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Beat-AML 2024 ELN-refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy. Blood Adv. 2024 Oct 22; 8(20):5297-5305.
Hoff FW, Blum WG, Huang Y, Welkie RL, Swords RT, Traer E, Stein EM, Lin TL, Archer KJ, Patel PA, Collins RH, Baer MR, Duong VH, Arellano ML, Stock W, Odenike O, Redner RL, Kovacsovics T, Deininger MW, Zeidner JF, Olin RL, Smith CC, Foran JM, Schiller GJ, Curran EK, Koenig KL, Heerema NA, Chen T, Martycz M, Stefanos M, Marcus SG, Rosenberg L, Druker BJ, Levine RL, Burd A, Yocum AO, Borate UM, Mims AS, Byrd JC, Madanat YF. PMID: 39110987.
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1 Fields:
Translation:
Humans
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Being Present-CML: A mindfulness-based intervention for patients with chronic myeloid leukemia taking tyrosine kinase inhibitors. Journal of Clinical Oncology. 2024 Sep 30; 20(10_suppl):353-353.
Schoenbeck SK, Dhruva DA, Lee LA, Parikshak PA, Smith SC, Shah SN, Atreya AC. .
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Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia. Nat Commun. 2024 Sep 18; 15(1):8191.
Peretz CAC, Kennedy VE, Walia A, Delley CL, Koh A, Tran E, Clark IC, Hayford CE, D'Amato C, Xue Y, Fontanez KM, May-Zhang AA, Smithers T, Agam Y, Wang Q, Dai HP, Roy R, Logan AC, Perl AE, Abate A, Olshen A, Smith CC. PMID: 39294124; PMCID: PMC11411136.
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Translation:
HumansCells
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LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia. Haematologica. 2024 08 01; 109(8):2533-2541.
Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El Haddad A, Kogan SC, Abdullaev Z, Chehab FF, Tasian SK, Smith CC, Loh ML, Stieglitz E. PMID: 38152053; PMCID: PMC11290546.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Mechanisms of Resistance to Targeted Therapies in AML. Annual Review of Cancer Biology. 2024 Jun 12; 8(1):81-96.
Jones JM, Smith SC. .
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Covalent-103: A phase 1, open-label, dose-escalation and expansion study of BMF-500, an oral covalent FLT3 inhibitor, in adults with acute leukemia (AL). Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):tps6589-tps6589.
Rotta RM, Abaza AY, Carraway CH, Christensen CB, Gandhi GM, Koller KP, Qasrawi QA, Schiller SG, Smith SC, Ahmed AU, Cacovean CA, Kowalczyk KN, Morris MS, Vimal VM, Yachamaneni YS, Butler BT, Wang WE, Ravandi-Kashani RF. .
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A phase 1 study of the irreversible FLT3 inhibitor FF-10101 in relapsed or refractory acute myeloid leukemia. Blood Adv. 2024 May 28; 8(10):2527-2535.
Levis M, Perl A, Schiller G, Fathi AT, Roboz G, Wang ES, Altman J, Rajkhowa T, Ando M, Suzuki T, Subach RA, Maier G, Madden T, Johansen M, Cheung K, Kurman M, Smith C. PMID: 38502195; PMCID: PMC11131057.
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PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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FLT3 targeting in the modern era: from clonal selection to combination therapies. Int J Hematol. 2024 Nov; 120(5):528-540.
Kennedy VE, Smith CC. PMID: 38112995; PMCID: PMC11513752.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Multiomic Single-Cell Sequencing May Distinguish BCR-ABL-Mutated Acute Myeloid Leukemia (AML) from Blast Crisis Chronic Myelogenous Leukemia (BC-CML). Blood. 2023 Nov 28; 142(Supplement 1):4334.
Kennedy KV, Peretz PC, Koh KA, Tran TE, Dhingra DD, Gulati GS, Sciambi SA, Sala-Torra SO, Beppu BL, Logan LA, Perl PA, Stock SW, Uy UG, Eisfeld EA, Radich RJ, Smith SC. .
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Influence of Pre-Treatment Features and Therapy Choice By Physicians on Overall Survival in Older Adults with Acute Myeloid Leukemia: A Report from the Beat AML Master Trial. Blood. 2023 Nov 28; 142(Supplement 1):4332.
Borate BU, Huang HY, Welkie WR, Swords SR, Traer TE, Stein SE, Lin LT, Madanat MY, Patel PP, Collins CR, Baer BM, Duong DV, Blum BW, Arellano AM, Stock SW, Odenike OO, Redner RR, Kovacsovics KT, Deininger DM, Zeidner ZJ, Olin OR, Smith SC, Foran FJ, Schiller SG, Curran CE, Koenig KK, Heerema HN, Chen CT, Martycz MM, Stefanos SM, Marcus MS, Rosenberg RL, Druker DB, Levine LR, Burd BA, Yocum YA, Mims MA, Byrd BJ. .
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RAS MULTI(ON) Inhibitor RMC-7977 Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 Inhibitors in AML Models. Blood. 2023 Nov 28; 142(Supplement 1):2793.
Popescu PB, Stieglitz SE, Smith SC. .
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Genomic Characterization of Newly Diagnosed Acute Myeloid Leukemia in Patients Age 60 Years and Older; A Report from the Beat AML Master Trial. Blood. 2023 Nov 28; 142(Supplement 1):4296.
Hoff HF, Huang HY, Welkie WR, Swords SR, Traer TE, Stein SE, Lin LT, Patel PP, Collins CR, Baer BM, Duong DV, Blum BW, Arellano AM, Stock SW, Odenike OO, Redner RR, Kovacsovics KT, Deininger DM, Zeidner ZJ, Olin OR, Smith SC, Foran FJ, Schiller SG, Curran CE, Koenig KK, Heerema HN, Chen CT, Martycz MM, Stefanos SM, Marcus MS, Rosenberg RL, Druker DB, Levine LR, Burd BA, Yocum YA, Borate BU, Mims MA, Byrd BJ, Madanat MY. .
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Threshold Attenuation of Perk Signaling Is Sufficient to Overcome RAS-Mediated FLT3 Inhibitor Resistance. Blood. 2023 Nov 28; 142(Supplement 1):4171.
Peretz PC, Tran TE, Popescu PB, Kennedy KV, Kumar KT, McGary ML, Tantisira TN, Wong WE, Rivera RJ, Xirenayi XS, Stieglitz SE, Smith SC, Hübner HJ. .
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Mediator Kinase/CDK8 Inhibition As a Strategy to Improve FLT3 Inhibitor Activity in Acute Myeloid Leukemia. Blood. 2023 Nov 28; 142(Supplement 1):4173.
Ferng FT, Pintar PS, Kennedy KV, Tarver TT, Kabir KS, Steri SV, Serrano SJ, Salangsang SF, Phojanakong PP, Hübner HJ, Morales MC, Rivera RJ, Logan LA, Braun BB, Stieglitz SE, Gilbert GL, Smith SC. .
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Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML. Cell Rep Med. 2023 11 21; 4(11):101290.
Popescu B, Stahlhut C, Tarver TC, Wishner S, Lee BJ, Peretz CAC, Luck C, Phojanakong P, Camara Serrano JA, Hongo H, Rivera JM, Xirenayi S, Chukinas JA, Steri V, Tasian SK, Stieglitz E, Smith CC. PMID: 37992684; PMCID: PMC10694768.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target. Nat Cancer. 2023 Nov; 4(11):1592-1609.
Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano JAC, Salangsang F, Phojanakong P, McMillan M, Gavallos V, Leavitt AD, Logan AC, Rooney CM, Eyquem J, Sinz A, Huang BJ, Stieglitz E, Smith CC, Moritz RL, Sidhu SS, Huang L, Wiita AP. PMID: 37904046; PMCID: PMC10663162.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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The FLT3N701K mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib. Am J Hematol. 2023 12; 98(12):E364-E368.
Joshi SK, Pittsenbarger J, Kennedy VE, Peretz CAC, Perl AE, Smith CC, Tyner JW, Druker BJ, Traer E. PMID: 37815132; PMCID: PMC10842343.
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1 Fields:
Translation:
Humans
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Association of geriatric measures and global frailty with cognitive decline after allogeneic hematopoietic cell transplantation in older adults. J Geriatr Oncol. 2023 11; 14(8):101623.
Huang LW, Shi Y, Andreadis C, Logan AC, Mannis GN, Smith CC, Gaensler KML, Martin TG, Damon LE, Boscardin WJ, Steinman MA, Olin RL. PMID: 37678052; PMCID: PMC11101048.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Standardising acute myeloid leukaemia classification systems: a perspective from a panel of international experts. Lancet Haematol. 2023 Sep; 10(9):e767-e776.
Shallis RM, Daver N, Altman JK, Komrokji RS, Pollyea DA, Badar T, Bewersdorf JP, Bhatt VR, de Botton S, de la Fuente Burguera A, Carraway HE, Desai P, Dillon R, Duployez N, El Chaer F, Fathi AT, Freeman SD, Gojo I, Grunwald MR, Jonas BA, Konopleva M, Lin TL, Mannis GN, Mascarenhas J, Michaelis LC, Mims AS, Montesinos P, Pozdnyakova O, Pratz KW, Schuh AC, Sekeres MA, Smith CC, Stahl M, Subklewe M, Uy GL, Voso MT, Walter RB, Wang ES, Zeidner JF, Žucenka A, Zeidan AM. PMID: 37572683.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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A phase 1/2 dose escalation study of the BCL-2 inhibitor ZN-d5 and the WEE1 inhibitor azenosertib (ZN-c3) in patients (Pts) with acute myeloid leukemia (AML). Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):tps7077-tps7077.
Smith SC, Vachhani VP, Garcia-Manero GG, Grieselhuber GN, Guru Murthy GG, Bhatia BA, Arora AJ, Izadi IH, Fiorino FA, Rampal RR. .
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Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification. bioRxiv. 2023 May 18.
Peretz CAC, Kennedy VE, Walia A, Delley CL, Koh A, Tran E, Clark IC, Hayford CE, D'Amato C, Xue Y, Fontanez KM, Roy R, Logan AC, Perl AE, Abate A, Olshen A, Smith CC. PMID: 37292835; PMCID: PMC10245585.
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Microfluidics-free single-cell genomics with templated emulsification. Nat Biotechnol. 2023 Nov; 41(11):1557-1566.
Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz CAC, Kim EA, Song S, Karlon W, Weissman JS, Smith CC, Gartner ZJ, Abate AR. PMID: 36879006; PMCID: PMC10635830.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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304 HLA-DPB1 Mismatch Permissiveness and Activating KIR Haplotypes Have Different Impact on Allogeneic Hematopoietic Cell Transplant Survival Outcomes in Acute Leukemias and Myelodysplastic Syndrome. Transplantation and Cellular Therapy. 2023 Feb 1; 29(2):s232-s233.
Lee LJ, Rajalingam RR, Kong KD, Ai AW, Andreadis AC, Damon DL, Dunavin DN, Gaensler GK, Kaplan KL, Martin MT, Olin OR, Sayre SP, Smith SC, Wolf WJ, Logan LA. .
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Multi-Omic Single-Cell Sequencing Reveals Genetic and Immunophenotypic Clonal Selection in Patients With FLT3-Mutated AML Treated With Gilteritinib/Venetoclax. Blood. 2022 Nov 15; 140(Supplement 1):2244-2246.
Kennedy KV, Peretz PC, Lee LP, Chyla CB, Sun SY, Dail DM, Hill HJ, Tran TE, Koh KA, Altman AJ, Daver DN, Levis LM, McCloskey MJ, Perl PA, Smith SC. .
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Multiomic Single-Cell Sequencing of Mixed Phenotypic Acute Leukemia (MPAL) Reveals Complex Immunophenotypic, Transcriptional, and Genetic Heterogeneity. Blood. 2022 Nov 15; 140(Supplement 1):9146-9147.
Peretz PC, Kennedy KV, Walia WA, Delley DC, Koh KA, Tran TE, Clark CI, Hayford HC, Xue XY, D'Amato DC, Fontanez FK, Roy RR, Olshen OA, Logan LA, Perl PA, Abate AA, Smith SC. .
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Improved Gvhd and Relapse Free Survival Outcomes in Older Acute Leukemia Patients Receiving Young Haploidentical Donor Vs Older Matched Sibling Donor Reduced Intensity Conditioning Hematopoietic Cell Transplants. Blood. 2022 Nov 15; 140(Supplement 1):4895-4896.
Tam TA, Logan LA, Choi CA, Fong FR, Damon DL, Olin OR, Dunavin DN, Sayre SP, Gaensler GK, Smith SC, Yan YL. .
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Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia. J Clin Oncol. 2022 12 10; 40(35):4048-4059.
Daver N, Perl AE, Maly J, Levis M, Ritchie E, Litzow M, McCloskey J, Smith CC, Schiller G, Bradley T, Tiu RV, Naqvi K, Dail M, Brackman D, Siddani S, Wang J, Chyla B, Lee P, Altman JK. PMID: 35849791; PMCID: PMC9746764.
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58 Fields:
Translation:
HumansCTClinical Trials
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Abstract LB516A: The irreversible FLT3 inhibitor FF-10101 is active against a diversity of FLT3 inhibitor resistance mechanisms. Cancer Research. 2022 Jun 15; 82(12_Supplement):lb516a-lb516a.
Ferng FT, Terada TD, Ando AM, Tarver TT, Chaudhary CF, Lin LK, Logan LA, Smith SC. .
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Clinical outcomes in patients with relapsed/refractory FLT3-mutated acute myeloid leukemia treated with gilteritinib who received prior midostaurin or sorafenib. Blood Cancer J. 2022 05 30; 12(5):84.
Perl AE, Hosono N, Montesinos P, Podoltsev N, Martinelli G, Panoskaltsis N, Recher C, Smith CC, Levis MJ, Strickland S, Röllig C, Groß-Langenhoff M, Chou WC, Lee JH, Yokoyama H, Hasabou N, Lu Q, Tiu RV, Altman JK. PMID: 35637252; PMCID: PMC9151663.
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19 Fields:
Translation:
Humans
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The Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms. Mol Cancer Ther. 2022 05 04; 21(5):844-854.
Ferng TT, Terada D, Ando M, Tarver TC, Chaudhary F, Lin KC, Logan AC, Smith CC. PMID: 35395091; PMCID: PMC9081245.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Molecular profile of FLT3-mutated relapsed/refractory patients with AML in the phase 3 ADMIRAL study of gilteritinib. Blood Adv. 2022 04 12; 6(7):2144-2155.
Smith CC, Levis MJ, Perl AE, Hill JE, Rosales M, Bahceci E. PMID: 35130342; PMCID: PMC9006281.
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PubMed Mentions:
26 Fields:
Translation:
HumansCTClinical Trials
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Patterns and Predictors of Functional Decline after Allogeneic Hematopoietic Cell Transplantation in Older Adults. Transplant Cell Ther. 2022 06; 28(6):309.e1-309.e9.
Huang LW, Sheng Y, Andreadis C, Logan AC, Mannis GN, Smith CC, Gaensler KML, Martin TG, Damon LE, Huang CY, Olin RL. PMID: 35247612; PMCID: PMC9198006.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Being Present-CML: A Distress Reduction Intervention for Patients with Chronic Myeloid Leukemia Taking Tyrosine Kinase Inhibitors. Blood. 2021 Nov 5; 138(Supplement 1):4051-4051.
Schoenbeck SK, Dhruva DA, Lee LA, Goyal GN, Yang YA, Park PS, Smith SC, Shah SN, Atreya AC. .
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Single Cell Sequencing of Pediatric Acute Myeloid Leukemia Reveals Clonal Evolution to Relapse on Combination Chemotherapy with Sorafenib. Blood. 2021 Nov 5; 138(Supplement 1):3470-3470.
Peretz PC, Kennedy KV, Ries RR, Meshinchi MS, Smith SC. .
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Venetoclax in Combination with Gilteritinib Demonstrates Molecular Clearance of FLT3 mutation in Relapsed/Refractory FLT3 -Mutated Acute Myeloid Leukemia. Blood. 2021 Nov 5; 138(Supplement 1):691-691.
Daver DN, Perl PA, Maly MJ, Levis LM, Ritchie RE, Litzow LM, McCloskey MJ, Smith SC, Schiller SG, Bradley BT, Tiu TR, Naqvi NK, Dail DM, Siddani SS, Wang WJ, Chyla CB, Lee LP, Altman AJ. .
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Allosteric SHP2 Inhibitor RMC4550 Synergizes with Venetoclax in FLT3 and KIT Mutant Acute Myeloid Leukemia. Blood. 2021 Nov 5; 138(Supplement 1):2231-2231.
Popescu PB, Stahlhut SC, Tarver TT, Ferng FT, Peretz PC, Wishner WS, Phojanakong PP, Steri SV, Wong WE, Rivera RJ, Stieglitz SE, Smith SC. .
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RNA Polymerase II Is a Therapeutic Target to Overcome FLT3 Inhibitor Resistance Mediated By the Bone Marrow Microenvironment. Blood. 2021 Nov 5; 138(Supplement 1):2236-2236.
Ferng FT, Tarver TT, Kabir KS, Braun BB, Logan LA, Gilbert GL, Smith SC. .
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Correction to: Pharmacokinetic Profile of Gilteritinib: A Novel FLT-3 Tyrosine Kinase Inhibitor. Clin Pharmacokinet. 2021 Sep; 60(9):1251.
James AJ, Smith CC, Litzow M, Perl AE, Altman JK, Shepard D, Kadokura T, Souda K, Patton M, Lu Z, Liu C, Moy S, Levis MJ, Bahceci E. PMID: 34297319; PMCID: PMC8416867.
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AML-091: Clinical Outcomes in Patients with Relapsed/Refractory Acute Myeloid Leukemia Treated with Gilteritinib Who Received Prior Midostaurin or Sorafenib. Clinical Lymphoma Myeloma & Leukemia. 2021 Sep 1; 21:s280.
Perl PA, Altman AJ, Hosono HN, Montesinos MP, Podoltsev PN, Martinelli MG, Smith SC, Levis LM, Röllig RC, Groß-Langenhoff GM, Hasabou HN, Lu LQ, Tiu TR. .
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Poster: AML-091: Clinical Outcomes in Patients with Relapsed/Refractory Acute Myeloid Leukemia Treated with Gilteritinib Who Received Prior Midostaurin or Sorafenib. Clinical Lymphoma Myeloma & Leukemia. 2021 Sep 1; 21:s210.
Perl PA, Altman AJ, Hosono HN, Montesinos MP, Podoltsev PN, Martinelli MG, Smith SC, Levis LM, Röllig RC, Groß-Langenhoff GM, Hasabou HN, Lu LQ, Tiu TR. .
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Poster: AML-162: Efficacy and Safety of Venetoclax in Combination with Gilteritinib for Relapsed/Refractory FLT3-Mutated Acute Myeloid Leukemia: Updated Analyses of a Phase 1b Study. Clinical Lymphoma Myeloma & Leukemia. 2021 Sep 1; 21:s212.
Altman AJ, Daver DN, Maly MJ, Levis LM, Ritchie RE, Litzow LM, McCloskey MJ, Smith SC, Schiller SG, Bradley BT, Tiu TR, Naqvi NK, Siddani SS, Wang WJ, Lee LP, Perl PA. .
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AML-162: Efficacy and Safety of Venetoclax in Combination with Gilteritinib for Relapsed/Refractory FLT3-Mutated Acute Myeloid Leukemia: Updated Analyses of a Phase 1b Study. Clinical Lymphoma Myeloma & Leukemia. 2021 Sep 1; 21:s285.
Altman AJ, Daver DN, Maly MJ, Levis LM, Ritchie RE, Litzow LM, McCloskey MJ, Smith SC, Schiller SG, Bradley BT, Tiu TR, Naqvi NK, Siddani SS, Wang WJ, Lee LP, Perl PA. .
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The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment. Haematologica. 2021 08 01; 106(8):2242-2245.
Tran TH, Nguyen JV, Stecula A, Akutagawa J, Moorman AV, Braun BS, Sali A, Mullighan CG, Shah NP, Dai Y, Devidas M, Roberts KG, Smith CC, Loh ML. PMID: 33626861; PMCID: PMC8327742.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia. Clin Cancer Res. 2021 07 15; 27(14):4003-4011.
Smith CC, Viny AD, Massi E, Kandoth C, Socci ND, Rapaport F, Najm M, Medina-Martinez JS, Papaemmanuil E, Tarver TC, Hsu HH, Le MH, West B, Bollag G, Taylor BS, Levine RL, Shah NP. PMID: 34103301; PMCID: PMC8282743.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Phase 1 first-in-human study of irreversible FLT3 inhibitor FF-10101-01 in relapsed or refractory acute myeloid leukemia. Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):7008-7008.
Levis LM, Smith SC, Perl PA, Schiller SG, Fathi FA, Roboz RG, Wang WE, Altman AJ, Ando AM, Suzuki ST, Subach SR, Maier MG, Madden MT, Johansen JM, Cheung CK, Kurman KM. .
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Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia. Nat Commun. 2021 03 11; 12(1):1583.
Demaree B, Delley CL, Vasudevan HN, Peretz CAC, Ruff D, Smith CC, Abate AR. PMID: 33707421; PMCID: PMC7952600.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib. Blood Adv. 2021 03 09; 5(5):1437-1441.
Peretz CAC, McGary LHF, Kumar T, Jackson H, Jacob J, Durruthy-Durruthy R, Levis MJ, Perl A, Huang BJ, Smith CC. PMID: 33666651; PMCID: PMC7948271.
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PubMed Mentions:
11 Fields:
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FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies. Front Oncol. 2020; 10:612880.
Kennedy VE, Smith CC. PMID: 33425766; PMCID: PMC7787101.
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64
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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. Lancet. 2021 12 19; 396(10267):1979-1993.
Ramasamy MN, Minassian AM, Ewer KJ, Flaxman AL, Folegatti PM, Owens DR, Voysey M, Aley PK, Angus B, Babbage G, Belij-Rammerstorfer S, Berry L, Bibi S, Bittaye M, Cathie K, Chappell H, Charlton S, Cicconi P, Clutterbuck EA, Colin-Jones R, Dold C, Emary KRW, Fedosyuk S, Fuskova M, Gbesemete D, Green C, Hallis B, Hou MM, Jenkin D, Joe CCD, Kelly EJ, Kerridge S, Lawrie AM, Lelliott A, Lwin MN, Makinson R, Marchevsky NG, Mujadidi Y, Munro APS, Pacurar M, Plested E, Rand J, Rawlinson T, Rhead S, Robinson H, Ritchie AJ, Ross-Russell AL, Saich S, Singh N, Smith CC, Snape MD, Song R, Tarrant R, Themistocleous Y, Thomas KM, Villafana TL, Warren SC, Watson MEE, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Faust SN, Pollard AJ, Oxford COVID Vaccine Trial Group. PMID: 33220855; PMCID: PMC7674972.
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PubMed Mentions:
827 Fields:
Translation:
HumansCellsCTClinical Trials
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Concurrent FLT3 Inhibitor and IDH Inhibitor Therapy in Patients with Acute Myeloid Leukemia (AML). Blood. 2020 Nov 5; 136(Supplement 1):11-12.
Fathi FA, Perl PA, Levis LM, Smith SC, Brunner BA, Takahashi TK, Amrein AP, Hock HH, Hobbs HG, Narayan NR, Moran MJ, Bergeron BM, Foster FJ, Daver DN, DiNardo DC. .
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Clinical Outcomes in Patients with Relapsed/Refractory Acute Myeloid Leukemia Treated with Gilteritinib Who Received Prior Midostaurin or Sorafenib. Blood. 2020 Nov 5; 136(Supplement 1):22-23.
Perl PA, Altman AJ, Hosono HN, Montesinos MP, Podoltsev PN, Martinelli MG, Smith SC, Levis LM, Röllig RC, Groß-Langenhoff GM, Hasabou HN, Lu LQ, Tiu TR. .
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Excellent Outcomes Achieved with Medical Management of Chronic Phase CML Patients with Non-Hematologic TKI Intolerance. Blood. 2020 Nov 5; 136(Supplement 1):41-42.
Schoenbeck SK, Tummala TS, Olin OR, Goyal GN, Dhruva DA, Damon DL, Logan LA, Smith SC, Shah SN. .
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Efficacy and Safety of Venetoclax in Combination with Gilteritinib for Relapsed/Refractory FLT3-Mutated Acute Myeloid Leukemia in the Expansion Cohort of a Phase 1b Study. Blood. 2020 Nov 5; 136(Supplement 1):20-22.
Daver DN, Altman AJ, Maly MJ, Levis LM, Ritchie RE, Litzow LM, McCloskey MJ, Smith SC, Schiller SG, Bradley BT, Tiu TR, Hong HW, Tong TB, Qin QQ, Dilley DK, Perl PA. .
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Cognitive Dysfunction Associated with Tyrosine Kinase Inhibitors in Patients with CML in Chronic Phase. Blood. 2020 Nov 5; 136(Supplement 1):2-3.
Schoenbeck SK, Tummala TS, Goyal GN, Smith SC, Shah SN. .
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Pharmacokinetic Profile of Gilteritinib: A Novel FLT-3 Tyrosine Kinase Inhibitor. Clin Pharmacokinet. 2020 10; 59(10):1273-1290.
James AJ, Smith CC, Litzow M, Perl AE, Altman JK, Shepard D, Kadokura T, Souda K, Patton M, Lu Z, Liu C, Moy S, Levis MJ, Bahceci E. PMID: 32304015; PMCID: PMC7550323.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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FLT3 Inhibition in Acute Myeloid Leukemia. Clin Lymphoma Myeloma Leuk. 2020 09; 20 Suppl 1:S5-S6.
Smith CC. PMID: 32862867.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia. Blood Adv. 2020 04 28; 4(8):1711-1721.
Smith CC, Levis MJ, Frankfurt O, Pagel JM, Roboz GJ, Stone RM, Wang ES, Severson PL, West BL, Le MH, Kayser S, Lam B, Hsu HH, Zhang C, Bollag G, Perl AE. PMID: 32330242; PMCID: PMC7189289.
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PubMed Mentions:
23 Fields:
Translation:
HumansCTClinical Trials
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Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations. Blood Adv. 2020 02 11; 4(3):514-524.
Tarver TC, Hill JE, Rahmat L, Perl AE, Bahceci E, Mori K, Smith CC. PMID: 32040554; PMCID: PMC7013266.
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PubMed Mentions:
33 Fields:
Translation:
Humans
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The growing landscape of FLT3 inhibition in AML. Hematology Am Soc Hematol Educ Program. 2019 12 06; 2019(1):539-547.
Smith CC. PMID: 31808872; PMCID: PMC6913436.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Single Cell Sequencing Reveals Evolution of Tumor Heterogeneity of Acute Myeloid Leukemia on Quizartinib. Blood. 2019 Nov 13; 134(Supplement_1):1440-1440.
Cohler Peretz CC, McGary ML, Kumar KT, Jackson JJ, Jacob JJ, Durruthy-Durruthy DR, Zhang ZC, Levis LM, Perl PA, Leung LA, Smith SC. .
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Direct Oral Anticoagulant Use and Outcomes in Patients with High and Intermediate Risk BCR-ABL-Negative Myeloproliferative Neoplasms. Blood. 2019 Nov 13; 134(Supplement_1):1165-1165.
Schoenbeck SK, Salmasi SG, Cerejo CM, Cornett CP, Damon DL, Logan LA, Olin OR, Leavitt LA, Smith SC. .
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Symptom Assessment in Patients with BCR-ABL-Negative Myeloproliferative Neoplasms at an Academic Medical Institution. Blood. 2019 Nov 13; 134(Supplement_1):5859-5859.
Schoenbeck SK, Cerejo CM, Cornett CP, Damon DL, Gaensler GK, Leavitt LA, Logan LA, Mannis MG, Olin OR, Salmasi SG, Sayre SP, Shah SN, Dhruva DA, Atreya AC, Smith SC. .
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Efficacy of Venetoclax Combination Therapy with Hypomethylating Agents in Patients with Relapsed Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation. Blood. 2019 Nov 13; 134(Supplement_1):5089-5089.
Mittal MV, Lo LM, Damon DL, Gaensler GK, Martin MT, Olin OR, Smith SC, Logan LA. .
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Combined Single-Cell DNA Genotyping and Protein Quantification (DAb-seq) in Acute Myeloid Leukemias Reveals Distinct Immunophenotypic Subsets Among Pathogenic Clones. Blood. 2019 Nov 13; 134(Supplement_1):2088-2088.
Demaree DB, Delley DC, Peretz PC, Vasudevan VH, Ruff RD, Ooi OA, Smith SC, Abate AA. .
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Emerging Mutations at Relapse in Patients with FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia Who Received Gilteritinib Therapy in the Phase 3 Admiral Trial. Blood. 2019 Nov 13; 134(Supplement_1):14-14.
Smith SC, Levis LM, Perl PA, Martinelli MG, Neubauer NA, Berman BE, Montesinos MP, Baer BM, Larson LR, Chou CW, Yokoyama YH, Recher RC, Yoon YS, Hill HJ, Rosales RM, Bahceci BE. .
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Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing. Leukemia. 2020 02; 34(2):662-666.
Chao AK, Meyer JA, Lee AG, Hecht A, Tarver T, Van Ziffle J, Koegel AK, Golden C, Braun BS, Sweet-Cordero EA, Smith CC, Dvorak CC, Loh ML, Stieglitz E. PMID: 31511612; PMCID: PMC6995757.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Functional Status as Measured by Geriatric Assessment Predicts Inferior Survival in Older Allogeneic Hematopoietic Cell Transplantation Recipients. Biol Blood Marrow Transplant. 2020 01; 26(1):189-196.
Huang LW, Sheng Y, Andreadis C, Logan AC, Mannis GN, Smith CC, Gaensler KML, Martin TG, Damon LE, Steinman MA, Huang CY, Olin RL. PMID: 31493541; PMCID: PMC6942208.
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PubMed Mentions:
22 Fields:
Translation:
HumansCTClinical Trials
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Use of FLT3 Inhibitors in AML. Clinical Lymphoma Myeloma & Leukemia. 2019 Sep 1; 19:s92-s94.
Smith SC. .
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PS1024 IMPACT OF MINIMAL RESIDUAL DISEASE AND COMPLETE REMISSION (CR)/CR WITH PARTIAL HEMATOLOGIC RECOVERY ON SURVIVAL AFTER GILTERITINIB THERAPY IN PATIENTS WITH FLT3-MUTATED RELAPSED/REFRACTORY AML. HemaSphere. 2019 Jun 30; 3(S1):461.
Levis LM, Perl PA, Altman AJ, Cortes CJ, Smith SC, Baer BM, Claxton CD, Jurcic JJ, Ritchie RE, Strickland SS, Tibes TR, Hill HJ, Rosales RM, Bahceci BE. .
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Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia. Cancer Discov. 2019 08; 9(8):1050-1063.
McMahon CM, Ferng T, Canaani J, Wang ES, Morrissette JJD, Eastburn DJ, Pellegrino M, Durruthy-Durruthy R, Watt CD, Asthana S, Lasater EA, DeFilippis R, Peretz CAC, McGary LHF, Deihimi S, Logan AC, Luger SM, Shah NP, Carroll M, Smith CC, Perl AE. PMID: 31088841.
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PubMed Mentions:
196 Fields:
Translation:
HumansCells
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Roman warfare: targeting of support cells in AML. Blood. 2019 02 07; 133(6):506-507.
Smith CC. PMID: 30733203.
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Translation:
Humans
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Impact of Minimal Residual Disease and Achievement of Complete Remission/Complete Remission with Partial Hematologic Recovery (CR/CRh) on Overall Survival Following Treatment with Gilteritinib in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) with FLT3 Mutations. Blood. 2018 Nov 29; 132(Supplement 1):1458-1458.
Levis LM, Perl PA, Altman AJ, Cortes CJ, Smith SC, Baer BM, Claxton CD, Jurcic JJ, Ritchie RE, Strickland SS, Tibes TR, Hill HJ, Rosales RM, Bahceci BE. .
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Functional Status Is Associated with Outcomes after Allogeneic Stem Cell Transplantation for Older Patients with Hematologic Malignancies. Blood. 2018 Nov 29; 132(Supplement 1):3599-3599.
Huang HL, Huang HC, Andreadis AC, Logan LA, Mannis MG, Smith SC, Gaensler GK, Martin MT, Damon DL, Steinman SM, Olin OR. .
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Longitudinal Monitoring of AML Tumors with High-Throughput Single-Cell DNA Sequencing Reveals Rare Clones Prognostic for Disease Progression and Therapy Response. Blood. 2018 Nov 29; 132(Supplement 1):1476-1476.
Eastburn ED, McMahon MC, Durruthy-Durruthy DR, Carroll CM, Smith SC, Perl PA. .
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Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2018 07; 19(7):889-903.
Cortes J, Perl AE, Döhner H, Kantarjian H, Martinelli G, Kovacsovics T, Rousselot P, Steffen B, Dombret H, Estey E, Strickland S, Altman JK, Baldus CD, Burnett A, Krämer A, Russell N, Shah NP, Smith CC, Wang ES, Ifrah N, Gammon G, Trone D, Lazzaretto D, Levis M. PMID: 29859851; PMCID: PMC8152787.
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PubMed Mentions:
141 Fields:
Translation:
HumansCTClinical Trials
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Post hoc exploratory analysis of two phase 2 trials of quizartinib monotherapy in patients (pts) with FLT3 -ITD–mutated (mu) relapsed/refractory (R/R) AML with or without prior 1st-generation FLT3 tyrosine kinase inhibitors (TKI) treatment. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):7017-7017.
Levis LM, Smith SC, Ishizuka IK, Kobayashi KK, Arunachalam AM, Wang WY, Lazzaretto LD, Cortes CJ. .
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Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study. Lancet Oncol. 2017 08; 18(8):1061-1075.
Perl AE, Altman JK, Cortes J, Smith C, Litzow M, Baer MR, Claxton D, Erba HP, Gill S, Goldberg S, Jurcic JG, Larson RA, Liu C, Ritchie E, Schiller G, Spira AI, Strickland SA, Tibes R, Ustun C, Wang ES, Stuart R, Röllig C, Neubauer A, Martinelli G, Bahceci E, Levis M. PMID: 28645776; PMCID: PMC5572576.
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PubMed Mentions:
248 Fields:
Translation:
HumansCellsCTClinical Trials
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Deep molecular response to gilteritinib to improve survival in FLT3 mutation-positive relapsed/refractory acute myeloid leukemia. Journal of Clinical Oncology. 2017 May 20; 35(15_suppl):7003-7003.
Altman AJ, Perl PA, Cortes CJ, Smith SC, Litzow LM, Hill HJ, Larson LR, Liu LC, Ritchie RE, Strickland SS, Wang WE, Neubauer NA, Martinelli MG, Bahceci BE, Levis LM. .
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Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis. Blood. 2017 07 06; 130(1):48-58.
Smith CC, Paguirigan A, Jeschke GR, Lin KC, Massi E, Tarver T, Chin CS, Asthana S, Olshen A, Travers KJ, Wang S, Levis MJ, Perl AE, Radich JP, Shah NP. PMID: 28490572; PMCID: PMC5501146.
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PubMed Mentions:
95 Fields:
Translation:
HumansCTClinical Trials
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Pharmacokinetics and pharmacodynamics of gilteritinib in patients with relapsed or refractory acute myeloid leukemia. Journal of Clinical Oncology. 2016 May 20; 34(15_suppl):7026-7026.
Smith SC, Levis LM, Litzow LM, Perl PA, Altman AJ, Gill GS, Yuen YG, Bonate BP, Kadokura KT, James JA, Liu LC, Nagase NI, Fisniku FO, Bahceci BE. .
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The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI Insight. 2016 Mar; 1(3):e85630.
Minson KA, Smith CC, DeRyckere D, Libbrecht C, Lee-Sherick AB, Huey MG, Lasater EA, Kirkpatrick GD, Stashko MA, Zhang W, Jordan CT, Kireev D, Wang X, Frye SV, Earp HS, Shah NP, Graham DK. PMID: 27158668; PMCID: PMC4855528.
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PubMed Mentions:
42 Fields:
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Long-term outcomes of patients with intermediate-risk acute myeloid leukemia treated with autologous hematopoietic cell transplant in first complete remission. Leuk Lymphoma. 2016 07; 57(7):1560-6.
Mannis GN, Martin TG, Damon LE, Logan AC, Olin RL, Flanders MD, Ai WZ, Gaensler KM, Kaplan LD, Sayre PH, Smith CC, Wolf JL, Andreadis C. PMID: 26490487.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Resistance to FLT3 Inhibitors. Resistance to Tyrosine Kinase Inhibitors. 2016 Jan 1; 131-145.
Ferng FT, Smith SC. .
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Recurrent Mutations in CCND3 Confer Clinical Resistance to FLT3 Inhibitors. Blood. 2015 Dec 3; 126(23):677-677.
Smith SC, Viny VA, Massi ME, Kandoth KC, Socci SN, Hsu HH, West WB, Bollag BG, Taylor TB, Levine LR, Shah SN. .
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Pharmacokinetic Profile and Pharmacodynamic Effects of ASP2215, a Selective, Potent Inhibitor of FLT3/AXL, in Patients with Relapsed or Refractory Acute Myeloid Leukemia: Results from a First-in-Human Phase 1/2 Study. Blood. 2015 Dec 3; 126(23):4836-4836.
Smith SC, Levis LM, Litzow LM, Perl PA, Altman AJ, Gill GS, Kadokura KT, Yuen YG, Fisniku FO, Liu LC, Nagase NI, Sargent SB, Welter WN, Bahceci BE. .
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Identifying Drug-Resistant Mutations in Ebf1-Pdgfrb Ph-like Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):1423-1423.
Tran TT, Nguyen NJ, Smith SC, Roberts RK, Mullighan MC, Shah SN, Loh LM. .
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Abstract NG02: Polyclonal and heterogeneous resistance to targeted therapy in leukemia. Molecular and Cellular Biology. 2015 Aug 1; ng02-ng02.
Smith SC, Paguirigan PA, Chin CC, Brown BM, Parker PW, Levis LM, Perl PA, Travers TK, Kasap KC, Radich RJ, Branford BS, Shah SN. .
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Results of a first-in-human, phase I/II trial of ASP2215, a selective, potent inhibitor of FLT3/Axl in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML). Journal of Clinical Oncology. 2015 May 20; 33(15_suppl):7003-7003.
Levis LM, Perl PA, Altman AJ, Cortes CJ, Ritchie RE, Larson LR, Smith SC, Wang WE, Strickland SS, Baer BM, Litzow LM, Claxton CD, Schiller SG, Ustun UC, Liu LC, Gill GS, Sargent SB, Bahceci BE. .
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Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov. 2015 Jun; 5(6):668-79.
Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, Powell B, Burton EA, Matusow B, Zhang J, Spevak W, Ibrahim PN, Le MH, Hsu HH, Habets G, West BL, Bollag G, Shah NP. PMID: 25847190; PMCID: PMC4522415.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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O4.2 Development of novel small molecule MerTK and Flt3 tyrosine kinase inhibitors for treatment of acute leukemia. Annals of Oncology. 2015 Mar 1; 26:ii6.
Graham GD, DeRyckere DD, Minson MK, Smith SC, Hill HA, Huey HM, Lasater LE, Wang WX, Shah SN, Frye FS, Earp EH. .
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Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors. Eur J Med Chem. 2015 Apr 13; 94:123-31.
Frett B, McConnell N, Smith CC, Wang Y, Shah NP, Li HY. PMID: 25765758; PMCID: PMC4666306.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83.
Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. PMID: 25776193.
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PubMed Mentions:
1 Fields:
Translation:
HumansCTClinical Trials
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Long-Term Outcomes of 133 Patients with Intermediate-Risk Acute Myeloid Leukemia Treated with High-Dose Chemotherapy and Autologous Stem Cell Rescue in First Complete Remission. Biology of Blood and Marrow Transplantation. 2015 Feb 1; 21(2):s141-s142.
Mannis MG, Martin MT, Damon DL, Logan LA, Ai AW, Gaensler GK, Kaplan KL, Mahindra MA, Olin OR, Sayre SP, Smith SC, Wolf WJ, Hwang HJ, Andreadis AC. .
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Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Elife. 2014 Dec 22; 3.
Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM. PMID: 25531068; PMCID: PMC4307180.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia. Blood. 2014 Dec 6; 124(21):3757-3757.
Minson MK, Smith SC, Lee-Sherick LA, DeRyckere DD, Lasater LE, Hill HA, Wang WX, Frye FS, Earp EH, Shah SN, Graham GD. .
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Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Rep. 2014 Nov 20; 9(4):1333-48.
Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Kobayashi M, Vemula S, Canela VH, Waskow ER, Visconte V, Tiu RV, Smith CC, Shah N, Bunting KD, Boswell HS, Liu Y, Chan RJ, Kapur R. PMID: 25456130; PMCID: PMC4380442.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients. J Geriatr Oncol. 2014 Jul; 5(3):238-44.
Keller JW, Andreadis C, Damon LE, Kaplan LD, Martin TG, Wolf JL, Ai WZ, Venstrom JM, Smith CC, Gaensler KM, Hwang J, Olin RL. PMID: 24894413.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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FLT3 inhibitors in AML: are we there yet? Curr Hematol Malig Rep. 2014 Jun; 9(2):174-85.
Sudhindra A, Smith CC. PMID: 24682858.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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Crenolanib is a selective type I pan-FLT3 inhibitor. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5319-24.
Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP. PMID: 24623852; PMCID: PMC3986131.
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PubMed Mentions:
105 Fields:
Translation:
HumansCells
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A Phase 1 Study of Targeted, Dose-Escalated Intravenous Busulfan in Combination with Etoposide As Preparative Therapy for Autologous Stem Cell Transplant in Acute Myeloid Leukemia. Biology of Blood and Marrow Transplantation. 2014 Feb 1; 20(2):s114-s115.
Mannis MG, Damon DL, Ai AW, Andreadis AC, Gaensler GK, Kaplan KL, Logan LA, Mahindra MA, Olin OR, Sayre SP, Smith SC, Venstrom VJ, Wolf WJ, Martin MT. .
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Comprehensive Geriatric Assessment Identifies Significant Functional Impairments in Older Hematopoietic Cell Transplant Recipients. Biology of Blood and Marrow Transplantation. 2014 Feb 1; 20(2):s65-s66.
Olin OR, Andreadis AC, Martin MT, Wolf WJ, Kaplan KL, Ai AW, Venstrom VJ, Logan LA, Smith SC, Gaensler GK, Hwang HJ, Damon DL. .
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Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor. Leuk Res. 2014 Mar; 38(3):316-22.
Verstovsek S, Tam CS, Wadleigh M, Sokol L, Smith CC, Bui LA, Song C, Clary DO, Olszynski P, Cortes J, Kantarjian H, Shah NP. PMID: 24374145; PMCID: PMC4414320.
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PubMed Mentions:
21 Fields:
Translation:
HumansCTClinical Trials
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Disease diversity and FLT3 mutations. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20860-1.
Smith CC. PMID: 24324154; PMCID: PMC3876196.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Mutations At The FLT3 Activation Loop D835 Residue Confer Differential Resistance To Clinically Active FLT3 Inhibitors. Blood. 2013 Nov 15; 122(21):3929-3929.
Lin LK, Smith SC, Salerno SS, Shah SN. .
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Delayed Hematopoietic Recovery After Autologous Stem Cell Transplantation In Patients Receiving Arsenic Trioxide-Based Therapy For Acute Promyelocytic Leukemia. Blood. 2013 Nov 15; 122(21):2172-2172.
Mannis MG, Damon DL, Ai AW, Andreadis AC, Gaensler GK, Gupta GN, Kaplan KL, Leavitt LA, Logan LA, Olin OR, Sayre SP, Smith SC, Venstrom VJ, Martin MT. .
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Preclinical and Clinical Resistance Mechanisms To The Investigational Selective FLT3 Inhibitor PLX3397 In FLT3-ITD+ Acute Myeloid Leukemia (AML). Blood. 2013 Nov 15; 122(21):3938-3938.
Smith SC, Lin LK, Lasater LE, Stewart SW, Damon DL, Kasarskis KA, Bashir BA, Pendleton PM, Sebra SR, Perl PA, Le LM, Zhang ZC, West WB, Shah SN. .
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Association of age-dependent liver injury and fibrosis with immune cell populations. Liver Int. 2013 Sep; 33(8):1175-86.
Collins BH, Holzknecht ZE, Lynn KA, Sempowski GD, Smith CC, Liu S, Parker W, Rockey DC. PMID: 23710620; PMCID: PMC4151465.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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The Role of Kinase Inhibitors in the Treatment of Patients with Acute Myeloid Leukemia. American Society of Clinical Oncology Educational Book. 2013 May 1; (33):313-318.
Smith SC, Shah SN. .
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Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. Blood. 2013 Apr 18; 121(16):3165-71.
Smith CC, Lasater EA, Zhu X, Lin KC, Stewart WK, Damon LE, Salerno S, Shah NP. PMID: 23430109; PMCID: PMC3630831.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) Is Predictive of Serious Adverse Events and Overall Survival in Older Allogeneic Transplant Recipients. Biology of Blood and Marrow Transplantation. 2013 Feb 1; 19(2):s293-s294.
Keller KJ, Damon DL, Kaplan KL, Martin MT, Wolf WJ, Ai AW, Andreadis AC, Venstrom VJ, Smith SC, Gaensler GK, Hwang HJ, Olin OR. .
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The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. Am Soc Clin Oncol Educ Book. 2013; 313-8.
Smith CC, Shah NP. PMID: 23714533.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Competitive Allele Specific TaqMan® PCR (castPCR™) Technology for Sensitive Detection of AC220-Resistant FLT3 Kinase Domain Mutations in Primary AML Patient Samples. Blood. 2012 Nov 16; 120(21):2559-2559.
Cheng CW, Lasater LE, Smith SC, Mokang MM, Bao BY, Shah SN. .
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Single Molecule Real Time (SMRT™) Sequencing Sensitively Detects the Evolution of Polyclonal and Compound BCR-ABL Mutations in Patients Who Relapse On Kinase Inhibitor Therapy. Blood. 2012 Nov 16; 120(21):917-917.
Smith SC, Brown BM, Parker PW, Lin LK, Travers TK, Wang WS, Branford BS, Shah SN. .
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Constitutively Activating Mutations At the FLT3 Activation Loop Residue D835 Are Associated with Clinical Resistance to AC220. Blood. 2012 Nov 16; 120(21):674-674.
Smith SC, Chin CJ, Lasater LE, Paguirigan PA, Lin LK, Stewart SW, Salerno SS, Damon DL, Levis LM, Perl PA, Travers TK, Kasarskis KA, Radich RJ, Shah SN. .
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Single-Cell Pharmacodynamic Monitoring of Ribosomal Protein S6 Phosphorylation During AC220 Therapy Demonstrates in Vivo FLT3 Inhibition in Circulating Leukemic Blasts and Accurately Detects the Development of AC220 Resistance. Blood. 2012 Nov 16; 120(21):2453-2453.
Perl PA, Jeschke JG, Smith SC, Mangan MJ, Luger LS, Carroll CM. .
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Crenolanib (CP-868,596) Is a Potent and Selective Type I FLT3 Inhibitor That Retains Activity Against AC220 Resistance-Causing FLT3 Kinase Domain Mutants. Blood. 2012 Nov 16; 120(21):141-141.
Smith SC, Lasater LE, Mccreery MM, Lin LK, Stewart SW, Damon DL, Perl PA, Jeschke JG, Sugita SM, Carroll CM, Kogan KS, Shah SN. .
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Mechanisms of Resistance to Targeted Therapies in Acute Myeloid Leukemia and Chronic Myeloid Leukemia. American Society of Clinical Oncology Educational Book. 2012 Jun 1; (32):685-689.
Smith SC, Shah SN. .
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Abstract 1893: Activating NRAS mutations are associated with FLT3-independent resistance to the clinically active FLT3 inhibitor AC220 in vitro. Experimental and Molecular Therapeutics. 2012 Apr 15; 1893-1893.
Lasater LE, Smith SC, Shah SN. .
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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature. 2012 Apr 15; 485(7397):260-3.
Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, Perl AE, Travers KJ, Wang S, Hunt JP, Zarrinkar PP, Schadt EE, Kasarskis A, Kuriyan J, Shah NP. PMID: 22504184; PMCID: PMC3390926.
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PubMed Mentions:
376 Fields:
Translation:
HumansCells
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Mechanisms of resistance to targeted therapies in acute myeloid leukemia and chronic myeloid leukemia. Am Soc Clin Oncol Educ Book. 2012; 685-9.
Smith CC, Shah NP. PMID: 24451819.
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PubMed Mentions: Fields:
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A Phase II Open-Label, Ac220 Monotherapy Efficacy Study In Patients with Refractory/Relapsed Flt3-Itd Positive Acute Myeloid Leukemia: Updated Interim Results. Blood. 2011 Nov 18; 118(21):2576-2576.
Cortes CJ, Perl PA, Smith SC, Kovacsovics KT, Dombret DH, Dohner DH, Steffen SB, Pigneux PA, Rousselot RP, Krauter KJ, Martinelli MG, Estey EE, Burnett BA, Ho HA, Ifrah IN, de Witt dT, Corringham CR, James JJ, Lilienfeld LD, Leo LE, Gammon GG, Levis LM. .
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Activity of Allosteric, Switch-Pocket, ABL/FLT3 Kinase Inhibitor DCC2036 Against Cultured and Primary AML Progenitors with FLT-ITD or FLT3 Kinase Domain Mutations. Blood. 2011 Nov 18; 118(21):2611-2611.
Fiskus FW, Smith SC, Smith SJ, Wise WS, Lasater LE, Damon DL, Salerno SS, Fleming FA, Reyes RR, Ganguly GS, Berger BM, Rutkoski RT, McGuirk MJ, Shah SN, Bhalla BK. .
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Single Molecule Real Time (SMRT™) Sequencing Sensitively Detects Polyclonal and Compound BCR-ABL in Patients Who Relapse on Kinase Inhibitor Therapy,. Blood. 2011 Nov 18; 118(21):3752-3752.
Smith SC, Brown BM, Chin CJ, Kasap KC, Salerno SS, Damon DL, Travers TK, Wang WS, Kasarskis KA, Schadt SE, Shah SN. .
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Analysis of in Vitro Activity of the Clinically-Active ABL/FLT3 Inhibitor Ponatinib (AP24534) Against AC220-Resistant FLT3-ITD Mutants. Blood. 2011 Nov 18; 118(21):930-930.
Smith SC, Damon DL, Zhu ZX, Salerno SS, Shah SN. .
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Phospho-Specific Flow Cytometry of Fixed Whole Blood Demonstrates In Vivo FLT3 Inhibition in Circulating Leukemic Blasts During AC220 Therapy and Accurately Detects the Development of Therapeutic Resistance,. Blood. 2011 Nov 18; 118(21):3502-3502.
Perl PA, Jeschke JG, Smith SC, Mangan MJ, Luger LS, Carroll CM. .
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Validation of FLT3-ITD As a Therapeutic Target in Human Acute Myeloid Leukemia. Blood. 2011 Nov 18; 118(21):937-937.
Smith SC, Chin CJ, Wang WQ, Salerno SS, Damon DL, Hunt HJ, Levis LM, Perl PA, Travers TK, Wang WS, Kasarskis KA, Schadt SE, Kuriyan KJ, Shah SN. .
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PLX3397 Is An Investigational Selective FLT3 Inhibitor That Retains Activity Against the Clinically-Relevant FLT3-ITD/F691L “Gatekeeper” Mutation in Vitro. Blood. 2011 Nov 18; 118(21):764-764.
Smith SC, Perl PA, Lasater LE, Zhang ZC, Jeschke JG, Damon DL, Carroll CM, Shah SN. .
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Is it downhill from here? Eliminating leukemic stem cells and curing chronic myeloid leukemia. Clin Cancer Res. 2011 Nov 01; 17(21):6605-7.
Smith CC, Shah NP. PMID: 21948230.
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PubMed Mentions: Fields:
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HumansCells
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Abstract 4737: Saturation mutagenesis of FLT3-ITD: AC220-resistance-conferring kinase domain mutations are restricted to a limited number of residues and are cross-resistant to sorafenib in vitro. Experimental and Molecular Therapeutics. 2011 Apr 15; 4737-4737.
Smith SC, Damon DL, Salerno SS, Shah SN. .
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Tyrosine kinase inhibitor therapy for chronic myeloid leukemia: approach to patients with treatment-naive or refractory chronic-phase disease. Hematology Am Soc Hematol Educ Program. 2011; 2011:121-7.
Smith CC, Shah NP. PMID: 22160023.
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7 Fields:
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Humans
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Cost-effectiveness of private umbilical cord blood banking. Obstet Gynecol. 2009 Oct; 114(4):848-855.
Kaimal AJ, Smith CC, Laros RK, Caughey AB, Cheng YW. PMID: 19888044.
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13 Fields:
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Humans
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Fluorometric assay for N-acetylprocainamide. Clin Chem. 1975 Dec; 21(13):1899-902.
Matusik E, Gibson TP. PMID: 160.
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3 Fields:
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Humans
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[The analgesic efficacy of pentazocine (fortalgesic winthrop) in suppositories with postoperative pains (author's transl)]. Ther Umsch. 1975 Nov; 32(11):730-5.
Rusch G, Chaker RB. PMID: 7026.
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HumansCTClinical Trials
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Metal substitutions incarbonic anhydrase: a halide ion probe study. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1281-6.
Smith RJ, Bryant RG. PMID: 3.
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11 Fields:
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HumansAnimalsCells