Loading...

Katerina Akassoglou, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2512
ORCID ORCID Icon0000-0002-2632-1465 Additional info
vCardDownload vCard
    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    New York University , New York, NY Postdoc 2003Neuroscience
    The Rockefeller University , New York, NYPostdoc 2002Neurovascular Biology
    University of Athens, Athens, Greece PhD1998Neuroimmunology
    University of Vienna , Vienna, Austria1996Neuropathology
    University of Athens, Athens, Greece BSc1996Biology
    Collapse Awards and Honors
    NMSS2019Barancik Prize for Innovation in MS Research
    Annals of Neurology 2018Annals of Neurology Editorial Board
    NINDS2016Research Program Award R35
    Conrad N. Hilton Foundation2015Marilyn Hilton Award for Innovation in MS Research
    ASPET2015Secretary/Treasurer Molecular Pharmacology
    ASPET2013Molecular Pharmacology Executive Committee Member
    F10002011F1000 Neuronal and Glial Cell Biology Section member
    NINDS2010EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration)
    The Vilcek Foundation 2009Vilcek Prize for Creative Promise Finalist Award
    Dana Foundation2007Dana Award in Brain and Immunoimaging
    ASPET & Eli Lilly2007The John J Abel Award in Pharmacology
    The White House2006Presidential Early Career Award for Scientists and Engineers
    International Fibrinogen Society2006Young Investigator Award
    International Society for Neurochemistry2002Young Investigator Award
    International Society for Fibrinolysis and Proteolysis2000Young Investigator Award
    Human Frontier Science Program (HFSP)1999Postdoctoral Fellowship
    International Society of Neuroimmunology (ISNI)1998Women in Neuroimmunology Award
    European League Against Rheumatism (EULAR)1998Young Investigator Award
    UK Multiple Sclerosis Society1997Best Poster Award
    European Molecular Biology Organization (EMBO)1996Short-term Fellowship
    University of Ioannina, Greece1996Young Investigator Award
    Hellenic State Fellowship Foundation 1990Best Undergraduate Student Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Akassoglou has pioneered studies in the investigation of vascular and immune mechanisms in neurologic diseases, and in particular the role of the blood clotting factors in CNS autoimmunity, trauma, and neurodegeneration. Her aim is to understand the mechanisms that control the communication between the brain, immune and vascular systems with the ultimate goal to design novel therapies for neurologic diseases—and in particular, multiple sclerosis and neurodegenerative diseases.

    Dr. Akassoglou identified blood clotting factors as major mediators of neurologic disease. She made the unanticipated discovery that the blood clotting factor fibrinogen is a major activator of innate immune responses in the CNS. She developed novel imaging tools to study the neurovascular interface and therapeutic strategies to protect from neuroimmune diseases by blocking the damaging effects of blood factors in the brain without affecting their beneficial effects in blood clotting. Dr. Akassoglou takes a multifaceted approach to her research, incorporating animal modeling, in vivo two-photon microscopy, drug discovery, preclinical translational research, and biomarker studies. Dr. Akassoglou has published over 80 papers in peer-reviewed journals and she is active in several national and international organizations, editorial boards, and funding agencies.

    Dr. Akassoglou earned a BSc degree in biology and a PhD in neurobiology at the University of Athens, Greece. She was trained in neuropathology at the University of Vienna before performing her postdoctoral work at the Rockefeller University, and New York University. She started her laboratory as an Assistant Professor at the Department of Pharmacology at the University of California, San Diego where she was promoted to Associate Professor with tenure. She is now a Senior Investigator at the Gladstone Institute of Neurological Disease, and a Professor in the Department of Neurology at the University of California, San Francisco. She is also the founder and Director of the Gladstone Center for In Vivo Imaging Research, Associate Adjunct Professor of Pharmacology at the University of California, San Diego, and Secretary/Treasurer of the Molecular Pharmacology Division of ASPET.

    Collapse Research 
    Collapse Research Activities and Funding
    Fibrinogen and vascular cognitive impairment: mechanisms, imaging, therapeutics
    NIH/NIA R01AG064926Aug 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Neurovascular Interactions: Mechanisms, imaging, therapeutic potential
    NIH R35NS097976Sep 1, 2016 - Aug 31, 2024
    Role: Principal Investigator
    Mechanisms of Fibrin Action in Neuronal Functions
    NIH R21NS082976Mar 15, 2014 - Feb 29, 2016
    Role: Principal Investigator
    2014 Plasminogen Activation and Extracellular Proteolysis Gordon Research Confere
    NIH R13HL121916Feb 1, 2014 - Jan 31, 2015
    Role: Principal Investigator
    Imaging signal transduction in the living mouse brain using two-photon microscopy
    NIH R01NS066361Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Mechanisms of Fibrin Action in Multiple Sclerosis
    NIH R01NS052189Jul 15, 2005 - Jun 30, 2018
    Role: Principal Investigator
    Mechanisms and functions of p75 neurotrophin receptor signaling in astrocytes
    NIH R01NS051470Mar 18, 2005 - Mar 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The immunology of blood: connecting the dots at the neurovascular interface. Nat Immunol. 2020 Jul; 21(7):710-712. Akassoglou K. PMID: 32577008.
      View in: PubMed   Mentions:    Fields:    
    2. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Nat Commun. 2020 01 31; 11(1):630. Pous L, Deshpande SS, Nath S, Mezey S, Malik SC, Schildge S, Bohrer C, Topp K, Pfeifer D, Fernández-Klett F, Doostkam S, Galanakis DK, Taylor V, Akassoglou K, Schachtrup C. PMID: 32005867.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord. Exp Neurol. 2019 12; 322:113046. Borjini N, Paouri E, Tognatta R, Akassoglou K, Davalos D. PMID: 31472115.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10488-10493. Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. PMID: 31068461.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019 03 20; 101(6):1099-1108.e6. Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K. PMID: 30737131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. Br J Anaesth. 2019 Mar; 122(3):350-360. Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang XM, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N. PMID: 30770053.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    8. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Pericytes: The Brain's Very First Responders? Neuron. 2018 10 10; 100(1):11-13. Rafalski VA, Merlini M, Akassoglou K. PMID: 30308164.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10172-10177. Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L. PMID: 30232263.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1. Dev Cell. 2018 08 06; 46(3):376-387.e7. Pathak A, Stanley EM, Hickman FE, Wallace N, Brewer B, Li D, Gluska S, Perlson E, Fuhrmann S, Akassoglou K, Bronfman F, Casaccia P, Burnette DT, Carter BD. PMID: 30086304.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain. 2018 06 01; 141(6):1637-1649. Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS. PMID: 29688408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics. Nat Rev Neurosci. 2018 05; 19(5):283-301. Petersen MA, Ryu JK, Akassoglou K. PMID: 29618808.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    14. In Vivo Imaging of CNS Injury and Disease. J Neurosci. 2017 11 08; 37(45):10808-10816. Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B. PMID: 29118209.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    15. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature. 2017 08 10; 548(7666):228-233. Xu T, Stewart KM, Wang X, Liu K, Xie M, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S. PMID: 28783731.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    17. Alzheimer disease makes new blood contacts. Blood. 2017 05 04; 129(18):2462-2463. Merlini M, Akassoglou K. PMID: 28473412.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Microglial NF?B-TNFa hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):5029-5034. Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV, Gan L. PMID: 28438992.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    19. Microglial complement receptor 3 regulates brain Aß levels through secreted proteolytic activity. J Exp Med. 2017 04 03; 214(4):1081-1092. Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. PMID: 28298456.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. J Neurosci. 2017 04 05; 37(14):3776-3788. Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Ryu JK, Akassoglou K, Mullins ES. PMID: 28275164.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy. Front Cell Neurosci. 2016; 10:303. Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE. PMID: 28119571.
      View in: PubMed   Mentions:
    22. Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation. Nat Immunol. 2016 12 16; 18(1):7-8. Bardehle S, Rafalski V, Akassoglou K. PMID: 27984564.
      View in: PubMed   Mentions:    Fields:    
    23. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):E6686-E6695. Zhang MD, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, Andreska T, Akassoglou K, Harkany T, Hökfelt TG, Terrando N. PMID: 27791037.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. PMID: 26941593.
      View in: PubMed   Mentions:
    25. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 26748707.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. Breaking boundaries-coagulation and fibrinolysis at the neurovascular interface. Front Cell Neurosci. 2015; 9:354. Bardehle S, Rafalski VA, Akassoglou K. PMID: 26441525.
      View in: PubMed   Mentions:
    27. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015 Sep 10; 6:8164. Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. PMID: 26353940.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    28. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-ß signaling and astrocyte functions. Nat Neurosci. 2015 Aug; 18(8):1077-80. Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. PMID: 26120963.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 Jun 01; 212(6):973. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25987725.
      View in: PubMed   Mentions: 4     Fields:    
    30. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 May 04; 212(5):607-17. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. PMID: 25918343.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    31. Stimulation of the a7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2015 Mar 17; 20:667-75. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. PMID: 25365546.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    32. Hypoxia Inducible Factor-1a in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease eNeuro. 2015 Mar-Apr; 2(2). Le Moan N, Baeten KM, Rafalski VA, Ryu JK, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K. PMID: 26213713.
      View in: PubMed   Mentions: 1     Fields:    
    33. Coagulation takes center stage in inflammation. Blood. 2015 Jan 15; 125(3):419-20. Akassoglou K. PMID: 25593329.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    34. Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia. 2014 Aug; 62(8):1345-60. Gyoneva S, Davalos D, Biswas D, Swanger SA, Garnier-Amblard E, Loth F, Akassoglou K, Traynelis SF. PMID: 24807189.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    35. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8. Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. PMID: 24740641.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    36. p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19; 33(25):10221-34. Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny IF, Sassone-Corsi P, Ptácek LJ, Akassoglou K. PMID: 23785138.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):305-10. Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. PMID: 23241407.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    38. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. PMID: 23223453.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansAnimalsCells
    39. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013 Feb; 9(2):97-104. Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. PMID: 23201900.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    40. In vivo imaging of the neurovascular unit in CNS disease. Intravital. 2012 Dec 01; 1(2):87-94. Merlini M, Davalos D, Akassoglou K. PMID: 25197615.
      View in: PubMed   Mentions:
    41. Mutant huntingtin impairs immune cell migration in Huntington disease. J Clin Invest. 2012 Dec; 122(12):4737-47. Kwan W, Träger U, Davalos D, Chou A, Bouchard J, Andre R, Miller A, Weiss A, Giorgini F, Cheah C, Möller T, Stella N, Akassoglou K, Tabrizi SJ, Muchowski PJ. PMID: 23160193.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    42. Glucose homeostasis and p75NTR: the sweet side of neurotrophin receptor signaling. Cell Cycle. 2012 Sep 01; 11(17):3151-2. Baeza-Raja B, Akassoglou K. PMID: 22894898.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5838-43. Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 22460790.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    44. p75 (NTR) and hypoxia: a breath of fresh air in neurotrophin receptor signaling. Cell Cycle. 2012 Mar 01; 11(5):829-30. Le Moan N, Baeza-Raja B, Akassoglou K. PMID: 22333586.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    45. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. PMID: 22198221.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    46. In vivo imaging of the mouse spinal cord using two-photon microscopy. J Vis Exp. 2012 Jan 05; (59):e2760. Davalos D, Akassoglou K. PMID: 22258623.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    47. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012; 3:1227. Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. PMID: 23187627.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    48. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec; 70(6):986-995. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. PMID: 22190370.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    49. Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1a. Mol Cell. 2011 Nov 04; 44(3):476-90. Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K. PMID: 22055192.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    50. Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke. Dev Neurobiol. 2011 Nov; 71(11):1018-39. Baeten KM, Akassoglou K. PMID: 21780303.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    51. Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol. 2012 Jan; 34(1):43-62. Davalos D, Akassoglou K. PMID: 22037947.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimals
    52. Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair. Cell Cycle. 2011 Jun 01; 10(11):1764-71. Schachtrup C, Le Moan N, Passino MA, Akassoglou K. PMID: 21555919.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    53. Chronic optical access through a polished and reinforced thinned skull. Nat Methods. 2010 Dec; 7(12):981-4. Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D. PMID: 20966916.
      View in: PubMed   Mentions: 135     Fields:    Translation:Animals
    54. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci. 2010 Apr 28; 30(17):5843-54. Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. PMID: 20427645.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    55. Fibrinogen signal transduction in the nervous system. J Thromb Haemost. 2009 Jul; 7 Suppl 1:151-4. Ryu JK, Davalos D, Akassoglou K. PMID: 19630789.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    56. Acute vascular disruption and aquaporin 4 loss after stroke. Stroke. 2009 Jun; 40(6):2182-90. Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD. PMID: 19372455.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    57. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci. 2009 Apr 15; 122(Pt 8):1155-62. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana WM, Gonias SL. PMID: 19299462.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    58. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1529-38. Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX. PMID: 18689502.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    59. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192.
      View in: PubMed   Mentions: 449     Fields:    Translation:AnimalsCells
    60. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods. 2008 Mar 30; 169(1):1-7. Davalos D, Lee JK, Smith WB, Brinkman B, Ellisman MH, Zheng B, Akassoglou K. PMID: 18192022.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    61. Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H220-8. Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX. PMID: 17982012.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    62. Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1273-7. Sachs BD, Akassoglou K. PMID: 17956328.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    63. Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11814-9. Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. PMID: 17606926.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    64. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol. 2007 Jun 18; 177(6):1119-32. Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. PMID: 17576803.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    65. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science. 2007 Mar 30; 315(5820):1853-6. Passino MA, Adams RA, Sikorski SL, Akassoglou K. PMID: 17395831.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    66. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med. 2007 Mar 19; 204(3):571-82. Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. PMID: 17339406.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    67. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem. 2007; 14(27):2925-36. Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. PMID: 18045138.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    68. P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun. 2006 Sep 01; 347(3):678-82. Arthur DB, Akassoglou K, Insel PA. PMID: 16842754.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    69. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. J Neurosci. 2006 Apr 05; 26(14):3798-804. Arthur DB, Georgi S, Akassoglou K, Insel PA. PMID: 16597733.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    70. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19138-43. Arthur DB, Akassoglou K, Insel PA. PMID: 16365320.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    71. Nerve growth factor-independent neuronal survival: a role for NO donors. Mol Pharmacol. 2005 Oct; 68(4):952-5. Akassoglou K. PMID: 16046659.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    72. Fibrin mechanisms and functions in nervous system pathology. Mol Interv. 2004 Jun; 4(3):163-76. Adams RA, Passino M, Sachs BD, Nuriel T, Akassoglou K. PMID: 15210870.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    73. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6698-703. Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, Probert L, Strickland S. PMID: 15096619.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    74. Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):5075-80. Akassoglou K, Malester B, Xu J, Tessarollo L, Rosenbluth J, Chao MV. PMID: 15051870.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    75. Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice. Neurosci Lett. 2003 Mar 06; 338(3):185-8. Akassoglou K, Akpinar P, Murray S, Strickland S. PMID: 12581827.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    76. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):709-14. Akassoglou K, Douni E, Bauer J, Lassmann H, Kollias G, Probert L. PMID: 12522266.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    77. Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. Neuron. 2002 Mar 14; 33(6):861-75. Akassoglou K, Yu WM, Akpinar P, Strickland S. PMID: 11906694.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    78. Nervous system pathology: the fibrin perspective. Biol Chem. 2002 Jan; 383(1):37-45. Akassoglou K, Strickland S. PMID: 11928820.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    79. Glial expression of tumor necrosis factor in transgenic animals: how do these models reflect the "normal situation"? Glia. 2001 Nov; 36(2):212-9. Probert L, Akassoglou K. PMID: 11596129.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    80. Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1784-92. Brodsky S, Chen J, Lee A, Akassoglou K, Norman J, Goligorsky MS. PMID: 11557572.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    81. TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease. Brain. 2000 Oct; 123 ( Pt 10):2005-19. Probert L, Eugster HP, Akassoglou K, Bauer J, Frei K, Lassmann H, Fontana A. PMID: 11004118.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    82. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. J Cell Biol. 2000 May 29; 149(5):1157-66. Akassoglou K, Kombrinck KW, Degen JL, Strickland S. PMID: 10831618.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    83. Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal. Brain Res. 1999 Sep 04; 840(1-2):125-37. Aloe L, Properzi F, Probert L, Akassoglou K, Kassiotis G, Micera A, Fiore M. PMID: 10517960.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    84. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol. 1999 03; 29(3):912-7. Kassiotis G, Bauer J, Akassoglou K, Lassmann H, Kollias G, Probert L. PMID: 10092095.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    85. Transgenic models of TNF induced demyelination. Adv Exp Med Biol. 1999; 468:245-59. Akassoglou K, Bauer J, Kassiotis G, Lassmann H, Kollias G, Probert L. PMID: 10635034.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    86. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol. 1998 Sep; 153(3):801-13. Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G, Probert L. PMID: 9736029.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    87. TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. J Neuroimmunol. 1997 Feb; 72(2):137-41. Probert L, Akassoglou K, Kassiotis G, Pasparakis M, Alexopoulou L, Kollias G. PMID: 9042105.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    88. Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J Immunol. 1997 Jan 01; 158(1):438-45. Akassoglou K, Probert L, Kontogeorgos G, Kollias G. PMID: 8977220.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    89. Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain. Brain Behav Immun. 1996 Jun; 10(2):126-38. Fiore M, Probert L, Kollias G, Akassoglou K, Alleva E, Aloe L. PMID: 8811936.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    90. Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice. J Leukoc Biol. 1996 Apr; 59(4):518-25. Probert L, Akassoglou K, Alexopoulou L, Douni E, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Kollias G. PMID: 8613699.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    91. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11294-8. Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G. PMID: 7479982.
      View in: PubMed   Mentions: 83     Fields:    Translation:Animals
    92. Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J Inflamm. 1995-1996; 47(1-2):27-38. Douni E, Akassoglou K, Alexopoulou L, Georgopoulos S, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Probert L, Kollias G. PMID: 8913927.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    Katerina's Networks
    Concepts (504)
    Derived automatically from this person's publications.
    _
    Co-Authors (67)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _