Ben Braun, MD, PhD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Address1450 Third St, #264
San Francisco CA 94158
Phone415-476-3831
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    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1998School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    NIH R01CA173085Jul 2, 2013 - May 31, 2018
    Role: Principal Investigator
    In Vivo Analysis of Oncogenic Kras in Leukemogenesis
    NIH K08CA103868Jul 1, 2005 - Aug 31, 2010
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma. EJNMMI Res. 2024 Jun 13; 14(1):54. Kumar P, Koach J, Nekritz E, Mukherjee S, Braun BS, DuBois SG, Nasholm N, Haas-Kogan D, Matthay KK, Weiss WA, Gustafson C, Seo Y. PMID: 38869684; PMCID: PMC11176152.
      View in: PubMed   Mentions:
    2. Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma. Res Sq. 2024 Jan 18. Kumar P, Koach J, Nekritz E, Mukherjee S, Braun BS, DuBois SG, Nasholm N, Haas-Kogan D, Matthay KK, Weiss WA, Gustafson C, Seo Y. PMID: 38313265; PMCID: PMC10836112.
      View in: PubMed   Mentions:
    3. Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia. Haematologica. 2023 05 01; 108(5):1272-1283. Pariury H, Fandel J, Bachl S, Ang KK, Markossian S, Wilson CG, Braun BS, Popescu B, Wohlfeil M, Beckman K, Xirenayi S, Roy RP, Olshen AB, Smith C, Arkin MR, Loh ML, Diaz-Flores E. PMID: 36700399; PMCID: PMC10153511.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Venetoclax in combination with chemotherapy as treatment for pediatric advanced hematologic malignancies. Pediatr Blood Cancer. 2023 06; 70(6):e30335. Marinoff AE, Aaronson K, Agrawal AK, Braun BS, Golden C, Huang BJ, Michlitsch J, Southworth E, Thrall A, Vo KT, Stieglitz E. PMID: 37036306; PMCID: PMC10133180.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia. Blood Adv. 2021 09 28; 5(18):3587-3591. Morales CE, Stieglitz E, Kogan SC, Loh ML, Braun BS. PMID: 34464969; PMCID: PMC8945579.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment. Haematologica. 2021 08 01; 106(8):2242-2245. Tran TH, Nguyen JV, Stecula A, Akutagawa J, Moorman AV, Braun BS, Sali A, Mullighan CG, Shah NP, Dai Y, Devidas M, Roberts KG, Smith CC, Loh ML. PMID: 33626861; PMCID: PMC8327742.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21). Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679; PMCID: PMC7710308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Paroxysmal cold hemoglobinuria successfully treated with complement inhibition. Blood Adv. 2019 11 26; 3(22):3575-3578. Lau-Braunhut SA, Stone H, Collins G, Berentsen S, Braun BS, Zinter MS. PMID: 31738828; PMCID: PMC6880888.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    9. Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing. Leukemia. 2020 02; 34(2):662-666. Chao AK, Meyer JA, Lee AG, Hecht A, Tarver T, Van Ziffle J, Koegel AK, Golden C, Braun BS, Sweet-Cordero EA, Smith CC, Dvorak CC, Loh ML, Stieglitz E. PMID: 31511612; PMCID: PMC6995757.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Tissue-Specific Oncogenic Activity of KRASA146T. Cancer Discov. 2019 06; 9(6):738-755. Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. PMID: 30952657; PMCID: PMC6548671.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    11. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019 05 01; 79(9):2339-2351. Diaz-Flores E, Comeaux EQ, Kim KL, Melnik E, Beckman K, Davis KL, Wu K, Akutagawa J, Bridges O, Marino R, Wohlfeil M, Braun BS, Mullighan CG, Loh ML. PMID: 30862722; PMCID: PMC6497548.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    12. Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia. Nat Commun. 2017 12 19; 8(1):2127. Stieglitz E, Mazor T, Olshen AB, Geng H, Gelston LC, Akutagawa J, Lipka DB, Plass C, Flotho C, Chehab FF, Braun BS, Costello JF, Loh ML. PMID: 29259179; PMCID: PMC5736624.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCellsCTClinical Trials
    13. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer Res. 2017 11 01; 77(21):5706-5711. Maertens O, McCurrach ME, Braun BS, De Raedt T, Epstein I, Huang TQ, Lauchle JO, Lee H, Wu J, Cripe TP, Clapp DW, Ratner N, Shannon K, Cichowski K. PMID: 28993414; PMCID: PMC5668167.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    14. Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras. Leukemia. 2016 06; 30(6):1335-43. Akutagawa J, Huang TQ, Epstein I, Chang T, Quirindongo-Crespo M, Cottonham CL, Dail M, Slusher BS, Friedman LS, Sampath D, Braun BS. PMID: 26965285; PMCID: PMC4889473.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2016 Jan; 126(1):404. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. PMID: 26727232; PMCID: PMC4701564.
      View in: PubMed   Mentions: 2     Fields:    
    16. Traxtile: Interactive editing of cell tracks in time-lapse images. Biotechniques. 2015 Aug; 59(2):82-6. Braun BS. PMID: 26260086; PMCID: PMC4560953.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015 Jan 15; 125(3):516-24. Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun BS, Abate A, Gerbing RB, Alonzo TA, Loh ML. PMID: 25395418; PMCID: PMC4296011.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    18. PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PMID: 24300897; PMCID: PMC4117477.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan; 123(1):335-9. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. PMID: 23221337; PMCID: PMC3533281.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    20. KIT's ship comes in. Blood. 2012 Sep 27; 120(13):2541-2. Braun BS. PMID: 23019203.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    21. Targeting oncogenic Ras signaling in hematologic malignancies. Blood. 2012 Oct 25; 120(17):3397-406. Ward AF, Braun BS, Shannon KM. PMID: 22898602; PMCID: PMC3482854.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    22. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Sci Transl Med. 2011 Mar 30; 3(76):76ra27. Lyubynska N, Gorman MF, Lauchle JO, Hong WX, Akutagawa JK, Shannon K, Braun BS. PMID: 21451123; PMCID: PMC3265440.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    23. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 2011 Apr 21; 117(16):4253-61. Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. PMID: 21398220; PMCID: PMC3087477.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    24. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. PMID: 21163920; PMCID: PMC3056645.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    25. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010 Sep; 42(9):794-800. Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. PMID: 20694012; PMCID: PMC4297285.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
    26. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. PMID: 20194733; PMCID: PMC2841878.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    27. The SPS affair: a complex tale of illicit proliferation. Cancer Cell. 2009 Aug 04; 16(2):87-8. Braun BS, Shannon K. PMID: 19647218.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 2009 Apr 07; 15(4):341-52. Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. PMID: 19345332; PMCID: PMC2669108.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    29. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. PMID: 19296721; PMCID: PMC2656550.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    30. Pediatric malignancies: update on sarcomas and leukemia development in children. Curr Opin Genet Dev. 2009 Feb; 19(1):92-6. Braun BS, Lessnick SL. PMID: 19186049.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Targeting Ras in myeloid leukemias. Clin Cancer Res. 2008 Apr 15; 14(8):2249-52. Braun BS, Shannon K. PMID: 18413813.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    32. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007 May 01; 109(9):3945-52. Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. PMID: 17192389; PMCID: PMC1874575.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    33. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006 Sep 15; 108(6):2041-4. Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. PMID: 16720837; PMCID: PMC1895533.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    34. Inherited predispositions and hyperactive Ras in myeloid leukemogenesis. Pediatr Blood Cancer. 2006 May 01; 46(5):579-85. Lauchle JO, Braun BS, Loh ML, Shannon K. PMID: 16261595.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    35. Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol. 2006 Feb; 54(2 Suppl):S22-7. Zhang IH, Zane LT, Braun BS, Maize J, Zoger S, Loh ML. PMID: 16427986.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. The sum is greater than the FGFR1 partner. Cancer Cell. 2004 Mar; 5(3):203-4. Braun BS, Shannon K. PMID: 15050910.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 01; 103(11):4243-50. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. PMID: 14982883.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    38. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):597-602. Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. PMID: 14699048; PMCID: PMC327193.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    39. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic. Nat Genet. 1997 Dec; 17(4):495-7. May WA, Arvand A, Thompson AD, Braun BS, Wright M, Denny CT. PMID: 9398859.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    40. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene. 1996 Dec 19; 13(12):2649-58. Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C. PMID: 9000139.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis. Mol Cell Biol. 1995 Aug; 15(8):4623-30. Braun BS, Frieden R, Lessnick SL, May WA, Denny CT. PMID: 7623854; PMCID: PMC230703.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    42. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene. 1995 Mar 16; 10(6):1229-34. Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN. PMID: 7700648.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    43. Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene. 1995 Feb 02; 10(3):423-31. Lessnick SL, Braun BS, Denny CT, May WA. PMID: 7845667.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    44. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol. 1993 Dec; 13(12):7393-8. May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT. PMID: 8246959; PMCID: PMC364810.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    45. Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen. Eur J Immunol. 1993 Mar; 23(3):591-9. Ku G, Kronenberg M, Peacock DJ, Tempst P, Banquerigo ML, Braun BS, Reeve JR, Brahn E. PMID: 7680609.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    46. Creation of a yeast artificial chromosome fragmentation vector based on lysine-2. Genet Anal Tech Appl. 1992 Jun; 9(3):86-90. Lewis BC, Shah NP, Braun BS, Denny CT. PMID: 1476795.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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