Jae Kyu Ryu, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Gladstone Institute of Neurological Disease, San Francisco Postdoctoral2013Neuroimmunology
    University of British Columbia, Vancouver, Canada Ph.D. 2008Pharmacology
    Collapse Awards and Honors
    American Heart Association 2016  - 2019Scientist Development Grant
    A Race to Erase MS2016  - 2018Young Investigator Award
    National Multiple Sclerosis Society 2011  - 2014Postdoctoral Fellowship
    American Heart Association 2009  - 2011Postdoctoral Fellowship

    Collapse Overview 

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 07; 24(7):1173-1187. Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. PMID: 37291385; PMCID: PMC10307624.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    2. SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy. bioRxiv. 2021 Oct 13. Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K. PMID: 34671772; PMCID: PMC8528086.
      View in: PubMed   Mentions: 1  
    3. BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis. Brain. 2021 09 04; 144(8):2291-2301. Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K. PMID: 34426831; PMCID: PMC8418337.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    4. Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma. Am J Pathol. 2021 03; 191(3):575-583. Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK. PMID: 33608067; PMCID: PMC7919853.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci. 2021 01; 24(1):19-23. Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. PMID: 33318667; PMCID: PMC8118167.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    6. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594; PMCID: PMC7523413.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    7. A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling. Transl Psychiatry. 2019 05 10; 9(1):141. Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS. PMID: 31076569; PMCID: PMC6510753.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    8. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10488-10493. Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. PMID: 31068461; PMCID: PMC6535008.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    9. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019 03 20; 101(6):1099-1108.e6. Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K. PMID: 30737131; PMCID: PMC6602536.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    10. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    11. Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain. 2018 06 01; 141(6):1637-1649. Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS. PMID: 29688408; PMCID: PMC5972667.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    12. Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics. Nat Rev Neurosci. 2018 05; 19(5):283-301. Petersen MA, Ryu JK, Akassoglou K. PMID: 29618808; PMCID: PMC6743980.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimals
    13. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804; PMCID: PMC5851281.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    14. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature. 2017 08 10; 548(7666):228-233. Xu T, Stewart KM, Wang X, Liu K, Xie M, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S. PMID: 28783731; PMCID: PMC6701955.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    15. Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity. J Exp Med. 2017 04 03; 214(4):1081-1092. Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. PMID: 28298456; PMCID: PMC5379986.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    16. Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. J Neurosci. 2017 04 05; 37(14):3776-3788. Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Ryu JK, Akassoglou K, Mullins ES. PMID: 28275164; PMCID: PMC5394895.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    17. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 26748707; PMCID: PMC4831919.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015 Sep 10; 6:8164. Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. PMID: 26353940; PMCID: PMC4579523.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    19. Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease. J Neuroinflammation. 2015 Aug 09; 12:144. Ryu JK, Cho T, Choi HB, Jantaratnotai N, McLarnon JG. PMID: 26255110; PMCID: PMC4529987.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    20. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci. 2015 Aug; 18(8):1077-80. Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. PMID: 26120963; PMCID: PMC4878404.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med. 2015 May 04; 212(5):607-17. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25918343; PMCID: PMC4419343.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    22. Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2015 Mar 17; 20:667-75. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. PMID: 25365546; PMCID: PMC4398668.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    23. Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease eNeuro. 2015 Mar-Apr; 2(2). Le Moan N, Baeten KM, Rafalski VA, Ryu JK, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K. PMID: 26213713; PMCID: PMC4511492.
      View in: PubMed   Mentions: 5     Fields:    
    24. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8. Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. PMID: 24740641; PMCID: PMC4049631.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    25. Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells. PLoS One. 2013; 8(10):e76860. Cho T, Ryu JK, Taghibiglou C, Ge Y, Chan AW, Liu L, Lu J, McLarnon JG, Wang YT. PMID: 24146937; PMCID: PMC3798289.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    26. Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease. Curr Alzheimer Res. 2013 Mar; 10(3):252-60. Ryu JK, Little JP, Klegeris A, Jantaratnotai N, McLarnon JG. PMID: 23534534.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron. 2012 Sep 20; 75(6):1094-104. Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J, MacVicar BA. PMID: 22998876; PMCID: PMC3630998.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    28. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012; 3:1227. Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. PMID: 23187627; PMCID: PMC3514498.
      View in: PubMed   Mentions: 296     Fields:    Translation:AnimalsCells
    29. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec; 70(6):986-995. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. PMID: 22190370; PMCID: PMC4556354.
      View in: PubMed   Mentions: 264     Fields:    Translation:AnimalsCells
    30. Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain. Int J Alzheimers Dis. 2011; 2011:918280. Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. PMID: 21969915; PMCID: PMC3182764.
      View in: PubMed   Mentions: 20  
    31. Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease. Neurobiol Dis. 2012 Jan; 45(1):438-49. Franciosi S, Ryu JK, Shim Y, Hill A, Connolly C, Hayden MR, McLarnon JG, Leavitt BR. PMID: 21946335.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    32. Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo. J Alzheimers Dis. 2011; 27(3):531-41. Hashioka S, McLarnon JG, Ryu JK, Youssef AM, Abd-El-Aziz AS, Neeland EG, Klegeris A. PMID: 21841251.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    33. Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model. J Neuropathol Exp Neurol. 2011 Jan; 70(1):13-22. Ryu JK, Jantaratnotai N, Serrano-Perez MC, McGeer PL, McLarnon JG. PMID: 21157381.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    34. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci. 2010 Apr 28; 30(17):5843-54. Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. PMID: 20427645; PMCID: PMC2871011.
      View in: PubMed   Mentions: 195     Fields:    Translation:AnimalsCells
    35. Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus. BMC Neurosci. 2010 Mar 26; 11:42. Kim YB, Ryu JK, Lee HJ, Lim IJ, Park D, Lee MC, Kim SU. PMID: 20346117; PMCID: PMC2861065.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    36. Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain. J Neuroinflammation. 2009 Dec 23; 6:39. Ryu JK, Cho T, Wang YT, McLarnon JG. PMID: 20030829; PMCID: PMC2804572.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    37. Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia. 2009 Jun; 57(8):898-907. Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU, Masuda J. PMID: 19115379.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    38. Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. J Neurosci. 2009 Jan 07; 29(1):3-13. Ryu JK, Cho T, Choi HB, Wang YT, McLarnon JG. PMID: 19129379; PMCID: PMC6664925.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    39. Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport. 2008 Nov 19; 19(17):1715-9. Ryu JK, McLarnon JG. PMID: 18852683.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    40. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med. 2009 Sep; 13(9A):2911-25. Ryu JK, McLarnon JG. PMID: 18657226; PMCID: PMC4498946.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    41. VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult. J Neuroinflammation. 2008 May 20; 5:18. Ryu JK, McLarnon JG. PMID: 18492281; PMCID: PMC2430697.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Expression and function of the P2X(7) receptor in rat C6 glioma cells. Cancer Lett. 2008 Feb 18; 260(1-2):79-87. Wei W, Ryu JK, Choi HB, McLarnon JG. PMID: 18039556.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    43. Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-alpha in an animal model of inflamed Alzheimer's disease brain. Neurobiol Dis. 2008 Feb; 29(2):254-66. Ryu JK, McLarnon JG. PMID: 17964176.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    44. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci. 2007 May 02; 27(18):4957-68. Choi HB, Ryu JK, Kim SU, McLarnon JG. PMID: 17475804; PMCID: PMC6672082.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    45. Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo. Glia. 2007 Mar; 55(4):439-51. Ryu JK, Tran KC, McLarnon JG. PMID: 17203474.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. J Neurosci. 2006 Nov 08; 26(45):11652-64. Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG. PMID: 17093087; PMCID: PMC6674791.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    47. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. J Neuropathol Exp Neurol. 2006 Nov; 65(11):1090-7. McLarnon JG, Ryu JK, Walker DG, Choi HB. PMID: 17086106.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    48. Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus. Exp Neurol. 2006 Apr; 198(2):552-7. Ryu JK, McLarnon JG. PMID: 16480717.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    49. Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B. Brain Res. 2005 Dec 20; 1066(1-2):120-8. Nagai A, Ryu JK, Terashima M, Tanigawa Y, Wakabayashi K, McLarnon JG, Kobayashi S, Masuda J, Kim SU. PMID: 16325785.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    50. Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Neurobiol Dis. 2005 Nov; 20(2):550-61. Ryu JK, Choi HB, McLarnon JG. PMID: 15916899.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    51. Induction of angiogenesis by platelet-activating factor in the rat striatum. Neuroreport. 2005 Sep 28; 16(14):1579-83. Tran KC, Ryu JK, McLarnon JG. PMID: 16148749.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    52. Induction of angiogenesis in the beta-amyloid peptide-injected rat hippocampus. Neuroreport. 2005 Feb 08; 16(2):129-32. Zand L, Ryu JK, McLarnon JG. PMID: 15671861.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    53. Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus. Glia. 2004 Oct; 48(1):85-90. Ryu JK, Franciosi S, Sattayaprasert P, Kim SU, McLarnon JG. PMID: 15326618.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    54. Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease. Neurobiol Dis. 2004 Jun; 16(1):68-77. Ryu JK, Kim J, Cho SJ, Hatori K, Nagai A, Choi HB, Lee MC, McLarnon JG, Kim SU. PMID: 15207263.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    55. Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease. Exp Neurol. 2004 May; 187(1):150-9. Ryu JK, Kim SU, McLarnon JG. PMID: 15081596.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    56. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiol Dis. 2003 Nov; 14(2):181-93. Choi SH, Lee DY, Ryu JK, Kim J, Joe EH, Jin BK. PMID: 14572441.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    57. Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease. Exp Neurol. 2003 Oct; 183(2):700-4. Ryu JK, Kim SU, McLarnon JG. PMID: 14552912.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    58. Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo. Neuroreport. 2003 Aug 06; 14(11):1429-33. Jantaratnotai N, Ryu JK, Kim SU, McLarnon JG. PMID: 12960758.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    59. Differential activation of subtype purinergic receptors modulates Ca(2+) mobilization and COX-2 in human microglia. Glia. 2003 Aug; 43(2):95-103. Choi HB, Hong SH, Ryu JK, Kim SU, McLarnon JG. PMID: 12838502.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    60. Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase. J Neurosci Res. 2003 May 01; 72(3):352-62. Ryu JK, Choi HB, Hatori K, Heisel RL, Pelech SL, McLarnon JG, Kim SU. PMID: 12692902.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    61. Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies. Neurobiol Dis. 2003 Mar; 12(2):121-32. Ryu JK, Nagai A, Kim J, Lee MC, McLarnon JG, Kim SU. PMID: 12667467.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    62. Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J Neurochem. 2002 Nov; 83(3):546-55. Choi HB, Khoo C, Ryu JK, van Breemen E, Kim SU, McLarnon JG. PMID: 12390516.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    63. Cystatin C induces neuronal cell death in vivo. Ann N Y Acad Sci. 2002 Nov; 977:315-21. Nagai A, Ryu JK, Kobayash S, Kim SU. PMID: 12480767.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    64. ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors. Neuroreport. 2002 Sep 16; 13(13):1611-5. Ryu JK, Kim J, Choi SH, Oh YJ, Lee YB, Kim SU, Jin BK. PMID: 12352612.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    65. Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res. 2002 Aug 01; 69(3):418-26. Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU. PMID: 12125082.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    66. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. 2002 Apr 01; 38(1):15-23. Ryu JK, Shin WH, Kim J, Joe EH, Lee YB, Cho KG, Oh YJ, Kim SU, Jin BK. PMID: 11921200.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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