoxins affect the brain and cognition. She has an ongoing project, funded by the Department of Veterans Affairs, that seeks to use cognitive tests, structural, and diffusion tensor imaging to examine the effects of low-level exposure to sarin on brain structure and brain function in Gulf War Veterans. Dr. Chao has another project that is funded by the US Army Military Operational Medicine Research Program. The purpose of this project is to investigate the links between post-traumatic stress disorder (PTSD) and dementia.

    Dr. Chao serves as an Academic Editor for PlosOne and she has previously served as a reviewer for 26 scientific journals. Dr. Chao has 25 published articles and she has written 58 abstracts, 44 peer-reviewed articles, and 5 significant publications resulting from her research.

    Expertise:
    Neuroscience

    Specialty:
    Brain, neurodegenerative process, neuropsychological and imaging techniques

    Professional Interests:
    Cognitive neuroscience, memory, attention, aging, neurodegenerative disorders, post-traumatic stress disorder, magnetic resonance imaging, spectroscopic imaging, functional magnetic resonance imaging

    Education and Training:
    • Bachelor of Science: University of California, Davis - Biological Science
    • Doctor of Philosophy: University of California, Davis - Neuroscience


    Collapse Research 
    Collapse Research Activities and Funding
    Pilot Test of Telephone-Delivered Cognitive Behavioral Therapy for Insomnia for Veterans with Gulf War Illness
    VA I21CX001428Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Pilot Test of Telephone-Delivered Cognitive Behavioral Therapy for Insomnia for Veterans with Gulf War Illness
    VA I21CX001428Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Pilot Test of Telephone-Delivered Cognitive Behavioral Therapy for Insomnia for Veterans with Gulf War Illness
    VA I21CX001428Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Longitudinal assessment of Gulf War veterans with suspected Sarin exposure
    VA I01CX000798Oct 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    CORTICAL AND LIMBIC CONTRIBUTIONS TO AUDITORY MEMORY
    NIH/NIMH F31MH010958Mar 23, 1995
    Role: Principal Investigator
    CORTICAL AND LIMBIC CONTRIBUTIONS TO AUDITORY MEMORY
    NIH/NIMH F31MH010958Mar 23, 1995
    Role: Principal Investigator
    CORTICAL AND LIMBIC CONTRIBUTIONS TO AUDITORY MEMORY
    NIH/NIMH F31MH010958Mar 23, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chao LL. Associations Between the Self-Reported Frequency of Hearing Chemical Alarms in Theater and Visuospatial Function in Gulf War Veterans. J Occup Environ Med. 2016 Oct; 58(10):1014-1020. PMID: 27513172.
      View in: PubMed
    2. Chao LL, Abadjian LR, Esparza IL, Reeb R. Insomnia Severity, Subjective Sleep Quality, and Risk for Obstructive Sleep Apnea in Veterans With Gulf War Illness. Mil Med. 2016 Sep; 181(9):1127-34. PMID: 27612364.
      View in: PubMed
    3. Chao LL, Reeb R, Esparza IL, Abadjian LR. Associations between the self-reported frequency of hearing chemical alarms in theater and regional brain volume in Gulf War Veterans. Neurotoxicology. 2016 Mar; 53:246-56. PMID: 26920621.
      View in: PubMed
    4. Chao LL, Tosun D, Woodward SH, Kaufer D, Neylan TC. Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. Front Behav Neurosci. 2015; 9:333. PMID: 26696852.
      View in: PubMed
    5. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Stud Health Technol Inform. 2015; 216:736-40. PMID: 26262149.
      View in: PubMed
    6. Frazier DT, Seider T, Bettcher BM, Mack WJ, Jastrzab L, Chao L, Weiner MW, DeCarli C, Reed BR, Mungas D, Chui HC, Kramer JH. The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort. Cerebrovasc Dis. 2014; 38(6):441-7. PMID: 25502351; PMCID: PMC4303029 [Available on 12/11/15].
    7. O'Donovan A, Chao LL, Paulson J, Samuelson KW, Shigenaga JK, Grunfeld C, Weiner MW, Neylan TC. Altered inflammatory activity associated with reduced hippocampal volume and more severe posttraumatic stress symptoms in Gulf War veterans. Psychoneuroendocrinology. 2015 Jan; 51:557-66. PMID: 25465168; PMCID: PMC4374733 [Available on 01/01/16].
    8. Chao LL, Kriger S, Buckley S, Ng P, Mueller SG. Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans. Neurotoxicology. 2014 Sep; 44:263-9. PMID: 25058901.
      View in: PubMed
    9. Mohlenhoff BS, Chao LL, Buckley ST, Weiner MW, Neylan TC. Are hippocampal size differences in posttraumatic stress disorder mediated by sleep pathology? Alzheimers Dement. 2014 Jun; 10(3 Suppl):S146-54. PMID: 24924666; PMCID: PMC4111235.
    10. Chao LL, Yaffe K, Samuelson K, Neylan TC. Hippocampal volume is inversely related to PTSD duration. Psychiatry Res. 2014 Jun 30; 222(3):119-23. PMID: 24742925.
      View in: PubMed
    11. Chao LL, Mohlenhoff BS, Weiner MW, Neylan TC. Associations between subjective sleep quality and brain volume in Gulf War veterans. Sleep. 2014 Mar; 37(3):445-52. PMID: 24587566; PMCID: PMC3920309.
    12. Chao L, Weiner M, Neylan T. Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Res. 2013 Sep 30; 213(3):193-201. PMID: 23816189.
      View in: PubMed
    13. Chao LL, Decarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack WJ, Chui HC, Weiner MW. Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One. 2013; 8(6):e65175. PMID: 23762308; PMCID: PMC3675157.
    14. Zhang Y, Schuff N, Camacho M, Chao LL, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW. MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS One. 2013; 8(6):e66367. PMID: 23762488; PMCID: PMC3675142.
    15. Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43. PMID: 23421601; PMCID: PMC3951683.
    16. Cardenas VA, Reed B, Chao LL, Chui H, Sanossian N, DeCarli CC, Mack W, Kramer J, Hodis HN, Yan M, Buonocore MH, Carmichael O, Jagust WJ, Weiner MW. Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults. Stroke. 2012 Nov; 43(11):2865-70. PMID: 22984010; PMCID: PMC3732460.
    17. Chao LL, Lenoci M, Neylan TC. Effects of post-traumatic stress disorder on occipital lobe function and structure. Neuroreport. 2012 May 9; 23(7):412-9. PMID: 22453299.
      View in: PubMed
    18. Chao LL, Abadjian L, Hlavin J, Meyerhoff DJ, Weiner MW. Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T. Neurotoxicology. 2011 Dec; 32(6):814-22. PMID: 21741405.
      View in: PubMed
    19. Mueller SG, Chao LL, Berman B, Weiner MW. Evidence for functional specialization of hippocampal subfields detected by MR subfield volumetry on high resolution images at 4 T. Neuroimage. 2011 Jun 1; 56(3):851-7. PMID: 21419225; PMCID: PMC3085574.
    20. Chao LL, Rothlind JC, Cardenas VA, Meyerhoff DJ, Weiner MW. Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans. Neurotoxicology. 2010 Sep; 31(5):493-501. PMID: 20580739; PMCID: PMC2934883.
    21. Chao LL, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):19-27. PMID: 20220321; PMCID: PMC2865220.
    22. Cardenas VA, Meyerhoff DJ, Studholme C, Kornak J, Rothlind J, Lampiris H, Neuhaus J, Grant RM, Chao LL, Truran D, Weiner MW. Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. J Neurovirol. 2009 Jul; 15(4):324-33. PMID: 19499454; PMCID: PMC2889153.
    23. Chao LL, Pa J, Duarte A, Schuff N, Weiner MW, Kramer JH, Miller BL, Freeman KM, Johnson JK. Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):245-52. PMID: 19812467; PMCID: PMC2760039.
    24. Cardenas VA, Chao LL, Studholme C, Yaffe K, Miller BL, Madison C, Buckley ST, Mungas D, Schuff N, Weiner MW. Brain atrophy associated with baseline and longitudinal measures of cognition. Neurobiol Aging. 2011 Apr; 32(4):572-80. PMID: 19446370; PMCID: PMC2891686.
    25. Pa J, Boxer A, Chao LL, Gazzaley A, Freeman K, Kramer J, Miller BL, Weiner MW, Neuhaus J, Johnson JK. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Ann Neurol. 2009 Apr; 65(4):414-23. PMID: 19399879; PMCID: PMC2680500.
    26. Chao LL, Mueller SG, Buckley ST, Peek K, Raptentsetseng S, Elman J, Yaffe K, Miller BL, Kramer JH, Madison C, Mungas D, Schuff N, Weiner MW. Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria. Neurobiol Aging. 2010 Mar; 31(3):368-77. PMID: 18550226; PMCID: PMC2814904.
    27. Chao LL, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW. Patterns of white matter atrophy in frontotemporal lobar degeneration. Arch Neurol. 2007 Nov; 64(11):1619-24. PMID: 17998444; PMCID: PMC2443735.
    28. Cardenas VA, Boxer AL, Chao LL, Gorno-Tempini ML, Miller BL, Weiner MW, Studholme C. Deformation-based morphometry reveals brain atrophy in frontotemporal dementia. Arch Neurol. 2007 Jun; 64(6):873-7. PMID: 17562936; PMCID: PMC2733361.
    29. Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv Exp Med Biol. 2006; 576:241-62; discussion 361-3. PMID: 16802717; PMCID: PMC1779762.
    30. Cardenas VA, Chao LL, Blumenfeld R, Song E, Meyerhoff DJ, Weiner MW, Studholme C. Using automated morphometry to detect associations between ERP latency and structural brain MRI in normal adults. Hum Brain Mapp. 2005 Jul; 25(3):317-27. PMID: 15834860; PMCID: PMC2443725.
    31. Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40. PMID: 15961190; PMCID: PMC1779763.
    32. Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9. PMID: 15653183.
      View in: PubMed
    33. Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, Wolkowitz OM, Jagust WJ, Chui HC, Miller BL, Yaffe K, Weiner MW. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients. Neurology. 2005 Jan 25; 64(2):282-9. PMID: 15668426; PMCID: PMC1851679.
    34. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. PMID: 15592130; PMCID: PMC1820853.
    35. Chao LL, Lindgren JA, Flenniken DL, Weiner MW. ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy. Clin Neurophysiol. 2004 Jul; 115(7):1583-91. PMID: 15203059; PMCID: PMC2367143.
    36. Meyerhoff DJ, Blumenfeld R, Truran D, Lindgren J, Flenniken D, Cardenas V, Chao LL, Rothlind J, Studholme C, Weiner MW. Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites. Alcohol Clin Exp Res. 2004 Apr; 28(4):650-61. PMID: 15100618; PMCID: PMC2365749.
    37. Chao LL, Cardenas VA, Meyerhoff DJ, Rothlind JC, Flenniken DL, Lindgren JA, Weiner MW. Abnormal contingent negative variation in HIV patients receiving antiretroviral therapy. Neuroreport. 2003 Nov 14; 14(16):2111-5. PMID: 14600507; PMCID: PMC2733942.
    38. Chao LL, Meyerhoff DJ, Cardenas VA, Rothlind JC, Weiner MW. Abnormal CNV in chronic heavy drinkers. Clin Neurophysiol. 2003 Nov; 114(11):2081-95. PMID: 14580606.
      View in: PubMed
    39. Chao LL, Weisberg J, Martin A. Experience-dependent modulation of category-related cortical activity. Cereb Cortex. 2002 May; 12(5):545-51. PMID: 11950772.
      View in: PubMed
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