Fernando Gonzalez, MD
Biography Brown University, Providence, RI | Sc.B. | 1997 | Neuroscience | Brown University, Providence, RI | M.D. | 2001 | School of Medicine | Harbor-UCLA Medical Center, Torrance, CA | | 2004 | Pediatrics | UCSF, San Francisco, CA | | 2007 | Neonatal-Perinatal Medicine | University of California, San Francisco, CA | | 2019 | Diversity, Equity, and Inclusion Champion Training |
Overview My research is focused on determining how the full-term brain responds to acute injury during the neonatal period, and strategies to enhance neuroplasticity and long-term functional outcomes. My specific research goals are to: (1) clearly define the neuronal subpopulations that are vulnerable to ischemia and critical for neurodevelopment, (2) determine the mechanisms of injury and endogenous repair in the immature brain, and (3) define therapeutic strategies to enhance long-term function. Specifically, I am interested in how the immature brain differs from the adult brain in its response to stroke, and how reparative mechanisms can be enhanced with delayed therapy. Throughout my training, I have had broad exposure to various aspects of central nervous system (CNS) development and repair, including: evaluation and inhibition of pain through direct CNS treatment; the effects of local injury on wound healing and phagocytosis; direct evaluation of behavioral, cognitive, and nociceptive function after injury; pathophysiologic mechanisms of early brain injury; and the effects of exogenous therapy on early brain injury. Of these experiences, the ones I found most compelling were those that linked rigorous basic science at the bench to investigation of human disease. For example, my research on the short-term effects of exogenous erythropoietin treatment on neurogenesis after early rodent stroke prompted a study to determine beneficial treatment strategies that improve long-term functional outcomes. This project showed that prolonged erythropoietin treatment is most effective for long-term behavioral improvement, a finding that informed clinical studies in humans to treat neonatal brain injury. My current research is focused on cell type-specific changes in the peri-infarct cortex, including alterations in cell fate, function, and circuit formation. This will have a significant impact in improving knowledge and identifying novel therapies to treat early injury. It is my clear desire to apply this type of translational approach to the field of neonatal brain injury, thereby unifying my interest in neuroscience and brain development with a goal of improving the care of the newborn.
Research ORNG Applications Bibliographic
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Enhanced Mesenchymal Stromal Cells or Erythropoietin Provide Long-Term Functional Benefit After Neonatal Stroke. Stroke. 2021 Jan; 52(1):284-293.
Larpthaveesarp A, Pathipati P, Ostrin S, Rajah A, Ferriero D, Gonzalez FF. PMID: 33349013.
View in: PubMed Mentions: Fields:
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Caffeine Restores Background EEG Activity Independent of Infarct Reduction after Neonatal Hypoxic Ischemic Brain Injury. Dev Neurosci. 2020; 42(1):72-82.
Sun H, Gonzalez F, McQuillen PS. PMID: 32810862.
View in: PubMed Mentions: Fields:
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A new genetic strategy for targeting microglia in development and disease. Elife. 2020 06 23; 9.
McKinsey GL, Lizama CO, Keown-Lang AE, Niu A, Santander N, Larpthaveesarp A, Chee E, Gonzalez FF, Arnold TD. PMID: 32573436.
View in: PubMed Mentions: 2 Fields:
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Whither pediatric physician-scientist training in the COVID-19 era. Pediatr Res. 2020 Jun 20.
Gonzalez FF, Heyman MB. PMID: 32575111.
View in: PubMed Mentions: Fields:
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Neuroprotection Strategies for Term Encephalopathy. Semin Pediatr Neurol. 2019 12; 32:100773.
Gonzalez FF. PMID: 31813519.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimals
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Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy. Pediatr Res. 2020 04; 87(5):879-884.
Wu YW, Goodman AM, Chang T, Mulkey SB, Gonzalez FF, Mayock DE, Juul SE, Mathur AM, Van Meurs K, McKinstry RC, Redline RW. PMID: 31261373.
View in: PubMed Mentions: 3 Fields:
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Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2019 06; 85(7):943-954.
Soul JS, Pressler R, Allen M, Boylan G, Rabe H, Portman R, Hardy P, Zohar S, Romero K, Tseng B, Bhatt-Mehta V, Hahn C, Denne S, Auvin S, Vinks A, Lantos J, Marlow N, Davis JM. PMID: 30584262.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2018 09; 84(3):399-402.
Cornet MC, Pasupuleti A, Fang A, Gonzalez F, Shimotake T, Ferriero DM, Glass HC, Cilio MR. PMID: 29895836.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial - Background, Aims, and Study Protocol. Neonatology. 2018; 113(4):331-338.
Juul SE, Comstock BA, Heagerty PJ, Mayock DE, Goodman AM, Hauge S, Gonzalez F, Wu YW. PMID: 29514165.
View in: PubMed Mentions: 13 Fields: Translation: HumansCTClinical Trials
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. J Vis Exp. 2017 04 21; (122).
Larpthaveesarp A, Gonzalez FF. PMID: 28518065.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016 06; 137(6).
Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA. PMID: 27244862.
View in: PubMed Mentions: 40 Fields: Translation: HumansCTClinical Trials
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Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. Neurobiol Dis. 2016 09; 93:57-63.
Larpthaveesarp A, Georgevits M, Ferriero DM, Gonzalez FF. PMID: 27142685.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Growth factors for the treatment of ischemic brain injury (growth factor treatment). Brain Sci. 2015 Apr 30; 5(2):165-77.
Larpthaveesarp A, Ferriero DM, Gonzalez FF. PMID: 25942688.
View in: PubMed Mentions:
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Erythropoietin: a novel therapy for hypoxic-ischaemic encephalopathy? Dev Med Child Neurol. 2015 Apr; 57 Suppl 3:34-9.
Wu YW, Gonzalez FF. PMID: 25800490.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimals
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Stem cells for neonatal stroke- the future is here. Front Cell Neurosci. 2014; 8:207.
van Velthoven CT, Gonzalez F, Vexler ZS, Ferriero DM. PMID: 25120432.
View in: PubMed Mentions:
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Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. Stroke. 2013 Mar; 44(3):753-8.
Gonzalez FF, Larpthaveesarp A, McQuillen P, Derugin N, Wendland M, Spadafora R, Ferriero DM. PMID: 23391775.
View in: PubMed Mentions: 39 Fields: Translation: AnimalsCells
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An overview of risk factors for poor neurodevelopmental outcome associated with prematurity. World J Pediatr. 2012 Nov; 8(4):293-300.
Xiong T, Gonzalez F, Mu DZ. PMID: 23151855.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia-ischemia. Pediatr Res. 2013 Jan; 73(1):12-7.
Fang AY, Gonzalez FF, Sheldon RA, Ferriero DM. PMID: 23085817.
View in: PubMed Mentions: 34 Fields: Translation: Animals
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Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics. 2012 Oct; 130(4):683-91.
Wu YW, Bauer LA, Ballard RA, Ferriero DM, Glidden DV, Mayock DE, Chang T, Durand DJ, Song D, Bonifacio SL, Gonzalez FF, Glass HC, Juul SE. PMID: 23008465.
View in: PubMed Mentions: 64 Fields: Translation: HumansCTClinical Trials
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Is erythropoietin the answer? Pediatr Res. 2011 Jan; 69(1):2-3.
Gonzalez FF, Fang A, Ferriero DM. PMID: 21150548.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Neonatal community-acquired pneumonia: pathogens and treatment. J Paediatr Child Health. 2010 Nov; 46(11):668-72.
Wang H, Tang J, Xiong Y, Li X, Gonzalez F, Mu D. PMID: 20796185.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. Dev Neurosci. 2010 Jul; 32(2):101-13.
Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P. PMID: 20453463.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Neuroprotection in the newborn infant. Clin Perinatol. 2009 Dec; 36(4):859-80, vii.
Gonzalez FF, Ferriero DM. PMID: 19944839.
View in: PubMed Mentions: 19 Fields: Translation: Humans
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Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev Neurosci. 2009; 31(5):403-11.
Gonzalez FF, Abel R, Almli CR, Mu D, Wendland M, Ferriero DM. PMID: 19672069.
View in: PubMed Mentions: 48 Fields: Translation: AnimalsCells
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Therapeutics for neonatal brain injury. Pharmacol Ther. 2008 Oct; 120(1):43-53.
Gonzalez FF, Ferriero DM. PMID: 18718848.
View in: PubMed Mentions: 30 Fields: Translation: Humans
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Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev Neurosci. 2007; 29(4-5):321-30.
Gonzalez FF, McQuillen P, Mu D, Chang Y, Wendland M, Vexler Z, Ferriero DM. PMID: 17762200.
View in: PubMed Mentions: 74 Fields: Translation: AnimalsCells
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Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonatal Ed. 2006 Nov; 91(6):F454-9.
Gonzalez FF, Miller SP. PMID: 17056843.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimals
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Chronic desipramine treatment desensitizes the rat to anesthetic and antinociceptive effects of the alpha2-adrenergic agonist dexmedetomidine. Anesthesiology. 1998 Jun; 88(6):1634-42.
Guo TZ, Reid K, Davies MF, Nacif-Coelho C, Rabin BC, Gonzalez F, Maze M. PMID: 9637658.
View in: PubMed Mentions: Fields: Translation: Animals
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Year | Publications |
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1998 | 1 | 2006 | 1 | 2007 | 1 | 2008 | 1 | 2009 | 2 | 2010 | 2 | 2011 | 1 | 2012 | 3 | 2013 | 1 | 2014 | 1 | 2015 | 2 | 2016 | 2 | 2017 | 1 | 2018 | 3 | 2019 | 2 | 2020 | 4 |
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