Janice Schwartz, MD

Title(s)Recalled Professor in Residence, Medicine
SchoolSchool of Medicine
Address490 Illinois Street, #8216
San Francisco CA 94158
Phone415-519-3161
ORCID ORCID Icon0000-0002-5171-7824 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Newcomb College, New Orleans, LA1970Biology
    Tulane University, School of Medicine, New Orleans, LAMD1974Medicine
    LACounty/USC , Los Angeles1975Internal Medicine
    Cedar-Sinai Medical Center, Los Angeles1977Internal Medicine
    Cedar Sinai Medical Center, Los Angeles1978Cardiology
    Stanford University, Stanford, CA1981Cardiology
    UCLA, Los Angeles1990Geriatrics
    Collapse Awards and Honors
    American Society of Clinical Pharmacology and Therapeutics2012William Abrams Award in Geriatric Clinical Pharmacology
    PhRMA2019Award of Excellence in Clinical Pharmacology

    Collapse Overview 
    Collapse Overview
    I graduated from Tulane Medical School, am a board-certified internist and cardiologist with significant experience in clinical pharmacology and geriatric medicine. My research goal has been to elucidate age-related and sex-related differences in pharmacokinetics and pharmacodynamics in order to improve medication therapy for older adults. I have studied models of aging from in vitro models of cardiac changes with aging to physiologic and pharmacokinetic investigations of healthy humans to population studies of community dwelling elderly, and frail elderly adults.

    My current work focuses on improving medication use in the very oldest people, in optimizing outcomes in older people receiving polypharmacy, and the translation and optimization of new therapeutic agents such as anticoagulants during clinical use to benefit the very oldest and frailest patients. I recently completed a ORISE visiting Professorship in the Office of Clinical Pharmacology at the FDA to stimulate initiatives to improve the drug evaluation and monitoring process for older adults and incorporate patient-centered outcomes into the drug evaluation process.

    Collapse Research 
    Collapse Research Activities and Funding
    LatinX/HIspanic Attitudes and Perspectives on Investigations and Studies- of New Drugs: LAPIS-ND.
    FDA 1U01FD007777Aug 16, 2022 - Aug 15, 2024
    Role: Principal Investigator
    Description: Participation of older adults self-described as Hispanic/Latino are amongst the lowest in clinical trials, yet Hispanic/Latinos compose rapidly growing segments of the U.S. and clinical populations. Their voice, concerns, desired outcomes, perceived incentives and barriers to participation are key to increasing their representation in the evaluation of new medical therapies. Our overall goal is to understand their perceptions about research, clinical trials, and obstacles, facilitators and priorities regarding participation in clinical trials by conducting focus groups with older Hispanics of Mexican origin.
    The MUM study: MUltimorbidity and Medications: the unheard perspective of older adults
    UCSF-Stanford CERSI (FDA) 2U01FD005978 Project #64 -Sep 1, 2021 - Aug 31, 2024
    Role: Principal Investigator
    Description: The goal is to hear the voice of “typical” older adults with multiple chronic conditions and any care partners to understand their perceptions about prescription drugs, medication safety, risk, pre-marketing evaluation—obstacles, facilitators and priorities regarding clinical trial participation, desired patient-centered outcomes and feasibility of performance and data collection (personal vs. digital). The goal is to conduct a survey of representative older adults with multimorbidity
    Principal Investigator, FDA: 2U01The MUM-URMA1 study: Multimorbidity and Medications: the unheard perspective of older Under-Represented Racial and Ethnic Minority Adults-phase 1
    FDA/CERSI 2U01FD005978-06, Project 71Sep 1, 2021 - Aug 30, 2024
    Role: Principal Investigator
    Description: Participants in clinical trials should reflect the individuals who may one day receive the therapeutic agent. Ensuring people from diverse backgrounds have the ability and motivation to participate in clinical trials is key to advancing health equity and in assuring the efficacy and safety of new medical therapies in groups likely to receive the medical therapies. Older adults consume more medications than any other patient group yet are under-represented in evaluations of new medications with representation of Chinese/Chinese Americans having amongst the lowest representation. Participation of older adults self-described as Asian are amongst the lowest in clinical trials yet compose rapidly growing segments of the U.S. population and the clinical population. Their voice, concerns, desired outcomes, incentives and barriers to participation are key to increasing their representation in new therapies.
    Direct-Acting Oral Anticoagulants: Anticoagulant Activity in Understudied Older NVAF Patients
    NIH R21AG067463Apr 15, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Description: The goal is to hear the voice of “typical” older adults with multiple chronic conditions and any care partners to understand their perceptions about prescription drugs, medication safety, risk, pre-marketing evaluation—obstacles, facilitators and priorities regarding clinical trial participation, desired patient-centered outcomes and feasibility of performance and data collection (personal vs. digital). The goal is to conduct a survey of representative older adults with multimorbidity
    Patient Perspectives on Adherence to Eliquis Use. (P.I., UCLA
    ARISTA-USA: American ThRombosis InveStigator IniTiated Research ProgrAm-USA N.A.Mar 26, 2020 - Mar 26, 2023
    Role: Co-investigator
    Description: The goal of the study is to determine why patients stop or do not start newer anticoagulant medications.
    Patient perspectives on primary nonadherence to statins
    NIA R21AG055832-01Jun 1, 2017 - May 31, 2020
    Role: Co-investigator
    Prevalence and Knowledge of Concurrent OTC Drug / Dietary Supplement- Eliquis Use.
    BMS/Pfizer. ARISTA-USA NAApr 1, 2016 - Dec 31, 2019
    Role: Co-investigator
    Distribution of free 25-OH D concentrations in clinical populations: normal and diseases states
    Future Diagnostics, BV and Diasource Inc. NAMar 2, 2015 - Jun 29, 2018
    Role: Principal Investigator
    Optimizing vitamin D in the elderly
    NIH R21AG041660Aug 15, 2012 - Jul 31, 2015
    Role: Principal Investigator
    Improving Medication Therapy for Older Patients with Common Co-morbidities
    NIH RC1AG036377Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Older Persons &Drugs: race, gender, and age effects
    NIH R56AG015982Sep 1, 1999 - Aug 31, 2011
    Role: Principal Investigator
    Older Persons &Drugs: race, gender, and age effects
    NIH R01AG015982Sep 1, 1999 - Sep 15, 2010
    Role: Principal Investigator
    GERIATRIC LEADERSHIP ACADEMIC AWARD
    NIH K07AG000768Dec 15, 1997 - Nov 30, 2002
    Role: Principal Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Investigator
    Research Training in Geriatric Medicine
    NIH T32AG000212Sep 1, 1991 - Apr 30, 2023
    Role: Co-Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH S15GM047084Jun 1, 1991 - May 31, 1992
    Role: Principal Investigator
    REGULATION OF CARDIAC RHYTHM AND CONDUCTION WITH AGING
    NIH R01AG009550Feb 1, 1991 - Oct 31, 1997
    Role: Principal Investigator
    EFFECT OF AGING ON CALCIUM BLOCKER KINETICS/DYNAMICS
    NIH R01AG005940Aug 1, 1986 - Jul 31, 1995
    Role: Principal Investigator
    EFFECT OF AGING ON CALCIUM BLOCKER KINETICS/DYNAMICS
    NIH K04AG000327Jan 1, 1986 - Dec 31, 1990
    Role: Principal Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000048Dec 1, 1977 - May 31, 2008
    Role: Co-Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000350Dec 1, 1976 - Nov 30, 1995
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator
    Patient Perspectives on Non-Adherence to Apixaban
    BMS/Pfizer. ARISTA-USA-- pending Pending
    Role: Co-investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A paradigm shift in evaluation of new medications for older adults-A mandate has arrived! J Am Geriatr Soc. 2024 Sep; 72(9):2892-2893. Schwartz JB. PMID: 38822639.
      View in: PubMed   Mentions:    Fields:    
    2. Current status of inclusion of older groups in evaluations of new medications: Gaps and implementation needs to fill them. J Am Geriatr Soc. 2024 Apr 10. Schwartz JB. PMID: 38600697.
      View in: PubMed   Mentions:    Fields:    
    3. Attitudes on participation in clinical drug trials: A nationally representative survey of older adults with multimorbidity. J Am Geriatr Soc. 2024 Jun; 72(6):1717-1727. Schwartz JB, Liu RY, Boscardin J, Liu Q, Lau SWJ, Khatri S, Tarn D. PMID: 38485469; PMCID: PMC11187642.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Representative enrolment of older adults in clinical trials: the time is now. Lancet Healthy Longev. 2023 Jul; 4(7):e301-e303. Schwartz JB. PMID: 37263282.
      View in: PubMed   Mentions: 1     Fields:    
    5. Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban: A Cross-Sectional Survey of Atrial Fibrillation Patients. JACC Adv. 2023 Jan; 2(1):100175. Tarn DM, Shih K, Tseng CH, Thomas A, Schwartz JB. PMID: 38939023; PMCID: PMC11198726.
      View in: PubMed   Mentions: 1  
    6. Participation of Older Adults in Clinical Trials for New Drug Applications and Biologics License Applications From 2010 Through 2019. JAMA Netw Open. 2022 10 03; 5(10):e2236149. Lau SWJ, Huang Y, Hsieh J, Wang S, Liu Q, Slattum PW, Schwartz JB, Huang SM, Temple R. PMID: 36239939; PMCID: PMC9568796.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    7. Polypharmacy in Older Heart Failure Patients: a Multidisciplinary Approach. Curr Heart Fail Rep. 2022 10; 19(5):290-302. Sukumar S, Orkaby AR, Schwartz JB, Marcum Z, Januzzi JL, Vaduganathan M, Warraich HJ. PMID: 35723783.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Apixaban Concentrations in Routine Clinical Care of Older Adults with Non-valvular Atrial Fibrillation. JACC ADV. 2022; 2(1):1-11. Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein, TE, Nutescu, EA, O’Brien, TJ, Tuck M, Perera M.A., Schwartz, JB.
    9. Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation. JACC Adv. 2022 Jun; 1(2). Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein TE, Nutescu EA, O'Brien TJ, Tuck M, Perera MA, Schwartz JB. PMID: 37961076; PMCID: PMC10643025.
      View in: PubMed   Mentions: 1  
    10. Roadmap to 2030 for Drug Evaluation in Older Adults. Clin Pharmacol Ther. 2022 08; 112(2):210-223. Liu Q, Schwartz JB, Slattum PW, Lau SWJ, Guinn D, Madabushi R, Burckart G, Califf R, Cerreta F, Cho C, Cook J, Gamerman J, Goldsmith P, van der Graaf PH, Gurwitz JH, Haertter S, Hilmer S, Huang SM, Inouye SK, Kanapuru B, Pirmohamed M, Posner P, Radziszewska B, Keipp Talbot H, Temple R. PMID: 34656074.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    11. Preventing Bleeding With Direct-Acting Oral Anticoagulants. J Am Coll Cardiol. 2021 10 19; 78(16):e127. Schwartz JB, Kogan SC, Fang MC. PMID: 34649705; PMCID: PMC10631742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Treatment for Alzheimer Disease-Sex and Gender Effects Need to Be Explicitly Analyzed and Reported in Clinical Trials. JAMA Netw Open. 2021 09 01; 4(9):e2124386. Schwartz JB, Weintraub S. PMID: 34515788.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Reasons for nonadherence to the direct oral anticoagulant apixaban for atrial fibrillation. J Am Geriatr Soc. 2021 12; 69(12):3683-3687. Tarn DM, Shih KJ, Schwartz JB. PMID: 34453325; PMCID: PMC8649070.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond. Br J Clin Pharmacol. 2021 09; 87(9):3459-3461. Hilmer SN, Petrovic M, Le Couteur DG, Schwartz JB, Thuermann P. PMID: 34342013; PMCID: PMC8444940.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    15. A challenge: The American Geriatric Society needs to address the lack of inclusion of older adults in new drug evaluation. J Am Geriatr Soc. 2021 09; 69(9):2684-2688. Slattum PW, Schwartz JB. PMID: 34062612.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. Res Pract Thromb Haemost. 2021 May; 5(4):e12528. Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB. PMID: 34013157; PMCID: PMC8114026.
      View in: PubMed   Mentions: 1  
    17. Primary nonadherence to statin medications: Survey of patient perspectives. Prev Med Rep. 2021 Jun; 22:101357. Tarn DM, Pletcher MJ, Tosqui R, Fernandez A, Tseng CH, Moriconi R, Bell DS, Barrientos M, Turner JA, Schwartz JB. PMID: 33842201; PMCID: PMC8020471.
      View in: PubMed   Mentions: 6  
    18. Something Old and Something New: The Time Is Right for Geriatric Engineering Programs. J Am Geriatr Soc. 2021 03; 69(3):613-615. Herr AE, Schwartz JB. PMID: 33421099.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Perceptions of Patients with Primary Nonadherence to Statin Medications. J Am Board Fam Med. 2021 Jan-Feb; 34(1):123-131. Tarn DM, Barrientos M, Pletcher MJ, Cox K, Turner J, Fernandez A, Schwartz JB. PMID: 33452090; PMCID: PMC8903053.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Polypharmacy: A Five-Step Call to Action for Family Physicians. Fam Med. 2020 11; 52(10):699-701. Tarn DM, Schwartz JB. PMID: 33151528.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Prevalence and Knowledge of Potential Interactions Between Over-the-Counter Products and Apixaban. J Am Geriatr Soc. 2020 01; 68(1):155-162. Tarn DM, Barrientos M, Wang AY, Ramaprasad A, Fang MC, Schwartz JB. PMID: 31658372; PMCID: PMC7141171.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation. J Am Geriatr Soc. 2019 09; 67(9):1902-1906. Sukumar S, Gulilat M, Linton B, Gryn SE, Dresser GK, Alfonsi JE, Schwarz UI, Kim RB, Schwartz JB. PMID: 31112620.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Pharmacotherapy Research Priorities in Older Adults With Cardiovascular Disease in Nursing Homes, Assisted Living, and Home Care: Report From a Satellite Symposium of the ACC, AGS, NIA Workshop. J Am Med Dir Assoc. 2019 06; 20(6):787-789. Zarowitz BJ, Nace DA, Brandt N, Schwartz JB. PMID: 30922866; PMCID: PMC11060503.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. Alzheimers Dement (Amst). 2019 Dec; 11:61-66. Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA. PMID: 31032394; PMCID: PMC6477776.
      View in: PubMed   Mentions: 48  
    25. Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. J Am Geriatr Soc. 2019 02; 67(2):371-380. Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW. PMID: 30536694; PMCID: PMC6724196.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    26. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab. 2018 09 01; 103(9):3278-3288. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. PMID: 29955795; PMCID: PMC6126881.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    27. Editorial Commentary: Blood pressure and cognition in the elderly. Trends Cardiovasc Med. 2019 01; 29(1):19-21. Schwartz JB. PMID: 30072095.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease. FASEB J. 2019 01; 33(1):231-238. Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D. PMID: 29924942; PMCID: PMC6355088.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    29. Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable. PLoS One. 2018; 13(4):e0196109. Moore KL, Patel K, Boscardin WJ, Steinman MA, Ritchie C, Schwartz JB. PMID: 29684077; PMCID: PMC5912775.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. High complement levels in astrocyte-derived exosomes of Alzheimer disease. Ann Neurol. 2018 03; 83(3):544-552. Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D. PMID: 29406582; PMCID: PMC5867263.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    31. Farewell to Our Good Friend, Outstanding Mentor, and Colleague Darrell R. Abernethy (1949-2017). Clin Pharmacol Ther. 2018 04; 103(4):552-555. Schwartz JB, Woosley RL, Peck CC. PMID: 29435985.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease. FASEB J. 2018 02; 32(2):888-893. Goetzl EJ, Abner EL, Jicha GA, Kapogiannis D, Schwartz JB. PMID: 29025866; PMCID: PMC5888398.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCellsCTClinical Trials
    33. Authors Have Incorrectly Calculated Need for Renal Dose Adjustments for NOACs. J Am Coll Cardiol. 2017 11 28; 70(21):2731-2732. Schwartz JB. PMID: 29169485.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Dosing Accuracy of Direct Oral Anticoagulants in an Academic Medical Center. J Hosp Med. 2017 07; 12(7):544-550. Schwartz J, Merrill S, de Leon N, Thompson A, Fang M. PMID: 28699943.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017 08; 31(8):3689-3694. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. PMID: 28476896; PMCID: PMC5503715.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    36. Dabigatran Compared With Rivaroxaban vs Warfarin. JAMA Intern Med. 2017 05 01; 177(5):741-742. Schwartz JB. PMID: 28460097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Letter to the Editor: "Effects of Testosterone Replacement on Electrocardiographic Parameters in Men: Findings From Two Randomized Trials". J Clin Endocrinol Metab. 2017 05 01; 102(5):1787. Schwartz JB, Rosano G, Channer KS. PMID: 28482077.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients. AAPS J. 2017 03; 19(2):551-556. Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK. PMID: 28070716; PMCID: PMC10118240.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Potential impact of substituting estimated Glomerular Filtration Rate for estimated Creatinine Clearance for dosing of Direct Oral Anticoagulants. J Am Geriatr Soc. 2016; 1996-2002. Schwartz, JB.
    40. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. FASEB J. 2016 12; 30(12):4141-4148. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. PMID: 27601437; PMCID: PMC5102122.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansCells
    41. Potential Effect of Substituting Estimated Glomerular Filtration Rate for Estimated Creatinine Clearance for Dosing of Direct Oral Anticoagulants. J Am Geriatr Soc. 2016 10; 64(10):1996-2002. Schwartz JB. PMID: 27549687.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    42. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. FASEB J. 2016 11; 30(11):3853-3859. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. PMID: 27511944; PMCID: PMC5067254.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    43. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72. Schwartz JB, Kane L, Bikle D. PMID: 26782853; PMCID: PMC4724876.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    44. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology. 2015 Jul 07; 85(1):40-7. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D. PMID: 26062630; PMCID: PMC4501943.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansCells
    45. Low neural exosomal levels of cellular survival factors in Alzheimer's disease. Ann Clin Transl Neurol. 2015 Jul; 2(7):769-73. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D. PMID: 26273689; PMCID: PMC4531059.
      View in: PubMed   Mentions: 113     Fields:    
    46. Cardiovascular physiology in the older adults. J Geriatr Cardiol. 2015 May; 12(3):196-201. Dai X, Hummel SL, Salazar JB, Taffet GE, Zieman S, Schwartz JB. PMID: 26089840; PMCID: PMC4460159.
      View in: PubMed   Mentions: 43  
    47. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. PMID: 25757956; PMCID: PMC4567539.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    48. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J. 2015 Feb; 29(2):589-96. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. PMID: 25342129; PMCID: PMC4314222.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansCells
    49. Primary prevention: do the very elderly require a different approach? Trends Cardiovasc Med. 2015 Apr; 25(3):228-39. Schwartz JB. PMID: 25560975; PMCID: PMC4374025.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    50. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. PMID: 25130657; PMCID: PMC4329112.
      View in: PubMed   Mentions: 449     Fields:    Translation:HumansCells
    51. Prescribing quality in older veterans: a multifocal approach. J Gen Intern Med. 2014 Oct; 29(10):1379-86. Steinman MA, Miao Y, Boscardin WJ, Komaiko KD, Schwartz JB. PMID: 25002159; PMCID: PMC4175643.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    52. Patterns of chronic co-morbid medical conditions in older residents of U.S. nursing homes: differences between the sexes and across the agespan. J Nutr Health Aging. 2014 Apr; 18(4):429-36. Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. PMID: 24676326; PMCID: PMC4099251.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    53. Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States. J Int Assoc Provid AIDS Care. 2014 May-Jun; 13(3):250-9. Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM. PMID: 24668135; PMCID: PMC4016117.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Variability in free 25(OH) vitamin D levels in clinical populations. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:156-8. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. PMID: 24240067; PMCID: PMC4022715.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    55. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J Clin Endocrinol Metab. 2013 Nov; 98(11):4400-9. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. PMID: 24030939; PMCID: PMC3816263.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    56. Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages. FASEB J. 2013 Dec; 27(12):5141-50. Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ. PMID: 24014820; PMCID: PMC3834783.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    57. Patterns of multimorbidity in elderly veterans. J Am Geriatr Soc. 2012 Oct; 60(10):1872-80. Steinman MA, Lee SJ, John Boscardin W, Miao Y, Fung KZ, Moore KL, Schwartz JB. PMID: 23035702; PMCID: PMC4133992.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    58. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. FASEB J. 2013 Jan; 27(1):342-9. Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ. PMID: 22972918; PMCID: PMC3528313.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    59. Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes. J Am Geriatr Soc. 2012 Apr; 60(4):756-64. Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. PMID: 22463062; PMCID: PMC3387922.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    60. Distinctive immunoregulatory effects of adenosine on T cells of older humans. FASEB J. 2012 Mar; 26(3):1301-10. Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ. PMID: 22121051; PMCID: PMC3289505.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    61. Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. J Clin Immunol. 2011 Oct; 31(5):744-51. Goetzl EJ, Schwartz JB, Huang MC. PMID: 21671128.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    62. Effects of testosterone on the Q-T interval in older men and older women with chronic heart failure. Int J Androl. 2011 Oct; 34(5 Pt 2):e415-21. Schwartz JB, Volterrani M, Caminiti G, Marazzi G, Fini M, Rosano GM, Iellamo F. PMID: 21615419.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    63. Failure of pharmacogenetic-based dosing algorithms to identify older patients requiring low daily doses of warfarin. J Am Med Dir Assoc. 2011 Nov; 12(9):633-8. Schwartz JB, Kane L, Moore K, Wu AH. PMID: 21450231.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    64. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clin Immunol. 2011 Feb; 138(2):201-11. Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ. PMID: 21130040; PMCID: PMC4642720.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    65. Gender specificity of altered human immune cytokine profiles in aging. FASEB J. 2010 Sep; 24(9):3580-9. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL. PMID: 20453111; PMCID: PMC2923363.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    66. Population analyses of atorvastatin clearance in patients living in the community and in nursing homes. Clin Pharmacol Ther. 2009 Nov; 86(5):497-502. Schwartz JB, Verotta D. PMID: 19571802.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    67. Clin Pharmacol Ther. Aging and medications: Past, Present, Future. 2009; 1(85):3-10. Schwartz JB and Abernethy, DR. 2009; 85 (1): 3-10.
    68. Clin Pharmacol Ther. Population analyses of atorvastatin in patients living in the community and nursing homes. 2009; 86:497-502. Verotta D, Schwartz JB.
    69. Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence. Clin Pharmacol Ther. 2009 Feb; 85(2):198-203. Schwartz JB. PMID: 18754003.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    70. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther. 2007 Jul; 82(1):87-96. Schwartz JB. PMID: 17495875.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    71. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. Circulation. 2006 Sep 26; 114(13):1380-7. Alexander KP, Chen AY, Newby LK, Schwartz JB, Redberg RF, Hochman JS, Roe MT, Gibler WB, Ohman EM, Peterson ED, CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Ea. PMID: 16982940.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    72. Erythromycin breath test results in elderly, very elderly, and frail elderly persons. Clin Pharmacol Ther. 2006 May; 79(5):440-8. Schwartz JB. PMID: 16678546.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    73. Population analyses of amlodipine in patients living in the community and patients living in nursing homes. Clin Pharmacol Ther. 2006 Jan; 79(1):114-24. Kang D, Verotta D, Schwartz JB. PMID: 16413246.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    74. Sample size computations for PK/PD population models. J Pharmacokinet Pharmacodyn. 2005 Dec; 32(5-6):685-701. Kang D, Schwartz JB, Verotta D. PMID: 16284914.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    75. What does the Medicare prescription drug legislation mean for the American cardiologist? Am J Geriatr Cardiol. 2005 Nov-Dec; 14(6):317-24. Schwartz JB, Redberg RF. PMID: 16276130.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    76. Estrogen and progestin use and the QT interval in postmenopausal women. Ann Noninvasive Electrocardiol. 2004 Oct; 9(4):366-74. Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. PMID: 15485516; PMCID: PMC6932472.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    77. A sample size computation method for non-linear mixed effects models with applications to pharmacokinetics models. Stat Med. 2004 Aug 30; 23(16):2551-66. Kang D, Schwartz JB, Verotta D. PMID: 15287084.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    78. Sudden cardiac death among women in the United States. Circulation. 2003 Nov 25; 108(21):e153; author reply e153. Schwartz JB. PMID: 14638535.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    79. Gender-specific implications for cardiovascular medication use in the elderly optimizing therapy for older women. Cardiol Rev. 2003 Sep-Oct; 11(5):275-98. Schwartz JB. PMID: 12943605.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    80. The influence of sex on pharmacokinetics. Clin Pharmacokinet. 2003; 42(2):107-21. Schwartz JB. PMID: 12537512.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimals
    81. Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking. Clin Pharmacol Ther. 2003 Jan; 73(1):31-40. Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB. PMID: 12545141.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    82. Pharmacologic agents for weight reduction. J Gend Specif Med. 2002 Sep-Oct; 5(5):16-21. Haller C, Schwartz JB. PMID: 12380196.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    83. Peripheral arterial disease: drug therapy. J Gend Specif Med. 2002 Jul-Aug; 5(4):16-20. Schwartz JB. PMID: 12192882.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    84. Pharmacogenetics: has it reached the clinic? J Gend Specif Med. 2002 Mar-Apr; 5(2):13-8. Schwartz JB. PMID: 11974670.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    85. Anticoagulant and thrombolytic therapies in women. J Gend Specif Med. 2002 Jan-Feb; 5(1):14-8. Schwartz JB. PMID: 11859682.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    86. Drug Interactions in the Elderly With Coronary Artery Disease - Do These Interfere With Effective Therapy? Am J Geriatr Cardiol. 1998 Jan; 7(1):14-21. Schwartz JB. PMID: 11416440.
      View in: PubMed   Mentions:    Fields:    
    87. Age-Related Pharmacodynamic Changes in the Elderly: Treatment Considerations in Heart Failure. Am J Geriatr Cardiol. 1996 Jan; 5(1):52-55. Schwartz JB. PMID: 11416366.
      View in: PubMed   Mentions:    Fields:    
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