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Ben Braun, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address550 16th. Street
San Francisco CA 94158
Phone415-514-4176
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    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1998School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    NIH R01CA173085Jul 2, 2013 - May 31, 2018
    Role: Principal Investigator
    In Vivo Analysis of Oncogenic Kras in Leukemogenesis
    NIH K08CA103868Jul 1, 2005 - Aug 31, 2010
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Akutagawa J, Huang TQ, Epstein I, Chang T, Quirindongo-Crespo M, Cottonham CL, Dail M, Slusher BS, Friedman LS, Sampath D, Braun B. Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras. Leukemia. 2016 Jun; 30(6):1335-43. PMID: 26965285.
      View in: PubMed
    2. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun B, Shannon K. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2016 Jan 4; 126(1):404. PMID: 26727232.
      View in: PubMed
    3. Braun B. Traxtile: Interactive editing of cell tracks in time-lapse images. Biotechniques. 2015 Aug; 59(2):82-6. PMID: 26260086; PMCID: PMC4560953 [Available on 02/01/16].
    4. Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun B, Abate A, Gerbing RB, Alonzo TA, Loh ML. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015 Jan 15; 125(3):516-24. PMID: 25395418; PMCID: PMC4296011 [Available on 01/15/16].
    5. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun B, Shannon K. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 3; 6(304):ra105. PMID: 24300897; PMCID: PMC4117477.
    6. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun B, Shannon K. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan; 123(1):335-9. PMID: 23221337; PMCID: PMC3533281.
    7. Braun B. KIT's ship comes in. Blood. 2012 Sep 27; 120(13):2541-2. PMID: 23019203.
      View in: PubMed
    8. Ward AF, Braun B, Shannon KM. Targeting oncogenic Ras signaling in hematologic malignancies. Blood. 2012 Oct 25; 120(17):3397-406. PMID: 22898602; PMCID: PMC3482854.
    9. Lyubynska N, Gorman MF, Lauchle JO, Hong WX, Akutagawa JK, Shannon K, Braun B. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Sci Transl Med. 2011 Mar 30; 3(76):76ra27. PMID: 21451123; PMCID: PMC3265440.
    10. Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun B. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 2011 Apr 21; 117(16):4253-61. PMID: 21398220; PMCID: PMC3087477.
    11. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun B, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32. PMID: 21163920; PMCID: PMC3056645.
    12. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun B, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11. PMID: 20194733; PMCID: PMC2841878.
    13. Braun B, Shannon K. The SPS affair: a complex tale of illicit proliferation. Cancer Cell. 2009 Aug 4; 16(2):87-8. PMID: 19647218.
      View in: PubMed
    14. Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun B, Passegué E. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 2009 Apr 7; 15(4):341-52. PMID: 19345332; PMCID: PMC2669108.
    15. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun B. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59. PMID: 19296721; PMCID: PMC2656550.
    16. Braun B, Lessnick SL. Pediatric malignancies: update on sarcomas and leukemia development in children. Curr Opin Genet Dev. 2009 Feb; 19(1):92-6. PMID: 19186049.
      View in: PubMed
    17. Braun B, Shannon K. Targeting Ras in myeloid leukemias. Clin Cancer Res. 2008 Apr 15; 14(8):2249-52. PMID: 18413813.
      View in: PubMed
    18. Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun B. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007 May 1; 109(9):3945-52. PMID: 17192389; PMCID: PMC1874575.
    19. Braun B, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006 Sep 15; 108(6):2041-4. PMID: 16720837; PMCID: PMC1895533.
    20. Lauchle JO, Braun B, Loh ML, Shannon K. Inherited predispositions and hyperactive Ras in myeloid leukemogenesis. Pediatr Blood Cancer. 2006 May 1; 46(5):579-85. PMID: 16261595.
      View in: PubMed
    21. Zhang IH, Zane LT, Braun B, Maize J, Zoger S, Loh ML. Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol. 2006 Feb; 54(2 Suppl):S22-7. PMID: 16427986.
      View in: PubMed
    22. Braun B, Shannon K. The sum is greater than the FGFR1 partner. Cancer Cell. 2004 Mar; 5(3):203-4. PMID: 15050910.
      View in: PubMed
    23. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun B, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 1; 103(11):4243-50. PMID: 14982883.
      View in: PubMed
    24. Braun B, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):597-602. PMID: 14699048; PMCID: PMC327193.
    25. Braun B, Frieden R, Lessnick SL, May WA, Denny CT. Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis. Mol Cell Biol. 1995 Aug; 15(8):4623-30. PMID: 7623854; PMCID: PMC230703.
    26. Lessnick SL, Braun B, Denny CT, May WA. Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene. 1995 Feb 2; 10(3):423-31. PMID: 7845667.
      View in: PubMed
    27. May WA, Lessnick SL, Braun B, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol. 1993 Dec; 13(12):7393-8. PMID: 8246959; PMCID: PMC364810.
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