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James Frank, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address
Phone415-221-4810
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    Collapse Overview 
    Collapse Overview
    Clinical: I care for critically ill Veterans as Co-Director of the Intensive Care Unit and attending physician at the San Francisco VAMC. I see outpatients in our general pulmonary clinic and direct the Pulmonary Amyotrophic Lateral Sclerosis (ALS) Clinic, which is part of the SFVAMC Multidisciplinary ALS Team. ALS (Lou Gehrig’s Disease) is twice as common in military veterans than in the general population. Our interprofessional ALS team approaches care with a patient-centered philosophy and treats all aspects of healthcare for our Veterans with ALS. In addition to patient care, I am actively involved in ICU quality improvement, clinical education and research.

    Education: I am actively involved in undergraduate and graduate medical education at UCSF because teaching students, residents and fellows is one the best parts of my job. I am a medical student coach in the UCSF Bridges Curriculum, course director for the VA Critical Care Medicine student elective, and teach a variety of topics in small group-format courses, including ethics and point-of-care ultrasound for students, residents and fellows. I develop and coordinate the curriculum for the multidisciplinary ICU rotation for residents from medicine, surgery, anesthesia and emergency medicine. I teach clinical simulation in the ICU as part of the UCSF/SFVA Clinical Simulation Program, and I am an ACLS instructor. I am a core faculty member and member of the program evaluation committee in the UCSF Pulmonary and Critical Care Fellowship. I teach a variety of fellow-level sessions on mechanical ventilation and non-invasive ventilation. I recently developed a clinical education track within the fellowship program and I am actively involved in redesigning our assessment process for fellows. My interests include several areas of investigation within education, including patient/family communication, interprofessional communication, patient handoffs, and using clinical simulation to teach ICU care.

    Research: My laboratory studies how lung epithelial barrier function is controlled, both in health and in disease. The epithelium in the lung is at the front line protecting the inside of the body from the outside world. Problems with the barrier function of the lung epithelium are at the center of several common lung diseases. Our goal is to develop new therapies that beneficially target the regulatory pathways controlling epithelial barrier function in diseases like ARDS, ventilator-associated lung injury, asthma and lung fibrosis.


    Collapse Research 
    Collapse Research Activities and Funding
    Claudin-18 deficiency in the pathogenesis of asthma
    NIH/NHLBI R21HL111707Aug 15, 2012 - May 31, 2014
    Role: Principal Investigator
    Regulation of alveolar epithelial barrier function by claudins
    NIH/NHLBI R01HL088440Aug 1, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Regulation of alveolar barrier function by claudins
    NIH/NHLBI R56HL088440Jul 1, 2007 - Aug 31, 2014
    Role: Principal Investigator
    VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    NIH/NHLBI K08HL069900Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Elicker BM, Jones KT, Naeger DM, Frank J. Imaging of Acute Lung Injury. Radiol Clin North Am. 2016 Nov; 54(6):1119-1132. PMID: 27719979.
      View in: PubMed
    2. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank J. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2016 Apr 20. PMID: 27215490.
      View in: PubMed
    3. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. Pulmonary epithelial barrier function: some new players and mechanisms. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8):L731-45. PMID: 25637609.
      View in: PubMed
    4. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank J. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):550-8. PMID: 24787463; PMCID: PMC4189483.
    5. Hirsch J, Chalkley RJ, Bentley T, Burlingame AL, Frank J. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell. Crit Care. 2014; 18(2):R50. PMID: 24666941; PMCID: PMC4056080.
    6. Frank J, Matthay MA. TGF-ß and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6. PMID: 24449829; PMCID: PMC3903208.
    7. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank J, Chapman HA, Christensen PJ, Kim KK. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-70. PMID: 24012677; PMCID: PMC3814683.
    8. Frank J. Claudins and alveolar epithelial barrier function in the lung. Ann N Y Acad Sci. 2012 Jun; 1257:175-83. PMID: 22671604.
      View in: PubMed
    9. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank J. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. PMID: 21741940; PMCID: PMC3157178.
    10. LaFemina MJ, Rokkam D, Chandrasena A, Pan J, Bajaj A, Johnson M, Frank J. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2010 Dec; 299(6):L724-34. PMID: 20833776; PMCID: PMC3006268.
    11. Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank J. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. J Immunol. 2009 Jun 15; 182(12):8056-62. PMID: 19494331; PMCID: PMC2737530.
    12. Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank J. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L219-27. PMID: 19447895; PMCID: PMC2742793.
    13. Zier LS, Burack JH, Micco G, Chipman AK, Frank J, White DB. Surrogate decision makers' responses to physicians' predictions of medical futility. Chest. 2009 Jul; 136(1):110-7. PMID: 19318665; PMCID: PMC2716715.
    14. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank J, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. PMID: 19104148.
      View in: PubMed
    15. Briot R, Frank J, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-75. PMID: 19017890; PMCID: PMC2714162.
    16. Zier LS, Burack JH, Micco G, Chipman AK, Frank J, Luce JM, White DB. Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers. Crit Care Med. 2008 Aug; 36(8):2341-7. PMID: 18596630; PMCID: PMC2628287.
    17. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank J, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381; PMCID: PMC2442403.
    18. Ganter MT, Roux J, Miyazawa B, Howard M, Frank J, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918; PMCID: PMC2739091.
    19. Frank J, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. PMID: 17901159.
      View in: PubMed
    20. Frank J, Erle DJ. Progress toward a systems biology approach to acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L290-1. PMID: 17575007.
      View in: PubMed
    21. Hirsch J, Hansen KC, Sapru A, Frank J, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. PMID: 17363773; PMCID: PMC1899270.
    22. Frank J, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9. PMID: 17351061; PMCID: PMC2764531.
    23. Frank J, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. PMID: 17167015; PMCID: PMC2764530.
    24. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank J, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779; PMCID: PMC1899321.
    25. Frank J, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8. PMID: 16877636.
      View in: PubMed
    26. Godzich M, Hodnett M, Frank J, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. PMID: 16793871.
      View in: PubMed
    27. Frank J, Matthay MA. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 1; 172(3):261-2. PMID: 16040787; PMCID: PMC2718469.
    28. Frank J, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
      View in: PubMed
    29. McAuley DF, Frank J, Fang X, Matthay MA. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. PMID: 15241090.
      View in: PubMed
    30. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 7; 278(45):43939-50. PMID: 12930837.
      View in: PubMed
    31. Frank J, Pittet JF, Lee H, Godzich M, Matthay MA. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L791-8. PMID: 12562562.
      View in: PubMed
    32. Frank J, Matthay MA. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. PMID: 12793874; PMCID: PMC270664.
    33. Frank J, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. PMID: 11790662.
      View in: PubMed
    34. Frank J, Wang Y, Osorio O, Matthay MA. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65. PMID: 11007557.
      View in: PubMed
    35. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Clin Chest Med. 2000 Sep; 21(3):477-90. PMID: 11019721.
      View in: PubMed
    36. Frank J, Nuckton TJ, Matthay MA. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6. PMID: 10921610.
      View in: PubMed
    37. Stulbarg MS, Frank J. Obstructive pulmonary disease. The clinician's perspective. Radiol Clin North Am. 1998 Jan; 36(1):1-13. PMID: 9465865.
      View in: PubMed
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