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    Scott Baraban, PhD

    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address533 Parnassus Ave, UC Hall
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Awards and Honors
      March of Dimes Foundation1999 - 2000Basil O’Connor Starter Scholar Award
      Esther A. & Joseph Klingenstein Fund2003 - 2004Fellowship Award in the Neurosciences
      UCSF2008William K. Bowes Jr. Endowed Chair in Neuroscience Research
      NINDS2015 - 2022Javits Neuroscience Investigator Award (R37)

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Dinday MT, Baraban SC. Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome(1,2,3). eNeuro. 2015 Jul-Aug; 2(4).
        View in: PubMed
      2. Grone BP, Baraban SC. Animal models in epilepsy research: legacies and new directions. Nat Neurosci. 2015 Mar; 18(3):339-43.
        View in: PubMed
      3. Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, Hunt RF, Lindtner S, Erdman CA, Pieper AA, Hamilton SP, Xu D, Baraban SC, Rubenstein JL. NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons. Neuron. 2014 Dec 3; 84(5):940-53.
        View in: PubMed PMC4258152
      4. Toyo-oka K, Wachi T, Hunt RF, Baraban SC, Taya S, Ramshaw H, Kaibuchi K, Schwarz QP, Lopez AF, Wynshaw-Boris A. 14-3-3e and ? regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014 Sep 3; 34(36):12168-81.
        View in: PubMed PMC4152612
      5. Sebe JY, Looke-Stewart E, Baraban SC. GABAB receptors in maintenance of neocortical circuit function. Exp Neurol. 2014 Nov; 261:163-70.
        View in: PubMed
      6. Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein JL. Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014 Apr 16; 82(2):350-64.
        View in: PubMed
      7. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 5; 81(3):574-87.
        View in: PubMed PMC3979971
      8. Baraban SC, Löscher W. What new modeling approaches will help us identify promising drug treatments? Adv Exp Med Biol. 2014; 813:283-94.
        View in: PubMed
      9. Howard MA, Rubenstein JL, Baraban SC. Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1):492-7.
        View in: PubMed PMC3890856
      10. Sebe JY, Looke-Stewart E, Dinday MT, Alvarez-Buylla A, Baraban SC. Neocortical integration of transplanted GABA progenitor cells from wild type and GABA(B) receptor knockout mouse donors. Neurosci Lett. 2014 Feb 21; 561:52-7.
        View in: PubMed
      11. Hunt RF, Girskis KM, Rubenstein JL, Alvarez-Buylla A, Baraban SC. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat Neurosci. 2013 Jun; 16(6):692-7.
        View in: PubMed PMC3665733
      12. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956.
        View in: PubMed PMC3641041
      13. Baraban SC. Forebrain electrophysiological recording in larval zebrafish. J Vis Exp. 2013; (71).
        View in: PubMed
      14. Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013; 4:2410.
        View in: PubMed PMC3891590
      15. Hunt RF, Baraban SC. The devil is in the details: stem cells for the treatment of epilepsy. Epilepsy Curr. 2012 Nov; 12(6):213-5.
        View in: PubMed PMC3577122
      16. Sebe JY, Bershteyn M, Hirotsune S, Wynshaw-Boris A, Baraban SC. ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. J Neurophysiol. 2013 Jan; 109(2):429-36.
        View in: PubMed PMC3545457
      17. Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A. Intrinsically determined cell death of developing cortical interneurons. Nature. 2012 Nov 1; 491(7422):109-13.
        View in: PubMed PMC3726009
      18. Hunt RF, Dinday MT, Hindle-Katel W, Baraban SC. LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus. J Neurosci. 2012 Sep 12; 32(37):12862-75.
        View in: PubMed PMC3752080
      19. Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, Choi M, Lee HY, Kirk A, Nelson-Williams C, Gibson G, Baraban SC, Lifton RP, Geschwind DH, Fu YH, Ptácek LJ. Familial cortical myoclonus with a mutation in NOL3. Ann Neurol. 2012 Aug; 72(2):175-83.
        View in: PubMed PMC3431191
      20. Hunt RF, Hortopan GA, Gillespie A, Baraban SC. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Exp Neurol. 2012 Sep; 237(1):199-206.
        View in: PubMed PMC3418450
      21. Chege SW, Hortopan GA, T Dinday M, Baraban SC. Expression and function of KCNQ channels in larval zebrafish. Dev Neurobiol. 2012 Feb; 72(2):186-98.
        View in: PubMed
      22. Ramirez IB, Pietka G, Jones DR, Divecha N, Alia A, Baraban SC, Hurlstone AF, Lowe M. Impaired neural development in a zebrafish model for Lowe syndrome. Hum Mol Genet. 2012 Apr 15; 21(8):1744-59.
        View in: PubMed PMC3313792
      23. Hortopan GA, Baraban SC. Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish. Dev Dyn. 2011 Aug; 240(8):1964-76.
        View in: PubMed PMC3137702
      24. Jones DL, Howard MA, Stanco A, Rubenstein JL, Baraban SC. Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. J Neurophysiol. 2011 May; 105(5):1984-91.
        View in: PubMed PMC3094166
      25. Sebe JY, Baraban SC. The promise of an interneuron-based cell therapy for epilepsy. Dev Neurobiol. 2011 Jan 1; 71(1):107-17.
        View in: PubMed PMC3059084
      26. Hortopan GA, Dinday MT, Baraban SC. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J Neurosci. 2010 Oct 13; 30(41):13718-28.
        View in: PubMed PMC2962868
      27. Sebe JY, Looke-Stewart EC, Estrada RC, Baraban SC. Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cells. Eur J Neurosci. 2010 Oct; 32(8):1310-8.
        View in: PubMed PMC2956765
      28. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14; 30(15):5334-45.
        View in: PubMed PMC2919857
      29. Hortopan GA, Dinday MT, Baraban SC. Zebrafish as a model for studying genetic aspects of epilepsy. Dis Model Mech. 2010 Mar-Apr; 3(3-4):144-8.
        View in: PubMed
      30. Greenwood JS, Wang Y, Estrada RC, Ackerman L, Ohara PT, Baraban SC. Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice. Ann Neurol. 2009 Nov; 66(5):644-53.
        View in: PubMed
      31. Battaglia G, Becker AJ, LoTurco J, Represa A, Baraban SC, Roper SN, Vezzani A. Basic mechanisms of MCD in animal models. Epileptic Disord. 2009 Sep; 11(3):206-14.
        View in: PubMed
      32. Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, García-Verdugo JM, Rubenstein JL, Alvarez-Buylla A. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A. 2009 Sep 8; 106(36):15472-7.
        View in: PubMed PMC2741275
      33. Jones DL, Baraban SC. Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice. J Neurophysiol. 2009 Aug; 102(2):648-58.
        View in: PubMed PMC2724351
      34. Richardson RM, Barbaro NM, Alvarez-Buylla A, Baraban SC. Developing cell transplantation for temporal lobe epilepsy. Neurosurg Focus. 2008; 24(3-4):E17.
        View in: PubMed
      35. Wang Y, Baraban SC. Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice. Hippocampus. 2008; 18(8):758-65.
        View in: PubMed
      36. Jones DL, Baraban SC. Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice. J Neurophysiol. 2007 Nov; 98(5):2737-46.
        View in: PubMed
      37. Baraban SC, Dinday MT, Castro PA, Chege S, Guyenet S, Taylor MR. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia. 2007 Jun; 48(6):1151-7.
        View in: PubMed PMC2211740
      38. Baraban SC. Emerging epilepsy models: insights from mice, flies, worms and fish. Curr Opin Neurol. 2007 Apr; 20(2):164-8.
        View in: PubMed
      39. Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann Neurol. 2007 Feb; 61(2):139-52.
        View in: PubMed
      40. Harrington EP, Möddel G, Najm IM, Baraban SC. Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero. Epilepsia. 2007 Jan; 48(1):158-68.
        View in: PubMed
      41. Wang Y, Baraban SC. Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse. Dev Neurosci. 2007; 29(1-2):91-8.
        View in: PubMed PMC2128724
      42. Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ. Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci. 2006 Sep 13; 26(37):9404-12.
        View in: PubMed PMC2133346
      43. Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban SC. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci. 2006 Jul 12; 26(28):7380-9.
        View in: PubMed PMC1550786
      44. Wang Y, Barbaro MF, Baraban SC. A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett. 2006 Jun 19; 401(1-2):35-9.
        View in: PubMed
      45. Paredes M, Pleasure SJ, Baraban SC. Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia. J Comp Neurol. 2006 Mar 1; 495(1):133-48.
        View in: PubMed PMC2827607
      46. Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC. Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J Neurosci. 2005 Oct 19; 25(42):9649-57.
        View in: PubMed
      47. Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68.
        View in: PubMed
      48. Calcagnotto ME, Baraban SC. Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats. J Neurophysiol. 2005 Jul; 94(1):153-62.
        View in: PubMed
      49. Baraban SC, Taylor MR, Castro PA, Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience. 2005; 131(3):759-68.
        View in: PubMed
      50. Takahashi DK, Dinday MT, Barbaro NM, Baraban SC. Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex. Epilepsia. 2004 Dec; 45(12):1525-30.
        View in: PubMed
      51. Baraban SC. Neuropeptide Y and epilepsy: recent progress, prospects and controversies. Neuropeptides. 2004 Aug; 38(4):261-5.
        View in: PubMed
      52. Cooper EC, Baraban SC. Pain without gain (of function): sodium channel dysfunction in epilepsy. Epilepsy Curr. 2004 Jul-Aug; 4(4):158-9.
        View in: PubMed PMC1176357
      53. Baraban SC, Tallent MK. Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability. Trends Neurosci. 2004 Mar; 27(3):135-42.
        View in: PubMed
      54. Barbaro NM, Takahashi DK, Baraban SC. A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro. Neuroscience. 2004; 128(3):655-63.
        View in: PubMed
      55. Sun QQ, Baraban SC, Prince DA, Huguenard JR. Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci. 2003 Oct 22; 23(29):9639-49.
        View in: PubMed
      56. Paredes MF, Greenwood J, Baraban SC. Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus. Neurosci Lett. 2003 Apr 3; 340(1):9-12.
        View in: PubMed
      57. Calcagnotto ME, Baraban SC. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar; 44(3):315-21.
        View in: PubMed
      58. Pentney AR, Baraban SC, Colmers WF. NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy. J Neurophysiol. 2002 Nov; 88(5):2745-54.
        View in: PubMed
      59. Calcagnotto ME, Paredes MF, Baraban SC. Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy. J Neurosci. 2002 Sep 1; 22(17):7596-605.
        View in: PubMed
      60. Paredes MF, Baraban SC. A review of gene expression patterns in the malformed brain. Mol Neurobiol. 2002 Aug; 26(1):109-16.
        View in: PubMed
      61. Smyth MD, Barbaro NM, Baraban SC. Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia. Epilepsy Res. 2002 Aug; 50(3):251-64.
        View in: PubMed
      62. Baraban SC. Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors. Epilepsia. 2002; 43 Suppl 5:9-13.
        View in: PubMed
      63. Guo H, Castro PA, Palmiter RD, Baraban SC. Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus. J Neurophysiol. 2002 Jan; 87(1):558-66.
        View in: PubMed
      64. Castro PA, Pleasure SJ, Baraban SC. Hippocampal heterotopia with molecular and electrophysiological properties of neocortical neurons. Neuroscience. 2002; 114(4):961-72.
        View in: PubMed
      65. Bikson M, Baraban SC, Durand DM. Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices. J Neurophysiol. 2002 Jan; 87(1):62-71.
        View in: PubMed
      66. Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci. 2001 Sep 1; 21(17):6626-34.
        View in: PubMed
      67. Aoki T, Baraban SC. Properties of a calcium-activated K(+) current on interneurons in the developing rat hippocampus. J Neurophysiol. 2000 Jun; 83(6):3453-61.
        View in: PubMed
      68. Baraban SC, Wenzel HJ, Hochman DW, Schwartzkroin PA. Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero. Epilepsy Res. 2000 Apr; 39(2):87-102.
        View in: PubMed
      69. Baraban SC, Wenzel HJ, Castro PA, Schwartzkroin PA. Hippocampal dysplasia in rats exposed to cocaine in utero. Brain Res Dev Brain Res. 1999 Nov 18; 117(2):213-7.
        View in: PubMed
      70. Marsh DJ, Baraban SC, Hollopeter G, Palmiter RD. Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23):13518-23.
        View in: PubMed PMC23980
      71. Bikson M, Ghai RS, Baraban SC, Durand DM. Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. J Neurophysiol. 1999 Nov; 82(5):2262-70.
        View in: PubMed
      72. Chevassus-au-Louis N, Baraban SC, Gaïarsa JL, Ben-Ari Y. Cortical malformations and epilepsy: new insights from animal models. Epilepsia. 1999 Jul; 40(7):811-21.
        View in: PubMed
      73. Schwartzkroin PA, Baraban SC, Hochman DW. Osmolarity, ionic flux, and changes in brain excitability. Epilepsy Res. 1998 Sep; 32(1-2):275-85.
        View in: PubMed
      74. Baraban SC, Schwartzkroin PA. Effects of hyposmolar solutions on membrane currents of hippocampal interneurons and mossy cells in vitro. J Neurophysiol. 1998 Feb; 79(2):1108-12.
        View in: PubMed
      75. Baraban SC. Neuropeptide Y and limbic seizures. Rev Neurosci. 1998; 9(2):117-28.
        View in: PubMed
      76. Palmiter RD, Erickson JC, Hollopeter G, Baraban SC, Schwartz MW. Life without neuropeptide Y. Recent Prog Horm Res. 1998; 53:163-99.
        View in: PubMed
      77. Baraban SC, Hollopeter G, Erickson JC, Schwartzkroin PA, Palmiter RD. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci. 1997 Dec 1; 17(23):8927-36.
        View in: PubMed
      78. Baraban SC, McCarthy EB, Schwartzkroin PA. Evidence for increased seizure susceptibility in rats exposed to cocaine in utero. Brain Res Dev Brain Res. 1997 Sep 20; 102(2):189-96.
        View in: PubMed
      79. Baraban SC, Bellingham MC, Berger AJ, Schwartzkroin PA. Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons. J Physiol. 1997 Feb 1; 498 ( Pt 3):679-89.
        View in: PubMed PMC1159184
      80. Baraban SC, Schwartzkroin PA. Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology. J Neurophysiol. 1997 Jan; 77(1):126-36.
        View in: PubMed
      81. Baraban SC, Schwartzkroin PA. Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment. Epilepsy Res. 1996 Apr; 23(3):189-94.
        View in: PubMed
      82. Guyenet PG, Koshiya N, Huangfu D, Baraban SC, Stornetta RL, Li YW. Role of medulla oblongata in generation of sympathetic and vagal outflows. Prog Brain Res. 1996; 107:127-44.
        View in: PubMed
      83. Hochman DW, Baraban SC, Owens JW, Schwartzkroin PA. Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science. 1995 Oct 6; 270(5233):99-102.
        View in: PubMed
      84. Baraban SC, Schwartzkroin PA. Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. Epilepsy Res. 1995 Oct; 22(2):145-56.
        View in: PubMed
      85. Baraban SC, Lothman EW, Lee A, Guyenet PG. Kappa opioid receptor-mediated suppression of voltage-activated potassium current in a catecholaminergic neuronal cell line. J Pharmacol Exp Ther. 1995 May; 273(2):927-33.
        View in: PubMed
      86. Baraban SC, Stornetta RL, Guyenet PG. Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla. Brain Res. 1995 Apr 10; 676(2):245-57.
        View in: PubMed
      87. Baraban SC, Lothman EW. Voltage-activated potassium currents in acutely dissociated hippocampal dentate gyrus neurons from neonatal rats. Brain Res Dev Brain Res. 1994 Sep 16; 81(2):309-13.
        View in: PubMed
      88. Baraban SC, Stornetta RL, Guyenet PG. Respiratory control of sympathetic nerve activity during naloxone-precipitated morphine withdrawal in rats. J Pharmacol Exp Ther. 1993 Apr; 265(1):89-95.
        View in: PubMed
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