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Hunter Shain, PhD

Title(s)Assistant Professor, Dermatology
SchoolSchool of Medicine
Address2340 Sutter Street
San Francisco CA 94115
Phone--
ORCID ORCID Icon0000-0002-2999-9706 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Illinois, Champaign, ILB.S.05/2006Biochemistry
    Stanford University, Palo Alto, CAPh.D.04/2012Cancer Biology
    University of California San Francisco, San Francisco, CAPostdoctoral Fellow

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma. Nat Commun. 2020 Jul 22; 11(1):3675. Cao W, Lee H, Wu W, Zaman A, McCorkle S, Yan M, Chen J, Xing Q, Sinnott-Armstrong N, Xu H, Sailani MR, Tang W, Cui Y, Liu J, Guan H, Lv P, Sun X, Sun L, Han P, Lou Y, Chang J, Wang J, Gao Y, Guo J, Schenk G, Shain AH, Biddle FG, Collisson E, Snyder M, Bivona TG. PMID: 32699215.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Author Correction: From melanocytes to melanomas. Nat Rev Cancer. 2020 Jun; 20(6):355. Shain AH, Bastian BC. PMID: 32382093.
      View in: PubMed   Mentions:    Fields:    
    3. Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7. Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC. PMID: 31618628.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression. J Invest Dermatol. 2020 02; 140(2):291-297. Zeng H, Judson-Torres RL, Shain AH. PMID: 31623932.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Targeted Genomic Profiling of Acral Melanoma. J Natl Cancer Inst. 2019 10 01; 111(10):1068-1077. Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. PMID: 30657954.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. MicroRNA Ratios Distinguish Melanomas from Nevi. J Invest Dermatol. 2020 01; 140(1):164-173.e7. Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL. PMID: 31580842.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. The genetic evolution of metastatic uveal melanoma. Nat Genet. 2019 07; 51(7):1123-1130. Shain AH, Bagger MM, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC, Kiilgaard JF. PMID: 31253977.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma. J Pathol. 2019 06; 248(2):164-178. Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G. PMID: 30690729.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma. Pigment Cell Melanoma Res. 2019 03; 32(2):269-279. Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A. PMID: 30156010.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 07 09; 34(1):45-55.e4. Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC. PMID: 29990500.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 07 09; 34(1):56-68.e9. Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL. PMID: 29990501.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Filling the gaps in the genomic catalogue of melanoma subtypes. Pigment Cell Melanoma Res. 2017 01; 30(6):508-509. Shain AH, Bastian BC. PMID: 28656717.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. PMID: 28935960.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science. 2017 09 29; 357(6358):1416-1420. Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D. PMID: 28818973.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    15. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 11; 240(3):282-290. Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. PMID: 27477320.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. From melanocytes to melanomas. Nat Rev Cancer. 2016 06; 16(6):345-58. Shain AH, Bastian BC. PMID: 27125352.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    17. CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing. PLoS Comput Biol. 2016 Apr; 12(4):e1004873. Talevich E, Shain AH, Botton T, Bastian BC. PMID: 27100738.
      View in: PubMed   Mentions: 114     Fields:    Translation:Humans
    18. The Genetic Evolution of Melanoma. N Engl J Med. 2016 03 10; 374(10):995-6. Shain AH, Bastian BC. PMID: 26962740.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12; 373(20):1926-36. Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. PMID: 26559571.
      View in: PubMed   Mentions: 129     Fields:    Translation:Humans
    20. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. PMID: 26343386.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    21. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015 May 27; 6:7174. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. PMID: 26013381.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    22. Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 2013 Sep 16; 14:624. Shain AH, Salari K, Giacomini CP, Pollack JR. PMID: 24041470.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet. 2013 Apr; 9(4):e1003464. Giacomini CP, Sun S, Varma S, Shain AH, Giacomini MM, Balagtas J, Sweeney RT, Lai E, Del Vecchio CA, Forster AD, Clarke N, Montgomery KD, Zhu S, Wong AJ, van de Rijn M, West RB, Pollack JR. PMID: 23637631.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    24. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS One. 2013; 8(1):e55119. Shain AH, Pollack JR. PMID: 23355908.
      View in: PubMed   Mentions: 138     Fields:    Translation:Humans
    25. Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma. Cancer Res. 2012 May 15; 72(10):2657-71. Del Vecchio CA, Jensen KC, Nitta RT, Shain AH, Giacomini CP, Wong AJ. PMID: 22419663.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    26. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E252-9. Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR. PMID: 22233809.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    27. SMURF1 amplification promotes invasiveness in pancreatic cancer. PLoS One. 2011; 6(8):e23924. Kwei KA, Shain AH, Bair R, Montgomery K, Karikari CA, van de Rijn M, Hidalgo M, Maitra A, Bashyam MD, Pollack JR. PMID: 21887346.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host. Clin Cancer Res. 2010 Jul 15; 16(14):3684-95. Tseng WW, Winer D, Kenkel JA, Choi O, Shain AH, Pollack JR, French R, Lowy AM, Engleman EG. PMID: 20534740.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
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