Shomyseh Sanjabi, PhD

Title(s)Associate Professor, Microbiology and Immunology
SchoolSchool of Medicine
Address35 Medical Center Way, #001
San Francisco CA 94143
Phone415-734-4814
ORCID ORCID Icon0000-0002-3097-9665 Additional info
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    Collapse Biography 
    Collapse education and training
    University of California, Los AngelesBS1997Microbiology and Molecular Genetics
    University of California, Los AngelesPhD2003Microbiology, Immunology, and Molecular Genetics
    Yale UniversityPostdoctoral 2010Immunobiology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Characterizing HIV latent reservoir in vivo
    NIH DP2AI112244Sep 30, 2013 - Aug 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abstract CT075: Phase 1a/1b dose-escalation study of efbalropendekin alfa (XmAb24306) as single-agent and with atezolizumab in solid tumors. Cancer Research. 2025 Apr 25; 85(8_Supplement_2):ct075-ct075. Tran TB, Spreafico SA, Knapen KD, Oh OD, Hamilton HE, Keenan KB, Khan KS, LoRusso LP, Fakih FM, Gordon GM, Jing JJ, Liu LY, Holder HP, Dogra DP, Kirschbrown KW, Shivva SV, Tracy TS, Monemi MS, Sanjabi SS, Ungewickell UA, McCoach MC, Kim KT. .
      View in: Publisher Site   Mentions:
    2. Abstract CT075: Phase 1a/1b dose-escalation study of efbalropendekin alfa (XmAb24306) as single-agent and with atezolizumab in solid tumors. Cancer Research. 2025 Apr 25; 85(8_Supplement_2):ct075-ct075. Tran TB, Spreafico SA, Knapen KD, Oh OD, Hamilton HE, Keenan KB, Khan KS, LoRusso LP, Fakih FM, Gordon GM, Jing JJ, Liu LY, Holder HP, Dogra DP, Kirschbrown KW, Shivva SV, Tracy TS, Monemi MS, Sanjabi SS, Ungewickell UA, McCoach MC, Kim KT. .
      View in: Publisher Site   Mentions:
    3. Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer. Cancer Immunol Res. 2025 Apr 02; 13(4):476-486. Galsky MD, Kockx M, Roels J, Van Elzen R, Guan X, Yuen K, Rishipathak D, Anker JF, Gnjatic S, Izadmehr S, Sanjabi S, Johnston RJ, Peterson M, Koeppen H, David JM, Gupta S, Bamias A, Arranz JA, Kikuchi E, De Santis M, Davis ID, Williams P, Bernhard S, Mellman I, Grande E, Banchereau R, Mariathasan S. PMID: 39853278; PMCID: PMC11962399.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Immune Monitoring during Cancer Immunotherapy. Manual of Molecular and Clinical Laboratory Immunology. 2024 Nov 22; 1144-1167. Shehata SH, Dogra DP, Sanjabi SS. .
      View in: Publisher Site   Mentions:
    5. Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy. Front Pharmacol. 2024; 15:1380000. Yadav R, Schubbert S, Holder PG, Chiang EY, Kiabi N, Bogaert L, Leung I, Rashid R, Avery KN, Bonzon C, Desjarlais JR, Sanjabi S, Sharma A, Lepherd M, Shelton A, Chan P, Liu Y, Joslyn L, Hosseini I, Stefanich EG, Kamath AV, Bernett MJ, Shivva V. PMID: 38887559; PMCID: PMC11181026.
      View in: PubMed   Mentions:
    6. Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro. Front Immunol. 2024; 15:1341804. Shehata HM, Dogra P, Gierke S, Holder P, Sanjabi S. PMID: 38515757; PMCID: PMC10954783.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer. Cell Rep Med. 2024 Feb 20; 5(2):101393. Galsky MD, Guan X, Rishipathak D, Rapaport AS, Shehata HM, Banchereau R, Yuen K, Varfolomeev E, Hu R, Han CJ, Li H, Liang Y, Vucic D, Wang L, Zhu J, Yu H, Herbst RH, Hajaj E, Kiner E, Bamias A, De Santis M, Davis ID, Arranz JÁ, Kikuchi E, Bernhard S, Williams P, Lee C, Mellman I, Sanjabi S, Johnston R, Black PC, Grande E, Mariathasan S. PMID: 38280376; PMCID: PMC10897541.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    8. Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors. Nat Commun. 2023 08 05; 14(1):4703. Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, Capietto AH, Cubas R, Modrusan Z, Sandoval W, Ziai J, Gould SE, Fu W, Wang Y, Koerber JT, Sanjabi S, Mellman I, Turley SJ, Müller S. PMID: 37543621; PMCID: PMC10404279.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    9. Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics. Eur J Pharm Sci. 2023 Jul 01; 186:106450. Lu D, Yadav R, Holder P, Chiang E, Sanjabi S, Poon V, Bernett M, Varma R, Liu K, Leung I, Bogaert L, Desjarlais J, Shivva V, Hosseini I, Ramanujan S. PMID: 37084985.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade. J Immunother Cancer. 2022 08; 10(8). Fehlings M, Kim L, Guan X, Yuen K, Tafazzol A, Sanjabi S, Zill OA, Rishipathak D, Wallace A, Nardin A, Ma S, Milojkovic A, Newell EW, Mariathasan S, Yadav M. PMID: 35981786; PMCID: PMC9394212.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    11. Single cell genome sequencing of laboratory mouse microbiota improves taxonomic and functional resolution of this model microbial community. PLoS One. 2022; 17(4):e0261795. Lyalina S, Stepanauskas R, Wu F, Sanjabi S, Pollard KS. PMID: 35417481; PMCID: PMC9007364.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. Expert Roundtable: leveraging cutting edge tools to convert I-O data into knowledge. Immuno Oncology Insights. 2021 Dec 1; 02(05):289-300. Sood SA, Prabhakaran PS, Goldmacher GG, Sanjabi SS. .
      View in: Publisher Site   Mentions:
    13. Molecular determinants of response to PD-L1 blockade across tumor types. Nat Commun. 2021 06 25; 12(1):3969. Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T. PMID: 34172722; PMCID: PMC8233428.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCTClinical Trials
    14. New cytometry tools for immune monitoring during cancer immunotherapy. Cytometry B Clin Cytom. 2021 01; 100(1):10-18. Sanjabi S, Lear S. PMID: 33432667.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. J Virol. 2020 12 22; 95(2). Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. PMID: 33115867; PMCID: PMC7944458.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract. Nat Commun. 2019 09 25; 10(1):4344. Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S. PMID: 31554802; PMCID: PMC6761111.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990; PMCID: PMC6715152.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    18. Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8939-E8947. Shehata HM, Khan S, Chen E, Fields PE, Flavell RA, Sanjabi S. PMID: 30126987; PMCID: PMC6156615.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    19. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 02; 14(2):e1006856. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. PMID: 29470552; PMCID: PMC5823470.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    20. B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol. 2018 07; 11(4):1158-1167. Trapecar M, Khan S, Cohn BL, Wu F, Sanjabi S. PMID: 29456247; PMCID: PMC6030459.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052; PMCID: PMC5684666.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    22. Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S40-S58. Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S. PMID: 28882067; PMCID: PMC5685216.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    23. Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections. Front Immunol. 2017; 8:1311. Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS. PMID: 29085369; PMCID: PMC5649203.
      View in: PubMed   Mentions: 24     Fields:    
    24. Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice. mSystems. 2017 Sep-Oct; 2(5). Sharpton T, Lyalina S, Luong J, Pham J, Deal EM, Armour C, Gaulke C, Sanjabi S, Pollard KS. PMID: 28904997; PMCID: PMC5585689.
      View in: PubMed   Mentions: 33     Fields:    
    25. Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection. Cold Spring Harb Perspect Biol. 2017 Jun 01; 9(6). Sanjabi S, Oh SA, Li MO. PMID: 28108486; PMCID: PMC5453394.
      View in: PubMed   Mentions: 290     Fields:    Translation:HumansAnimalsCells
    26. Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. J Exp Med. 2016 12 12; 213(13):2913-2929. Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. PMID: 27852793; PMCID: PMC5154948.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    27. Generation of colonic T-cell mediated protective immunity after rectal infection with LCMV. The Journal of Immunology. 2016 May 1; 196(1_Supplement):208.16-208.16. Trapecar TM, Cohen CB, Khan KS, Woodruff WE, Luong LJ, Sanjabi SS. .
      View in: Publisher Site   Mentions:
    28. Delay in CD8 T-cell priming impairs viral control after vaginal LCMV transmission. The Journal of Immunology. 2016 May 1; 196(1_Supplement):208.23-208.23. Khan KS, Woodruff WE, Trapecar TM, Sanjabi SS. .
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    29. 127 Role of TGF-beta signaling in circulating and tissue resident memory CD8+ T cells. Cytokine. 2013 Sep 1; 63(3):273. Ishigame IH, Sanjabi SS, Flavell FR. .
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    30. 54 Role of transforming growth factor-beta signaling in CD8+ T cells in mucosal anti-viral immune responses. Cytokine. 2013 Sep 1; 63(3):256. Cohn CB, Pham PJ, Sanjabi SS. .
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    31. 128 Truncated form of transforming growth factor-ß receptor II, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. Cytokine. 2013 Sep 1; 63(3):273. Ishigame IH, Mosaheb MM, Sanjabi SS, Flavell FR. .
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    32. Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. J Immunol. 2013 Jun 15; 190(12):6340-50. Ishigame H, Mosaheb MM, Sanjabi S, Flavell RA. PMID: 23686479; PMCID: PMC3690649.
      View in: PubMed   Mentions: 26     Fields:    
    33. Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6961-6. Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA. PMID: 23569233; PMCID: PMC3637710.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    34. The interplay between TGFß and c?c cytokine signaling in CD8+ T cell biology (46.19). The Journal of Immunology. 2011 Apr 1; 186(1_Supplement):46.19-46.19. Sanjabi SS, Pham PJ, Mosaheb MM, Ishigame IH, Flavell FR. .
      View in: Publisher Site   Mentions:
    35. The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol. 2010 Aug; 10(8):554-67. Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limón P. PMID: 20616810; PMCID: PMC3885992.
      View in: PubMed   Mentions: 479     Fields:    
    36. Interaction between TGFbeta and the common gamma chain cytokines during an inflammatory immune response. Cell Cycle. 2010 Feb 01; 9(3):428-30. Sanjabi S, Flavell RA. PMID: 20107324.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling. J Immunol Methods. 2010 Feb 28; 353(1-2):111-4. Sanjabi S, Flavell RA. PMID: 20060833; PMCID: PMC2845397.
      View in: PubMed   Mentions: 8     Fields:    
    38. Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity. 2009 Jul 17; 31(1):131-44. Sanjabi S, Mosaheb MM, Flavell RA. PMID: 19604492; PMCID: PMC2765785.
      View in: PubMed   Mentions: 96     Fields:    
    39. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9785-90. Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA. PMID: 19497879; PMCID: PMC2701053.
      View in: PubMed   Mentions: 19     Fields:    
    40. Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol. 2009 Aug; 9(4):447-53. Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA. PMID: 19481975; PMCID: PMC2755239.
      View in: PubMed   Mentions: 271     Fields:    
    41. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J Immunol. 2007 Jun 01; 178(11):6777-88. Wang J, Wang X, Hussain S, Zheng Y, Sanjabi S, Ouaaz F, Beg AA. PMID: 17513725.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    42. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity. 2006 Sep; 25(3):455-71. Li MO, Sanjabi S, Flavell RA. PMID: 16973386.
      View in: PubMed   Mentions: 324     Fields:    Translation:AnimalsCells
    43. Transforming growth factor-beta: recent advances on its role in immune tolerance. Curr Rheumatol Rep. 2006 Apr; 8(2):138-44. Kriegel MA, Li MO, Sanjabi S, Wan YY, Flavell RA. PMID: 16569373.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    44. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 2006; 24:99-146. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. PMID: 16551245.
      View in: PubMed   Mentions: 806     Fields:    Translation:HumansAnimalsCells
    45. Gene Regulation and Function: It's Rocking Science. Immunity. 2006 Jan 1; 24(1):119. Dong DC, Sanjabi SS, Eynon EE. .
      View in: Publisher Site   Mentions:
    46. Gene regulation and function: its rocking science. Immunity. 2005 Dec; 23(6):557-60. Dong C, Sanjabi S, Eynon E. PMID: 16392168.
      View in: PubMed   Mentions:    Fields:    
    47. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. PMID: 16166378; PMCID: PMC1221885.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    48. Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat Immunol. 2001 Jan; 2(1):51-7. Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST. PMID: 11135578.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    49. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12705-10. Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST. PMID: 11058167; PMCID: PMC18828.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
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