James Frank, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 4137
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    Collapse Biography 
    Collapse Education and Training
    University of Colorado School of MedicineM.D.
    University of California, San FranciscoInternal Medicine Residency
    University of California, San FranciscoPulmonary & Critical Care Medicine Fellowship
    University of California, San Francisco2017Diversity, Equity, and Inclusion Champion Training
    American Association of Medical Colleges (AAMC)2020Medical Education Research Certificate
    Collapse Awards and Honors
    UCSF2020 • Excellence and Innovation in Graduate Medical Education Award
    UCSF2020• Induction - Haile T. Debas Academy of Medical Educators
    UCSF School of Medicine 2020• Bridges Curriculum Foundations 1 and 2 Teaching Award: Outstanding Coach

    Collapse Overview 
    Collapse Overview
    James Frank, MD, MA is a clinician-educator and Professor of Medicine at the University of California San Francisco where he focuses on medical education across undergraduate and graduate learners. He is a medical student coach in the UCSF Bridges Curriculum and course director for the medical student critical care immersion experience at the San Francisco VA Medical Center. He is the program director for the UCSF Pulmonary and Critical Care Fellowship Program. His clinical work includes critical care medicine and serving as co-director of the ICU at the SFVA. He also helps lead the SFVA pulmonary embolism response team, thoracentesis service and Neuromuscular/Amyotrophic Lateral Sclerosis respiratory clinic. His academic interests include teaching quality improvement and communication skills, professional coaching, and curriculum development and implementation. Dr. Frank also has expertise in designing and teaching biomedical research skills and he ran a successful translational research program during his early career.

    Collapse Research 
    Collapse Research Activities and Funding
    Claudin-18 deficiency in the pathogenesis of asthma
    NIH R21HL111707Aug 15, 2012 - May 31, 2014
    Role: Principal Investigator
    Regulation of alveolar epithelial barrier function by claudins
    NIH R01HL088440Aug 1, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Regulation of alveolar barrier function by claudins
    NIH R56HL088440Jul 1, 2007 - Aug 31, 2016
    Role: Principal Investigator
    VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    NIH K08HL069900Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs. Med Educ Online. 2021 Dec; 26(1):1946237. Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM. PMID: 34187346.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices. Acad Med. 2020 Dec 08. Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM. PMID: 33298691.
      View in: PubMed   Mentions: 5     Fields:    
    3. Family Meetings on Behalf of Patients with Serious Illness. N Engl J Med. 2020 Sep 10; 383(11):e71. Widera E, Anderson WG, Santhosh L, McKee KY, Smith AK, Frank J. PMID: 32905678.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. When to rule out COVID-19: How many negative RT-PCR tests are needed? Respir Med Case Rep. 2020; 31:101192. Isikbay M, Henry TS, Frank JA, Hope MD. PMID: 32837902.
      View in: PubMed   Mentions:
    5. Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis. Ann Intern Med. 2018 07 17; 169(2):106-115. Ghasemiesfe M, Ravi D, Vali M, Korenstein D, Arjomandi M, Frank J, Austin PC, Keyhani S. PMID: 29971337.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    6. Imaging of Acute Lung Injury. Radiol Clin North Am. 2016 Nov; 54(6):1119-1132. Elicker BM, Jones KT, Naeger DM, Frank JA. PMID: 27719979.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 01; 139(1):72-81.e1. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. PMID: 27215490.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    8. Pulmonary epithelial barrier function: some new players and mechanisms. . 2015 Apr 15; 308(8):L731-45. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. PMID: 25637609.
      View in: PubMed   Mentions:
    9. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):550-8. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank JA. PMID: 24787463.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    10. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell. Crit Care. 2014 Mar 25; 18(2):R50. Hirsch J, Chalkley RJ, Bentley T, Burlingame AL, Frank JA. PMID: 24666941.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    11. TGF-β and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6. Frank JA, Matthay MA. PMID: 24449829.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    12. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-1570. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. PMID: 24012677.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    13. Claudin-4 promotes epithelial repair and restoration of barrier function via interactions with the small GTPase Rap1. The FASEB Journal. 2013 Apr 1; 27:256.3-256.3. Katherine Sutherland, Trevor Bentley, Michael LaFemina, James Frank. .
      View in: Publisher Site   Mentions:
    14. Claudins and alveolar epithelial barrier function in the lung. Ann N Y Acad Sci. 2012 Jun; 1257:175-83. Frank JA. PMID: 22671604.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    15. Claudin-4 interacts with the small GTPase Rap1 and accelerates epithelial repair. The FASEB Journal. 2012 Apr 1; 26:698.2-698.2. Katherine Marie Sutherland, Trevor Bentley, Michael LaFemina, Gwen Ho, Jan Hirsch, James Frank. .
      View in: Publisher Site   Mentions:
    16. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA. PMID: 21741940.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    17. Claudin-4 promotes repair and barrier function in lung epithelia. The FASEB Journal. 2011 Apr 1; 25:865.6-865.6. Deepti Rokkam, Jan Hirsch, Gwen Ho, Chris Griffin, Michael J LaFemina, James A Frank. .
      View in: Publisher Site   Mentions:
    18. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. . 2010 Dec; 299(6):L724-34. LaFemina MJ, Rokkam D, Chandrasena A, Pan J, Bajaj A, Johnson M, Frank JA. PMID: 20833776.
      View in: PubMed   Mentions:
    19. Claudin-4 is required for EGFR-mediated alveolar epithelial migration. The FASEB Journal. 2010 Apr 1; 24:999.3-999.3. Deepti Rokkam, Gwendolyn Ho, James A. Frank. .
      View in: Publisher Site   Mentions:
    20. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. J Immunol. 2009 Jun 15; 182(12):8056-62. Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA. PMID: 19494331.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    21. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. . 2009 Aug; 297(2):L219-27. Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank JA. PMID: 19447895.
      View in: PubMed   Mentions:
    22. Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung. The FASEB Journal. 2009 Apr 1; 23:771.1-771.1. Jae Woo Lee, Naveen Gupta, Xiaohui Fang, James A. Frank, Raphael Briot, Michael A. Matthay. .
      View in: Publisher Site   Mentions:
    23. The Balance Evaluation Systems Test (BESTest) to differentiate balance deficits. Phys Ther. 2009 May; 89(5):484-98. Horak FB, Wrisley DM, Frank J. PMID: 19329772.
      View in: PubMed   Mentions: 147     Fields:    Translation:Humans
    24. Surrogate decision makers' responses to physicians' predictions of medical futility. Chest. 2009 Jul; 136(1):110-117. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, White DB. PMID: 19318665.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    25. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. PMID: 19104148.
      View in: PubMed   Mentions: 199     Fields:    Translation:HumansAnimalsCells
    26. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. PMID: 19017890.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    27. Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers. Crit Care Med. 2008 Aug; 36(8):2341-7. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, Luce JM, White DB. PMID: 18596630.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    28. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. PMID: 18496381.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. PMID: 18276918.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    30. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. Frank JA, Pittet JF, Wray C, Matthay MA. PMID: 17901159.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    31. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. PMID: 17363773.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. . 2007 Jul; 293(1):L52-9. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. PMID: 17351061.
      View in: PubMed   Mentions:
    33. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. Frank JA, Parsons PE, Matthay MA. PMID: 17167015.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    34. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. PMID: 17079779.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    35. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. . 2006 Dec; 291(6):L1191-8. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. PMID: 16877636.
      View in: PubMed   Mentions:
    36. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. PMID: 16793871.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 01; 172(3):261-2. Frank JA, Matthay MA. PMID: 16040787.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Effect of pharmacological inhibition of chloride transport on lung fluid balance in acute Escherichia coli pneumonia in mice. Critical Care. 2005 Mar 1; 9(Suppl 1):p90. L Robriquet, Y Song, H Folkesson, J Frank, A Verkman, M Matthay. .
      View in: Publisher Site   Mentions:
    39. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. PMID: 15644667.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    40. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. McAuley DF, Frank JA, Fang X, Matthay MA. PMID: 15241090.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    41. Effect of sustained inflation recruitment maneuvers on lung endothelial and alveolar epithelial injury in experimental acute lung injury. Critical Care. 2004 Feb 1; 8(Suppl 1):p23. J Frank, D McAuley, J Gutierrez, B Daniel, L Dobbs, M Matthay. .
      View in: Publisher Site   Mentions:
    42. Altered proteomic patterns in rat alveolar epithelial type II cells after ventilation with high and low tidal volumes. Critical Care. 2004 Feb 1; 8(Suppl 1):p24. J Hirsch, K Hansen, J Frank, R Chalkley, X Fang, A Burlingame, M Matthay. .
      View in: Publisher Site   Mentions:
    43. Clinically relevant concentrations of beta agonists may stimulate alveolar fluid clearance in acute respiratory distress syndrome. Critical Care. 2004 Feb 1; 8(Suppl 1):p33. G Perkins, D McAuley, J Frank, D Thickett, X Fang, M Matthay. .
      View in: Publisher Site   Mentions:
    44. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. PMID: 12930837.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    45. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. . 2003 May; 284(5):L791-8. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA. PMID: 12562562.
      View in: PubMed   Mentions:
    46. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. Frank JA, Matthay MA. PMID: 12793874.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    47. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. PMID: 11790662.
      View in: PubMed   Mentions: 83     Fields:    Translation:Animals
    48. Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction. Mechanisms of Organ Dysfunction in Critical Illness. 2002 Jan 1; 38:222-226. M. A. Matthay, L. B. Ware, J. A. Frank. .
      View in: Publisher Site   Mentions:
    49. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65. Frank JA, Wang Y, Osorio O, Matthay MA. PMID: 11007557.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    50. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Clin Chest Med. 2000 Sep; 21(3):477-90. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. PMID: 11019721.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    51. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6. Frank JA, Nuckton TJ, Matthay MA. PMID: 10921610.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    52. Obstructive pulmonary disease. The clinician's perspective. Radiol Clin North Am. 1998 Jan; 36(1):1-13. Stulbarg MS, Frank JA. PMID: 9465865.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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