Brian Feldman, MD, PhD
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Title(s) | Associate Professor, Pediatrics |
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School | School of Medicine |
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Address | 1550 Fourth St San Francisco CA 94158
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Phone | 415-514-0610 |
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vCard | Download vCard |
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Biography Stanford University, Stanford | MD, PhD | | Medicine | Harvard University, Boston | | | Pediatrics | UCSF, San Francisco | | | Pediatric Endocrinology |
University of California, San Francisco | 2018 | | Walter L. Miller Distinguished Professorship | The American Society for Clinical Investigation | 2017 | | Elected Member, ASCI | Endocrine Society | 2013 | | Early Investigator Award | Stanford University | 2012 | | Bechtel Endowed Faculty Scholar | NIH | 2010 | | NIH Director's New Innovator Award | Society for Pediatric Research | 2008 | | Young Investigator Award | Stanford University | 2016 | | Basic Science Research Award of Excellence |
Overview Brian Feldman, MD, PhD Walter L. Miller Distinguished Professor University of California, San Francisco Department of Pediatrics Division of Pediatric Endocrinology
A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.
Research ORNG Applications Bibliographic
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A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chem Biol. 2020 06 19; 15(6):1381-1391.
Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ. PMID: 32255605.
View in: PubMed Mentions: Fields:
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A novel platform for isotype-specific testing of autoantibodies. PLoS One. 2019; 14(2):e0211596.
Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ. PMID: 30730939.
View in: PubMed Mentions: Fields: Translation: Humans
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A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte. 2018; 7(4):273-276.
Jung Y, Feldman BJ. PMID: 30153756.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell Rep. 2017 Nov 28; 21(9):2367-2375.
Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ. PMID: 29186676.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nat Commun. 2017 09 22; 8(1):669.
Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ. PMID: 28939843.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte. 2017 Oct 02; 6(4):293-297.
Wong JC, Feldman BJ. PMID: 28700319.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. J Steroid Biochem Mol Biol. 2018 03; 177:155-158.
Aggarwal A, Feldman D, Feldman BJ. PMID: 28710021.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight. 2017 01 26; 2(2):e90427.
Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M. PMID: 28138562.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal. 2016 10 25; 9(451):ra103.
Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. PMID: 27811141.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology. 2016 Apr; 157(4):1341-7.
Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ. PMID: 26934299.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocr Relat Cancer. 2016 Apr; 23(4):251-64.
Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D. PMID: 26817629.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology. 2016 Jan; 157(1):91-7.
Ji L, Gupta M, Feldman BJ. PMID: 26488808.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient. Pediatrics. 2015 Nov; 136(5):e1377-81.
Banerjee RR, Marina N, Katznelson L, Feldman BJ. PMID: 26459648.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. . 2015 Aug; 14(8):1951-61.
Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M. PMID: 25934710.
View in: PubMed Mentions:
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BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell Metab. 2015 Apr 07; 21(4):596-608.
Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. PMID: 25863249.
View in: PubMed Mentions: 54 Fields: Translation: HumansAnimalsCells
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Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. J Lipid Res. 2015 May; 56(5):1068-78.
Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN. PMID: 25840986.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PLoS One. 2015; 10(2):e0118449.
Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. PMID: 25706805.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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The development of next-generation screening and diagnostic platforms will change diabetes care. Expert Rev Mol Diagn. 2015 Mar; 15(3):291-4.
Kumar RB, Gupta M, Feldman BJ. PMID: 25583407.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. Stem Cell Reports. 2014 Dec 09; 3(6):1147-58.
Krueger KC, Costa MJ, Du H, Feldman BJ. PMID: 25458893.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
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A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nat Med. 2014 Aug; 20(8):948-53.
Zhang B, Kumar RB, Dai H, Feldman BJ. PMID: 25038825.
View in: PubMed Mentions: 35 Fields: Translation: Humans
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The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May; 14(5):342-57.
Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. PMID: 24705652.
View in: PubMed Mentions: 306 Fields: Translation: HumansCells
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Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor. Mol Endocrinol. 2013 Oct; 27(10):1632-42.
Malloy PJ, Feldman BJ. PMID: 23906633.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Horm Mol Biol Clin Investig. 2013 Aug; 14(1):15-24.
Krueger KC, Feldman BJ. PMID: 25436716.
View in: PubMed Mentions: 1 Fields:
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Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). PLoS One. 2013; 8(6):e65885.
Armstrong SP, Seeber RM, Ayoub MA, Feldman BJ, Pfleger KD. PMID: 23762448.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and ß-Arrestins. Front Endocrinol (Lausanne). 2010; 1:12.
Kocan M, Dalrymple MB, Seeber RM, Feldman BJ, Pfleger KD. PMID: 22654789.
View in: PubMed Mentions:
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Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70.
Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. PMID: 21228270.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7.
So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. PMID: 19805059.
View in: PubMed Mentions: 106 Fields: Translation: AnimalsCells
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Glucocorticoids influence on mesenchymal stem cells and implications for metabolic disease. Pediatr Res. 2009 Feb; 65(2):249-51.
Feldman BJ. PMID: 19262295.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis. Mol Endocrinol. 2009 Apr; 23(4):559-71.
Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KD. PMID: 19179480.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9.
So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. PMID: 18408151.
View in: PubMed Mentions: 48 Fields: Translation: AnimalsCells
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Is your metabolism determined by (cell) fate? Pediatr Res. 2007 Jun; 61(6):636-9.
Feldman BJ. PMID: 17426662.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Report of a hürthle cell neoplasm in a peripubertal girl. Thyroid. 2007 Feb; 17(2):175-8.
Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal SM. PMID: 17316121.
View in: PubMed Mentions: Fields: Translation: Humans
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Cardiac troponin increases among runners in the Boston Marathon. Ann Emerg Med. 2007 Feb; 49(2):137-43, 143.e1.
Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS. PMID: 17145114.
View in: PubMed Mentions: 33 Fields: Translation: Humans
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Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:66-70.
Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE. PMID: 17261972.
View in: PubMed Mentions: Fields: Translation: Humans
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Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80.
Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. PMID: 17030820.
View in: PubMed Mentions: 71 Fields: Translation: AnimalsCells
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Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. Am J Med. 2006 Jul; 119(7 Suppl 1):S54-8.
Gitelman SE, Feldman BJ, Rosenthal SM. PMID: 16843086.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. J Pediatr. 2006 Jan; 148(1):128-31.
Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE. PMID: 16423613.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 05; 352(18):1884-90.
Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. PMID: 15872203.
View in: PubMed Mentions: 68 Fields: Translation: HumansCells
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Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid. Pediatr Cardiol. 2002 Jul-Aug; 23(4):469-71.
Feldman BJ, Rosenthal D. PMID: 12170369.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001 Oct; 1(1):34-45.
Feldman BJ, Feldman D. PMID: 11900250.
View in: PubMed Mentions: 725 Fields: Translation: Humans
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A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood. 2000 Sep 01; 96(5):1906-13.
Feldman BJ, Hampton T, Cleary ML. PMID: 10961893.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene. 1997 Nov 27; 15(22):2735-42.
Feldman BJ, Reid TR, Cleary ML. PMID: 9401000.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene. 1997 Oct 23; 15(17):2059-67.
LeBrun DP, Matthews BP, Feldman BJ, Cleary ML. PMID: 9366523.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Mol Cell Biol. 1994 Dec; 14(12):8071-7.
Fox ME, Feldman BJ, Chu G. PMID: 7969145.
View in: PubMed Mentions: 14 Fields: Translation: Animals
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Year | Publications |
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1994 | 1 | 1997 | 2 | 2000 | 1 | 2001 | 1 | 2002 | 1 | 2005 | 1 | 2006 | 5 | 2007 | 2 | 2008 | 1 | 2009 | 3 | 2011 | 2 | 2013 | 3 | 2014 | 3 | 2015 | 7 | 2016 | 3 | 2017 | 5 | 2018 | 1 | 2019 | 1 | 2020 | 1 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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