-
Future investigative directions for novel therapeutic targets in head and neck cancer. Expert Rev Anticancer Ther. 2024 Oct 16; 1-18.
Nguyen JP, Woerner LC, Johnson DE, Grandis JR. PMID: 39412140.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimals
-
CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer. Head Neck. 2024 Sep 30.
Cui Z, Kang H, Li H, Lee ED, Lee YS, Peterson CN, Long SR, Grandis JR, Johnson DE. PMID: 39347568.
View in:
PubMed Mentions: Fields:
-
Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets. Commun Biol. 2023 10 12; 6(1):1036.
Chung DH, Kong S, Young NJ, Chuo SW, Shiah JV, Connelly EJ, Rohweder PJ, Born A, Manglik A, Grandis JR, Johnson DE, Craik CS. PMID: 37828150; PMCID: PMC10570357.
View in:
PubMed Mentions:
1 Translation:
Cells
-
To Tip or Not to Tip: A New Combination for Precision Medicine in Head and Neck Cancer. Cancer Res. 2023 10 02; 83(19):3162-3164.
Lee RH, Johnson DE, Grandis JR. PMID: 37779427; PMCID: PMC10733978.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Therapeutic implications of transcriptomics in head and neck cancer patient-derived xenografts. PLoS One. 2023; 18(3):e0282177.
Lee RH, Roy R, Li H, Hechmer A, Zhu TR, Izgutdina A, Olshen AB, Johnson DE, Grandis JR. PMID: 36857322; PMCID: PMC9977000.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Author Correction: Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2023 Jan 19; 9(1):4.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. PMID: 36658129.
View in:
PubMed Mentions:
11 Fields:
-
Transcription Factors and Cancer: Approaches to Targeting. Cancer J. 2023 Jan-Feb 01; 29(1):38-46.
Shiah JV, Johnson DE, Grandis JR. PMID: 36693157; PMCID: PMC9881838.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
The mutational profiles and corresponding therapeutic implications of PI3K mutations in cancer. Adv Biol Regul. 2023 01; 87:100934.
VanLandingham NK, Nazarenko A, Grandis JR, Johnson DE. PMID: 36402737; PMCID: PMC9992323.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
STAT3 Activation as a Predictive Biomarker for Ruxolitinib Response in Head and Neck Cancer. Clin Cancer Res. 2022 11 01; 28(21):4737-4746.
Qureshy Z, Li H, Zeng Y, Rivera J, Cheng N, Peterson CN, Kim MO, Ryan WR, Ha PK, Bauman JE, Wang SJ, Long SR, Johnson DE, Grandis JR. PMID: 35929989; PMCID: PMC10024606.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Emerging tyrosine kinase inhibitors for head and neck cancer. Expert Opin Emerg Drugs. 2022 09; 27(3):333-344.
Long Z, Grandis JR, Johnson DE. PMID: 36131561; PMCID: PMC9987561.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
NSAIDs Overcome PIK3CA Mutation-Mediated Resistance to EGFR Inhibition in Head and Neck Cancer Preclinical Models. Cancers (Basel). 2022 Jan 20; 14(3).
Li H, Peyser ND, Zeng Y, Ha PK, Johnson DE, Grandis JR. PMID: 35158773; PMCID: PMC8833811.
View in:
PubMed Mentions:
1
-
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. J Clin Invest. 2021 11 15; 131(22).
Jin N, Keam B, Cho J, Lee MJ, Kim HR, Torosyan H, Jura N, Ng PK, Mills GB, Li H, Zeng Y, Barbash Z, Tarcic G, Kang H, Bauman JE, Kim MO, VanLandingham NK, Swaney DL, Krogan NJ, Johnson DE, Grandis JR. PMID: 34779417; PMCID: PMC8592538.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer. JCI Insight. 2021 10 22; 6(20).
Bouhaddou M, Lee RH, Li H, Bhola NE, O'Keefe RA, Naser M, Zhu TR, Nwachuku K, Duvvuri U, Olshen AB, Roy R, Hechmer A, Bolen J, Keysar SB, Jimeno A, Mills GB, Vandenberg S, Swaney DL, Johnson DE, Krogan NJ, Grandis JR. PMID: 34546978; PMCID: PMC8564908.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
-
Head and Neck Cancer among American Indian and Alaska Native Populations in California, 2009-2018. Cancers (Basel). 2021 Oct 16; 13(20).
Warren BR, Grandis JR, Johnson DE, Villa A. PMID: 34680342; PMCID: PMC8534223.
View in:
PubMed Mentions:
1
-
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science. 2021 Oct; 374(6563):eabf2911.
Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez-Morales D, Obernier K, Kreisberg JF, Kim M, Johnson DE, Jura N, Grandis JR, Gutkind JS, Ideker T, Krogan NJ. PMID: 34591642; PMCID: PMC9005332.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
-
Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes. Clin Cancer Res. 2021 10 01; 27(19):5168-5187.
Lee RH, Kang H, Yom SS, Smogorzewska A, Johnson DE, Grandis JR. PMID: 34045293; PMCID: PMC8626541.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction. Cell Death Dis. 2021 08 06; 12(8):775.
Cui Z, Dabas H, Leonard BC, Shiah JV, Grandis JR, Johnson DE. PMID: 34362880; PMCID: PMC8346537.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
PD-L1 is upregulated via BRD2 in head and neck squamous cell carcinoma models of acquired cetuximab resistance. Head Neck. 2021 11; 43(11):3364-3373.
Bhola NE, Njatcha C, Hu L, Lee ED, Shiah JV, Kim MO, Johnson DE, Grandis JR. PMID: 34346116; PMCID: PMC8664160.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020 11 26; 6(1):92.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. PMID: 33243986; PMCID: PMC7944998.
View in:
PubMed Mentions:
1320 Fields:
Translation:
HumansCells
-
Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides. Mol Cancer Ther. 2021 02; 20(2):219-228.
Shiah JV, Grandis JR, Johnson DE. PMID: 33203730; PMCID: PMC7888537.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Head and neck squamous cell carcinoma. Nature Reviews Disease Primers. In Press. 2020.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR.
-
CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers. Mol Cancer Res. 2021 01; 19(1):14-24.
Cui Z, Kang H, Grandis JR, Johnson DE. PMID: 32883697; PMCID: PMC7840145.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Targeting the JAK/STAT pathway in solid tumors. J Cancer Metastasis Treat. 2020; 6.
Qureshy Z, Johnson DE, Grandis JR. PMID: 33521321; PMCID: PMC7845926.
View in:
PubMed Mentions:
47
-
Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. Mol Cancer Ther. 2020 07; 19(7):1562-1571.
Izumi H, Wang Z, Goto Y, Ando T, Wu X, Zhang X, Li H, Johnson DE, Grandis JR, Gutkind JS. PMID: 32430488; PMCID: PMC7357849.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118679.
Lee MJ, Jin N, Grandis JR, Johnson DE. PMID: 32061630; PMCID: PMC7671657.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance. PLoS One. 2020; 15(1):e0227261.
O'Keefe RA, Bhola NE, Lee DS, Johnson DE, Grandis JR. PMID: 31914141; PMCID: PMC6948745.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Targeting STAT3 in Cancer with Nucleotide Therapeutics. Cancers (Basel). 2019 10 29; 11(11).
Lau YK, Ramaiyer M, Johnson DE, Grandis JR. PMID: 31671769; PMCID: PMC6896109.
View in:
PubMed Mentions:
25
-
Gene targets of sulforaphane in head and neck squamous cell carcinoma. Mol Med Rep. 2019 Dec; 20(6):5335-5344.
Hu L, Li H, Lee ED, Grandis JR, Bauman JE, Johnson DE. PMID: 31661135; PMCID: PMC6854598.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer. Adv Biol Regul. 2020 01; 75:100653.
Cai Y, Yousef A, Grandis JR, Johnson DE. PMID: 31594701; PMCID: PMC7056575.
View in:
PubMed Mentions:
20 Fields:
Translation:
Humans
-
ATR inhibition sensitizes HPV- and HPV+ head and neck squamous cell carcinoma to cisplatin. Oral Oncol. 2019 08; 95:35-42.
Leonard BC, Lee ED, Bhola NE, Li H, Sogaard KK, Bakkenist CJ, Grandis JR, Johnson DE. PMID: 31345392; PMCID: PMC6827881.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
-
Investigational multitargeted kinase inhibitors in development for head and neck neoplasms. Expert Opin Investig Drugs. 2019 04; 28(4):351-363.
Sola AM, Johnson DE, Grandis JR. PMID: 30753792; PMCID: PMC6857634.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
-
Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 02 04; 216(2):419-427.
Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. PMID: 30683736; PMCID: PMC6363423.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCTClinical Trials
-
Modulation of the PI3K/mTOR pathways. In: Improving the therapeutic ratio in head and neck cancer. Editor: Randy Kimple. Elsevier. Pgs. 89-105. ISBN: 978-0-12-817868-3. 2019.
Galstyan A, Cho J, Johnson DE, Grandis JR.
-
An update: emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs. 2018 12; 23(4):283-299.
Lee YS, Johnson DE, Grandis JR. PMID: 30376740; PMCID: PMC6525082.
View in:
PubMed Mentions:
21 Fields:
Translation:
Humans
-
STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2018 09; 17(9):1917-1926.
Njatcha C, Farooqui M, Kornberg A, Johnson DE, Grandis JR, Siegfried JM. PMID: 29891486; PMCID: PMC6125196.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
-
Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. Int J Mol Sci. 2018 May 30; 19(6).
Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE. PMID: 29848966; PMCID: PMC6032396.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
New Therapies in Head and Neck Cancer. Trends Cancer. 2018 05; 4(5):385-396.
Santuray RT, Johnson DE, Grandis JR. PMID: 29709262; PMCID: PMC6226306.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimals
-
A phase-1 study of dasatinib plus all-trans retinoic acid in acute myeloid leukemia. Leuk Lymphoma. 2018 11; 59(11):2595-2601.
Redner RL, Beumer JH, Kropf P, Agha M, Boyiadzis M, Dorritie K, Farah R, Hou JZ, Im A, Lim SH, Raptis A, Sehgal A, Christner SM, Normolle D, Johnson DE. PMID: 29616864; PMCID: PMC6201295.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCTClinical Trials
-
Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2018 05 01; 78(9):2383-2395.
Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. PMID: 29440171; PMCID: PMC6537867.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
-
Leveraging Genomics for Head and Neck Cancer Treatment. J Dent Res. 2018 06; 97(6):603-613.
Kemmer JD, Johnson DE, Grandis JR. PMID: 29420101; PMCID: PMC5960879.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018 04; 15(4):234-248.
Johnson DE, O'Keefe RA, Grandis JR. PMID: 29405201; PMCID: PMC5858971.
View in:
PubMed Mentions:
1222 Fields:
Translation:
HumansCells
-
Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer. Semin Radiat Oncol. 2018 01; 28(1):2-11.
Cho J, Johnson DE, Grandis JR. PMID: 29173752; PMCID: PMC6293987.
View in:
PubMed Mentions:
17 Fields:
Translation:
Humans
-
Targeting members of the epidermal growth factor receptor family to improve response to chemotherapy. In: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Chapter 1, pgs. 1-23. Editor: DE Johnson. Elsevier. ISBN: 978-0-12-816432-7,. 2018.
O’Keefe RA, Grandis JR, Johnson DE.
-
The JNK pathway in drug resistance. In: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Chapter 4, pgs. 87-100. Editor: DE Johnson. Elsevier. ISBN: 978-0-12-816432-7,. 2018.
Hu L, Zou F, Grandis JR, Johnson DE.
-
PIK3CA mutations in colorectal and breast cancer: impact on oncogenesis and response to nonsteroidal anti-inflammatory drugs. In: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Chapter 6, pgs. 123-144. Editor: DE Johnson. Elsevier. ISBN: 978-0-12-816432-7,. 2018.
Zhu RT, Gutkind JS, Johnson DE, Grandis JR.
-
STAT3 as a major contributor to chemoresistance. In: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Chapter 7, pgs. 145-167. Editor: DE Johnson. Elsevier. ISBN: 978-0-12-816432-7,. 2018.
Lee DS, Grandis JR, Johnson DE.
-
Jak/STAT signaling in head and neck cancer. In: Molecular Determinants of Head and Neck Cancer. Editors: Burtness B and Golemis E. Springer. Pgs. 155-184. ISBN: 978-3-319-78762-6. 2018.
Cedars E, Johnson DE, Grandis JR.
-
Signaling by cell surface death receptors: Alterations in head and neck cancer. Adv Biol Regul. 2018 01; 67:170-178.
Leonard BC, Johnson DE. PMID: 29066276; PMCID: PMC5854325.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
EGFR-targeted therapies in the post-genomic era. Cancer Metastasis Rev. 2017 09; 36(3):463-473.
Xu MJ, Johnson DE, Grandis JR. PMID: 28866730; PMCID: PMC5693744.
View in:
PubMed Mentions:
111 Fields:
Translation:
HumansAnimals
-
When the Damage Is Done: Selecting Patients for Head and Neck Cancer Chemoprevention Trials. Cancer Prev Res (Phila). 2017 09; 10(9):489-490.
Johnson DE, Bauman JE. PMID: 28821544; PMCID: PMC5915371.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients. Clin Cancer Res. 2017 Jun 15; 23(12):3072-3083.
Brand TM, Hartmann S, Bhola NE, Peyser ND, Li H, Zeng Y, Isaacson Wechsler E, Ranall MV, Bandyopadhyay S, Duvvuri U, LaVallee TM, Jordan RCK, Johnson DE, Grandis JR. PMID: 27986750; PMCID: PMC5474133.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
-
Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. PLoS One. 2016; 11(11):e0166185.
Peyser ND, Pendleton K, Gooding WE, Lui VW, Johnson DE, Grandis JR. PMID: 27855189; PMCID: PMC5113908.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
A sensible approach to targeting STAT3-mediated transcription. Ann Transl Med. 2016 Oct; 4(Suppl 1):S57.
Bhola NE, Johnson DE, Grandis JR. PMID: 27868025; PMCID: PMC5104644.
View in:
PubMed Mentions:
-
Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prev Res (Phila). 2016 Jul; 9(7):547-57.
Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. PMID: 27339168; PMCID: PMC4930727.
-
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2016 Aug; 9(8):657-63.
Peyser ND, Wang L, Zeng Y, Acquafondata M, Freilino M, Li H, Sen M, Gooding WE, Satake M, Wang Z, Johnson DE, Grandis JR. PMID: 27267892; PMCID: PMC4970880.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer. Oncogene. 2016 Mar 03; 35(9):1163-9.
Peyser ND, Freilino M, Wang L, Zeng Y, Li H, Johnson DE, Grandis JR. PMID: 25982282; PMCID: PMC4651851.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
-
Chemoprevention targets for tobacco-related head and neck cancer: past lessons and future directions. Oral Oncol. 2015 Jun; 51(6):557-64.
Sheth SH, Johnson DE, Kensler TW, Bauman JE. PMID: 25868717.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
-
An ATRActive future for differentiation therapy in AML. Blood Rev. 2015 Jul; 29(4):263-8.
Johnson DE, Redner RL. PMID: 25631637; PMCID: PMC4494875.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
-
Overcoming inherent resistance to proteasome inhibitors in head and neck cancer: challenges and new Approaches. In: Resistance to Proteasome Inhibitors in Cancer. Editor: Q. Ping Dou. Springer. ISBN: 978-3-319-06752-0. 2015.
Kass JI, Grandis JR, and Johnson DE.
-
You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia. Leukemia. 2015 Mar; 29(3):517-25.
Sehgal AR, Konig H, Johnson DE, Tang D, Amaravadi RK, Boyiadzis M, Lotze MT. PMID: 25541151; PMCID: PMC4825874.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCells
-
Carfilzomib and oprozomib synergize with histone deacetylase inhibitors in head and neck squamous cell carcinoma models of acquired resistance to proteasome inhibitors. Cancer Biol Ther. 2014 Sep; 15(9):1142-52.
Zang Y, Kirk CJ, Johnson DE. PMID: 24915039; PMCID: PMC4128857.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
STAT transcription factors in normal and cancer stem cells. Adv Biol Regul. 2014 Sep; 56:30-44.
Dorritie KA, Redner RL, Johnson DE. PMID: 24931719.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. Mol Oncol. 2014 Oct; 8(7):1220-30.
Li C, Egloff AM, Sen M, Grandis JR, Johnson DE. PMID: 24816188; PMCID: PMC4198498.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
-
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia. 2014 Sep; 28(9):1774-83.
Im AP, Sehgal AR, Carroll MP, Smith BD, Tefferi A, Johnson DE, Boyiadzis M. PMID: 24699305; PMCID: PMC4234093.
View in:
PubMed Mentions:
119 Fields:
Translation:
Humans
-
The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumors. Endocr Relat Cancer. 2015 Feb; 22(1):T1-17.
Johnson DE. PMID: 24659480; PMCID: PMC4170053.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansAnimals
-
Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects. Mol Med. 2014 Mar 18; 20:46-56.
Sen M, Paul K, Freilino ML, Li H, Li C, Johnson DE, Wang L, Eiseman J, Grandis JR. PMID: 24395569; PMCID: PMC3951464.
View in:
PubMed Mentions:
20 Fields:
Translation:
Animals
-
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1114-9.
Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR. PMID: 24395800; PMCID: PMC3903220.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansCells
-
Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells. Oral Oncol. 2014 Feb; 50(2):120-7.
Yazbeck VY, Li C, Grandis JR, Zang Y, Johnson DE. PMID: 24216166; PMCID: PMC3944051.
View in:
PubMed Mentions:
14 Fields:
Translation:
Humans
-
STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. Leukemia. 2014 Feb; 28(2):248-57.
Dorritie KA, McCubrey JA, Johnson DE. PMID: 23797472.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest. Cell Cycle. 2013 Mar 15; 12(6):923-34.
Li C, Johnson DE. PMID: 23421999; PMCID: PMC3637351.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4. Autophagy. 2012 Dec; 8(12):1873-4.
Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE. PMID: 22995770; PMCID: PMC3541310.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
-
Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy. Clin Cancer Res. 2012 Oct 15; 18(20):5639-49.
Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE. PMID: 22929803; PMCID: PMC3473099.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res. 2012 Sep 15; 18(18):4986-96.
Sen M, Joyce S, Panahandeh M, Li C, Thomas SM, Maxwell J, Wang L, Gooding WE, Johnson DE, Grandis JR. PMID: 22825581; PMCID: PMC3445706.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
-
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov. 2012 Aug; 2(8):694-705.
Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Chen X, Kaminski N, Pandit K, Johnson DE, Grandis JR. PMID: 22719020; PMCID: PMC3668699.
-
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, et al. PMID: 22966490; PMCID: PMC3404883.
View in:
PubMed Mentions:
1817 Fields:
Translation:
HumansAnimals
-
Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit. Chin J Cancer. 2012 Jul; 31(7):319-26.
Johnson DE. PMID: 22257382; PMCID: PMC3607312.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Defective apoptosis signaling in cancer. In: Cell Death Signaling in Cancer Biology and Treatment. Chapter 1, pgs. 1-34. Editor: DE Johnson. Springer. ISBN: 978-1-4614-5846-3,. 2012.
Johnson DE.
-
Leading small molecule inhibitors of anti-apoptotic Bcl-2 family members. In: Cell Death Signaling in Cancer Biology and Treatment. Chapter 9, pgs. 231-253. Editor: DE Johnson. Springer. ISBN: 978-1-4614-5846-3,. 2012.
Yazbeck VY and Johnson DE.
-
Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation. Cancer Lett. 2012 Jan 01; 314(1):102-7.
Li C, Johnson DE. PMID: 21993018; PMCID: PMC3225600.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansCells
-
Dasatinib promotes ATRA-induced differentiation of AML cells. Leukemia. 2010 Mar; 24(3):663-5.
Kropf PL, Wang L, Zang Y, Redner RL, Johnson DE. PMID: 20033056.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
-
Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis. 2009 Nov; 30(11):1848-56.
Leeman-Neill RJ, Wheeler SE, Singh SV, Thomas SM, Seethala RR, Neill DB, Panahandeh MC, Hahm ER, Joyce SC, Sen M, Cai Q, Freilino ML, Li C, Johnson DE, Grandis JR. PMID: 19762335; PMCID: PMC2783003.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
-
CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients. Cell Cycle. 2009 Aug 15; 8(16):2578-85.
Ju S, Qiu H, Zhou X, Zhu B, Lv X, Huang X, Li J, Zhang Y, Liu L, Ge Y, Johnson DE, Ju S, Shu Y. PMID: 19597336.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death. Mol Cancer Ther. 2009 Aug; 8(8):2211-20.
Li C, Zang Y, Sen M, Leeman-Neill RJ, Man DS, Grandis JR, Johnson DE. PMID: 19638453; PMCID: PMC2768047.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
-
Src family kinase gene targets during myeloid differentiation: identification of the EGR-1 gene as a direct target. Leukemia. 2009 Oct; 23(10):1933-5.
Jones JE, Wang L, Kropf PL, Duan R, Johnson DE. PMID: 19494839; PMCID: PMC2762004.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway. Mol Pharmacol. 2009 May; 75(5):1231-9.
Li R, Zang Y, Li C, Patel NS, Grandis JR, Johnson DE. PMID: 19246337; PMCID: PMC2672802.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
-
Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother Pharmacol. 2009 May; 63(6):983-95.
Sen M, Tosca PJ, Zwayer C, Ryan MJ, Johnson JD, Knostman KA, Giclas PC, Peggins JO, Tomaszewski JE, McMurray TP, Li C, Leibowitz MS, Ferris RL, Gooding WE, Thomas SM, Johnson DE, Grandis JR. PMID: 18766340; PMCID: PMC3422883.
View in:
PubMed Mentions:
26 Fields:
Translation:
Animals
-
Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells. Mol Cancer Ther. 2008 Jun; 7(6):1647-55.
Li C, Li R, Grandis JR, Johnson DE. PMID: 18566236; PMCID: PMC2534142.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
-
Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. Mol Pharmacol. 2008 Jun; 73(6):1632-42.
Boehm AL, Sen M, Seethala R, Gooding WE, Freilino M, Wong SM, Wang S, Johnson DE, Grandis JR. PMID: 18326051; PMCID: PMC3437602.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
-
Gefitinib potentiates myeloid cell differentiation by ATRA. Leukemia. 2008 Aug; 22(8):1624-7.
Miranda MB, Duan R, Thomas SM, Grandis JR, Redner RL, Jones JE, Johnson DE. PMID: 18305561; PMCID: PMC2596306.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Inhibitors of the Bcl-2 protein family as sensitizers to anticancer agents. In: Sensitization of Cancer Cells to Chemo/Immuno/Radio Therapy. Editors: B Bonavida and B Teicher. Humana Press, Inc., pgs. 243-261. ISBN: 978-1-59745-474-2. 2008.
Johnson DE.
-
Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation. Mol Cancer Ther. 2007 Dec; 6(12 Pt 1):3081-90.
Miranda MB, Redner RL, Johnson DE. PMID: 18065491.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis. Adv Enzyme Regul. 2008; 48:98-112.
Johnson DE. PMID: 18155170; PMCID: PMC2633125.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells. Neoplasia. 2007 Oct; 9(10):801-11.
Li R, Boehm AL, Miranda MB, Shangary S, Grandis JR, Johnson DE. PMID: 17971900; PMCID: PMC2040207.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
Signal transduction pathways that contribute to myeloid differentiation. Leukemia. 2007 Jul; 21(7):1363-77.
Miranda MB, Johnson DE. PMID: 17443228.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
-
Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: the role of STAT1. Mol Pharmacol. 2007 May; 71(5):1435-43.
Lui VW, Boehm AL, Koppikar P, Leeman RJ, Johnson D, Ogagan M, Childs E, Freilino M, Grandis JR. PMID: 17325127.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
-
Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res. 2006 Jun 01; 66(11):5828-35.
Herman-Antosiewicz A, Johnson DE, Singh SV. PMID: 16740722.
View in:
PubMed Mentions:
139 Fields:
Translation:
HumansCells
-
Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk Res. 2005 Nov; 29(11):1293-306.
Miranda MB, Xu H, Torchia JA, Johnson DE. PMID: 16164983.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death. Mol Cancer Ther. 2005 May; 4(5):733-42.
Emert-Sedlak L, Shangary S, Rabinovitz A, Miranda MB, Delach SM, Johnson DE. PMID: 15897237.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansCells
-
(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. Mol Cancer Ther. 2005 Jan; 4(1):23-31.
Oliver CL, Miranda MB, Shangary S, Land S, Wang S, Johnson DE. PMID: 15657350.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
-
Sequence and helicity requirements for the proapoptotic activity of Bax BH3 peptides. Mol Cancer Ther. 2004 Nov; 3(11):1343-54.
Shangary S, Oliver CL, Tillman TS, Cascio M, Johnson DE. PMID: 15542773.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
-
Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene. 2004 Jul 22; 23(33):5594-606.
Xiao D, Choi S, Johnson DE, Vogel VG, Johnson CS, Trump DL, Lee YJ, Singh SV. PMID: 15184882.
View in:
PubMed Mentions:
102 Fields:
Translation:
HumansCells
-
The intrinsic (mitochondrial) death pathway and new cancer therapeutics: Bcl-2 family in focus. In: Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases. Editors: M Los and SB Gibson. Kluwer Academic Press. ISBN: 0-387-23384-9,. 2004.
Shangary S, Oliver CL, Johnson DE.
-
Responsiveness to the retinoic acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming growth factor alpha/epidermal growth factor receptor autocrine signaling in head and neck squamous carcinoma cells. Clin Cancer Res. 2003 Sep 15; 9(11):4205-13.
Lango M, Wentzel AL, Song JI, Xi S, Johnson DE, Lamph WW, Miller L, Grandis JR. PMID: 14519647.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family. Leukemia. 2003 Aug; 17(8):1470-81.
Shangary S, Johnson DE. PMID: 12886234.
View in:
PubMed Mentions:
18 Fields:
Translation:
Humans
-
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4138-43.
Leong PL, Andrews GA, Johnson DE, Dyer KF, Xi S, Mai JC, Robbins PD, Gadiparthi S, Burke NA, Watkins SF, Grandis JR. PMID: 12640143; PMCID: PMC153061.
View in:
PubMed Mentions:
131 Fields:
Translation:
HumansCells
-
Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells. Leukemia. 2003 Feb; 17(2):390-400.
Miranda MB, Dyer KF, Grandis JR, Johnson DE. PMID: 12592339.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. Exp Cell Res. 2002 Aug 15; 278(2):209-14.
Basu A, Johnson DE, Woolard MD. PMID: 12169276.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Peptides derived from BH3 domains of Bcl-2 family members: a comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell death. Biochemistry. 2002 Jul 30; 41(30):9485-95.
Shangary S, Johnson DE. PMID: 12135371.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines. Leukemia. 2002 Apr; 16(4):683-92.
Miranda MB, McGuire TF, Johnson DE. PMID: 11960350.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansCells
-
Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem Biophys Res Commun. 2001 Sep 07; 286(5):1003-10.
Antoku K, Maser RS, Scully WJ, Delach SM, Johnson DE. PMID: 11527400.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
-
A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol. 2001 Jul 01; 167(1):350-6.
Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A, Hanson DA, Kluck RM, Hitoshi Y, Johnson DE, Froelich CJ, Thompson CB, Newmeyer DD, Anel A, Clayberger C, Krensky AM. PMID: 11418670.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
-
Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. Oncogene. 2001 May 24; 20(23):2918-26.
Fattman CL, Delach SM, Dou QP, Johnson DE. PMID: 11420704.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
-
Tumor-induced apoptosis of T cells: amplification by a mitochondrial cascade. Cancer Res. 2000 Dec 15; 60(24):6811-7.
Gastman BR, Yin XM, Johnson DE, Wieckowski E, Wang GQ, Watkins SC, Rabinowich H. PMID: 11156370.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Analysis of the role of conserved cysteine residues in the bcl-2 oncoprotein. Biochem Biophys Res Commun. 2000 Oct 14; 277(1):171-8.
Maser RS, Antoku K, Scully WJ, Cho RL, Johnson DE. PMID: 11027659.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
p21WAF1 prevents down-modulation of the apoptotic inhibitor protein c-IAP1 and inhibits leukemic apoptosis. Mol Med. 2000 Sep; 6(9):736-49.
Steinman RA, Johnson DE. PMID: 11071269; PMCID: PMC1949984.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Noncaspase proteases in apoptosis. Leukemia. 2000 Sep; 14(9):1695-703.
Johnson DE. PMID: 10995018.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
-
Programmed cell death regulation: basic mechanisms and therapeutic opportunities. Leukemia. 2000 Aug; 14(8):1340-4.
Johnson DE. PMID: 10942226.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res. 2000 Jul 10; 258(1):223-35.
Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A, Naval J. PMID: 10912804.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansCells
-
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4227-32.
Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y, Kim JD. PMID: 10760290; PMCID: PMC18206.
View in:
PubMed Mentions:
212 Fields:
Translation:
HumansAnimalsCells
-
Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. Cancer Res. 2000 Apr 01; 60(7):1818-23.
Johnson DE, Gastman BR, Wieckowski E, Wang GQ, Amoscato A, Delach SM, Rabinowich H. PMID: 10766165.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events. Blood. 2000 Mar 15; 95(6):2015-23.
Gastman BR, Johnson DE, Whiteside TL, Rabinowich H. PMID: 10706869.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
-
Characterization of caspase proteases in cytokine-dependent myeloid progenitor cells using enzyme affinity labeling. J Cell Biochem. 1999 Apr 01; 73(1):79-89.
Cho RL, Johnson DE. PMID: 10088726.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Caspase-mediated degradation of T-cell receptor zeta-chain. Cancer Res. 1999 Apr 01; 59(7):1422-7.
Gastman BR, Johnson DE, Whiteside TL, Rabinowich H. PMID: 10197606.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res. 1998 Nov; 4(11):2913-21.
Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. PMID: 9829760.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
IL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells. Leukemia. 1998 May; 12(5):682-9.
Antoku K, Liu Z, Johnson DE. PMID: 9593265.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Regulation of survival pathways by IL-3 and induction of apoptosis following IL-3 withdrawal. Front Biosci. 1998 Mar 15; 3:d313-24.
Johnson DE. PMID: 9488657.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
Bcl-2- and CrmA-inhibitable dephosphorylation and cleavage of retinoblastoma protein during etoposide-induced apoptosis. Int J Mol Med. 1998 Jan; 1(1):131-6.
An B, Johnson DE, Jin JR, Antoku K, Dou QP. PMID: 9852210.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Inhibition of caspase proteases by CrmA enhances the resistance of human leukemic cells to multiple chemotherapeutic agents. Leukemia. 1997 Oct; 11(10):1665-72.
Antoku K, Liu Z, Johnson DE. PMID: 9324287.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family. J Cell Biochem. 1997 Mar 15; 64(4):586-94.
Dou QP, An B, Antoku K, Johnson DE. PMID: 9093908.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis. Am J Physiol. 1997 Feb; 272(2 Pt 1):C675-84.
Fabisiak JP, Kagan VE, Ritov VB, Johnson DE, Lazo JS. PMID: 9124312.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression. J Biol Chem. 1995 Nov 17; 270(46):27948-53.
Morishita K, Johnson DE, Williams LT. PMID: 7499271.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res. 1993; 60:1-41.
Johnson DE, Williams LT. PMID: 8417497.
View in:
PubMed Mentions:
263 Fields:
Translation:
HumansAnimalsCells
-
Signalling by receptor tyrosine kinases. Annu Rev Biochem. 1993; 62:453-81.
Fantl WJ, Johnson DE, Williams LT. PMID: 7688944.
View in:
PubMed Mentions:
213 Fields:
Translation:
AnimalsCells
-
Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol. 1992 Jan; 12(1):82-8.
Werner S, Duan DS, de Vries C, Peters KG, Johnson DE, Williams LT. PMID: 1309595; PMCID: PMC364071.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
-
The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol. 1991 Sep; 11(9):4627-34.
Johnson DE, Lu J, Chen H, Werner S, Williams LT. PMID: 1652059; PMCID: PMC361347.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansCells
-
Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1095-9.
Keegan K, Johnson DE, Williams LT, Hayman MJ. PMID: 1847508; PMCID: PMC50963.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
-
Characterization of the FGFR-3 gene and its gene product. Ann N Y Acad Sci. 1991; 638:400-2.
Keegan K, Johnson DE, Williams LT, Hayman MJ. PMID: 1723860.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol Cell Biol. 1990 Sep; 10(9):4728-36.
Johnson DE, Lee PL, Lu J, Williams LT. PMID: 2167437; PMCID: PMC361071.
View in:
PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
-
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science. 1989 Jul 07; 245(4913):57-60.
Lee PL, Johnson DE, Cousens LS, Fried VA, Williams LT. PMID: 2544996.
View in:
PubMed Mentions:
138 Fields:
Translation:
AnimalsCells
-
DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia. Mol Biol Med. 1986 Dec; 3(6):483-94.
Breakefield XO, Ozelius L, Bothwell MA, Chao MV, Axelrod F, Kramer PL, Kidd KK, Lanahan AA, Johnson DE, Ross AH, et al. PMID: 2886891.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Expression and structure of the human NGF receptor. Cell. 1986 Nov 21; 47(4):545-54.
Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, Bothwell M, Chao M. PMID: 3022937.
View in:
PubMed Mentions:
195 Fields:
Translation:
HumansAnimalsCells
-
The epidermal growth factor (EGF) receptor gene studied using gene transfer. Int J Neurosci. 1985 Apr; 26(1-2):129-40.
Strazdis J, Lanahan A, Johnson DE, Bothwell M, Kucherlapati R. PMID: 2987144.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells