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James Frank, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 4137
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CA2017Diversity, Equity, and Inclusion Champion Training
    American Association of Medical Colleges, (AAMC)2020Medical Education Research Certificate
    Collapse Awards and Honors
    UCSF2020 • Excellence and Innovation in Graduate Medical Education Award
    UCSF2020• Induction - Haile T. Debas Academy of Medical Educators
    UCSF School of Medicine 2020• Bridges Curriculum Foundations 1 and 2 Teaching Award: Outstanding Coach

    Collapse Overview 
    Collapse Overview
    Clinical: I care for Veterans as Co-Director of the Intensive Care Unit and attending physician at the San Francisco VAMC. I see outpatients in our general pulmonary clinic and the pulmonary amyotrophic lateral sclerosis (ALS) clinic, which is part of the SFVAMC Multidisciplinary ALS Team. I also help lead the pulmonary embolism response team and the thoracentesis service at the SFVAMC. In addition to patient care, I am actively involved in ICU quality improvement, clinical education and research.

    Education: I have a passion for undergraduate and graduate medical education at UCSF. I serve as Program Director for the UCSF Pulmonary and Critical Care Fellowship Program, and I'm actively involved in projects focused on curriculum, assessment, fellow well-being, patient communication, and improving diversity, equity and inclusion as a means to increase the excellence of our program and our specialty. In the School of Medicine, I am a medical student coach for the UCSF Bridges Curriculum, and course director for the VA Critical Care Medicine student elective. I co-direct the ICU rotation for medicine, anesthesia, surgery, neurology and emergency medicine residents at the SFVA.
    My specific interests include program/curriculum development and implementation, student and trainee well-being, teaching quality improvement and patient safety, and teaching critical care concepts, including communication skills, mechanical ventilation and point of care ultrasound.

    Research: My education research interests include patient/family communication, teaching quality improvement at the GME level, and improving trainee well-being.

    Collapse Research 
    Collapse Research Activities and Funding
    Claudin-18 deficiency in the pathogenesis of asthma
    NIH/NHLBI R21HL111707Aug 15, 2012 - May 31, 2014
    Role: Principal Investigator
    Regulation of alveolar epithelial barrier function by claudins
    NIH/NHLBI R01HL088440Aug 1, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Regulation of alveolar barrier function by claudins
    NIH/NHLBI R56HL088440Jul 1, 2007 - Aug 31, 2014
    Role: Principal Investigator
    VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    NIH/NHLBI K08HL069900Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. When to Rule Out COVID-19: How Many Negative RT-PCR Tests Are Needed? Respir Med Case Rep. 2020 Aug 18; 101192. Isikbay M, Henry TS, Frank JA, Hope MD. PMID: 32837902.
      View in: PubMed   Mentions:
    2. Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis. Ann Intern Med. 2018 07 17; 169(2):106-115. Ghasemiesfe M, Ravi D, Vali M, Korenstein D, Arjomandi M, Frank J, Austin PC, Keyhani S. PMID: 29971337.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    3. Imaging of Acute Lung Injury. Radiol Clin North Am. 2016 Nov; 54(6):1119-1132. Elicker BM, Jones KT, Naeger DM, Frank JA. PMID: 27719979.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 01; 139(1):72-81.e1. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. PMID: 27215490.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    5. Pulmonary epithelial barrier function: some new players and mechanisms. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8):L731-45. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. PMID: 25637609.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    6. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):550-8. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank JA. PMID: 24787463.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    7. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell. Crit Care. 2014 Mar 25; 18(2):R50. Hirsch J, Chalkley RJ, Bentley T, Burlingame AL, Frank JA. PMID: 24666941.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    8. TGF-ß and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6. Frank JA, Matthay MA. PMID: 24449829.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    9. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-1570. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. PMID: 24012677.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    10. Claudin-4 promotes epithelial repair and restoration of barrier function via interactions with the small GTPase Rap1. The FASEB Journal. 2013 Apr 1; 27:256.3-256.3. Katherine Sutherland, Trevor Bentley, Michael LaFemina, James Frank. .
      View in: Publisher Site   Mentions:
    11. Claudins and alveolar epithelial barrier function in the lung. Ann N Y Acad Sci. 2012 Jun; 1257:175-83. Frank JA. PMID: 22671604.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    12. Claudin-4 interacts with the small GTPase Rap1 and accelerates epithelial repair. The FASEB Journal. 2012 Apr 1; 26:698.2-698.2. Katherine Marie Sutherland, Trevor Bentley, Michael LaFemina, Gwen Ho, Jan Hirsch, James Frank. .
      View in: Publisher Site   Mentions:
    13. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA. PMID: 21741940.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    14. Claudin-4 promotes repair and barrier function in lung epithelia. The FASEB Journal. 2011 Apr 1; 25:865.6-865.6. Deepti Rokkam, Jan Hirsch, Gwen Ho, Chris Griffin, Michael J LaFemina, James A Frank. .
      View in: Publisher Site   Mentions:
    15. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2010 Dec; 299(6):L724-34. LaFemina MJ, Rokkam D, Chandrasena A, Pan J, Bajaj A, Johnson M, Frank JA. PMID: 20833776.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    16. Claudin-4 is required for EGFR-mediated alveolar epithelial migration. The FASEB Journal. 2010 Apr 1; 24:999.3-999.3. Deepti Rokkam, Gwendolyn Ho, James A. Frank. .
      View in: Publisher Site   Mentions:
    17. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. J Immunol. 2009 Jun 15; 182(12):8056-62. Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA. PMID: 19494331.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    18. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L219-27. Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank JA. PMID: 19447895.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    19. Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung. The FASEB Journal. 2009 Apr 1; 23:771.1-771.1. Jae Woo Lee, Naveen Gupta, Xiaohui Fang, James A. Frank, Raphael Briot, Michael A. Matthay. .
      View in: Publisher Site   Mentions:
    20. The Balance Evaluation Systems Test (BESTest) to differentiate balance deficits. Phys Ther. 2009 May; 89(5):484-98. Horak FB, Wrisley DM, Frank J. PMID: 19329772.
      View in: PubMed   Mentions: 108     Fields:    Translation:Humans
    21. Surrogate decision makers' responses to physicians' predictions of medical futility. Chest. 2009 Jul; 136(1):110-117. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, White DB. PMID: 19318665.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. PMID: 19104148.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    23. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. PMID: 19017890.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    24. Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers. Crit Care Med. 2008 Aug; 36(8):2341-7. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, Luce JM, White DB. PMID: 18596630.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    25. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. PMID: 18496381.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. PMID: 18276918.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    27. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. Frank JA, Pittet JF, Wray C, Matthay MA. PMID: 17901159.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    28. Progress toward a systems biology approach to acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L290-1. Frank JA, Erle DJ. PMID: 17575007.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    29. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. PMID: 17363773.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. PMID: 17351061.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    31. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. Frank JA, Parsons PE, Matthay MA. PMID: 17167015.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    32. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. PMID: 17079779.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    33. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. PMID: 16877636.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    34. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. PMID: 16793871.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    35. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 01; 172(3):261-2. Frank JA, Matthay MA. PMID: 16040787.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    36. Effect of pharmacological inhibition of chloride transport on lung fluid balance in acute Escherichia coli pneumonia in mice. Critical Care. 2005 Mar 1; 9(Suppl 1):p90. L Robriquet, Y Song, H Folkesson, J Frank, A Verkman, M Matthay. .
      View in: Publisher Site   Mentions:
    37. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. PMID: 15644667.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    38. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. McAuley DF, Frank JA, Fang X, Matthay MA. PMID: 15241090.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    39. Effect of sustained inflation recruitment maneuvers on lung endothelial and alveolar epithelial injury in experimental acute lung injury. Critical Care. 2004 Feb 1; 8(Suppl 1):p23. J Frank, D McAuley, J Gutierrez, B Daniel, L Dobbs, M Matthay. .
      View in: Publisher Site   Mentions:
    40. Altered proteomic patterns in rat alveolar epithelial type II cells after ventilation with high and low tidal volumes. Critical Care. 2004 Feb 1; 8(Suppl 1):p24. J Hirsch, K Hansen, J Frank, R Chalkley, X Fang, A Burlingame, M Matthay. .
      View in: Publisher Site   Mentions:
    41. Clinically relevant concentrations of beta agonists may stimulate alveolar fluid clearance in acute respiratory distress syndrome. Critical Care. 2004 Feb 1; 8(Suppl 1):p33. G Perkins, D McAuley, J Frank, D Thickett, X Fang, M Matthay. .
      View in: Publisher Site   Mentions:
    42. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. PMID: 12930837.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    43. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L791-8. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA. PMID: 12562562.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    44. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. Frank JA, Matthay MA. PMID: 12793874.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    45. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. PMID: 11790662.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    46. Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction. Mechanisms of Organ Dysfunction in Critical Illness. 2002 Jan 1; 38:222-226. M. A. Matthay, L. B. Ware, J. A. Frank. .
      View in: Publisher Site   Mentions:
    47. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65. Frank JA, Wang Y, Osorio O, Matthay MA. PMID: 11007557.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    48. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Clin Chest Med. 2000 Sep; 21(3):477-90. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. PMID: 11019721.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    49. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6. Frank JA, Nuckton TJ, Matthay MA. PMID: 10921610.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    50. Obstructive pulmonary disease. The clinician's perspective. Radiol Clin North Am. 1998 Jan; 36(1):1-13. Stulbarg MS, Frank JA. PMID: 9465865.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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