Brian Feldman, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-514-0610
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, StanfordMD, PhDMedicine
    Harvard University, BostonPediatrics
    UCSF, San FranciscoPediatric Endocrinology
    Collapse Awards and Honors
    University of California, San Francisco2018Walter L. Miller Distinguished Professorship
    The American Society for Clinical Investigation2017Elected Member, ASCI
    Endocrine Society2013Early Investigator Award
    Stanford University2012Bechtel Endowed Faculty Scholar
    NIH2010NIH Director's New Innovator Award
    Society for Pediatric Research2008Young Investigator Award
    Stanford University2016Basic Science Research Award of Excellence

    Collapse Overview 
    Collapse Overview
    Brian Feldman, MD, PhD
    Walter L. Miller Distinguished Professor
    University of California, San Francisco
    Department of Pediatrics
    Division of Pediatric Endocrinology



    A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.

    Collapse Research 
    Collapse Research Activities and Funding
    Integrated Systemic and Adipose Depot-Specific Regulation of Adipogenesis
    NIH R01DK114217Jul 15, 2017 - May 31, 2022
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH P30DK098722Aug 1, 2015 - Jul 31, 2025
    Role: Co-Investigator
    Using Components of the Circadian Clock to Regulate Stem Cell Fate Decisions
    NIH DP2OD006740Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    The Role of Glucocorticoids in Cell Fate Determination
    NIH K08DK073697Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Training Program in Pediatric Endocrinology
    NIH T32DK007161Jul 1, 1976 - Jun 30, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight. 2021 05 10; 6(9). Cheung SY, Sayeed M, Nakuluri K, Li L, Feldman BJ. PMID: 33986190; PMCID: PMC8262332.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chem Biol. 2020 06 19; 15(6):1381-1391. Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ. PMID: 32255605; PMCID: PMC8031368.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. A novel platform for isotype-specific testing of autoantibodies. PLoS One. 2019; 14(2):e0211596. Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ. PMID: 30730939; PMCID: PMC6366878.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte. 2018; 7(4):273-276. Jung Y, Feldman BJ. PMID: 30153756; PMCID: PMC6768266.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell Rep. 2017 Nov 28; 21(9):2367-2375. Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ. PMID: 29186676; PMCID: PMC5728416.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    6. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nat Commun. 2017 09 22; 8(1):669. Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ. PMID: 28939843; PMCID: PMC5610267.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    7. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte. 2017 Oct 02; 6(4):293-297. Wong JC, Feldman BJ. PMID: 28700319; PMCID: PMC5736246.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. J Steroid Biochem Mol Biol. 2018 03; 177:155-158. Aggarwal A, Feldman D, Feldman BJ. PMID: 28710021; PMCID: PMC5764828.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    9. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight. 2017 01 26; 2(2):e90427. Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M. PMID: 28138562; PMCID: PMC5256132.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    10. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal. 2016 10 25; 9(451):ra103. Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. PMID: 27811141; PMCID: PMC8087215.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    11. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology. 2016 Apr; 157(4):1341-7. Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ. PMID: 26934299; PMCID: PMC4816742.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocr Relat Cancer. 2016 Apr; 23(4):251-64. Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D. PMID: 26817629; PMCID: PMC4889430.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology. 2016 Jan; 157(1):91-7. Ji L, Gupta M, Feldman BJ. PMID: 26488808; PMCID: PMC4701879.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient. Pediatrics. 2015 Nov; 136(5):e1377-81. Banerjee RR, Marina N, Katznelson L, Feldman BJ. PMID: 26459648.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Mol Cancer Ther. 2015 Aug; 14(8):1951-61. Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M. PMID: 25934710; PMCID: PMC4549392.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    16. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell Metab. 2015 Apr 07; 21(4):596-608. Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. PMID: 25863249; PMCID: PMC4394191.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    17. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. J Lipid Res. 2015 May; 56(5):1068-78. Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN. PMID: 25840986; PMCID: PMC4409283.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PLoS One. 2015; 10(2):e0118449. Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. PMID: 25706805; PMCID: PMC4338276.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    19. The development of next-generation screening and diagnostic platforms will change diabetes care. Expert Rev Mol Diagn. 2015 Mar; 15(3):291-4. Kumar RB, Gupta M, Feldman BJ. PMID: 25583407; PMCID: PMC4627787.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. Stem Cell Reports. 2014 Dec 09; 3(6):1147-58. Krueger KC, Costa MJ, Du H, Feldman BJ. PMID: 25458893; PMCID: PMC4264060.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    21. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nat Med. 2014 Aug; 20(8):948-53. Zhang B, Kumar RB, Dai H, Feldman BJ. PMID: 25038825; PMCID: PMC4736508.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    22. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May; 14(5):342-57. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. PMID: 24705652.
      View in: PubMed   Mentions: 489     Fields:    Translation:HumansCells
    23. Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor. Mol Endocrinol. 2013 Oct; 27(10):1632-42. Malloy PJ, Feldman BJ. PMID: 23906633; PMCID: PMC3787131.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    24. Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Horm Mol Biol Clin Investig. 2013 Aug; 14(1):15-24. Krueger KC, Feldman BJ. PMID: 25436716.
      View in: PubMed   Mentions: 2     Fields:    
    25. Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). PLoS One. 2013; 8(6):e65885. Armstrong SP, Seeber RM, Ayoub MA, Feldman BJ, Pfleger KD. PMID: 23762448; PMCID: PMC3675069.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and �-Arrestins. Front Endocrinol (Lausanne). 2010; 1:12. Kocan M, Dalrymple MB, Seeber RM, Feldman BJ, Pfleger KD. PMID: 22654789; PMCID: PMC3356007.
      View in: PubMed   Mentions: 15     Fields:    
    27. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. PMID: 21228270; PMCID: PMC3058992.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    28. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7. So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. PMID: 19805059; PMCID: PMC2757402.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    29. Glucocorticoids influence on mesenchymal stem cells and implications for metabolic disease. Pediatr Res. 2009 Feb; 65(2):249-51. Feldman BJ. PMID: 19262295; PMCID: PMC2716735.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis. Mol Endocrinol. 2009 Apr; 23(4):559-71. Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KD. PMID: 19179480; PMCID: PMC2667710.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    31. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9. So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. PMID: 18408151; PMCID: PMC2311370.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    32. Is your metabolism determined by (cell) fate? Pediatr Res. 2007 Jun; 61(6):636-9. Feldman BJ. PMID: 17426662.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    33. Report of a hürthle cell neoplasm in a peripubertal girl. Thyroid. 2007 Feb; 17(2):175-8. Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal SM. PMID: 17316121.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Cardiac troponin increases among runners in the Boston Marathon. Ann Emerg Med. 2007 Feb; 49(2):137-43, 143.e1. Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS. PMID: 17145114.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    35. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:66-70. Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE. PMID: 17261972.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80. Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. PMID: 17030820; PMCID: PMC1592529.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    37. Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. Am J Med. 2006 Jul; 119(7 Suppl 1):S54-8. Gitelman SE, Feldman BJ, Rosenthal SM. PMID: 16843086.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    38. Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. J Pediatr. 2006 Jan; 148(1):128-31. Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE. PMID: 16423613.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    39. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 05; 352(18):1884-90. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. PMID: 15872203; PMCID: PMC5340184.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    40. Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid. Pediatr Cardiol. 2002 Jul-Aug; 23(4):469-71. Feldman BJ, Rosenthal D. PMID: 12170369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001 Oct; 1(1):34-45. Feldman BJ, Feldman D. PMID: 11900250.
      View in: PubMed   Mentions: 840     Fields:    Translation:Humans
    42. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood. 2000 Sep 01; 96(5):1906-13. Feldman BJ, Hampton T, Cleary ML. PMID: 10961893.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    43. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene. 1997 Nov 27; 15(22):2735-42. Feldman BJ, Reid TR, Cleary ML. PMID: 9401000.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    44. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene. 1997 Oct 23; 15(17):2059-67. LeBrun DP, Matthews BP, Feldman BJ, Cleary ML. PMID: 9366523.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Mol Cell Biol. 1994 Dec; 14(12):8071-7. Fox ME, Feldman BJ, Chu G. PMID: 7969145; PMCID: PMC359345.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
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