Hunter Shain, PhD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
Address2340 Sutter Street, #N326
San Francisco CA 94115
ORCID ORCID Icon0000-0002-2999-9706 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Illinois, Champaign, ILB.S.05/2006Biochemistry
    Stanford University, Palo Alto, CAPh.D.04/2012Cancer Biology
    University of California San Francisco, San Francisco, CAPostdoctoral Fellow

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma. bioRxiv. 2024 Jul 24. Tandukar B, Deivendran D, Chen L, Cruz-Pacheco N, Sharma H, Xu A, Bandari AK, Chen DB, George C, Marty A, Cho RJ, Cheng J, Saylor D, Gerami P, Arron ST, Bastian BC, Shain AH. PMID: 39091884; PMCID: PMC11291049.
      View in: PubMed   Mentions:
    2. The genetic evolution of acral melanoma. Nat Commun. 2024 Jul 21; 15(1):6146. Wang M, Fukushima S, Sheen YS, Ramelyte E, Cruz-Pacheco N, Shi C, Liu S, Banik I, Aquino JD, Sangueza Acosta M, Levesque M, Dummer R, Liau JY, Chu CY, Shain AH, Yeh I, Bastian BC. PMID: 39034322; PMCID: PMC11271482.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Cutaneous squamous cell carcinoma progression: what does a meta-analysis of transcriptomic studies tell us? Br J Dermatol. 2024 Jul 17. Rentroia-Pacheco B, Shain AH. PMID: 39018446.
      View in: PubMed   Mentions:    Fields:    
    4. A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response. Sci Immunol. 2024 01 26; 9(91):eadi2848. Wu D, Hailer AA, Wang S, Yuan M, Chan J, El Kurdi A, Rahim M, Kondo A, Han D, Ali H, D'Angio B, Mayer A, Klufas D, Kim E, Shain AH, Choi J, Bhutani T, Simpson G, Grekin RC, Ricardo-Gonzalez R, Purdom E, North JP, Cheng JB, Cho RJ. PMID: 38277466.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma. Cell. 2024 01 04; 187(1):166-183.e25. Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel LF, Pulido-Vicuña CA, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, Damsky W, Chen L, Karagianni D, Cinque S, Kint S, Vandereyken K, Rombaut B, Voet T, Vernaillen F, Annaert W, Lambrechts D, Boecxstaens V, Saeys Y, van den Oord J, Bosisio F, Karras P, Shain AH, Bosenberg M, Leucci E, Paschen A, Rambow F, Bechter O, Marine JC. PMID: 38181739.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. STmut: a framework for visualizing somatic alterations in spatial transcriptomics data of cancer. Genome Biol. 2023 11 30; 24(1):273. Chen L, Chang D, Tandukar B, Deivendran D, Pozniak J, Cruz-Pacheco N, Cho RJ, Cheng J, Yeh I, Marine C, Bastian BC, Ji AL, Shain AH. PMID: 38037084; PMCID: PMC10688493.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. The genetic evolution of acral melanoma. bioRxiv. 2023 Oct 19. Wang M, Fukushima S, Sheen YS, Ramelyte E, Pacheco NC, Shi C, Liu S, Banik I, Aquino JD, Acosta MS, Levesque M, Dummer R, Liau JY, Chu CY, Shain AH, Yeh I, Bastian BC. PMID: 37904969; PMCID: PMC10614839.
      View in: PubMed   Mentions: 1  
    8. Melanoma Genomics: Shifting Focus from Inter- to Intrapatient Variation. Cancer Discov. 2023 06 02; 13(6):1294-1296. Shain AH. PMID: 37264823.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes. Genome Med. 2022 06 16; 14(1):65. Wang M, Banik I, Shain AH, Yeh I, Bastian BC. PMID: 35706047; PMCID: PMC9202124.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. Hepatocellular neoplasms with loss of liver fatty acid binding protein: Clinicopathologic features and molecular profiling. Hum Pathol. 2022 04; 122:60-71. Joseph NM, Blank A, Shain AH, Gill RM, Umetsu SE, Shafizadeh N, Torbenson MS, Kakar S. PMID: 35104461.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. BRAFV600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB. Elife. 2021 11 23; 10. McNeal AS, Belote RL, Zeng H, Urquijo M, Barker K, Torres R, Curtin M, Shain AH, Andtbacka RH, Holmen S, Lum DH, McCalmont TH, VanBrocklin MW, Grossman D, Wei ML, Lang UE, Judson-Torres RL. PMID: 34812139; PMCID: PMC8610417.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. The landscape of driver mutations in cutaneous squamous cell carcinoma. NPJ Genom Med. 2021 Jul 16; 6(1):61. Chang D, Shain AH. PMID: 34272401; PMCID: PMC8285521.
      View in: PubMed   Mentions: 35  
    13. Two Trajectories to Melanoma on the Hands and Feet. JAMA Dermatol. 2021 07 01; 157(7):769-770. Shain AH. PMID: 33978680.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma. Life Sci Alliance. 2021 09; 4(9). Bowman RL, Hennessey RC, Weiss TJ, Tallman DA, Crawford ER, Murphy BM, Webb A, Zhang S, La Perle KM, Burd CJ, Levine RL, Shain AH, Burd CE. PMID: 34210801; PMCID: PMC8321651.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    15. Publisher Correction: The genomic landscapes of individual melanocytes from human skin. Nature. 2021 Feb; 590(7844):E20. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. PMID: 33469220.
      View in: PubMed   Mentions:    Fields:    
    16. The genomic landscapes of individual melanocytes from human skin. Nature. 2020 10; 586(7830):600-605. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. PMID: 33029006; PMCID: PMC7581540.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    17. Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma. Nat Commun. 2020 07 22; 11(1):3675. Cao W, Lee H, Wu W, Zaman A, McCorkle S, Yan M, Chen J, Xing Q, Sinnott-Armstrong N, Xu H, Sailani MR, Tang W, Cui Y, Liu J, Guan H, Lv P, Sun X, Sun L, Han P, Lou Y, Chang J, Wang J, Gao Y, Guo J, Schenk G, Shain AH, Biddle FG, Collisson E, Snyder M, Bivona TG. PMID: 32699215; PMCID: PMC7376194.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    18. Author Correction: From melanocytes to melanomas. Nat Rev Cancer. 2020 Jun; 20(6):355. Shain AH, Bastian BC. PMID: 32382093.
      View in: PubMed   Mentions: 1     Fields:    
    19. Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7. Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC. PMID: 31618628; PMCID: PMC6939448.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    20. The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression. J Invest Dermatol. 2020 02; 140(2):291-297. Zeng H, Judson-Torres RL, Shain AH. PMID: 31623932; PMCID: PMC6983335.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Targeted Genomic Profiling of Acral Melanoma. J Natl Cancer Inst. 2019 10 01; 111(10):1068-1077. Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. PMID: 30657954; PMCID: PMC6792090.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    22. MicroRNA Ratios Distinguish Melanomas from Nevi. J Invest Dermatol. 2020 01; 140(1):164-173.e7. Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL. PMID: 31580842; PMCID: PMC6926155.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    23. The genetic evolution of metastatic uveal melanoma. Nat Genet. 2019 07; 51(7):1123-1130. Shain AH, Bagger MM, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC, Kiilgaard JF. PMID: 31253977; PMCID: PMC6632071.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    24. Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma. J Pathol. 2019 06; 248(2):164-178. Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G. PMID: 30690729.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    25. The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma. Pigment Cell Melanoma Res. 2019 03; 32(2):269-279. Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A. PMID: 30156010.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 07 09; 34(1):45-55.e4. Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC. PMID: 29990500; PMCID: PMC6319271.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    27. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 07 09; 34(1):56-68.e9. Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL. PMID: 29990501; PMCID: PMC6084788.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    28. Filling the gaps in the genomic catalogue of melanoma subtypes. Pigment Cell Melanoma Res. 2017 01; 30(6):508-509. Shain AH, Bastian BC. PMID: 28656717.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. PMID: 28935960; PMCID: PMC5608693.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    30. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science. 2017 09 29; 357(6358):1416-1420. Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D. PMID: 28818973; PMCID: PMC5942222.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    31. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 11; 240(3):282-290. Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. PMID: 27477320; PMCID: PMC5071153.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    32. From melanocytes to melanomas. Nat Rev Cancer. 2016 06; 16(6):345-58. Shain AH, Bastian BC. PMID: 27125352.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansCells
    33. CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing. PLoS Comput Biol. 2016 Apr; 12(4):e1004873. Talevich E, Shain AH, Botton T, Bastian BC. PMID: 27100738; PMCID: PMC4839673.
      View in: PubMed   Mentions: 823     Fields:    Translation:Humans
    34. The Genetic Evolution of Melanoma. N Engl J Med. 2016 03 10; 374(10):995-6. Shain AH, Bastian BC. PMID: 26962740.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    35. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12; 373(20):1926-36. Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. PMID: 26559571.
      View in: PubMed   Mentions: 365     Fields:    Translation:Humans
    36. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. PMID: 26343386; PMCID: PMC4589486.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    37. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015 May 27; 6:7174. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. PMID: 26013381; PMCID: PMC4446791.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    38. Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 2013 Sep 16; 14:624. Shain AH, Salari K, Giacomini CP, Pollack JR. PMID: 24041470; PMCID: PMC3848637.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    39. Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet. 2013 Apr; 9(4):e1003464. Giacomini CP, Sun S, Varma S, Shain AH, Giacomini MM, Balagtas J, Sweeney RT, Lai E, Del Vecchio CA, Forster AD, Clarke N, Montgomery KD, Zhu S, Wong AJ, van de Rijn M, West RB, Pollack JR. PMID: 23637631; PMCID: PMC3636093.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    40. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS One. 2013; 8(1):e55119. Shain AH, Pollack JR. PMID: 23355908; PMCID: PMC3552954.
      View in: PubMed   Mentions: 274     Fields:    Translation:Humans
    41. Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma. Cancer Res. 2012 May 15; 72(10):2657-71. Del Vecchio CA, Jensen KC, Nitta RT, Shain AH, Giacomini CP, Wong AJ. PMID: 22419663.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    42. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E252-9. Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR. PMID: 22233809; PMCID: PMC3277150.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    43. SMURF1 amplification promotes invasiveness in pancreatic cancer. PLoS One. 2011; 6(8):e23924. Kwei KA, Shain AH, Bair R, Montgomery K, Karikari CA, van de Rijn M, Hidalgo M, Maitra A, Bashyam MD, Pollack JR. PMID: 21887346; PMCID: PMC3161761.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    44. Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host. Clin Cancer Res. 2010 Jul 15; 16(14):3684-95. Tseng WW, Winer D, Kenkel JA, Choi O, Shain AH, Pollack JR, French R, Lowy AM, Engleman EG. PMID: 20534740; PMCID: PMC3085509.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
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