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Susan Noworolski, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentRadiology
Address185 Berry Street
San Francisco CA 94143
Phone415-353-9409
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1999 Graduate Division (Bioengineering)
    Collapse Awards and Honors
    Journal of Magnetic Resonance Imaging2011Distinguished Reviewer
    American Cancer Society2005Mentored Research Scholar
    UC Regents’1996  - 1997Fellowship
    College Scientists Foundation1995  - 1996Fellowship Achievement Award
    National Science Foundation1991  - 1994Fellowship

    Collapse Overview 
    Collapse Overview
    Susan Noworolski, PhD, is an Associate Adjunct Professor of Radiology in the Body Imaging Research Group and the Abdominal and Pelvic MRI Group at the University of California, San Francisco. Dr. Noworolski supervises the in vivo prostate-imaging group at The Center for Molecular and Functional Imaging, and implements protocols and writes software to improve imaging and processing. Dr. Noworolski completed her BSE in Biomedical Engineering and Electrical Engineering at The Johns Hopkins University in Baltimore, Maryland, and she received her PhD in Bioengineering from UCSF and UCB.

    Dr. Noworolski’s research focuses on developing magnetic resonance imaging techniques and processing methods to improve the robustness and interpretation of MR measures by reducing artifacts and on studying diseases, disorders and healthy processes in the abdomen and pelvis. In Dr. Noworolski’s prostate cancer research, she is concentrating on building tools to evaluate DCE MRI and other MR metrics obtained in men with prostate cancer to identify cancer and to help eliminate cancers with different levels of aggressiveness.

    Dr. Noworolski is the recipient of a five-year American Cancer Society grant and a recent five-year NIH 01 for DCE MRI research in prostate. She has 32 published articles, and she has written 97 abstracts and 5 significant publications related to her research.

    Expertise:
    Abdominal and Pelvic MRI

    Specialty:
    Prostate cancer, fatty liver disease, MR spectroscopy, brain cancer, head and neck cancer

    Professional Interests:
    Magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging, magnetic resonance spectroscopic imaging, artifact reduction, image processing, cancer, fatty liver disease, prostate cancer, dietary interventions, obesity

    Education and Training:
    • Bachelor of Science: Johns Hopkins University, Baltimore, Maryland - Biomedical Engineering and
    • Bachelor of Science: Johns Hopkins University, Baltimore, Maryland - Electrical Engineering
    • Doctor of Philosophy: University of California, San Francisco and Berkeley - Bioengineering


    Collapse Research 
    Collapse Research Activities and Funding
    DCE MRI to Improve Prostate Cancer Identification and Characterization
    NIH/NCI R01CA148708Apr 1, 2010 - Jan 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Starobinets O, Simko JP, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski S. Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard. NMR Biomed. 2017 Dec; 30(12). PMID: 28961382.
      View in: PubMed
    2. Price JC, Dodge JL, Ma Y, Scherzer R, Korn N, Tillinghast K, Peters MG, Noworolski S, Tien PC. Controlled attenuation parameter and magnetic resonance spectroscopy-measured liver steatosis are discordant in obese HIV-infected adults. AIDS. 2017 Sep 24; 31(15):2119-2125. PMID: 28723710.
      View in: PubMed
    3. Schwarz JM, Noworolski S, Erkin-Cakmak A, Korn NJ, Wen MJ, Tai VW, Jones GM, Palii SP, Velasco-Alin M, Pan K, Patterson BW, Gugliucci A, Lustig RH, Mulligan K. Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity. Gastroenterology. 2017 Sep; 153(3):743-752. PMID: 28579536.
      View in: PubMed
    4. Starobinets O, Kurhanewicz J, Noworolski S. Improved multiparametric MRI discrimination between low-risk prostate cancer and benign tissues in a small cohort of 5a-reductase inhibitor treated individuals as compared with an untreated cohort. NMR Biomed. 2017 May; 30(5). PMID: 28164396.
      View in: PubMed
    5. Price JC, Ma Y, Scherzer R, Korn N, Tillinghast K, Peters MG, Noworolski S, Tien PC. Human immunodeficiency virus-infected and uninfected adults with non-genotype 3 hepatitis C virus have less hepatic steatosis than adults with neither infection. Hepatology. 2017 Mar; 65(3):853-863. PMID: 27981599.
      View in: PubMed
    6. Kardashian A, Ma Y, Scherzer R, Price JC, Sarkar M, Korn N, Tillinghast K, Peters MG, Noworolski S, Tien PC. Sex differences in the association of HIV infection with hepatic steatosis. AIDS. 2017 Jan 28; 31(3):365-373. PMID: 27831949.
      View in: PubMed
    7. Choi JY, Yang J, Noworolski S, Behr S, Chang AJ, Simko JP, Nguyen HG, Carroll PR, Kurhanewicz J, Seo Y, et al. 18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons. Radiology. 2017 Feb; 282(2):429-436. PMID: 27513849.
      View in: PubMed
    8. Gugliucci A, Lustig RH, Caccavello R, Erkin-Cakmak A, Noworolski S, Tai VW, Wen MJ, Mulligan K, Schwarz JM. Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome. Atherosclerosis. 2016 Oct; 253:171-177. PMID: 27451002.
      View in: PubMed
    9. Starobinets O, Korn N, Iqbal S, Noworolski S, Zagoria R, Kurhanewicz J, Westphalen AC. Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation. Abdom Radiol (NY). 2016 May; 41(5):817-30. PMID: 27193785.
      View in: PubMed
    10. Lustig RH, Mulligan K, Noworolski S, Tai VW, Wen MJ, Erkin-Cakmak A, Gugliucci A, Schwarz JM. Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. Obesity (Silver Spring). 2016 Feb; 24(2):453-60. PMID: 26499447; PMCID: PMC4736733 [Available on 02/01/17].
    11. Westphalen AC, Noworolski S, Harisinghani M, Jhaveri KS, Raman SS, Rosenkrantz AB, Wang ZJ, Zagoria RJ, Kurhanewicz J. High-Resolution 3-T Endorectal Prostate MRI: A Multireader Study of Radiologist Preference and Perceived Interpretive Quality of 2D and 3D T2-Weighted Fast Spin-Echo MR Images. AJR Am J Roentgenol. 2016 Jan; 206(1):86-91. PMID: 26491891; PMCID: PMC4721575.
    12. Schwarz JM, Noworolski S, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, Herraiz LA, Tai VW, Bergeron N, Bersot TP, Rao MN, Schambelan M, Mulligan K. Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat. J Clin Endocrinol Metab. 2015 Jun; 100(6):2434-42. PMID: 25825943; PMCID: PMC4454806.
    13. Flavell RR, Westphalen AC, Liang C, Sotto CC, Noworolski S, Vigneron DB, Wang ZJ, Kurhanewicz J. Abnormal findings on multiparametric prostate magnetic resonance imaging predict subsequent biopsy upgrade in patients with low risk prostate cancer managed with active surveillance. Abdom Imaging. 2014 Oct; 39(5):1027-35. PMID: 24740760; PMCID: PMC4169752.
    14. Korn N, Kurhanewicz J, Banerjee S, Starobinets O, Saritas E, Noworolski S. Reduced-FOV excitation decreases susceptibility artifact in diffusion-weighted MRI with endorectal coil for prostate cancer detection. Magn Reson Imaging. 2015 Jan; 33(1):56-62. PMID: 25200645; PMCID: PMC4342000.
    15. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski S, Link TM, Imboden JB, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73. PMID: 25086074.
      View in: PubMed
    16. Anwar M, Westphalen AC, Jung AJ, Noworolski S, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV. Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology. Radiother Oncol. 2014 Feb; 110(2):303-8. PMID: 24444524; PMCID: PMC3969841.
    17. Starobinets O, Guo R, Simko JP, Kuchinsky K, Kurhanewicz J, Carroll PR, Greene KL, Noworolski S. Semiautomatic registration of digital histopathology images to in vivo MR images in molded and unmolded prostates. J Magn Reson Imaging. 2014 May; 39(5):1223-9. PMID: 24136783; PMCID: PMC3984354.
    18. Noworolski S, Lam MM, Merriman RB, Ferrell L, Qayyum A. Liver steatosis: concordance of MR imaging and MR spectroscopic data with histologic grade. Radiology. 2012 Jul; 264(1):88-96. PMID: 22723561; PMCID: PMC3380413.
    19. Qayyum A, Nystrom M, Noworolski S, Chu P, Mohanty A, Merriman R. MRI steatosis grading: development and initial validation of a color mapping system. AJR Am J Roentgenol. 2012 Mar; 198(3):582-8. PMID: 22357996.
      View in: PubMed
    20. Eatesam M, Noworolski S, Tien PC, Nystrom M, Dodge JL, Merriman RB, Qayyum A. Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques. J Magn Reson Imaging. 2012 Jan; 35(1):103-9. PMID: 22034200; PMCID: PMC3241899.
    21. Li X, Yu A, Virayavanich W, Noworolski S, Link TM, Imboden J. Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):211-7. PMID: 21987483.
      View in: PubMed
    22. Reed G, Cunha JA, Noworolski S, Kurhanewicz J, Vigneron D, Hsu IC, Pouliot J. Interactive, multi-modality image registrations for combined MRI/MRSI-planned HDR prostate brachytherapy. J Contemp Brachytherapy. 2011 Mar 31; 3(1):26-31. PMID: 23606866.
      View in: PubMed
    23. Chung HT, Noworolski S, Kurhanewicz J, Weinberg V, Roach Iii M. A pilot study of endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging changes with dutasteride in patients with low risk prostate cancer. BJU Int. 2011 Oct; 108(8 Pt 2):E164-70. PMID: 21435153.
      View in: PubMed
    24. Ghotb A, Noworolski S, Madden E, Scherzer R, Qayyum A, Pannell J, Ferrell L, Peters M, Tien PC. Adipose tissue and metabolic factors associated with steatosis in HIV/HCV coinfection: histology versus magnetic resonance spectroscopy. J Acquir Immune Defic Syndr. 2010 Oct; 55(2):228-31. PMID: 20512045; PMCID: PMC2943991.
    25. Noworolski S, Reed GD, Kurhanewicz J, Vigneron DB. Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate. J Magn Reson Imaging. 2010 Sep; 32(3):654-62. PMID: 20815064; PMCID: PMC2957824.
    26. Klifa C, Carballido-Gamio J, Wilmes L, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski S, Hylton N. Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort. Magn Reson Imaging. 2010 Jan; 28(1):8-15. PMID: 19631485; PMCID: PMC4087111.
    27. Noworolski S, Tien PC, Merriman R, Vigneron DB, Qayyum A. Respiratory motion-corrected proton magnetic resonance spectroscopy of the liver. Magn Reson Imaging. 2009 May; 27(4):570-6. PMID: 18993007; PMCID: PMC2917604.
    28. Bahl M, Qayyum A, Westphalen AC, Noworolski S, Chu PW, Ferrell L, Tien PC, Bass NM, Merriman RB. Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurement as biomarkers. Radiology. 2008 Oct; 249(1):160-6. PMID: 18796674; PMCID: PMC2657853.
    29. Noworolski S, Vigneron DB, Chen AP, Kurhanewicz J. Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues. Magn Reson Imaging. 2008 Oct; 26(8):1071-80. PMID: 18508221; PMCID: PMC2610684.
    30. Noworolski S, Crane JC, Vigneron DB, Kurhanewicz J. A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostate. J Magn Reson Imaging. 2008 May; 27(5):1077-82. PMID: 18407539; PMCID: PMC2832222.
    31. Kim Y, Hsu IC, Lessard E, Kurhanewicz J, Noworolski S, Pouliot J. Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSI. Radiother Oncol. 2008 Jul; 88(1):148-55. PMID: 18083260; PMCID: PMC4523126.
    32. Ratiney H, Noworolski S, Sdika M, Srinivasan R, Henry RG, Nelson SJ, Pelletier D. Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging data. MAGMA. 2007 Jun; 20(3):143-55. PMID: 17602253; PMCID: PMC2798973.
    33. Alterovitz R, Goldberg K, Pouliot J, Hsu IC, Kim Y, Noworolski S, Kurhanewicz J. Registration of MR prostate images with biomechanical modeling and nonlinear parameter estimation. Med Phys. 2006 Feb; 33(2):446-54. PMID: 16532952.
      View in: PubMed
    34. Kim Y, Hsu IC, Pouliot J, Noworolski S, Vigneron DB, Kurhanewicz J. Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration. Med Phys. 2005 Dec; 32(12):3569-78. PMID: 16475755.
      View in: PubMed
    35. Noworolski S, Henry RG, Vigneron DB, Kurhanewicz J. Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI. Magn Reson Med. 2005 Feb; 53(2):249-55. PMID: 15678552.
      View in: PubMed
    36. Noworolski S, Fischbein NJ, Kaplan MJ, Lu Y, Nelson SJ, Carvajal L, Henry RG. Challenges in dynamic contrast-enhanced MRI imaging of cervical lymph nodes to detect metastatic disease. J Magn Reson Imaging. 2003 Apr; 17(4):455-62. PMID: 12655585.
      View in: PubMed
    37. Fischbein NJ, Noworolski S, Henry RG, Kaplan MJ, Dillon WP, Nelson SJ. Assessment of metastatic cervical adenopathy using dynamic contrast-enhanced MR imaging. AJNR Am J Neuroradiol. 2003 Mar; 24(3):301-11. PMID: 12637272.
      View in: PubMed
    38. Vigneron DB, Barkovich AJ, Noworolski S, von dem Bussche M, Henry RG, Lu Y, Partridge JC, Gregory G, Ferriero DM. Three-dimensional proton MR spectroscopic imaging of premature and term neonates. AJNR Am J Neuroradiol. 2001 Aug; 22(7):1424-33. PMID: 11498441.
      View in: PubMed
    39. Mueller-Lisse UG, Swanson MG, Vigneron DB, Hricak H, Bessette A, Males RG, Wood PJ, Noworolski S, Nelson SJ, Barken I, Carroll PR, Kurhanewicz J. Time-dependent effects of hormone-deprivation therapy on prostate metabolism as detected by combined magnetic resonance imaging and 3D magnetic resonance spectroscopic imaging. Magn Reson Med. 2001 Jul; 46(1):49-57. PMID: 11443710.
      View in: PubMed
    40. Dowling C, Bollen AW, Noworolski S, McDermott MW, Barbaro NM, Day MR, Henry RG, Chang SM, Dillon WP, Nelson SJ, Vigneron DB. Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens. AJNR Am J Neuroradiol. 2001 Apr; 22(4):604-12. PMID: 11290466.
      View in: PubMed
    41. McKnight TR, Noworolski S, Vigneron DB, Nelson SJ. An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. J Magn Reson Imaging. 2001 Feb; 13(2):167-77. PMID: 11169821.
      View in: PubMed
    42. Vigneron D, Bollen A, McDermott M, Wald L, Day M, Moyher-Noworolski S, Henry R, Chang S, Berger M, Dillon W, Nelson S. Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors. Magn Reson Imaging. 2001 Jan; 19(1):89-101. PMID: 11295350.
      View in: PubMed
    43. Henry RG, Vigneron DB, Fischbein NJ, Grant PE, Day MR, Noworolski S, Star-Lack JM, Wald LL, Dillon WP, Chang SM, Nelson SJ. Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas. AJNR Am J Neuroradiol. 2000 Feb; 21(2):357-66. PMID: 10696024.
      View in: PubMed
    44. Noworolski S, Nelson SJ, Henry RG, Day MR, Wald LL, Star-Lack J, Vigneron DB. High spatial resolution 1H-MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain. Magn Reson Med. 1999 Jan; 41(1):21-9. PMID: 10025607.
      View in: PubMed
    45. Wald LL, Nelson SJ, Day MR, Noworolski S, Henry RG, Huhn SL, Chang S, Prados MD, Sneed PK, Larson DA, Wara WM, McDermott M, Dillon WP, Gutin PH, Vigneron DB. Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy. J Neurosurg. 1997 Oct; 87(4):525-34. PMID: 9322843.
      View in: PubMed
    46. Moyher SE, Wald LL, Nelson SJ, Hallam D, Dillon WP, Norman D, Vigneron DB. High resolution T2-weighted imaging of the human brain using surface coils and an analytical reception profile correction. J Magn Reson Imaging. 1997 May-Jun; 7(3):512-7. PMID: 9170035.
      View in: PubMed
    47. Wald LL, Moyher SE, Day MR, Nelson SJ, Vigneron DB. Proton spectroscopic imaging of the human brain using phased array detectors. Magn Reson Med. 1995 Sep; 34(3):440-5. PMID: 7500884.
      View in: PubMed
    48. Wald LL, Carvajal L, Moyher SE, Nelson SJ, Grant PE, Barkovich AJ, Vigneron DB. Phased array detectors and an automated intensity-correction algorithm for high-resolution MR imaging of the human brain. Magn Reson Med. 1995 Sep; 34(3):433-9. PMID: 7500883.
      View in: PubMed
    49. Moyher SE, Vigneron DB, Nelson SJ. Surface coil MR imaging of the human brain with an analytic reception profile correction. J Magn Reson Imaging. 1995 Mar-Apr; 5(2):139-44. PMID: 7766974.
      View in: PubMed
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