B Michael Silber, PhD
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Title(s) | Professor, Bioengineering |
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School | School of Pharmacy |
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Address | Location Required Varies CA 00000
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Phone | 650-269-8044 |
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vCard | Download vCard |
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Biography University of California San Francisco, Graduate School | PhD | 1981 | Pharmaceutical Chemistry and Pharmacology | University of California San Francisco | Postdoctoral Fellowship | 1977 | Clinical Pharmacy | University of Southern California | Doctor of Pharmacy | 1976 | Clinical Pharmacy |
Overview Dr. Silber is Professor, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco (UCSF), Schools of Medicine and Pharmacy. Until recently, he was also Professor of Neurology and Chief of Drug Discovery R & D at UCSF’s Institute for Neurodegenerative Diseases, which he led. Current research interests include discovering, developing and launching innovative breakthrough therapeutic and diagnostic products for diseases with high unmet medical need, including pain, inflammation, cancer, eye, neurodegenerative, and infectious diseases.
He is also President and CEO of Reiley Pharmaceuticals focused on breakthrough products for pain, cancer and infectious disease, President and CEO of MacRegen focused on breakthrough drugs for age-related macular degeneration, Senior Advisor at Clinakos, Novakos, and Neurokos, and Scientific Advisory Board member of NextBio/Illumina and Optivia. He was previously President and CEO of Elmedtech, Senior VP of R & D at Roche, VP of R & D and CSO at ALZA/J & J, Director of R & D at Pfizer, Senior Director of R & D at Cetus, and Director of R & D at Lederle Labs.
Dr. Silber has contributed to the discovery, preclinical and clinical development, registration, or commercial success of 23 FDA approved drugs (12 of which have been block busters) and drug devices and diagnostics in many disease areas. He is the author of more than 215 peer-reviewed publications, book chapters, patents, abstracts, and invited presentations.
He has discovered and developed medicines and breakthrough technologies in pain, neurological and neurodegenerative (e.g., Alzheimer’s, Parkinson’s, ALS, MS, FTD, TBI, CTE, CJD), psychotherapeutic (e.g., depression, schizophrenia, ADHD), cancer, eye disease, obesity, diabetes, infectious, lipid, inflammatory, cardiovascular, skin, and respiratory diseases.
Hobbies include mentoring graduate and health profession students, tennis, skiing, photography, and travel.
Bibliographic
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Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice. J Pharmacol Exp Ther. 2016 09; 358(3):537-47.
Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB. PMID: 27317802.
View in: PubMed Mentions: 8 Fields: Translation: Animals
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Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12.
Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. PMID: 26224882.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimals
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Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorg Med Chem. 2014 Mar 15; 22(6):1960-72.
PMID: 24530226.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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OMICS in Neuroscience, Giovanni Coppola Editor. From Small Molecule Leads to Clinical Candidates in Neurological Diseases. 2014; 291-314.
Silber, B.M. View Publication.
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Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15; 21(24):7999-8012.
PMID: 24183589.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice. J Pharmacol Exp Ther. 2013 Nov; 347(2):325-38.
PMID: 23965382.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds. ACS Med Chem Lett. 2013 Jul 11; 4(7):647-650.
PMID: 23977416.
View in: PubMed Mentions:
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Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds. ACS Med Chem Lett. 2013 Apr 11; 4(4):397-401.
PMID: 23847718.
View in: PubMed Mentions:
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2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem. 2013 May; 8(5):847-57.
PMID: 23509039.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50.
PMID: 23417511.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity. Eur J Med Chem. 2011 Sep; 46(9):4125-32.
PMID: 21726921.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24; 54(4):1010-21.
PMID: 21247166.
View in: PubMed Mentions: 33 Fields: Translation: AnimalsCells
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Driving drug discovery: the fundamental role of academic labs. Sci Transl Med. 2010 May 05; 2(30):30cm16.
Silber BM. PMID: 20445199.
View in: PubMed Mentions: 23 Fields: Translation: Humans
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Toward a 21st-century health care system: recommendations for health care reform. Ann Intern Med. 2009 Apr 07; 150(7):493-5.
Arrow K, Auerbach A, Bertko J, Brownlee S, Casalino LP, Cooper J, Crosson FJ, Enthoven A, Falcone E, Feldman RC, Fuchs VR, Garber AM, Gold MR, Goldman D, Hadfield GK, Hall MA, Horwitz RI, Hooven M, Jacobson PD, Jost TS, Kotlikoff LJ, Levin J, Levine S, Levy R, Linscott K, Luft HS, Mashal R, McFadden D, Mechanic D, Meltzer D, Newhouse JP, Noll RG, Pietzsch JB, Pizzo P, Reischauer RD, Rosenbaum S, Sage W, Schaeffer LD, Sheen E, Silber BM, Skinner J, Shortell SM, Thier SO, Tunis S, Wulsin L, Yock P, Nun GB, Bryan S, Luxenburg O, van de Ven WP. PMID: 19258550.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Pharmacogenetics, Edited by Werner Kalow, Urs Meyer and Rachel Tyndale. Pharmacogenomics, Biomarkers and the Promise of Personalized Medicine. 2001; 11-31.
Silber, B Michael.
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CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting. AAPS PharmSci. 2000; 2(4):E33.
McElroy S, Sachse C, Brockmoller J, Richmond J, Lira M, Friedman D, Roots I, Silber BM, Milos PM. PMID: 11741249.
View in: PubMed Mentions: 7 Fields: Translation: HumansCTClinical Trials
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in Biomarkers and Surrogate Endpoints: Clinical Research and Applications, edited by G. Downing. The Importance of Biomarkers in Drug Discovery and Development-Focus on Alzheimer's Disease. 2000.
Silber, B.M.
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Proceedings of the First International Pharmacogenomics and Pharmacogenetics Forum, edited by T. Noguchi and Y. Fujita. Use of Genetic Variation-Response Outcome Relationships in Drug Development and Discovery. 1999.
Silber, B.M.
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The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. J Pharmacol Exp Ther. 1997 Oct; 283(1):46-58.
Obach RS, Baxter JG, Liston TE, Silber BM, Jones BC, MacIntyre F, Rance DJ, Wastall P. PMID: 9336307.
View in: PubMed Mentions: 148 Fields: Translation: HumansAnimals
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A novel quantitative method for determining the biodistribution of radiolabeled xenobiotics using whole-body cryosectioning and autoradioluminography. J Pharmacol Exp Ther. 1995 Feb; 272(2):953-62.
Potchoiba MJ, Tensfeldt TG, Nocerini MR, Silber BM. PMID: 7853213.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Pharmacokinetics of tiqueside (beta-tigogenin cellobioside) in dogs, rats, rabbits, and monkeys. J Pharm Sci. 1995 Jan; 84(1):12-4.
Inskeep PB, Connolly AG, Cole MJ, Luther EW, Biehl ML, Marzetta CA, Savoy YE, Silber BM. PMID: 7714734.
View in: PubMed Mentions: Fields: Translation: Animals
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Pharmacokinetic principles in the design of immediate-release components in sustained-release formulations with zero-order release characteristics. J Pharm Sci. 1991 Feb; 80(2):142-8.
Cheung WK, Silber BM, Yacobi A. PMID: 2051317.
View in: PubMed Mentions: Fields:
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Pharmacokinetics of YTR830H in healthy human subjects. J Chemother. 1989 Jul; 1(4 Suppl):505-6.
Cheung WK, Greene DS, Kuye O, Smith MP, Holder A, Fernandez P, Houston A, Faulkner RD, Silber BM. PMID: 16312505.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Pharmacokinetics of YTR830H and piperacillin after intravenous coadministration. J Chemother. 1989 Jul; 1(4 Suppl):507-8.
Cheung WK, Greene DS, Kuye O, Shin K, Tonelli AP, Houston A, Hibberd M, Faulkner RD, Silber BM. PMID: 16312506.
View in: PubMed Mentions: Fields: Translation: Humans
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Bioequivalency of oral suspension formulations of cefixime. Biopharm Drug Dispos. 1989 Mar-Apr; 10(2):205-11.
Faulkner RD, Sia LL, Barone JS, Forbes SJ, Silber BM. PMID: 2706319.
View in: PubMed Mentions: Fields: Translation: HumansCTClinical Trials
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Pharmacokinetics of Nilvadipine After Multiple Dosing to Steady-State. Drug Dev. Indus. Pharm.
. 1989; (15):51-63.
Cheung, W.K., Sia, L.L., Hibberd, M., Pearse, S., Woodward, D.L., Desjardins, R.E., Bernstein, J., Yacobi, A., and Silber, B.M.
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Importance of oral dosing rate on the hemodynamic and pharmacokinetic profile on nilvadipine. J Clin Pharmacol. 1988 Nov; 28(11):1001-7.
Cheung WK, Sia LL, Woodward DL, Graveline JF, Desjardins RE, Yacobi A, Silber BM. PMID: 3243913.
View in: PubMed Mentions: 2 Fields: Translation: HumansCTClinical Trials
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Pharmacokinetic evaluation of a sustained-release formulation of trihexyphenidyl in healthy volunteers. J Pharm Sci. 1988 Sep; 77(9):748-50.
Cheung WK, Stravinski SS, Engel SI, Sia LL, Yacobi A, Silber BM. PMID: 3225767.
View in: PubMed Mentions: Fields: Translation: HumansCTClinical Trials
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Absolute bioavailability of cefixime in man. J Clin Pharmacol. 1988 Aug; 28(8):700-6.
Faulkner RD, Fernandez P, Lawrence G, Sia LL, Falkowski AJ, Weiss AI, Yacobi A, Silber BM. PMID: 3216036.
View in: PubMed Mentions: 19 Fields: Translation: HumansCells
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Pharmacokinetics of cefixime in the young and elderly. J Antimicrob Chemother. 1988 Jun; 21(6):787-94.
Faulkner RD, Bohaychuk W, Lanc RA, Haynes JD, Desjardins RE, Yacobi A, Silber BM. PMID: 3410802.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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In vitro protein binding interaction studies involving cefixime. Biopharm Drug Dispos. 1988 May-Jun; 9(3):315-20.
Bialer M, Wu WH, Faulkner RD, Silber BM, Yacobi A. PMID: 3395672.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Relationship between the pharmacokinetic and pharmacodynamic profile of nilvadipine in the dog. Drug Metab Dispos. 1988 Mar-Apr; 16(2):222-7.
Wu WH, Henderson BM, Lanc R, Garnes D, Yacobi A, Silber BM. PMID: 2898337.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Pharmacokinetics of nilvadipine after single oral doses in healthy volunteers. Int J Clin Pharmacol Res. 1988; 8(5):299-305.
Cheung WK, Woodward DL, Shin K, Hibberd M, Pearse S, Desjardins RE, Yacobi A, Silber BM. PMID: 3229870.
View in: PubMed Mentions: 1 Fields: Translation: HumansCTClinical Trials
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The pharmacokinetics of cefixime in the fasted and fed state. Eur J Clin Pharmacol. 1988; 34(5):525-8.
Faulkner RD, Bohaychuk W, Haynes JD, Desjardins RE, Yacobi A, Silber BM. PMID: 3203716.
View in: PubMed Mentions: 11 Fields: Translation: Humans
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Changes in tissue concentrations of 14C-doxorubicin caused by mitoxantrone, mithramycin A and vinblastine in the rat. Res Commun Chem Pathol Pharmacol. 1988 Jan; 59(1):61-8.
Cheung WK, Aiache M, Yacobi A, Silber BM. PMID: 2965402.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Bioequivalency of Solid Oral Dosage Forms of Cefixime. Int. J. Pharmaceut. 1988; (43):53-58.
Faulkner, R.D., Sia, L.L., Look, Z.M., Barone, J.S., Forbes, St. J., Weiss, A.I., and Silber, B.M.
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Drug Absorption from Sustained Release Formulations, Edited by A. Yacobi and E. Halperin-Walega. Utilizing Pharmacokinetic Principles in the Design of Controlled or Sustained Release Formulations. 1988; 1-33.
Silber, B.M., Cheung, W.K., and Yacobi, A.
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Determination of cefixime in biological samples by reversed-phase high-performance liquid chromatography. J Chromatogr. 1987 Nov 27; 422:145-52.
Falkowski AJ, Look ZM, Noguchi H, Silber BM. PMID: 3437003.
View in: PubMed Mentions: 7 Fields: Translation: Humans
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Pharmacokinetic profile of cefixime in man. Pediatr Infect Dis J. 1987 Oct; 6(10):963-70.
Faulkner RD, Yacobi A, Barone JS, Kaplan SA, Silber BM. PMID: 3696837.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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Pharmacokinetics of cefixime after once-a-day and twice-a-day dosing to steady state. J Clin Pharmacol. 1987 Oct; 27(10):807-12.
Faulkner RD, Bohaychuk W, Desjardins RE, Look ZM, Haynes JD, Weiss AI, Silber BM. PMID: 3429686.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Liquid-chromatographic determination of five orally active cephalosporins--cefixime, cefaclor, cefadroxil, cephalexin, and cephradine--in human serum. Clin Chem. 1987 Oct; 33(10):1788-90.
McAteer JA, Hiltke MF, Silber BM, Faulkner RD. PMID: 3665031.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Pharmacokinetics of cefixime after oral and intravenous doses in dogs: bioavailability assessment for a drug showing nonlinear serum protein binding. Res Commun Chem Pathol Pharmacol. 1987 Apr; 56(1):21-32.
Bialer M, Wu WH, Look ZM, Silber BM, Yacobi A. PMID: 3589152.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Dose-dependent pharmacokinetics of a new oral cephalosporin, cefixime, in the dog. Pharm Res. 1987 Feb; 4(1):33-7.
Bialer M, Batra VK, Morrison JA, Silber BM, Look ZM, Yacobi A. PMID: 3508527.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Decapeptyl: Release from Microcapsules and Testosterone Suppression in the Dog, The Pharmacology and Toxicology of Proteins, pp. 337-349. 1987.
Tonelli, A.P., Nicolau, G., Lawter, J.R., Silber, B.M., Lanc, R.A., Lanzilotti, A.R., Dente, A.R., McWilliams, W.E., and Yacobi, A.
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Pharmacokinetic Approach to the Rational Design of Controlled or Sustained Release Formulations. J. Control. Rel. 1987; 3(5):263-270.
Cheung, W.K., Yacobi, A. and Silber, B.M.
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Sustained and Controlled Release Drug Delivery Systems, 2nd Edition, edited by J.R. Robinson and V.H. Lee. Pharmacokinetic-Pharmacodynamic Basis of Controlled Drug Delivery. 1987; 213-251.
Silber, B.M., Bialer, M., and Yacobi, A.
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The relationship between drug input and mean residence time in the body. Biopharm Drug Dispos. 1986 Nov-Dec; 7(6):577-83.
Bialer M, Look ZM, Silber BM, Yacobi A. PMID: 3828487.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Nonlinear formation of propranolol metabolites in dogs after portacaval transpositions. J Pharmacokinet Biopharm. 1984 Aug; 12(4):401-12.
Lo MW, Pond SM, Effeney DJ, Silber BM, Riegelman S, Tozer TN. PMID: 6527232.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Pharmacokinetics: A Modern View, edited by L.Z. Benet and G. Levy. Stereoselective Disposition and Glucuronidation of Propranolol in Man. 1984; 478-481.
Silber, B.M. and Holford, N.H.G.
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Pharmacokinetics: A Modern View, edited by L.Z. Benet and G. Levy. The Use of the Portacaval Transposition Technique to Study Gastrointestinal and Hepatic Metabolism of Propranolol in the Dog. 1984; 474-477.
Lo, M.W., Effeney, D.J., Pond, S.M., and Silber, B.M.
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Chemical aspects of propranolol metabolism. Synthesis and identification of 3-(4-hydroxy-1-naphthoxy)propane-1,2-diol as a metabolite of propranolol in the dog, in man and in the rat liver 9000g supernatant fraction. Res Commun Chem Pathol Pharmacol. 1983 Nov; 42(2):235-44.
Gupte SM, Bartels MJ, Kerr BM, Laganiere S, Silber BM, Nelson WL. PMID: 6658188.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Dose-dependent elimination of propranolol and its major metabolites in humans. J Pharm Sci. 1983 Jul; 72(7):725-32.
Silber BM, Holford NH, Riegelman S. PMID: 6886977.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Stereoselective disposition and glucuronidation of propranolol in humans. J Pharm Sci. 1982 Jun; 71(6):699-704.
Silber B, Holford NH, Riegelman S. PMID: 7097538.
View in: PubMed Mentions: 24 Fields: Translation: Humans
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A technique to study hepatic and intestinal drug metabolism separately in the dog. J Pharmacol Exp Ther. 1982 May; 221(2):507-11.
Effeney DJ, Pond SM, Lo MW, Silber BM, Riegelman S. PMID: 7077540.
View in: PubMed Mentions: 5 Fields: Translation: Animals
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Lack of gastrointestinal metabolism of propranolol in dogs after portacaval transposition. J Pharmacol Exp Ther. 1982 May; 221(2):512-5.
Lo MW, Effeney DJ, Pond SM, Silber BM, Riegelman S. PMID: 7077541.
View in: PubMed Mentions: 6 Fields: Translation: Animals
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An automated HPLC method for the assay of propranolol and its basic metabolites in plasma and urine. J Chromatogr Sci. 1982 Mar; 20(3):126-31.
Lo MW, Silber B, Riegelman S. PMID: 7076780.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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In vivo effects of the cytochrome P-450 suicide substrate 2-isopropyl-4-pentenamide (allylisopropylacetamide) on the disposition and metabolic pattern of propranolol. J Pharmacol Exp Ther. 1981 Oct; 219(1):125-33.
Silber B, Mico BA, Ortiz de Montellano PR, Dols DM, Riegelman S. PMID: 7288600.
View in: PubMed Mentions: Fields: Translation: Animals
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Stereospecific assay for (-)- and (+)-propranolol in human and dog plasma. J Pharmacol Exp Ther. 1980 Dec; 215(3):643-8.
Silber B, Riegelman S. PMID: 7441523.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimals
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The influence of heparin administration on the plasma protein binding and disposition of propranolol. Res Commun Chem Pathol Pharmacol. 1980 Mar; 27(3):419-29.
Silber B, Lo M, Riegelman S. PMID: 7384636.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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[Hepatic and renal toxicity of enflurane (author's transl)]. Anesth Analg (Paris). 1980; 37(7-8):427-8.
Bernad PG, Silber B, Mathieu A. PMID: 7425324.
View in: PubMed Mentions: Fields: Translation: Humans
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Drug Level Monitoring, edited by W. Sadee and G.C.M. Beelen. Acetazolamide; Hydrochlorthiazide; Tetrahydrocannabinol. 1980; 117-119; 268-270; 447-453.
Silber, B.M.
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Spironolactone-associated digoxin radioimmunoassay interference. Clin Chem. 1979 Jan; 25(1):48-50.
Silber B, Sheiner LB, Powers JL, Winter ME, Sadée W. PMID: 761378.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Year | Publications |
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1991 | 1 | 1995 | 2 | 1997 | 1 | 1999 | 1 | 2000 | 2 | 2001 | 1 | 2009 | 1 | 2010 | 1 | 2011 | 2 | 2013 | 6 | 2014 | 2 | 2015 | 1 | 2016 | 1 |
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