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    Scott Baraban, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address533 Parnassus Ave, UC Hall
    San Francisco CA 94143
    Phone415-476-9473

       Biography 
       Awards and Honors
      Esther A. & Joseph Klingenstein Fund2003 - 2004Fellowship Award in the Neurosciences
      March of Dimes Foundation1999 - 2000Basil O’Connor Starter Scholar Award
      UCSF2008William K. Bowes Jr. Endowed Chair in Neuroscience Research

       ORNG Applications 
       Websites
       Featured Videos
       In The News
       Awarded Grants
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein JL. Lhx6 Directly Regulates Arx and CXCR7 to Determine Cortical Interneuron Fate and Laminar Position. Neuron. 2014 Apr 16; 82(2):350-64.
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      2. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 5; 81(3):574-87.
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      3. Baraban SC, Löscher W. What new modeling approaches will help us identify promising drug treatments? Adv Exp Med Biol. 2014; 813:283-94.
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      4. Howard MA, Rubenstein JL, Baraban SC. Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1):492-7.
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      5. Sebe JY, Looke-Stewart E, Dinday MT, Alvarez-Buylla A, Baraban SC. Neocortical integration of transplanted GABA progenitor cells from wild type and GABAB receptor knockout mouse donors. Neurosci Lett. 2014 Feb 21; 561:52-7.
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      6. Hunt RF, Girskis KM, Rubenstein JL, Alvarez-Buylla A, Baraban SC. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat Neurosci. 2013 Jun; 16(6):692-7.
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      7. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956.
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      8. Baraban SC. Forebrain electrophysiological recording in larval zebrafish. J Vis Exp. 2013; (71).
        View in: PubMed
      9. Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013; 4:2410.
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      10. Hunt RF, Baraban SC. The devil is in the details: stem cells for the treatment of epilepsy. Epilepsy Curr. 2012 Nov; 12(6):213-5.
        View in: PubMed
      11. Sebe JY, Bershteyn M, Hirotsune S, Wynshaw-Boris A, Baraban SC. ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. J Neurophysiol. 2013 Jan; 109(2):429-36.
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      12. Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A. Intrinsically determined cell death of developing cortical interneurons. Nature. 2012 Nov 1; 491(7422):109-13.
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      13. Hunt RF, Dinday MT, Hindle-Katel W, Baraban SC. LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus. J Neurosci. 2012 Sep 12; 32(37):12862-75.
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      14. Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, Choi M, Lee HY, Kirk A, Nelson-Williams C, Gibson G, Baraban SC, Lifton RP, Geschwind DH, Fu YH, Ptácek LJ. Familial cortical myoclonus with a mutation in NOL3. Ann Neurol. 2012 Aug; 72(2):175-83.
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      15. Hunt RF, Hortopan GA, Gillespie A, Baraban SC. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Exp Neurol. 2012 Sep; 237(1):199-206.
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      16. Chege SW, Hortopan GA, T Dinday M, Baraban SC. Expression and function of KCNQ channels in larval zebrafish. Dev Neurobiol. 2012 Feb; 72(2):186-98.
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      17. Ramirez IB, Pietka G, Jones DR, Divecha N, Alia A, Baraban SC, Hurlstone AF, Lowe M. Impaired neural development in a zebrafish model for Lowe syndrome. Hum Mol Genet. 2012 Apr 15; 21(8):1744-59.
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      18. Hortopan GA, Baraban SC. Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish. Dev Dyn. 2011 Aug; 240(8):1964-76.
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      19. Jones DL, Howard MA, Stanco A, Rubenstein JL, Baraban SC. Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. J Neurophysiol. 2011 May; 105(5):1984-91.
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      20. Sebe JY, Baraban SC. The promise of an interneuron-based cell therapy for epilepsy. Dev Neurobiol. 2011 Jan 1; 71(1):107-17.
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      21. Hortopan GA, Dinday MT, Baraban SC. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J Neurosci. 2010 Oct 13; 30(41):13718-28.
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      22. Sebe JY, Looke-Stewart EC, Estrada RC, Baraban SC. Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cells. Eur J Neurosci. 2010 Oct; 32(8):1310-8.
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      23. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14; 30(15):5334-45.
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      24. Hortopan GA, Dinday MT, Baraban SC. Zebrafish as a model for studying genetic aspects of epilepsy. Dis Model Mech. 2010 Mar-Apr; 3(3-4):144-8.
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      25. Greenwood JS, Wang Y, Estrada RC, Ackerman L, Ohara PT, Baraban SC. Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice. Ann Neurol. 2009 Nov; 66(5):644-53.
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      26. Battaglia G, Becker AJ, LoTurco J, Represa A, Baraban SC, Roper SN, Vezzani A. Basic mechanisms of MCD in animal models. Epileptic Disord. 2009 Sep; 11(3):206-14.
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      27. Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, García-Verdugo JM, Rubenstein JL, Alvarez-Buylla A. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A. 2009 Sep 8; 106(36):15472-7.
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      28. Jones DL, Baraban SC. Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice. J Neurophysiol. 2009 Aug; 102(2):648-58.
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      29. Wang Y, Baraban SC. Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice. Hippocampus. 2008; 18(8):758-65.
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      30. Richardson RM, Barbaro NM, Alvarez-Buylla A, Baraban SC. Developing cell transplantation for temporal lobe epilepsy. Neurosurg Focus. 2008; 24(3-4):E17.
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      31. Jones DL, Baraban SC. Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice. J Neurophysiol. 2007 Nov; 98(5):2737-46.
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      32. Baraban SC, Dinday MT, Castro PA, Chege S, Guyenet S, Taylor MR. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia. 2007 Jun; 48(6):1151-7.
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      33. Baraban SC. Emerging epilepsy models: insights from mice, flies, worms and fish. Curr Opin Neurol. 2007 Apr; 20(2):164-8.
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      34. Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann Neurol. 2007 Feb; 61(2):139-52.
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      35. Wang Y, Baraban SC. Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse. Dev Neurosci. 2007; 29(1-2):91-8.
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      36. Harrington EP, Möddel G, Najm IM, Baraban SC. Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero. Epilepsia. 2007 Jan; 48(1):158-68.
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      37. Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ. Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci. 2006 Sep 13; 26(37):9404-12.
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      38. Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban SC. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci. 2006 Jul 12; 26(28):7380-9.
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      39. Wang Y, Barbaro MF, Baraban SC. A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett. 2006 Jun 19; 401(1-2):35-9.
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      40. Paredes M, Pleasure SJ, Baraban SC. Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia. J Comp Neurol. 2006 Mar 1; 495(1):133-48.
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      41. Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC. Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J Neurosci. 2005 Oct 19; 25(42):9649-57.
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      42. Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68.
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      43. Calcagnotto ME, Baraban SC. Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats. J Neurophysiol. 2005 Jul; 94(1):153-62.
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      44. Baraban SC, Taylor MR, Castro PA, Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience. 2005; 131(3):759-68.
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      45. Takahashi DK, Dinday MT, Barbaro NM, Baraban SC. Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex. Epilepsia. 2004 Dec; 45(12):1525-30.
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      46. Baraban SC. Neuropeptide Y and epilepsy: recent progress, prospects and controversies. Neuropeptides. 2004 Aug; 38(4):261-5.
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      47. Cooper EC, Baraban SC. Pain without gain (of function): sodium channel dysfunction in epilepsy. Epilepsy Curr. 2004 Jul-Aug; 4(4):158-9.
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      48. Baraban SC, Tallent MK. Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability. Trends Neurosci. 2004 Mar; 27(3):135-42.
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      49. Barbaro NM, Takahashi DK, Baraban SC. A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro. Neuroscience. 2004; 128(3):655-63.
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      50. Sun QQ, Baraban SC, Prince DA, Huguenard JR. Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci. 2003 Oct 22; 23(29):9639-49.
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      51. Paredes MF, Greenwood J, Baraban SC. Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus. Neurosci Lett. 2003 Apr 3; 340(1):9-12.
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      52. Calcagnotto ME, Baraban SC. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar; 44(3):315-21.
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      53. Pentney AR, Baraban SC, Colmers WF. NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy. J Neurophysiol. 2002 Nov; 88(5):2745-54.
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      54. Calcagnotto ME, Paredes MF, Baraban SC. Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy. J Neurosci. 2002 Sep 1; 22(17):7596-605.
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      55. Paredes MF, Baraban SC. A review of gene expression patterns in the malformed brain. Mol Neurobiol. 2002 Aug; 26(1):109-16.
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      56. Smyth MD, Barbaro NM, Baraban SC. Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia. Epilepsy Res. 2002 Aug; 50(3):251-64.
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      57. Castro PA, Pleasure SJ, Baraban SC. Hippocampal heterotopia with molecular and electrophysiological properties of neocortical neurons. Neuroscience. 2002; 114(4):961-72.
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      58. Guo H, Castro PA, Palmiter RD, Baraban SC. Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus. J Neurophysiol. 2002 Jan; 87(1):558-66.
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      59. Baraban SC. Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors. Epilepsia. 2002; 43 Suppl 5:9-13.
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      60. Bikson M, Baraban SC, Durand DM. Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices. J Neurophysiol. 2002 Jan; 87(1):62-71.
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      61. Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci. 2001 Sep 1; 21(17):6626-34.
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      62. Aoki T, Baraban SC. Properties of a calcium-activated K(+) current on interneurons in the developing rat hippocampus. J Neurophysiol. 2000 Jun; 83(6):3453-61.
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      63. Baraban SC, Wenzel HJ, Hochman DW, Schwartzkroin PA. Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero. Epilepsy Res. 2000 Apr; 39(2):87-102.
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      64. Baraban SC, Wenzel HJ, Castro PA, Schwartzkroin PA. Hippocampal dysplasia in rats exposed to cocaine in utero. Brain Res Dev Brain Res. 1999 Nov 18; 117(2):213-7.
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      65. Marsh DJ, Baraban SC, Hollopeter G, Palmiter RD. Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23):13518-23.
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      66. Bikson M, Ghai RS, Baraban SC, Durand DM. Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. J Neurophysiol. 1999 Nov; 82(5):2262-70.
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      67. Chevassus-au-Louis N, Baraban SC, Gaïarsa JL, Ben-Ari Y. Cortical malformations and epilepsy: new insights from animal models. Epilepsia. 1999 Jul; 40(7):811-21.
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      68. Schwartzkroin PA, Baraban SC, Hochman DW. Osmolarity, ionic flux, and changes in brain excitability. Epilepsy Res. 1998 Sep; 32(1-2):275-85.
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      69. Baraban SC, Schwartzkroin PA. Effects of hyposmolar solutions on membrane currents of hippocampal interneurons and mossy cells in vitro. J Neurophysiol. 1998 Feb; 79(2):1108-12.
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      70. Baraban SC. Neuropeptide Y and limbic seizures. Rev Neurosci. 1998; 9(2):117-28.
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      71. Palmiter RD, Erickson JC, Hollopeter G, Baraban SC, Schwartz MW. Life without neuropeptide Y. Recent Prog Horm Res. 1998; 53:163-99.
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      72. Baraban SC, Hollopeter G, Erickson JC, Schwartzkroin PA, Palmiter RD. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci. 1997 Dec 1; 17(23):8927-36.
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      73. Baraban SC, McCarthy EB, Schwartzkroin PA. Evidence for increased seizure susceptibility in rats exposed to cocaine in utero. Brain Res Dev Brain Res. 1997 Sep 20; 102(2):189-96.
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      74. Baraban SC, Bellingham MC, Berger AJ, Schwartzkroin PA. Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons. J Physiol. 1997 Feb 1; 498 ( Pt 3):679-89.
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      75. Baraban SC, Schwartzkroin PA. Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology. J Neurophysiol. 1997 Jan; 77(1):126-36.
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      76. Baraban SC, Schwartzkroin PA. Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment. Epilepsy Res. 1996 Apr; 23(3):189-94.
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      77. Guyenet PG, Koshiya N, Huangfu D, Baraban SC, Stornetta RL, Li YW. Role of medulla oblongata in generation of sympathetic and vagal outflows. Prog Brain Res. 1996; 107:127-44.
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      78. Hochman DW, Baraban SC, Owens JW, Schwartzkroin PA. Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science. 1995 Oct 6; 270(5233):99-102.
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      79. Baraban SC, Schwartzkroin PA. Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. Epilepsy Res. 1995 Oct; 22(2):145-56.
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      80. Baraban SC, Lothman EW, Lee A, Guyenet PG. Kappa opioid receptor-mediated suppression of voltage-activated potassium current in a catecholaminergic neuronal cell line. J Pharmacol Exp Ther. 1995 May; 273(2):927-33.
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      81. Baraban SC, Stornetta RL, Guyenet PG. Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla. Brain Res. 1995 Apr 10; 676(2):245-57.
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      82. Baraban SC, Lothman EW. Voltage-activated potassium currents in acutely dissociated hippocampal dentate gyrus neurons from neonatal rats. Brain Res Dev Brain Res. 1994 Sep 16; 81(2):309-13.
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      83. Baraban SC, Stornetta RL, Guyenet PG. Respiratory control of sympathetic nerve activity during naloxone-precipitated morphine withdrawal in rats. J Pharmacol Exp Ther. 1993 Apr; 265(1):89-95.
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