Smita Patel, PhD

Title(s)Staff Research Associate IV, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #301
San Francisco CA 94158
Phone415-502-7015
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    PhD

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Expression and Purification of Recombinant Human Mitochondrial RNA Polymerase (POLRMT) and the Initiation Factors TFAM and TFB2M. Bio Protoc. 2023 Dec 05; 13(23):e4892. Hsieh AH, Reardon SD, Munozvilla-Cabellon JH, Shen J, Patel SS, Mishanina TV. PMID: 38094251; PMCID: PMC10714150.
      View in: PubMed   Mentions:
    2. Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy. PLoS Pathog. 2020 02; 16(2):e1008222. Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. PMID: 32017806; PMCID: PMC6999861.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    3. Familial Parkinson's point mutation abolishes multiple system atrophy prion replication. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):409-414. Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB. PMID: 29279394; PMCID: PMC5777081.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    4. Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines. JAMA Neurol. 2017 12 01; 74(12):1464-1472. Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB. PMID: 29059326; PMCID: PMC5822201.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    5. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8187-E8196. Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. PMID: 27911827; PMCID: PMC5167200.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    6. Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions. J Virol. 2016 11 01; 90(21):9558-9569. Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB. PMID: 27440899; PMCID: PMC5068510.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. Towards authentic transgenic mouse models of heritable PrP prion diseases. Acta Neuropathol. 2016 10; 132(4):593-610. Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB. PMID: 27350609; PMCID: PMC5152593.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    8. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. PMID: 26324905; PMCID: PMC4586853.
      View in: PubMed   Mentions: 366     Fields:    Translation:HumansAnimalsCells
    9. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4949-58. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. PMID: 26286986; PMCID: PMC4568231.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    10. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. PMID: 26224882; PMCID: PMC4576665.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    11. Finding the right match fast. Cell. 2015 Feb 26; 160(5):809-811. Nandakumar D, Patel SS. PMID: 25723158.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Evidence that bank vole PrP is a universal acceptor for prions. PLoS Pathog. 2014 Apr; 10(4):e1003990. Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB. PMID: 24699458; PMCID: PMC3974871.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    13. Relaxed rotational and scrunching changes in P266L mutant of T7 RNA polymerase reduce short abortive RNAs while delaying transition into elongation. PLoS One. 2014; 9(3):e91859. Tang GQ, Nandakumar D, Bandwar RP, Lee KS, Roy R, Ha T, Patel SS. PMID: 24651161; PMCID: PMC3961267.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    14. Switching from single-stranded to double-stranded DNA limits the unwinding processivity of ring-shaped T7 DNA helicase. Nucleic Acids Res. 2013 Apr; 41(7):4219-29. Jeong YJ, Rajagopal V, Patel SS. PMID: 23446275; PMCID: PMC3627605.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    15. Identification of I137M and other mutations that modulate incubation periods for two human prion strains. J Virol. 2012 Jun; 86(11):6033-41. Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB. PMID: 22438549; PMCID: PMC3372217.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsPHPublic Health
    16. Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3498-503. Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB. PMID: 22331873; PMCID: PMC3295307.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    17. Conserved properties of human and bovine prion strains on transmission to guinea pigs. Lab Invest. 2011 Sep; 91(9):1326-36. Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB. PMID: 21727894; PMCID: PMC3164925.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Human prion strain selection in transgenic mice. Ann Neurol. 2010 Aug; 68(2):151-61. Giles K, Glidden DV, Patel S, Korth C, Groth D, Lemus A, DeArmond SJ, Prusiner SB. PMID: 20695008; PMCID: PMC2935907.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    19. Mitochondrial transcription factor Mtf1 traps the unwound non-template strand to facilitate open complex formation. J Biol Chem. 2010 Feb 05; 285(6):3949-3956. Paratkar S, Patel SS. PMID: 20008320; PMCID: PMC2824207.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    20. Single strand binding proteins increase the processivity of DNA unwinding by the hepatitis C virus helicase. J Mol Biol. 2008 Feb 08; 376(1):69-79. Rajagopal V, Patel SS. PMID: 18155046; PMCID: PMC2249756.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    21. Mechanisms of a ring shaped helicase. Nucleic Acids Res. 2006; 34(15):4216-24. Donmez I, Patel SS. PMID: 16935879; PMCID: PMC1616965.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    22. Sequential release of promoter contacts during transcription initiation to elongation transition. J Mol Biol. 2006 Jul 07; 360(2):466-83. Bandwar RP, Tang GQ, Patel SS. PMID: 16780876.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    23. T7 RNA polymerase-induced bending of promoter DNA is coupled to DNA opening. Biochemistry. 2006 Apr 18; 45(15):4936-46. Tang GQ, Patel SS. PMID: 16605261.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    24. Rapid binding of T7 RNA polymerase is followed by simultaneous bending and opening of the promoter DNA. Biochemistry. 2006 Apr 18; 45(15):4947-56. Tang GQ, Patel SS. PMID: 16605262.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    25. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem. 2005 Dec 23; 280(51):41789-92. Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D. PMID: 16263726; PMCID: PMC1421377.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    26. DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase. Nature. 2005 May 19; 435(7040):370-3. Stano NM, Jeong YJ, Donmez I, Tummalapalli P, Levin MK, Patel SS. PMID: 15902262; PMCID: PMC1563444.
      View in: PubMed   Mentions: 94     Fields:    Translation:Cells
    27. A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase. Nat Struct Mol Biol. 2005 May; 12(5):429-35. Levin MK, Gurjar M, Patel SS. PMID: 15806107.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    28. The DNA-unwinding mechanism of the ring helicase of bacteriophage T7. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7264-9. Jeong YJ, Levin MK, Patel SS. PMID: 15123793; PMCID: PMC409907.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    29. Fluorescence methods for studying the kinetics and thermodynamics of transcription initiation. Methods Enzymol. 2003; 370:668-86. Patel SS, Bandwar RP. PMID: 14712683.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    30. The energetics of consensus promoter opening by T7 RNA polymerase. J Mol Biol. 2002 Nov 15; 324(1):63-72. Bandwar RP, Patel SS. PMID: 12421559.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    31. T7 DNA helicase: a molecular motor that processively and unidirectionally translocates along single-stranded DNA. J Mol Biol. 2002 Aug 30; 321(5):807-19. Kim DE, Narayan M, Patel SS. PMID: 12206763.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    32. The intercalating beta-hairpin of T7 RNA polymerase plays a role in promoter DNA melting and in stabilizing the melted DNA for efficient RNA synthesis. J Mol Biol. 2002 Feb 01; 315(5):1009-25. Stano NM, Patel SS. PMID: 11827472.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
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