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Jorge Palop, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentNeurology
AddressLocation Required
Varies CA 00000
Phone415-734-2661
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    Collapse Research 
    Collapse Research Activities and Funding
    Restoring Brain Functions in Alzheimer Models with Interneuron Transplants
    NIH/NIA R01AG047313May 15, 2014 - Apr 30, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Palop J, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016 12; 17(12):777-792. PMID: 27829687.
      View in: PubMed
    2. Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop J, Akassoglou K. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-ß signaling and astrocyte functions. Nat Neurosci. 2015 Aug; 18(8):1077-80. PMID: 26120963; PMCID: PMC4878404.
    3. Heng MY, Lin ST, Verret L, Huang Y, Kamiya S, Padiath QS, Tong Y, Palop J, Huang EJ, Ptácek LJ, Fu YH. Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. J Clin Invest. 2013 Jun; 123(6):2719-29. PMID: 23676464; PMCID: PMC3668844.
    4. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop J, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):E2895-903. PMID: 22869752; PMCID: PMC3479491.
    5. Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop J. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012 Apr 27; 149(3):708-21. PMID: 22541439; PMCID: PMC3375906.
    6. Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop J, Noebels JL, Mucke L. Amyloid-ß/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):700-11. PMID: 21228179; PMCID: PMC3325794.
    7. Palop J, Roberson ED, Cobos I. Step-by-step in situ hybridization method for localizing gene expression changes in the brain. Methods Mol Biol. 2011; 670:207-30. PMID: 20967593.
      View in: PubMed
    8. Palop J, Mucke L, Roberson ED. Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling. Methods Mol Biol. 2011; 670:245-62. PMID: 20967595.
      View in: PubMed
    9. Harris JA, Devidze N, Verret L, Ho K, Halabisky B, Thwin MT, Kim D, Hamto P, Lo I, Yu GQ, Palop J, Masliah E, Mucke L. Transsynaptic progression of amyloid-ß-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron. 2010 Nov 04; 68(3):428-41. PMID: 21040845; PMCID: PMC3050043.
    10. Peebles CL, Yoo J, Thwin MT, Palop J, Noebels JL, Finkbeiner S. Arc regulates spine morphology and maintains network stability in vivo. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18173-8. PMID: 20921410; PMCID: PMC2964216.
    11. Buttini M, Masliah E, Yu GQ, Palop J, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol. 2010 Aug; 177(2):563-9. PMID: 20595630; PMCID: PMC2913361.
    12. Palop J, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci. 2010 Jul; 13(7):812-8. PMID: 20581818; PMCID: PMC3072750.
    13. Gittis AH, Nelson AB, Thwin MT, Palop J, Kreitzer AC. Distinct roles of GABAergic interneurons in the regulation of striatal output pathways. J Neurosci. 2010 Feb 10; 30(6):2223-34. PMID: 20147549; PMCID: PMC2836801.
    14. Sun B, Halabisky B, Zhou Y, Palop J, Yu G, Mucke L, Gan L. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 2009 Dec 04; 5(6):624-33. PMID: 19951690; PMCID: PMC2823799.
    15. Palop J, Mucke L. Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin? Neuromolecular Med. 2010 Mar; 12(1):48-55. PMID: 19838821; PMCID: PMC3319077.
    16. Palop J, Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol. 2009 Apr; 66(4):435-40. PMID: 19204149; PMCID: PMC2812914.
    17. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop J, Bonventre JV, Mucke L. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci. 2008 Nov; 11(11):1311-8. PMID: 18931664; PMCID: PMC2597064.
    18. Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop J, Wu T, Scearce-Levie K, Mucke L. Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008 May 07; 28(19):5007-17. PMID: 18463254; PMCID: PMC3315282.
    19. Palop J, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007 Sep 06; 55(5):697-711. PMID: 17785178.
      View in: PubMed
    20. Cheng IH, Scearce-Levie K, Legleiter J, Palop J, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem. 2007 Aug 17; 282(33):23818-28. PMID: 17548355.
      View in: PubMed
    21. Roberson ED, Scearce-Levie K, Palop J, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 04; 316(5825):750-4. PMID: 17478722.
      View in: PubMed
    22. Chin J, Massaro CM, Palop J, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L. Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. J Neurosci. 2007 Mar 14; 27(11):2727-33. PMID: 17360894.
      View in: PubMed
    23. Deipolyi AR, Fang S, Palop J, Yu GQ, Wang X, Mucke L. Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiol Aging. 2008 Feb; 29(2):253-66. PMID: 17126954.
      View in: PubMed
    24. Palop J, Chin J, Mucke L. A network dysfunction perspective on neurodegenerative diseases. Nature. 2006 Oct 19; 443(7113):768-73. PMID: 17051202.
      View in: PubMed
    25. Palop J, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L. Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. J Neurosci. 2005 Oct 19; 25(42):9686-93. PMID: 16237173.
      View in: PubMed
    26. Chin J, Palop J, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2005 Oct 19; 25(42):9694-703. PMID: 16237174.
      View in: PubMed
    27. Cheng IH, Palop J, Esposito LA, Bien-Ly N, Yan F, Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med. 2004 Nov; 10(11):1190-2. PMID: 15502844.
      View in: PubMed
    28. Chin J, Palop J, Yu GQ, Kojima N, Masliah E, Mucke L. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci. 2004 May 12; 24(19):4692-7. PMID: 15140940.
      View in: PubMed
    29. Palop J, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9572-7. PMID: 12881482; PMCID: PMC170959.
    30. López-García C, Varea E, Palop J, Nacher J, Ramirez C, Ponsoda X, Molowny A. Cytochemical techniques for zinc and heavy metals localization in nerve cells. Microsc Res Tech. 2002 Mar 01; 56(5):318-31. PMID: 11877810.
      View in: PubMed
    31. Nacher J, Palop J, Ramirez C, Molowny A, Lopez-Garcia C. Early histological maturation in the hippocampus of the guinea pig. Brain Behav Evol. 2000 Jun; 56(1):38-44. PMID: 11025343.
      View in: PubMed
    32. Nacher J, Ramírez C, Palop J, Molowny A, Luis de la Iglesia JA, López-García C. Radial glia and cell debris removal during lesion-regeneration of the lizard medial cortex. Histol Histopathol. 1999 Jan; 14(1):89-101. PMID: 9987654.
      View in: PubMed
    33. Nacher J, Ramírez C, Palop J, Artal P, Molowny A, López-García C. Microglial cells during the lesion-regeneration of the lizard medial cortex. Histol Histopathol. 1999 Jan; 14(1):103-17. PMID: 9987655.
      View in: PubMed
    34. Sanchez-Andres JV, Palop J, Ramirez C, Nacher J, Molowny A, Lopez-Gracia C. Zinc-positive presynaptic boutons of the rabbit hippocampus during early postnatal development. Brain Res Dev Brain Res. 1997 Nov 12; 103(2):171-83. PMID: 9427481.
      View in: PubMed
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