My research program seeks to advance understanding of risk factors for heart disease and stroke in order to improve prevention, risk stratification, and treatment of these disorders. These investigations leverage molecular epidemiology and cardiovascular imaging to identify biochemical markers and endophenotypes involved in the initiation, development and progression of cardiovascular diseases.
My work involves various NIH-funded longitudinal cohort studies, including the Cardiovascular Health Study, the Strong Heart Study, the Multi-Ethnic Study of Atherosclerosis, the Hispanic Community Heath Study / Study of Latinos, and the Women’s Interagency HIV Study. A major focus is the interrelationship of glucose and lipid metabolism, bone and mineral disease, and cardiovascular disorders, particularly in the context of aging and HIV. A new thrust is the application of next-generation sequencing technologies and advances in non-invasive imaging to make inroads into pathophysiology and potential therapeutics.