James Frank, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-221-4810 ext. 4137
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Clinical: I care for critically ill Veterans as Co-Director of the Intensive Care Unit and attending physician at the San Francisco VAMC. I also see outpatients in our general pulmonary clinic and direct the Pulmonary Amyotrophic Lateral Sclerosis (ALS) Clinic, which is part of the SFVAMC Multidisciplinary ALS Team. ALS (Lou Gehrig’s Disease) is twice as common in military veterans than in the general population. Our interprofessional ALS team approaches care with a patient-centered philosophy and manages all aspects of healthcare for our Veterans with ALS. In addition to patient care, I am actively involved in ICU quality improvement, clinical education and research.

    Education: I am actively involved in undergraduate and graduate medical education at UCSF because teaching students, residents and fellows is one the best parts of my job. I serve as Program Director for the UCSF Pulmonary and Critical Care Fellowship Program, and I'm actively involved in projects focused on our curriculum, assessment, and fellow well being. In the School of Medicine, I am a medical student coach for the UCSF Bridges Curriculum, course director for the VA Critical Care Medicine student elective, and do small group teaching on a variety of topics. One of primary interests is teaching point of care ultrasound to students, residents and fellows. I also develop and coordinate the curriculum for the multidisciplinary ICU rotation for residents from medicine, surgery, anesthesia and emergency medicine, and medical students. My interests include areas of investigation within education, including patient/family communication, interprofessional communication, patient handoffs, and using clinical simulation to teach ICU care.

    Research: My research interests include patient-ventilator interaction, bedside ultrasound in the intensive care unit, and patient/family communication. I have expertise in lung epithelial barrier function in health and in disease, particularly regulatory pathways controlling epithelial barrier function in ARDS, ventilator-associated lung injury, asthma and lung fibrosis.

    Collapse Research 
    Collapse Research Activities and Funding
    Claudin-18 deficiency in the pathogenesis of asthma
    NIH/NHLBI R21HL111707Aug 15, 2012 - May 31, 2014
    Role: Principal Investigator
    Regulation of alveolar epithelial barrier function by claudins
    NIH/NHLBI R01HL088440Aug 1, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Regulation of alveolar barrier function by claudins
    NIH/NHLBI R56HL088440Jul 1, 2007 - Aug 31, 2014
    Role: Principal Investigator
    NIH/NHLBI K08HL069900Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ghasemiesfe M, Ravi D, Vali M, Korenstein D, Arjomandi M, Frank J, Austin PC, Keyhani S. Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis. Ann Intern Med. 2018 Jul 17; 169(2):106-115. PMID: 29971337.
      View in: PubMed
    2. Elicker BM, Jones KT, Naeger DM, Frank JA. Imaging of Acute Lung Injury. Radiol Clin North Am. 2016 Nov; 54(6):1119-1132. PMID: 27719979.
      View in: PubMed
    3. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 01; 139(1):72-81.e1. PMID: 27215490.
      View in: PubMed
    4. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. Pulmonary epithelial barrier function: some new players and mechanisms. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8):L731-45. PMID: 25637609.
      View in: PubMed
    5. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank JA. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):550-8. PMID: 24787463; PMCID: PMC4189483.
    6. Hirsch J, Chalkley RJ, Bentley T, Burlingame AL, Frank JA. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell. Crit Care. 2014 Mar 25; 18(2):R50. PMID: 24666941; PMCID: PMC4056080.
    7. Frank JA, Matthay MA. TGF-ß and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6. PMID: 24449829; PMCID: PMC3903208.
    8. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-1570. PMID: 24012677; PMCID: PMC3814683.
    9. Frank JA. Claudins and alveolar epithelial barrier function in the lung. Ann N Y Acad Sci. 2012 Jun; 1257:175-83. PMID: 22671604; PMCID: PMC4864024.
    10. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. PMID: 21741940; PMCID: PMC3157178.
    11. LaFemina MJ, Rokkam D, Chandrasena A, Pan J, Bajaj A, Johnson M, Frank JA. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2010 Dec; 299(6):L724-34. PMID: 20833776; PMCID: PMC3006268.
    12. Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. J Immunol. 2009 Jun 15; 182(12):8056-62. PMID: 19494331; PMCID: PMC2737530.
    13. Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank JA. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L219-27. PMID: 19447895; PMCID: PMC2742793.
    14. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, White DB. Surrogate decision makers' responses to physicians' predictions of medical futility. Chest. 2009 Jul; 136(1):110-117. PMID: 19318665.
      View in: PubMed
    15. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. PMID: 19104148.
      View in: PubMed
    16. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. PMID: 19017890; PMCID: PMC2714162.
    17. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, Luce JM, White DB. Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers. Crit Care Med. 2008 Aug; 36(8):2341-7. PMID: 18596630.
      View in: PubMed
    18. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381; PMCID: PMC2442403.
    19. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918; PMCID: PMC2739091.
    20. Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. PMID: 17901159.
      View in: PubMed
    21. Frank JA, Erle DJ. Progress toward a systems biology approach to acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L290-1. PMID: 17575007.
      View in: PubMed
    22. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. PMID: 17363773; PMCID: PMC1899270.
    23. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9. PMID: 17351061; PMCID: PMC2764531.
    24. Frank JA, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. PMID: 17167015; PMCID: PMC2764530.
    25. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779; PMCID: PMC1899321.
    26. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8. PMID: 16877636.
      View in: PubMed
    27. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. PMID: 16793871.
      View in: PubMed
    28. Frank JA, Matthay MA. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 01; 172(3):261-2. PMID: 16040787; PMCID: PMC2718469.
    29. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
      View in: PubMed
    30. McAuley DF, Frank JA, Fang X, Matthay MA. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. PMID: 15241090.
      View in: PubMed
    31. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. PMID: 12930837.
      View in: PubMed
    32. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L791-8. PMID: 12562562.
      View in: PubMed
    33. Frank JA, Matthay MA. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. PMID: 12793874; PMCID: PMC270664.
    34. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. PMID: 11790662.
      View in: PubMed
    35. Frank JA, Wang Y, Osorio O, Matthay MA. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65. PMID: 11007557.
      View in: PubMed
    36. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Clin Chest Med. 2000 Sep; 21(3):477-90. PMID: 11019721.
      View in: PubMed
    37. Frank JA, Nuckton TJ, Matthay MA. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6. PMID: 10921610.
      View in: PubMed
    38. Stulbarg MS, Frank JA. Obstructive pulmonary disease. The clinician's perspective. Radiol Clin North Am. 1998 Jan; 36(1):1-13. PMID: 9465865.
      View in: PubMed