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    Yvonne Ou, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address10 Koret Way
    San Francisco CA 94143
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      Harvard CollegeB.A.Biochemical Sciences
      Harvard Medical SchoolM.D.
      Brigham & Women's HospitalInternshipInternal Medicine
      Jules Stein Eye Institute/UCLAResidencyOphthalmology
      Duke UniversityClinical and Research FellowshipGlaucoma

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      Our laboratory studies the cellular and synaptic mechanisms of glaucomatous neurodegeneration. We are particularly interested in understanding the earliest steps of inner retina circuit disassembly in response to injury. Our research program combines imaging and analysis of specific cell and synaptic labels in the retina, rodent models of experimental glaucoma, novel genetic tools in which specific cell types are labeled, and the tools of molecular/cell biology and physiology to address a series of questions that, unanswered, have prevented progress in the field: 1) What are the early steps of compartmentalized neurodegeneration of the ganglion cell in glaucoma? 2) Are there specific ganglion cell types that are more susceptible to intraocular pressure (IOP) elevation? 3) Are there specific inner retinal circuits that are more susceptible to IOP elevation? As a clinician-scientist, I am motivated to advance our field not only by answering these fundamental questions, but also by translating the knowledge gained into improvements in diagnostic and treatment modalities in glaucoma. For example, a detailed understanding of the earliest structural and functional changes that occur in glaucoma will allow us to design treatments that can rescue RGCs, perhaps the most susceptible RGCs, before irreversible cell death occurs. Our long-term goal is to understand the mechanisms underlying ganglion cell degeneration and circuit remodeling in glaucoma in order to improve diagnosis and treatment.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L. Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension. J Neurosci. 2016 Aug 31; 36(35):9240-52. PMID: 27581463.
        View in: PubMed
      2. Della Santina L, Ou Y, et al. Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp Eye Res. 2016 Jun 16. PMID: 27319294.
        View in: PubMed
      3. Schallhorn JM, Schallhorn SC, Ou Y. Factors that influence intraocular pressure changes after myopic and hyperopic LASIK and photorefractive keratectomy: a large population study. Ophthalmology. 2015 Mar; 122(3):471-9. PMID: 25444636.
        View in: PubMed
      4. Lin CC, Chen A, Jeng BH, Porco TC, Ou Y, Han Y. Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation. Invest Ophthalmol Vis Sci. 2014 Apr; 55(4):2244-50. PMID: 24557348.
        View in: PubMed
      5. Law SK, Tamboli DA, Ou Y, Giaconi JA, Caprioli J. Development of a resident training module for systematic optic disc evaluation in glaucoma. J Glaucoma. 2012 Dec; 21(9):601-7. PMID: 21602706.
        View in: PubMed
      6. Ou Y, Grossman DS, Lee PP, Sloan FA. Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis. Ophthalmic Epidemiol. 2012 Oct; 19(5):285-92. PMID: 22978529; PMCID: PMC3523354.
      7. Ou Y, Caprioli J. Surgical management of pediatric glaucoma. Dev Ophthalmol. 2012; 50:157-72. PMID: 22517182.
        View in: PubMed
      8. Ou Y, Goldberg I, Migdal C, Lee PP. A critical appraisal and comparison of the quality and recommendations of glaucoma clinical practice guidelines. Ophthalmology. 2011 Jun; 118(6):1017-23. PMID: 21507487.
        View in: PubMed
      9. Ou Y, Yu F, Law SK, Coleman AL, Caprioli J. Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma. Arch Ophthalmol. 2009 Nov; 127(11):1436-41. PMID: 19901208.
        View in: PubMed
      10. Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP. Transcriptional modification by a CASK-interacting nucleosome assembly protein. Neuron. 2004 Apr 8; 42(1):113-28. PMID: 15066269.
        View in: PubMed
      11. Wang TF, Ou Y, Guidotti G. The transmembrane domains of ectoapyrase (CD39) affect its enzymatic activity and quaternary structure. J Biol Chem. 1998 Sep 18; 273(38):24814-21. PMID: 9733785.
        View in: PubMed
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