Kelly Wentworth, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address2540 23rd Street, #2805
San Francisco CA 94110
ORCID ORCID Icon0000-0002-3711-1121 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Rochester, Rochester, NYBA2003Biology
    University of Connecticut School of Medicine, Farmington, CTMD2008Medicine
    University of Washington, Seattle, WA2011Residency-Internal Medicine
    University of California, San Francisco, CA2017Fellowship- Diabetes, Endocrinology and Metabolism
    University of California, San Francisco, CA2019non-ACGME Endocrinology Research Fellowship

    Collapse Overview 
    Collapse overview
    My research focuses on understanding the role of Gs-protein coupled receptor signaling in skeletal development, with a focused interest in craniofacial fibrous dysplasia of the bone (FD) and McCune-Albright syndrome (MAS).

    Collapse Research 
    Collapse research activities and funding
    Elucidating the Role of TGF-Beta Signaling in Craniofacial Fibrous Dysplasia of the Bone
    NIH R03DE033746Sep 24, 2024 - Sep 23, 2026
    Role: Principal Investigator
    Identification and Signaling Characterization of GNAS R201H/C Selective Inhibitors for FD/MAS
    University of Pennsylvania/Million Dollar Bike Ride Program Feb 1, 2022 - Mar 1, 2023
    Role: Co-Investigator
    Description: This study will test compounds that selectively bind GNAS R201* and assess whether they decrease cAMP signaling. The goal is to identify compounds that could selectively inhibit the mutated protein that causes fibrous dysplasia of the bone.
    ASBMR Rising Star Award
    American Society of Bone and Mineral Research Sep 1, 2021 - Sep 1, 2024
    Dissecting the Cellular and Molecular Mechanisms Contributing to Craniofacial Fibrous Dysplasia
    NIH K08DE028946Sep 1, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Elucidating the Role of GNAS Mosaicism in Fibrous Dysplastic Lesions
    Million Dollar Bike Ride Grant Program Feb 1, 2019 - Feb 1, 2020
    Role: Principal Investigator
    A Human Pluripotent Stem Cell Model for Elucidating Cell Fate Defects in McCune-Albright Syndrome
    NIH F32HD091025Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Eli and Edythe Broad Stem Cell Fellowship Jul 1, 2016 - Jul 1, 2017

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice. J Bone Miner Res. 2024 May 02; 39(4):382-398. Lounev V, Groppe JC, Brewer N, Wentworth KL, Smith V, Xu M, Schomburg L, Bhargava P, Al Mukaddam M, Hsiao EC, Shore EM, Pignolo RJ, Kaplan FS. PMID: 38477818.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    2. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024 04 02; 14(1):7526. Atomwise AIMS Program. PMID: 38565852; PMCID: PMC10987645.
      View in: PubMed   Mentions: 21     Fields:    
    3. Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone. JBMR Plus. 2024 May; 8(5):ziae011. Lung H, Wentworth KL, Moody T, Zamarioli A, Ram A, Ganesh G, Kang M, Ho S, Hsiao EC. PMID: 38577521; PMCID: PMC10994528.
      View in: PubMed   Mentions: 1  
    4. Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review. J Bone Miner Res. 2022 12; 37(12):2586-2601. Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM. PMID: 36153665; PMCID: PMC10364481.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    5. Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models. J Bone Miner Res. 2022 11; 37(11):2058-2076. Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor KE, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC. PMID: 36153796; PMCID: PMC9950781.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    6. Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty. J Clin Endocrinol Metab. 2022 08 18; 107(9):e3944-e3952. Singh S, Morshed S, Motamedi D, Kidane J, Paul A, Hsiao EC, Wentworth KL. PMID: 35451005; PMCID: PMC9387692.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans. Pain. 2023 01 01; 164(1):43-58. Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC. PMID: 35442931; PMCID: PMC9582048.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva. Orphanet J Rare Dis. 2022 03 04; 17(1):107. Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC. PMID: 35246171; PMCID: PMC8894823.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva. Orphanet J Rare Dis. 2020 07 29; 15(1):193. Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC. PMID: 32727600; PMCID: PMC7389682.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-γ agonist palovarotene: a case report. BMC Musculoskelet Disord. 2020 Apr 03; 21(1):204. Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC. PMID: 32245464; PMCID: PMC7126417.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome. Front Endocrinol (Lausanne). 2019; 10:925. Lung H, Hsiao EC, Wentworth KL. PMID: 32038487; PMCID: PMC6993052.
      View in: PubMed   Mentions: 6     Fields:    
    12. New Frontiers in Osteoporosis Therapy. Annu Rev Med. 2020 01 27; 71:277-288. Cheng C, Wentworth K, Shoback DM. PMID: 31509477.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    13. Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken. JAMA Intern Med. 2019 Sep 01; 179(9):1227-1229. Wentworth K, Shoback D. PMID: 31305872.
      View in: PubMed   Mentions: 1     Fields:    
    14. Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva. Br J Clin Pharmacol. 2019 06; 85(6):1180-1187. Wentworth KL, Masharani U, Hsiao EC. PMID: 30501012; PMCID: PMC6533435.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    15. NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI Insight. 2018 11 15; 3(22). Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC. PMID: 30429363; PMCID: PMC6302947.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    16. Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva. Bone. 2018 04; 109:104-110. Wentworth KL, Bigay K, Chan TV, Ho JP, Morales BM, Connor J, Brooks E, Shahriar Salamat M, Sanchez HC, Wool G, Pignolo RJ, Kaplan FS, Hsiao EC. PMID: 29033382.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    17. A Novel T55A Variant of Gs α Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis. Case Rep Endocrinol. 2016; 2016:2691385. Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao EC. PMID: 27579188; PMCID: PMC4992514.
      View in: PubMed   Mentions: 3  
    18. Pocket change: a simple educational intervention increases hospitalist documentation of comorbidities and improves hospital quality performance measures. Qual Manag Health Care. 2015 Apr-Jun; 24(2):74-8. Sparks R, Salskov AH, Chang AS, Wentworth KL, Gupta PP, Staiger TO, Anawalt BD. PMID: 25830615.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Three hospital admissions in 9 days to diagnose azathioprine hypersensitivity in a patient with Crohn's disease. Am J Ther. 2015 Mar-Apr; 22(2):e28-32. Mookherjee S, Narayanan M, Uchiyama T, Wentworth KL. PMID: 23782763.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Faculty development for hospitalists: structured peer observation of teaching. J Hosp Med. 2014 Apr; 9(4):244-50. Mookherjee S, Monash B, Wentworth KL, Sharpe BA. PMID: 24446215.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
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