Dan Johnson, PhD

Title(s)Professor, Otolaryngology
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
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    Princeton UniversityPhD - Molecular Biology
    Princeton UniversityMA - Molecular Biology

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    Daniel Johnson, PhD, is Professor and Vice Chair of Research in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He obtained a bachelor of science in chemistry and a bachelor of arts in mathematics, both from North Park University in Chicago, Illinois. Dr. Johnson earned his MA and PhD in molecular biology from Princeton University, followed by a postdoctoral fellowship at the University of California, San Francisco. Prior to joining UCSF Otolaryngology, Dr. Johnson was a Professor in the Division of Hematology/Oncology, Department of Medicine, and Department of Pharmacology and Chemical Biology at the University of Pittsburgh, Pennsylvania. Dr. Johnson was also the Scientific Director of the Acute Leukemia Working group at the University of Pittsburgh Cancer Institute.

    Dr. Johnson has published 68 original papers and 21 reviews and book chapters, and is Editor for the book entitled “Cell Death Signaling in Cancer Biology and Treatment”. He has maintained continuous NIH funding as a principal investigator since 1995, and has served as a standing member for both NIH and ACS study sections. Dr. Johnson continues to play an active role on multiple review panels for the NIH, VA, and other granting agencies. Since 2001 he has served as a Section Editor for Leukemia, the top-ranked journal for hematologic malignancies, and has also served as Editor for Cancer Research and Oncology Research. Dr. Johnson places a high priority on translating findings from his lab to the clinic, and has facilitated the development of clinical trials in both leukemia and head and neck cancer.

    Dr. Johnson greatly values teaching and serving as a mentor for individuals with a broad variety of educational backgrounds. He has served as primary mentor for 32 trainees in his lab. Most of his trainees have gone on to higher academic or clinical positions, including 10 who are now junior faculty at academic institutions. He was the first lab-based faculty to be awarded the G. David Roodman Excellence in Mentorship Award by the University of Pittsburgh Hematology/Oncology Clinical Fellows. At the University of Pittsburgh he also was a leader for the Career Mentoring Program for junior faculty, and taught extensively in both the graduate and medical schools.

    Head and Neck Oncology

    Molecular biology and molecular genetics of head and neck cancer, anti-cancer drug development

    Professional Interests:
    Development of new therapeutic strategies and agents for head and neck cancer, mechanisms of chemotherapy resistance, cell death mechanisms, mentoring

    Education and Training:
    • Graduate School: Princeton University, NJ – M.A., Molecular Biology
    • Graduate School: Princeton University, NJ – Ph.D., Molecular Biology
    • Postdoctoral Fellowship: University of California, San Francisco

    Awards and Honors:
    • 2015-present – Oncology Research Editorial Board
    • 2014 – G. David Roodman Excellence in Mentorship Award from Hematology/Oncology Fellows
    • 2010-2013 – Cancer Research Editorial Board
    • 2007 – Hillman Fellow for Innovative Cancer Research
    • 2001-present – Leukemia Section Editor
    • 1999-present – Leukemia Editorial Board
    • 1994-95 – Fellow of the Lymphoma Research Foundation of America
    • 1990 – Henry Christian Outstanding Abstract in Cardiology, AFCR
    • 1988-1992 – Fellow of the Cardiovascular Research Institute, UCSF
    • 1989 – American Heart Association Postdoctoral Fellowship
    • 1982 – Graduated summa cum laude, North Park College
    • 1981 – Walter E. Olson Memorial Scholarship Fund
    • 1981 – J. Paul Bennett Chemistry Award
    • 1980-82 – President, North Park University Mathematics Society
    • 1979 – Oscar E. Olson Memorial Scholarship Fund in Mathematics

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CYLD alterations in the tumorigenesis and progression of human papillomavirus-associated head and neck cancers. Mol Cancer Res. 2020 Sep 03. Cui Z, Kang H, Grandis JR, Johnson DE. PMID: 32883697.
      View in: PubMed   Mentions:    Fields:    
    2. Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118679. Lee MJ, Jin N, Grandis JR, Johnson DE. PMID: 32061630.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance. PLoS One. 2020; 15(1):e0227261. O'Keefe RA, Bhola NE, Lee DS, Johnson DE, Grandis JR. PMID: 31914141.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Targeting STAT3 in Cancer with Nucleotide Therapeutics. Cancers (Basel). 2019 10 29; 11(11). Lau YK, Ramaiyer M, Johnson DE, Grandis JR. PMID: 31671769.
      View in: PubMed   Mentions:
    5. Gene targets of sulforaphane in head and neck squamous cell carcinoma. Mol Med Rep. 2019 Dec; 20(6):5335-5344. Hu L, Li H, Lee ED, Grandis JR, Bauman JE, Johnson DE. PMID: 31661135.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer. Adv Biol Regul. 2020 01; 75:100653. Cai Y, Yousef A, Grandis JR, Johnson DE. PMID: 31594701.
      View in: PubMed   Mentions: 1     Fields:    
    7. ATR inhibition sensitizes HPV- and HPV+ head and neck squamous cell carcinoma to cisplatin. Oral Oncol. 2019 08; 95:35-42. Leonard BC, Lee ED, Bhola NE, Li H, Sogaard KK, Bakkenist CJ, Grandis JR, Johnson DE. PMID: 31345392.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Investigational multitargeted kinase inhibitors in development for head and neck neoplasms. Expert Opin Investig Drugs. 2019 04; 28(4):351-363. Sola AM, Johnson DE, Grandis JR. PMID: 30753792.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. An update: emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs. 2018 12; 23(4):283-299. Lee YS, Johnson DE, Grandis JR. PMID: 30376740.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. Int J Mol Sci. 2018 May 30; 19(6). Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE. PMID: 29848966.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. New Therapies in Head and Neck Cancer. Trends Cancer. 2018 05; 4(5):385-396. Santuray RT, Johnson DE, Grandis JR. PMID: 29709262.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    12. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2018 05 01; 78(9):2383-2395. Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. PMID: 29440171.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018 04; 15(4):234-248. Johnson DE, O'Keefe RA, Grandis JR. PMID: 29405201.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    14. Signaling by cell surface death receptors: Alterations in head and neck cancer. Adv Biol Regul. 2018 01; 67:170-178. Leonard BC, Johnson DE. PMID: 29066276.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. EGFR-targeted therapies in the post-genomic era. Cancer Metastasis Rev. 2017 09; 36(3):463-473. Xu MJ, Johnson DE, Grandis JR. PMID: 28866730.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    16. When the Damage Is Done: Selecting Patients for Head and Neck Cancer Chemoprevention Trials. Cancer Prev Res (Phila). 2017 09; 10(9):489-490. Johnson DE, Bauman JE. PMID: 28821544.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients. Clin Cancer Res. 2017 Jun 15; 23(12):3072-3083. Brand TM, Hartmann S, Bhola NE, Peyser ND, Li H, Zeng Y, Isaacson Wechsler E, Ranall MV, Bandyopadhyay S, Duvvuri U, LaVallee TM, Jordan RCK, Johnson DE, Grandis JR. PMID: 27986750.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. PLoS One. 2016; 11(11):e0166185. Peyser ND, Pendleton K, Gooding WE, Lui VW, Johnson DE, Grandis JR. PMID: 27855189.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. A sensible approach to targeting STAT3-mediated transcription. Ann Transl Med. 2016 Oct; 4(Suppl 1):S57. Bhola NE, Johnson DE, Grandis JR. PMID: 27868025.
      View in: PubMed   Mentions:
    20. STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2016 Aug; 9(8):657-63. Peyser ND, Wang L, Zeng Y, Acquafondata M, Freilino M, Li H, Sen M, Gooding WE, Satake M, Wang Z, Johnson DE, Grandis JR. PMID: 27267892.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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